Understanding the role of PIN1 in hepatocellular carcinoma

Prolyl isomerase Pin1 promotes survival in EGFR-mutant lung adenocarcinoma cells with an epithelial–mesenchymal transition phenotype

(2016) Yuji Sakuma et al.   LABORATORY INVESTIGATION

Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α

(2016) Hyeong-jun Han et al.   PLoS One

Impairment of the Pin1/E2F1 axis in the anti-proliferative effect of bortezomib in hepatocellular carcinoma cells

(2015) Rossella Farra et al.   BIOCHIMIE

Pin1 facilitates NF-κB activation and promotes tumour progression in human hepatocellular carcinoma

(2015) Kimio Shinoda et al.   BRITISH JOURNAL OF CANCER

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

(2015) Shuo Wei et al.   NATURE MEDICINE

Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage

(2015) Y Tong et al.   Cell Death & Disease

MicroRNA-296-5p (miR-296-5p) functions as a tumor suppressor in prostate cancer by directly targeting Pin1

(2014) Kuen-Haur Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Prolyl Isomerase Pin1 Acts Downstream of miR200c to Promote Cancer Stem-like Cell Traits in Breast Cancer

(2014) M.-L. Luo et al.   CANCER RESEARCH

The prolyl isomerase Pin1 regulates hypoxia-inducible transcription factor (HIF) activity

(2014) Maroua Jalouli et al.   CELLULAR SIGNALLING

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Expression and significance of Pin1, β-catenin and cyclin D1 in hepatocellular carcinoma

(2014) RAN AO et al.   Molecular Medicine Reports

PIN1 Inhibits Apoptosis in Hepatocellular Carcinoma through Modulation of the Antiapoptotic Function of Survivin

(2013) Chi-Wai Cheng et al.   AMERICAN JOURNAL OF PATHOLOGY

MicroRNAs in Cancer

(2013) Gianpiero Di Leva et al.   Annual Review of Pathology-Mechanisms of Disease

SENP1 deSUMOylates and Regulates Pin1 Protein Activity and Cellular Function

(2013) Chun-Hau Chen et al.   CANCER RESEARCH

Regulation of the MicroRNA 200b (miRNA-200b) by Transcriptional Regulators PEA3 and ELK-1 Protein Affects Expression of Pin1 Protein to Control Anoikis

(2013) Xusen Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex

(2013) Y.-C. Lee et al.   JOURNAL OF CELL SCIENCE

First microRNA mimic enters clinic

(2013) Aaron Bouchie   NATURE BIOTECHNOLOGY

The Enhanced Metastatic Potential of Hepatocellular Carcinoma (HCC) Cells with Sorafenib Resistance

(2013) Ariel Ka-Man Chow et al.   PLoS One

Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1

(2012) F Rizzolio et al.   CELL DEATH AND DIFFERENTIATION

FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-κB signaling

(2012) J Wang et al.   ONCOGENE

Mixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular function

(2012) V. Rangasamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential alterations of microrna expression in hepatocellular carcinoma development and venous metastasis

(2011) Chun-Ming Wong et al.   HEPATOLOGY

Death-Associated Protein Kinase 1 Phosphorylates Pin1 and Inhibits Its Prolyl Isomerase Activity and Cellular Function

(2011) Tae Ho Lee et al.   MOLECULAR CELL

Inhibition of gamma-secretase affects proliferation of leukemia and hepatoma cell lines through Notch signaling

(2010) Saipin Suwanjunee et al.   ANTI-CANCER DRUGS

An international, multicenter phase II trial of bortezomib in patients with hepatocellular carcinoma

(2010) George P. Kim et al.   INVESTIGATIONAL NEW DRUGS

Dipentamethylene thiuram monosulfide is a novel inhibitor of Pin1

(2009) Yota Tatara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of Pin1 induction in epithelial-mesenchymal transition of tamoxifen-resistant breast cancer cells

(2009) Mi Ra Kim et al.   CANCER SCIENCE

The prolyl isomerase Pin1 interacts with a ribosomal protein S6 kinase to enhance insulin-induced AP-1 activity and cellular transformation

(2009) N. Y. Lee et al.   CARCINOGENESIS

A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity

(2009) J. Lu et al.   CARCINOGENESIS

Pin1 Promotes Transforming Growth Factor-β-induced Migration and Invasion

(2009) Isao Matsuura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective ablation of Notch3 in HCC enhances doxorubicin’s death promoting effect by a p53 dependent mechanism

(2009) Catia Giovannini et al.   JOURNAL OF HEPATOLOGY

FAK Phosphorylation by ERK Primes Ras-Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST

(2009) Yanhua Zheng et al.   MOLECULAR CELL

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

(2009) Alessandra Rustighi et al.   NATURE CELL BIOLOGY

Induction of vascular endothelial growth factor by peptidyl-prolyl isomerase Pin1 in breast cancer cells

(2008) Mi Ra Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Down-regulation of Myeloid Cell Leukemia-1 through Inhibiting Erk/Pin 1 Pathway by Sorafenib Facilitates Chemosensitization in Breast Cancer

(2008) Q. Ding et al.   CANCER RESEARCH

Chromosome instability in human hepatocellular carcinoma depends on p53 status and aflatoxin exposure

(2008) Pascal Pineau et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE