ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair

HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation

(2013) Francesca Siepi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Src kinase modulates the apoptotic p53 pathway by altering HIPK2 localization

(2013) Timan Polonio-Vallon et al.   CELL CYCLE

Prolyl isomerization: A new PIN code for DSB repair

(2013) Alessandro A Sartori et al.   CELL CYCLE

Prolyl Isomerase PIN1 Regulates DNA Double-Strand Break Repair by Counteracting DNA End Resection

(2013) Martin Steger et al.   MOLECULAR CELL

Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death

(2013) N. Bitomsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis

(2012) Thomas G. Hofmann et al.   BIOESSAYS

The prolyl-isomerase Pin1 activates the mitochondrial death program of p53

(2012) G Sorrentino et al.   CELL DEATH AND DIFFERENTIATION

CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation

(2012) Arne Nedergaard Kousholt et al.   JOURNAL OF CELL BIOLOGY

HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop

(2012) Vera V. Saul et al.   Journal of Molecular Cell Biology

A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer

(2011) Javier E. Girardini et al.   CANCER CELL

Prolyl cis/trans isomerase signalling pathways in cancer

(2011) Martin Theuerkorn et al.   CURRENT OPINION IN PHARMACOLOGY

Peptidyl-prolyl cis–trans isomerase Pin1 in ageing, cancer and Alzheimer disease

(2011) Tae Ho Lee et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

(2011) J-H Mao et al.   ONCOGENE

Cutaneous HPV23 E6 Prevents p53 Phosphorylation through Interaction with HIPK2

(2011) Dorothea Muschik et al.   PLoS One

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin

(2011) A. Grison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins

(2011) Yih-Cherng Liou et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hyper telomere recombination accelerates replicative senescence and may promote premature aging

(2010) R. T. Hagelstrom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilization of HIPK2 by escape from proteasomal degradation mediated by the E3 ubiquitin ligase Siah1

(2009) Se-Yong Kim et al.   CANCER LETTERS

Pin1 as an anticancer drug target

(2009) G.G. Xu et al.   DRUG NEWS & PERSPECTIVES

CtIP Links DNA Double-Strand Break Sensing to Resection

(2009) Zhongsheng You et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Mutant p53 Gain-of-Function in Cancer

(2009) M. Oren et al.   Cold Spring Harbor Perspectives in Biology

DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates

(2008) Jennifer Illuzzi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance

(2008) Tae Ho Lee et al.   NATURE CELL BIOLOGY

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR

(2008) Melanie Winter et al.   NATURE CELL BIOLOGY

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY