Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellular carcinoma development

A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

(2017) Elena Campaner et al.   Nature Communications

Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways

(2017) Xin-Hua Liao et al.   Scientific Reports

Let-7 inhibits self-renewal of hepatocellular cancer stem-like cells through regulating the epithelial-mesenchymal transition and the Wnt signaling pathway

(2016) Bin Jin et al.   BMC CANCER

ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5

(2016) Hui-Lung Sun et al.   CANCER CELL

All trans-retinoic acid analogs promote cancer cell apoptosis through non-genomic Crabp1 mediating ERK1/2 phosphorylation

(2016) Shawna D. Persaud et al.   Scientific Reports

Impairment of the Pin1/E2F1 axis in the anti-proliferative effect of bortezomib in hepatocellular carcinoma cells

(2015) Rossella Farra et al.   BIOCHIMIE

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

(2015) Shuo Wei et al.   NATURE MEDICINE

Advances in targeted therapies for hepatocellular carcinoma in the genomic era

(2015) Josep M. Llovet et al.   Nature Reviews Clinical Oncology

Dysregulation of microRNA biogenesis and gene silencing in cancer

(2015) Akiko Hata et al.   Science Signaling

MicroRNA-29B (mir-29b) regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3

(2015) Yue Teng et al.   Oncotarget

Dysregulation of microRNA biogenesis and gene silencing in cancer

(2015) Akiko Hata et al.   Science Signaling

EASL–EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma

(2015) et al.   JOURNAL OF HEPATOLOGY

Pin1 inhibitors: Pitfalls, progress and cellular pharmacology

(2013) Jonathan D. Moore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: Role of E2F1 and transcription factor dimerization partner 2

(2013) Bo Wang et al.   HEPATOLOGY

Cationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor

(2013) Shu-hao Hsu et al.   Nanomedicine-Nanotechnology Biology and Medicine

MicroRNAs and other non-coding RNAs as targets for anticancer drug development

(2013) Hui Ling et al.   NATURE REVIEWS DRUG DISCOVERY

Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver

(2012) Shu-hao Hsu et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis

(2012) Wei-Chih Tsai et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

Medical therapies for hepatocellular carcinoma: a critical view of the evidence

(2012) Augusto Villanueva et al.   Nature Reviews Gastroenterology & Hepatology

Overexpression of microRNA-29b induces apoptosis of multiple myeloma cells through down regulating Mcl-1

(2011) Yi-Kun Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epigallocatechin-gallate Suppresses Tumorigenesis by Directly Targeting Pin1

(2011) D. V. Urusova et al.   Cancer Prevention Research

MicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a

(2011) Sara Toffanin et al.   GASTROENTEROLOGY

Sequential alterations of microrna expression in hepatocellular carcinoma development and venous metastasis

(2011) Chun-Ming Wong et al.   HEPATOLOGY

Evaluation of Pharmacokinetic, Biodistribution, Pharmacodynamic, and Toxicity Profile of Free Juglone and Its Sterically Stabilized Liposomes

(2011) B. Kiran Aithal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

(2010) Andrew Potter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-based design of novel human Pin1 inhibitors (II)

(2010) Liming Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

MicroRNA control of signal transduction

(2010) Masafumi Inui et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structure-based design of novel human Pin1 inhibitors (I)

(2009) Chuangxing Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

Multimodal approaches to the treatment of hepatocellular carcinoma

(2009) Giuseppe Cabibbo et al.   Nature Reviews Gastroenterology & Hepatology

Causes and consequences of microRNA dysregulation in cancer

(2009) Carlo M. Croce   NATURE REVIEWS GENETICS

Juglone Inactivates Cysteine-rich Proteins Required for Progression through Mitosis

(2008) Claudia Fila et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sorafenib in advanced hepatocellular carcinoma – We have won a battle not the war

(2008) Peter R. Galle   JOURNAL OF HEPATOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE