Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease

Methylation status of O6-methylguanine-DNA-methyl transferase promoter region in non-small-cell lung cancer patients with brain metastasis

(2012) Kenji Hashimoto et al.   Clinical & Translational Oncology

Mammalian phospholipase D physiological and pathological roles

(2011) X. Peng et al.   Acta Physiologica

The TSP motif in AP180 inhibits phospholipase D1 activity resulting in increased efficacy of anticancer drug via its direct binding to carboxyl terminal of phospholipase D1

(2011) Ju Hwan Cho et al.   CANCER LETTERS

MicroRNA-95 Promotes Cell Proliferation and Targets Sorting Nexin 1 in Human Colorectal Carcinoma

(2011) Z. Huang et al.   CANCER RESEARCH

SNX25 regulates TGF-β signaling by enhancing the receptor degradation

(2011) Xinbao Hao et al.   CELLULAR SIGNALLING

The mechanism of cell membrane ruffling relies on a phospholipase D2 (PLD2), Grb2 and Rac2 association

(2011) Madhu Mahankali et al.   CELLULAR SIGNALLING

Phospholipase D2 induces stress fiber formation through mediating nucleotide exchange for RhoA

(2011) Hyeona Jeon et al.   CELLULAR SIGNALLING

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

Evidence for Two CRIB Domains in Phospholipase D2 (PLD2) That the Enzyme Uses to Specifically Bind to the Small GTPase Rac2

(2011) Hong-Juan Peng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A presynaptic endosomal trafficking pathway controls synaptic growth signaling

(2011) Avital A. Rodal et al.   JOURNAL OF CELL BIOLOGY

Translocation dynamics of sorting nexin 27 in activated T cells

(2011) E. Rincon et al.   JOURNAL OF CELL SCIENCE

Expression of Sorting Nexin 18 (SNX18) Is Dynamically Regulated in Developing Spinal Motor Neurons

(2011) Shiori Nakazawa et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Cell Invasion of Highly Metastatic MTLn3 Cancer Cells Is Dependent on Phospholipase D2 (PLD2) and Janus Kinase 3 (JAK3)

(2011) Karen M. Henkels et al.   JOURNAL OF MOLECULAR BIOLOGY

Deficiency of Sorting Nexin 27 (SNX27) Leads to Growth Retardation and Elevated Levels of N-Methyl-D-Aspartate Receptor 2C (NR2C)

(2011) L. Cai et al.   MOLECULAR AND CELLULAR BIOLOGY

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

(2011) Martin Harterink et al.   NATURE CELL BIOLOGY

SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors

(2011) Paul Temkin et al.   NATURE CELL BIOLOGY

A Conserved Role for SNX9-Family Members in the Regulation of Phagosome Maturation during Engulfment of Apoptotic Cells

(2011) Johann Almendinger et al.   PLoS One

VPS29 Is Not an Active Metallo-Phosphatase but Is a Rigid Scaffold Required for Retromer Interaction with Accessory Proteins

(2011) James D. Swarbrick et al.   PLoS One

Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27

(2011) B. Balana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phox homology band 4.1/ezrin/radixin/moesin-like proteins function as molecular scaffolds that interact with cargo receptors and Ras GTPases

(2011) R. Ghai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Salmonella-induced tubular networks

(2011) Nina Schroeder et al.   TRENDS IN MICROBIOLOGY

Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33

(2010) Bastian Dislich et al.   BIOCHEMICAL JOURNAL

Adaptor protein sorting nexin 17 interacts with the scavenger receptor FEEL-1/stabilin-1 and modulates its expression on the cell surface

(2010) Hideki Adachi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Platelet derived growth factor increases phospholipase D1 but not phospholipase D2 expression via NFκB signaling pathway and enhances invasion of breast cancer cells

(2010) Dong Woo Kang et al.   CANCER LETTERS

Pooled Analysis of Phosphatidylinositol 3-Kinase Pathway Variants and Risk of Prostate Cancer

(2010) S. Koutros et al.   CANCER RESEARCH

Sorting nexin 3 (SNX3) is a component of a tubular endosomal network induced by Salmonella and involved in maturation of the Salmonella-containing vacuole

(2010) Virginie Braun et al.   CELLULAR MICROBIOLOGY

Vesicle Transport: A New Player in APP Trafficking

(2010) David J. Owen et al.   CURRENT BIOLOGY

Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella

(2010) Markus C Kerr et al.   EMBO JOURNAL

Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin

(2010) Zi Zhao Lieu et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Tumor suppressor p27Kip1 undergoes endolysosomal degradation through its interaction with sorting nexin 6

(2010) José J. Fuster et al.   FASEB JOURNAL

Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing

(2010) Hirokazu Okada et al.   FASEB JOURNAL

The E3 ubiquitin ligase Itch regulates sorting nexin 9 through an unconventional substrate recognition domain

