A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action

Glucocorticoid receptor signalling activates YAP in breast cancer

(2017) Giovanni Sorrentino et al.   Nature Communications

PIN1 in breast development and cancer: a clinical perspective

(2016) Alessandra Rustighi et al.   CELL DEATH AND DIFFERENTIATION

Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer

(2016) Dawid Walerych et al.   NATURE CELL BIOLOGY

Prolyl isomerases in gene transcription

(2015) Steven D. Hanes   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

(2015) Edward Harder et al.   Journal of Chemical Theory and Computation

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

(2015) Shuo Wei et al.   NATURE MEDICINE

Emerging strategies to effectively target autophagy in cancer

(2015) V W Rebecca et al.   ONCOGENE

Prodrug Applications for Targeted Cancer Therapy

(2014) Irene Giang et al.   AAPS Journal

Prolyl Isomerase Pin1 Acts Downstream of miR200c to Promote Cancer Stem-like Cell Traits in Breast Cancer

(2014) M.-L. Luo et al.   CANCER RESEARCH

Prolyl isomerase Pin1 in cancer

(2014) Zhimin Lu et al.   CELL RESEARCH

Structure-Based Virtual Screening Approach for Discovery of Covalently Bound Ligands

(2014) Dora Toledo Warshaviak et al.   Journal of Chemical Information and Modeling

Pin1 inhibitors: Pitfalls, progress and cellular pharmacology

(2013) Jonathan D. Moore et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Prolyl-isomerase Pin1 controls normal and cancer stem cells of the breast

(2013) Alessandra Rustighi et al.   EMBO Molecular Medicine

Identification of DNMT1 Selective Antagonists Using a Novel Scintillation Proximity Assay

(2013) Jessica A. Kilgore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pin1 Regulates the Dynamics of c-Myc DNA Binding To Facilitate Target Gene Regulation and Oncogenesis

(2013) A. S. Farrell et al.   MOLECULAR AND CELLULAR BIOLOGY

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

(2012) Wenjun Guo et al.   CELL

Inhibitor Mediated Protein Degradation

(2012) Marcus J.C. Long et al.   CHEMISTRY & BIOLOGY

DNA damage by reactive species: Mechanisms, mutation and repair

(2012) N R Jena   JOURNAL OF BIOSCIENCES

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

(2011) Javier E. Girardini et al.   CANCER CELL

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Pin1 Deficiency Causes Endothelial Dysfunction and Hypertension

(2011) Valorie L. Chiasson et al.   HYPERTENSION

Cell death assays for drug discovery

(2011) Oliver Kepp et al.   NATURE REVIEWS DRUG DISCOVERY

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis

(2011) H-Z Chen et al.   ONCOGENE

Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins

(2011) Yih-Cherng Liou et al.   TRENDS IN BIOCHEMICAL SCIENCES

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

(2010) Andrew Potter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The prolyl isomerase Pin1 acts as a novel molecular switch for TNF- -induced priming of the NADPH oxidase in human neutrophils

(2010) T. Boussetta et al.   BLOOD

Guidelines for the welfare and use of animals in cancer research

(2010) P Workman et al.   BRITISH JOURNAL OF CANCER

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

(2009) Alessandra Rustighi et al.   NATURE CELL BIOLOGY

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

(2009) Dunyaporn Trachootham et al.   NATURE REVIEWS DRUG DISCOVERY

Pinning down HER2–ER crosstalk in SMRT regulation

(2009) Akihide Ryo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Down-regulation of Myeloid Cell Leukemia-1 through Inhibiting Erk/Pin 1 Pathway by Sorafenib Facilitates Chemosensitization in Breast Cancer

(2008) Q. Ding et al.   CANCER RESEARCH

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Juglone Inactivates Cysteine-rich Proteins Required for Progression through Mitosis

(2008) Claudia Fila et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability

(2008) Prudence B Lam et al.   Molecular Cancer

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS