In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P
Published 2012 View Full Article
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Title
In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P
Authors
Keywords
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Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 109, Issue 43, Pages 17472-17477
Publisher
Proceedings of the National Academy of Sciences
Online
2012-10-10
DOI
10.1073/pnas.1203106109
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Note: Only part of the references are listed.- Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636
- (2012) Diego Sbrissa et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P2and PI(5)P
- (2012) Yanling Zhang et al. EMBO JOURNAL
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- (2012) Dave Bridges et al. MOLECULAR BIOLOGY OF THE CELL
- Distinctive genetic and clinical features of CMT4J: a severe neuropathy caused by mutations in the PI(3,5)P2 phosphatase FIG4
- (2011) Garth Nicholson et al. BRAIN
- The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development
- (2011) Ognian C. Ikonomov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Shigella flexneri Infection Generates the Lipid PI5P to Alter Endocytosis and Prevent Termination of EGFR Signaling
- (2011) D. Ramel et al. Science Signaling
- Pathogenic Mechanism of the FIG4 Mutation Responsible for Charcot-Marie-Tooth Disease CMT4J
- (2011) Guy M. Lenk et al. PLoS Genetics
- Genetic Interaction between MTMR2 and FIG4 Phospholipid Phosphatases Involved in Charcot-Marie-Tooth Neuropathies
- (2011) Ilaria Vaccari et al. PLoS Genetics
- Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS
- (2009) Clement Y. Chow et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2
- (2009) Cole J. Ferguson et al. HUMAN MOLECULAR GENETICS
- PIKfyve Regulation of Endosome-Linked Pathways
- (2009) Jane de Lartigue et al. TRAFFIC
- Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration
- (2008) Xuebao Zhang et al. BRAIN
- VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse
- (2008) Natsuko Jin et al. EMBO JOURNAL
- A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding
- (2008) Harold B J Jefferies et al. EMBO REPORTS
- ArPIKfyve Homomeric and Heteromeric Interactions Scaffold PIKfyve and Sac3 in a Complex to Promote PIKfyve Activity and Functionality
- (2008) Diego Sbrissa et al. JOURNAL OF MOLECULAR BIOLOGY
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