Prolyl isomerase Pin1: a promoter of cancer and a target for therapy

Structure and function of the human parvulins Pin1 and Par14/17

(2018) Anja Matena et al.   BIOLOGICAL CHEMISTRY

Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors

(2018) Guonan Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pin1 impairs microRNA biogenesis by mediating conformation change of XPO5 in hepatocellular carcinoma

(2018) Jiao Li et al.   CELL DEATH AND DIFFERENTIATION

Downregulation of microRNA-370 in esophageal squamous-cell carcinoma is associated with cancer progression and promotes cancer cell proliferation via upregulating PIN1

(2018) Mingzhi Chen et al.   GENE

Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellular carcinoma development

(2018) Wenchen Pu et al.   HEPATOLOGY

A novel controlled release formulation of the Pin1 inhibitor ATRA to improve liver cancer therapy by simultaneously blocking multiple cancer pathways

(2018) Dayun Yang et al.   JOURNAL OF CONTROLLED RELEASE

Primary Biliary Cholangitis in British Columbia First Nations: Clinical features and discovery of novel genetic susceptibility loci

(2018) Sirisha Asuri et al.   LIVER INTERNATIONAL

N6-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications

(2018) Yang Wang et al.   NATURE NEUROSCIENCE

Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease

(2018) Jodie Birch et al.   PHARMACOLOGY & THERAPEUTICS

Multivalent Interactions with Fbw7 and Pin1 Facilitate Recognition of c-Jun by the SCF Fbw7 Ubiquitin Ligase

(2018) Veronika Csizmok et al.   STRUCTURE

The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation

(2018) Morris Nechama et al.   Nature Communications

Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution

(2018) Mirjana Efremova et al.   Nature Communications

The prolyl isomerase Pin1 increases β-cell proliferation and enhances insulin secretion

(2017) Yusuke Nakatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hedgehog signaling drives medulloblastoma growth via CDK6

(2017) David R. Raleigh et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding

(2017) Peng Liao et al.   MOLECULAR CELL

Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1

(2017) Chen Liu et al.   Molecular Medicine Reports

Manipulating PML SUMOylation via Silencing UBC9 and RNF4 Regulates Cardiac Fibrosis

(2017) Yu Liu et al.   MOLECULAR THERAPY

Cellular senescence in gastrointestinal diseases: from pathogenesis to therapeutics

(2017) Nina Frey et al.   Nature Reviews Gastroenterology & Hepatology

The inflammatory microenvironment and microbiome in prostate cancer development

(2017) Karen S. Sfanos et al.   Nature Reviews Urology

Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4

(2017) X Hu et al.   ONCOGENE

Rhein exhibits antitumorigenic effects by interfering with the interaction between prolyl isomerase Pin1 and c-Jun

(2017) Jin Hyoung Cho et al.   ONCOLOGY REPORTS

Generation of a cell-permeable cycloheptapeptidyl inhibitor against the peptidyl–prolyl isomerase Pin1

(2017) Walaa Bedewy et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Involvement of prolyl isomerase PIN1 in the cell cycle progression and proliferation of hepatic oval cells

(2017) Prabodh Risal et al.   PATHOLOGY RESEARCH AND PRACTICE

Reduced Retinoblastoma Protein Expression Is Associated with Decreased Patient Survival in Medullary Thyroid Cancer

(2017) Anisley Valenciaga et al.   THYROID

PIN1 Modulates Huntingtin Levels and Aggregate Accumulation: An In vitro Model

(2017) Alisia Carnemolla et al.   Frontiers in Cellular Neuroscience

Loss of PBRM1 rescues VHL dependent replication stress to promote renal carcinogenesis

(2017) Judit Espana-Agusti et al.   Nature Communications

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

(2017) Elena Campaner et al.   Nature Communications

miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression

(2017) Ka-Wai Leong et al.   Oncotarget

Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1

(2016) Yuan-Chin Lee et al.   APOPTOSIS

Sensitizing effect of juglone is mediated by down regulation of Notch1 signaling pathway in trastuzumab-resistant SKBR3 cells

(2016) Soraya Sajadimajd et al.   APOPTOSIS

Critical role of XBP1 in cancer signalling is regulated by PIN1

(2016) U. Chae et al.   BIOCHEMICAL JOURNAL

Synthesis and Pin1 inhibitory activity of thiazole derivatives

(2016) Hailong Zhao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ligand stimulation of CD95 induces activation of Plk3 followed by phosphorylation of caspase-8

(2016) Christina Helmke et al.   CELL RESEARCH

The DNA damage-induced cell death response: a roadmap to kill cancer cells

(2016) Sonja Matt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pin1 modulates chemo-resistance by up-regulating FoxM1 and the involvements of Wnt/β-catenin signaling pathway in cervical cancer

(2016) Tao Wang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis

(2016) Xinjian Li et al.   MOLECULAR CELL

Cancer Metabolism: Fueling More than Just Growth

(2016) Namgyu Lee et al.   MOLECULES AND CELLS

Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression

(2016) G Franciosa et al.   ONCOGENE

PIN1 in hepatocellular carcinoma is associated with TP53 gene status

(2016) Jun Sang Bae et al.   ONCOLOGY REPORTS

Mint3 potentiates TLR3/4- and RIG-I–induced IFN-β expression and antiviral immune responses

(2016) Wanwan Huai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Understanding the role of PIN1 in hepatocellular carcinoma

(2016) Chi-Wai Cheng et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc

(2016) Luana D’Artista et al.   Oncotarget

In vivo genetic dissection of tumor growth and the Warburg effect

(2016) Cheng-Wei Wang et al.   eLife

Pin1-Targeted Therapy for Systemic Lupus Erythematosus

(2016) Shuo Wei et al.   Arthritis & Rheumatology

Determinants of eosinophil survival and apoptotic cell death

(2015) Zhong-Jian Shen et al.   APOPTOSIS

The role of Pin1 protein in aging of human tendon stem/progenitor cells

(2015) Lei Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity

(2015) John S Del Rosario et al.   BMC NEUROSCIENCE

Pin1 facilitates NF-κB activation and promotes tumour progression in human hepatocellular carcinoma

(2015) Kimio Shinoda et al.   BRITISH JOURNAL OF CANCER

Translational control of PML contributes to TNFα-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs

(2015) K-S Hsu et al.   CELL DEATH AND DIFFERENTIATION

Bach1 Represses Wnt/β-Catenin Signaling and AngiogenesisNovelty and Significance

(2015) Li Jiang et al.   CIRCULATION RESEARCH

Pin1 promotes prostate cancer cell proliferation and migration through activation of Wnt/β-catenin signaling

(2015) Z. Zhu et al.   Clinical & Translational Oncology

Landscape of Pin1 in the cell cycle

(2015) Cheng-Han Lin et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Peptidylprolyl Isomerase Pin1 Directly Enhances the DNA Binding Functions of Estrogen Receptor α

(2015) Prashant Rajbhandari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1

(2015) Benjamin A. Hilton et al.   MOLECULAR CELL

Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis

(2015) Ariele Viacava Follis et al.   MOLECULAR CELL

Human Chromosome Segregation Involves Multi-Layered Regulation of Separase by the Peptidyl-Prolyl-Isomerase Pin1

(2015) Susanne Hellmuth et al.   MOLECULAR CELL

Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation

(2015) J. Marsolier et al.   NATURE

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

(2015) Shuo Wei et al.   NATURE MEDICINE

Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease

(2015) Chun-Hau Chen et al.   NEUROBIOLOGY OF DISEASE

Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling

(2015) F Kruiswijk et al.   ONCOGENE

Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity

(2015) Sara Helander et al.   STRUCTURE

Nutrient deprivation-related OXPHOS/glycolysis interconversion via HIF-1α/C-MYC pathway in U251 cells

(2015) Zhongjian Liu et al.   TUMOR BIOLOGY

MicroRNA-296-5p (miR-296-5p) functions as a tumor suppressor in prostate cancer by directly targeting Pin1

(2014) Kuen-Haur Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Diallyl trisulfide inhibits estrogen receptor-α activity in human breast cancer cells

(2014) Eun-Ryeong Hahm et al.   BREAST CANCER RESEARCH AND TREATMENT

SCP Phosphatases Suppress Renal Cell Carcinoma by Stabilizing PML and Inhibiting mTOR/HIF Signaling

