Translational control of PML contributes to TNFα-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs

First Mnks degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines

(2015) Senthilmurugan Ramalingam et al.   Oncotarget

TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and future

(2014) Lisa M. Sedger et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2α

(2014) Bo-Jhih Guan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitogen-Activated Protein Kinase-Interacting Kinase Regulates mTOR/AKT Signaling and Controls the Serine/Arginine-Rich Protein Kinase-Responsive Type 1 Internal Ribosome Entry Site-Mediated Translation and Viral Oncolysis

(2014) M. C. Brown et al.   JOURNAL OF VIROLOGY

Induction of Viral, 7-Methyl-Guanosine Cap-Independent Translation and Oncolysis by Mitogen-Activated Protein Kinase-Interacting Kinase-Mediated Effects on the Serine/Arginine-Rich Protein Kinase

(2014) M. C. Brown et al.   JOURNAL OF VIROLOGY

β-Transducin Repeat-containing Protein 1 (β-TrCP1)-mediated Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptor (SMRT) Protein Degradation Promotes Tumor Necrosis Factor α (TNFα)-induced Inflammatory Gene Expression

(2013) Kuo-Sheng Hsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function

(2013) S. Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-translational modifications of PML: consequences and implications

(2013) Xiwen Cheng et al.   Frontiers in Oncology

Microarray analysis revealing common and distinct functions of promyelocytic leukemia protein (PML) and tumor necrosis factor alpha (TNFα) signaling in endothelial cells

(2012) Xiwen Cheng et al.   BMC GENOMICS

Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS-induced cellular senescence

(2012) Pier Paolo Scaglioni et al.   EMBO Molecular Medicine

A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics

(2012) Ellen Van Damme et al.   International Journal of Biological Sciences

Promyelocytic Leukemia Protein (PML) Regulates Endothelial Cell Network Formation and Migration in Response to Tumor Necrosis Factor α (TNFα) and Interferon α (IFNα)

(2012) Xiwen Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells

(2012) Y Shi et al.   ONCOGENE

So you want to know if your message has an IRES?

(2012) Sunnie R. Thompson   Wiley Interdisciplinary Reviews-RNA

Protein Phosphatase 2A Promotes Endothelial Survival via Stabilization of Translational Inhibitor 4E-BP1 Following Exposure to Tumor Necrosis Factor-α

(2011) Carla Janzen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey

(2011) B. B. Aggarwal et al.   BLOOD

A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression

(2011) Wei-Chien Yuan et al.   CANCER CELL

Cellular IRES-mediated translation

(2011) Anton A Komar et al.   CELL CYCLE

The Mechanism of Insulin-stimulated 4E-BP Protein Binding to Mammalian Target of Rapamycin (mTOR) Complex 1 and Its Contribution to mTOR Complex 1 Signaling

(2011) Joseph Rapley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Requirement of rRNA Methylation for 80S Ribosome Assembly on a Cohort of Cellular Internal Ribosome Entry Sites

(2011) A. Basu et al.   MOLECULAR AND CELLULAR BIOLOGY

The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival

(2010) Matthew J. Wheater et al.   CANCER BIOLOGY & THERAPY

PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3

(2010) Marion Jeanne et al.   CANCER CELL

PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release

(2010) C. Giorgi et al.   SCIENCE

PML Nuclear Bodies

(2010) V. Lallemand-Breitenbach et al.   Cold Spring Harbor Perspectives in Biology

Role of MCP-1 in tumor necrosis factor-α-induced endothelial dysfunction in type 2 diabetic mice

(2009) Jiyeon Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-α via the p38 mitogen-activated protein kinase pathway

(2009) Yanmin Zhang et al.   FASEB JOURNAL

An internal ribosomal entry site mediates redox-sensitive translation of Nrf2

(2009) Wenge Li et al.   NUCLEIC ACIDS RESEARCH

Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses

(2009) S. Joshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-mediated Selective mRNA Translation by an Internal Ribosome Entry Site-independent Mechanism

(2008) Regina M. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Arsenic Trioxide-induced Cellular Responses by Mnk1 and Mnk2

(2008) Blazej Dolniak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase 7 Promotes PML Sumoylation and Is Essential for PML Nuclear Body Formation

(2008) C. Gao et al.   MOLECULAR AND CELLULAR BIOLOGY

Signal-dependent Regulation of Transcription by Histone Deacetylase 7 Involves Recruitment to Promyelocytic Leukemia Protein Nuclear Bodies

(2008) Chengzhuo Gao et al.   MOLECULAR BIOLOGY OF THE CELL

PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop

(2008) Eleonora Lapi et al.   MOLECULAR CELL