(2010) Claudia Baumann et al.   FEBS Journal

Autoregulation of phospholipase D activity is coupled to selective induction of phospholipase D1 expression to promote invasion of breast cancer cells

(2010) Dong Woo Kang et al.   INTERNATIONAL JOURNAL OF CANCER

Transcriptomic signature of cell lines isolated from canine mammary adenocarcinoma metastases to lungs

(2010) M. Król et al.   JOURNAL OF APPLIED GENETICS

Mechanism of Aldolase Control of Sorting Nexin 9 Function in Endocytosis

(2010) Erumbi S. Rangarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PX-RICS-14-3-3ζ/θ Complex Couples N-cadherin-β-Catenin with Dynein-Dynactin to Mediate Its Export from the Endoplasmic Reticulum

(2010) Tsutomu Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane

(2010) Benjamin E.L. Lauffer et al.   JOURNAL OF CELL BIOLOGY

SNX18 shares a redundant role with SNX9 and modulates endocytic trafficking at the plasma membrane

(2010) J. Park et al.   JOURNAL OF CELL SCIENCE

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics

(2010) M. E. Harbour et al.   JOURNAL OF CELL SCIENCE

Sorting nexin 6 interacts with breast cancer metastasis suppressor-1 and promotes transcriptional repression

(2010) José Rivera et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Diagnosis and fine mapping of a deletion in distal 11q in two Chinese patients with developmental delay

(2010) Taoyun Ji et al.   JOURNAL OF HUMAN GENETICS

Design, Synthesis, and Biological Evaluation of HalogenatedN-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: Discovery of an Isoform-Selective Small Molecule Phospholipase D2 Inhibitor

(2010) Robert R. Lavieri et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phospholipase D2 Ablation Ameliorates Alzheimer's Disease-Linked Synaptic Dysfunction and Cognitive Deficits

(2010) T. G. Oliveira et al.   JOURNAL OF NEUROSCIENCE

Characterization of PXK as a Protein Involved in Epidermal Growth Factor Receptor Trafficking

(2010) H. Takeuchi et al.   MOLECULAR AND CELLULAR BIOLOGY

Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling

(2010) Nan Lu et al.   MOLECULAR BIOLOGY OF THE CELL

SGK3 Is an Estrogen-Inducible Kinase Promoting Estrogen-Mediated Survival of Breast Cancer Cells

(2010) Yuanzhong Wang et al.   MOLECULAR ENDOCRINOLOGY

The endocytic matrix

(2010) Giorgio Scita et al.   NATURE

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cloning of expressed sequence tags (ESTs) representing putative epileptogenesis-related genes and the localization of their expression in the normal brain

(2010) Marzena Stefaniuk et al.   NEUROSCIENCE LETTERS

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of NOXO1 Activity through Reversible Interactions with p22phox and NOXA1

(2010) Sujit Dutta et al.   PLoS One

The SNX-PX-BAR Family in Macropinocytosis: The Regulation of Macropinosome Formation by SNX-PX-BAR Proteins

(2010) Jack T. H. Wang et al.   PLoS One

Retromer Is Required for Apoptotic Cell Clearance by Phagocytic Receptor Recycling

(2010) D. Chen et al.   SCIENCE

A Novel, Retromer-Independent Role for Sorting Nexins 1 and 2 in RhoG-Dependent Membrane Remodeling

(2010) Derek C. Prosser et al.   TRAFFIC

WASH, WHAMM and JMY: regulation of Arp2/3 complex and beyond

(2010) Klemens Rottner et al.   TRENDS IN CELL BIOLOGY

Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner

(2010) Asuka Nanbo et al.   PLoS Pathogens

Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: Identification of sorting nexin 19 as a novel factor

(2009) Akinori Kan et al.   ARTHRITIS AND RHEUMATISM

Sorting nexin 8 regulates endosome-to-Golgi transport

(2009) Anne Berit Dyve et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rethinking phosphatidylinositol 3-monophosphate

(2009) Marco Falasca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Phylogeny of the SNARE vesicle fusion machinery yields insights into the conservation of the secretory pathway in fungi

(2009) Nickias Kienle et al.   BMC EVOLUTIONARY BIOLOGY

AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer

(2009) Krishna M. Vasudevan et al.   CANCER CELL

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

The retromer component SNX6 interacts with dynactin p150Glued and mediates endosome-to-TGN transport

(2009) Zhi Hong et al.   CELL RESEARCH

Sorting nexin 3, a protein upregulated by lithium, contains a novel phosphatidylinositol-binding sequence and mediates neurite outgrowth in N1E-115 cells

(2009) Reiko Mizutani et al.   CELLULAR SIGNALLING

The role of ADAMs in disease pathophysiology

(2009) Michael J. Duffy et al.   CLINICA CHIMICA ACTA

The Retromer Coat Complex Coordinates Endosomal Sorting and Dynein-Mediated Transport, with Carrier Recognition by the trans-Golgi Network