(2014) Y.-C. Lin et al.   CANCER RESEARCH

Interleukin-22 promotes epithelial cell transformation and breast tumorigenesis via MAP3K8 activation

(2014) K. Kim et al.   CARCINOGENESIS

Prolyl isomerase Pin1 in cancer

(2014) Zhimin Lu et al.   CELL RESEARCH

HPV16 E2 enhances the expression of NF-κB and STAT3 target genes and potentiates NF-κB activation by inflammatory mediators

(2014) Devan Prabhavathy et al.   CELLULAR IMMUNOLOGY

The prolyl isomerase Pin1 regulates hypoxia-inducible transcription factor (HIF) activity

(2014) Maroua Jalouli et al.   CELLULAR SIGNALLING

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

(2014) Francesco Paneni et al.   EUROPEAN HEART JOURNAL

Novel Regulation of CD80/CD86-induced Phosphatidylinositol 3-Kinase Signaling by NOTCH1 Protein in Interleukin-6 and Indoleamine 2,3-Dioxygenase Production by Dendritic Cells

(2014) Chandana Koorella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIN1 Inhibition Suppresses Osteoclast Differentiation and Inflammatory Responses

(2014) Y.-A. Cho et al.   JOURNAL OF DENTAL RESEARCH

Pin1 induction in the fibrotic liver and its roles in TGF-β1 expression and Smad2/3 phosphorylation

(2014) Jin Won Yang et al.   JOURNAL OF HEPATOLOGY

Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal

(2014) M. Kanatsu-Shinohara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implication of PMLIV in Both Intrinsic and Innate Immunity

(2014) Faten El Asmi et al.   PLoS Pathogens

ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair

(2014) Tilman Polonio-Vallon et al.   Frontiers in Oncology

PIN1 Inhibits Apoptosis in Hepatocellular Carcinoma through Modulation of the Antiapoptotic Function of Survivin

(2013) Chi-Wai Cheng et al.   AMERICAN JOURNAL OF PATHOLOGY

Destabilization of KLF10, a tumor suppressor, relies on thr93 phosphorylation and isomerase association

(2013) Yu-Chyi Hwang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inflammation Amplifier, a New Paradigm in Cancer Biology

(2013) T. Atsumi et al.   CANCER RESEARCH

SENP1 deSUMOylates and Regulates Pin1 Protein Activity and Cellular Function

(2013) Chun-Hau Chen et al.   CANCER RESEARCH

Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast

(2013) Alessandra Rustighi et al.   EMBO Molecular Medicine

Prolyl isomerase Pin1 negatively regulates the stability of SUV39H1 to promote tumorigenesis in breast cancer

(2013) Prem Khanal et al.   FASEB JOURNAL

Differential Regulation of Cellular Senescence and Differentiation by Prolyl Isomerase Pin1 in Cardiac Progenitor Cells

(2013) Haruhiro Toko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the MicroRNA 200b (miRNA-200b) by Transcriptional Regulators PEA3 and ELK-1 Protein Affects Expression of Pin1 Protein to Control Anoikis

(2013) Xusen Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitotic Regulation of SEPT9 Protein by Cyclin-dependent Kinase 1 (Cdk1) and Pin1 Protein Is Important for the Completion of Cytokinesis

(2013) Mathew P. Estey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex

(2013) Y.-C. Lee et al.   JOURNAL OF CELL SCIENCE

Pin1-FADD Interactions Regulate Fas-Mediated Apoptosis in Activated Eosinophils

(2013) J. Oh et al.   JOURNAL OF IMMUNOLOGY

Prolyl Isomerase PIN1 Regulates DNA Double-Strand Break Repair by Counteracting DNA End Resection

(2013) Martin Steger et al.   MOLECULAR CELL

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Pin1 promotes GR transactivation by enhancing recruitment to target genes

(2013) T. M. Poolman et al.   NUCLEIC ACIDS RESEARCH

Pin1 modulates ERα levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation

(2013) P Rajbhandari et al.   ONCOGENE

Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death

(2013) N. Bitomsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sweeten PAMPs: role of sugar complexed PAMPs in innate immunity and vaccine biology

(2013) Ranjeet Singh Mahla   Frontiers in Immunology

Controlling DNA-end resection: a new task for CDKs

(2013) Lorenza P. Ferretti et al.   Frontiers in Genetics

Dual function of Pin1 in NR4A nuclear receptor activation: Enhanced activity of NR4As and increased Nur77 protein stability

(2012) Claudia M. van Tiel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates

(2012) M. Kwissa et al.   BLOOD

Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1

(2012) F Rizzolio et al.   CELL DEATH AND DIFFERENTIATION

The prolyl-isomerase Pin1 activates the mitochondrial death program of p53

(2012) G Sorrentino et al.   CELL DEATH AND DIFFERENTIATION

Amurensin G inhibits angiogenesis and tumor growth of tamoxifen-resistant breast cancer via Pin1 inhibition

(2012) Jung-Ae Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Role of Pin1 Protein in the Pathogenesis of Nonalcoholic Steatohepatitis in a Rodent Model

(2012) Yusuke Nakatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pin1 Protein Regulates Smad Protein Signaling and Pulmonary Fibrosis

(2012) Zhong-Jian Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TLR7/8 Agonist CL097 Primes N -Formyl-Methionyl-Leucyl-Phenylalanine–Stimulated NADPH Oxidase Activation in Human Neutrophils: Critical Role of p47phox Phosphorylation and the Proline Isomerase Pin1

(2012) Karama Makni-Maalej et al.   JOURNAL OF IMMUNOLOGY

TPA-induced cell transformation provokes a complex formation between Pin1 and 90 kDa ribosomal protein S6 kinase 2

(2012) Young Sik Cho et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Negative Regulation of the Stability and Tumor Suppressor Function of Fbw7 by the Pin1 Prolyl Isomerase

(2012) Sang-Hyun Min et al.   MOLECULAR CELL

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

Prolyl isomerase Pin1 downregulates tumor suppressor RUNX3 in breast cancer

(2012) Y-H Nicole Tsang et al.   ONCOGENE

FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-κB signaling

(2012) J Wang et al.   ONCOGENE

Indoleamine 2,3 dioxygenase and metabolic control of immune responses

(2012) David H. Munn et al.   TRENDS IN IMMUNOLOGY

A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression

(2011) Wei-Chien Yuan et al.   CANCER CELL

A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

(2011) Javier E. Girardini et al.   CANCER CELL

Epigallocatechin-gallate Suppresses Tumorigenesis by Directly Targeting Pin1

(2011) D. V. Urusova et al.   Cancer Prevention Research

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size

(2011) Yanyun Gu et al.   DIABETES

A Smad action turnover switch operated by WW domain readers of a phosphoserine code

(2011) E. Aragon et al.   GENES & DEVELOPMENT

Mitogen-activated Protein Kinase Extracellular Signal-regulated Kinase 2 Phosphorylates and Promotes Pin1 Protein-dependent Promyelocytic Leukemia Protein Turnover

(2011) Jun Hee Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Estrogen Receptor   N-Terminus Conformation and Function by Peptidyl Prolyl Isomerase Pin1

(2011) P. Rajbhandari et al.   MOLECULAR AND CELLULAR BIOLOGY

Ras-Induced and Extracellular Signal-Regulated Kinase 1 and 2 Phosphorylation-Dependent Isomerization of Protein Tyrosine Phosphatase (PTP)-PEST by PIN1 Promotes FAK Dephosphorylation by PTP-PEST

(2011) Y. Zheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

(2011) Taro Hitosugi et al.   MOLECULAR CELL

Death-Associated Protein Kinase 1 Phosphorylates Pin1 and Inhibits Its Prolyl Isomerase Activity and Cellular Function

(2011) Tae Ho Lee et al.   MOLECULAR CELL

PI3-Kinase/p38 kinase-dependent E2F1 activation is critical for pin1 induction in tamoxifen-resistant breast cancer cells

(2011) Kwang Youl Lee et al.   MOLECULES AND CELLS

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

(2011) Weiwei Yang et al.   NATURE

Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon–mediated immunity

(2011) Adrian Tun-Kyi et al.   NATURE IMMUNOLOGY

Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells

(2011) P Khanal et al.   ONCOGENE

RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor α

(2011) B Huang et al.   ONCOGENE

Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis

(2011) H-Z Chen et al.   ONCOGENE

BTG2 antagonizes Pin1 in response to mitogens and telomere disruption during replicative senescence

(2010) Keith Wheaton et al.   AGING CELL

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

Structure-based design of novel human Pin1 inhibitors (II)

(2010) Liming Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The prolyl isomerase Pin1 acts as a novel molecular switch for TNF- -induced priming of the NADPH oxidase in human neutrophils

(2010) T. Boussetta et al.   BLOOD

Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells

(2010) Soo Jin Oh et al.   FOOD AND CHEMICAL TOXICOLOGY

The Prolyl Isomerase Pin1 Induces LC-3 Expression and Mediates Tamoxifen Resistance in Breast Cancer

(2010) Gwang Mo Namgoong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Permeable Cyclic Peptidyl Inhibitors against Human Peptidylprolyl Isomerase Pin1

(2010) Tao Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pin1 acts as a modulator of cell proliferation through alteration in NF-κB but not β-catenin/TCF4 signalling in a subset of endometrial carcinoma cells

(2010) Makoto Saegusa et al.   JOURNAL OF PATHOLOGY

Elevated PIN1 expression by C/EBPα-p30 blocks C/EBPα-induced granulocytic differentiation through c-Jun in AML

(2010) J A Pulikkan et al.   LEUKEMIA

Structure-based design of novel human Pin1 inhibitors (I)

(2009) Chuangxing Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-guided design of α-amino acid-derived Pin1 inhibitors

(2009) Andrew J. Potter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of the Peptidyl-Prolyl-Isomerase Pin1 Enhances the Responses of Acute Myeloid Leukemia Cells to Retinoic Acid via Stabilization of RAR  and PML-RAR 

(2009) M. Gianni' et al.   CANCER RESEARCH

Peptidyl-Prolyl Isomerase Pin1 Markedly Enhances the Oncogenic Activity of the Rel Proteins in the Nuclear Factor- B Family

(2009) G. Fan et al.   CANCER RESEARCH

The Peptidyl-Prolyl Isomerase Pin1 Regulates Cytokinesis through Cep55

(2009) A. van der Horst et al.   CANCER RESEARCH

Mutant p53 Drives Invasion by Promoting Integrin Recycling

(2009) Patricia A.J. Muller et al.   CELL

Pin1 Down-regulates Transforming Growth Factor-β (TGF-β) Signaling by Inducing Degradation of Smad Proteins

(2009) Ayako Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pin1 Promotes Transforming Growth Factor-β-induced Migration and Invasion

(2009) Isao Matsuura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Role of Pin1 Induction in Type II Collagen-Mediated Rheumatoid Arthritis

(2009) H. G. Jeong et al.   JOURNAL OF IMMUNOLOGY

TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response

(2009) K. Yang et al.   JOURNAL OF IMMUNOLOGY

Enhancement of vascular endothelial growth factor-mediated angiogenesis in tamoxifen-resistant breast cancer cells: role of Pin1 overexpression

(2009) M. R. Kim et al.   MOLECULAR CANCER THERAPEUTICS

FAK Phosphorylation by ERK Primes Ras-Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST

(2009) Yanhua Zheng et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

(2009) Alessandra Rustighi et al.   NATURE CELL BIOLOGY

The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation

(2009) Zhong-Jian Shen et al.   NATURE IMMUNOLOGY

The prolyl isomerase Pin1 regulates the NF-κB signaling pathway and interleukin-8 expression in glioblastoma

(2009) G P Atkinson et al.   ONCOGENE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Down-regulation of Myeloid Cell Leukemia-1 through Inhibiting Erk/Pin 1 Pathway by Sorafenib Facilitates Chemosensitization in Breast Cancer

(2008) Q. Ding et al.   CANCER RESEARCH

TGFβ in Cancer

(2008) Joan Massagué   CELL

Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT

(2008) Kristopher J. Stanya et al.   JOURNAL OF CELL BIOLOGY

Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance

(2008) Tae Ho Lee et al.   NATURE CELL BIOLOGY