(2009) Thomas Wassmer et al.   DEVELOPMENTAL CELL

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

(2009) Timothy S. Gomez et al.   DEVELOPMENTAL CELL

CtBP1/BARS is an activator of phospholipase D1 necessary for agonist-induced macropinocytosis

(2009) Yuki Haga et al.   EMBO JOURNAL

Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8

(2009) Anbing Shi et al.   EMBO JOURNAL

Amphipathic motifs in BAR domains are essential for membrane curvature sensing

(2009) Vikram K Bhatia et al.   EMBO JOURNAL

Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells

(2009) Dong Woo Kang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Targeting phospholipase D with small-molecule inhibitors as a potential therapeutic approach for cancer metastasis

(2009) Wenjuan Su et al.   Future Oncology

The Phox Domain of Sorting Nexin 5 Lacks Phosphatidylinositol 3-Phosphate (PtdIns(3)P) Specificity and Preferentially Binds to Phosphatidylinositol 4,5-Bisphosphate (PtdIns(4,5)P2)

(2009) Leonardus M. I. Koharudin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Trafficking of Presenilin 1 Is Regulated by β-Amyloid Precursor Protein and Phospholipase D1

(2009) Yun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sorting Nexin 33 Induces Mammalian Cell Micronucleated Phenotype and Actin Polymerization by Interacting with Wiskott-Aldrich Syndrome Protein

(2009) Juan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation

(2009) S. S. Stylli et al.   JOURNAL OF CELL SCIENCE

Isoform-Selective Interaction of the Adaptor Protein Tks5/FISH with Sos1 and Dynamins

(2009) Arne C. Rufer et al.   JOURNAL OF MOLECULAR BIOLOGY

Sorting Nexin 17 Interacts Directly with Kinesin Superfamily KIF1Bβ Protein

(2009) Dae-Hyun Seog et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Phospholipase D1 Regulates Lymphocyte Adhesion via Upregulation of Rap1 at the Plasma Membrane

(2009) A. Mor et al.   MOLECULAR AND CELLULAR BIOLOGY

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

(2009) Sarah A Scott et al.   Nature Chemical Biology

Kinesin superfamily motor proteins and intracellular transport

(2009) Nobutaka Hirokawa et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Identification of Genes With Differential Expression in Chemoresistant Epithelial Ovarian Cancer Using High-Density Oligonucleotide Microarrays

(2009) Woong Ju et al.   ONCOLOGY RESEARCH

SNX4 in Complex with Clathrin and Dynein: Implications for Endosome Movement

(2009) Sigrid S. Skånland et al.   PLoS One

SNX–BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting

(2009) Jan R.T. van Weering et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Defining Macropinocytosis

(2009) Markus C. Kerr et al.   TRAFFIC

Analysis of Articulation Between Clathrin and Retromer in Retrograde Sorting on Early Endosomes

(2009) Vincent Popoff et al.   TRAFFIC

Structural Basis of Membrane Invagination by F-BAR Domains

(2008) Adam Frost et al.   CELL

Membrane traffic in the secretory pathway

(2008) M. Vicinanza et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Retromer

(2008) Juan S Bonifacino et al.   CURRENT OPINION IN CELL BIOLOGY

MIT Domainia

(2008) James H. Hurley et al.   DEVELOPMENTAL CELL

Function and dysfunction of the PI system in membrane trafficking

(2008) Mariella Vicinanza et al.   EMBO JOURNAL

A role for the podosome/invadopodia scaffold protein Tks5 in tumor growth in vivo

(2008) B BLOUW et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

SLIC-1/sorting nexin 20: A novel sorting nexin that directs subcellular distribution of PSGL-1

(2008) Ulrich Y. Schaff et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Signaling from endosomes: Location makes a difference

(2008) Lukasz Sadowski et al.   EXPERIMENTAL CELL RESEARCH

An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor

(2008) Megan E. Cavet et al.   FASEB JOURNAL

PX-RICS mediates ER-to-Golgi transport of the N-cadherin/ -catenin complex

(2008) T. Nakamura et al.   GENES & DEVELOPMENT

Getting a GRASP on CASP: properties and role of the cytohesin-associated scaffolding protein in immunity

(2008) Adam J MacNeil et al.   IMMUNOLOGY AND CELL BIOLOGY

Cellular roles of ADAM12 in health and disease

(2008) Marie Kveiborg et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A Novel Sorting Nexin Modulates Endocytic Trafficking and α-Secretase Cleavage of the Amyloid Precursor Protein

(2008) Susanne Schöbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic Phospholipase A2α Is Targeted to the p47phox-PX Domain of the Assembled NADPH Oxidase via a Novel Binding Site in Its C2 Domain

(2008) Zeev Shmelzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes

(2008) Jiyeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Consequences of Tyrosine Phosphorylation in the LRP1 Cytoplasmic Domain

(2008) Gina N. Betts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequential signals toward podosome formation in NIH-src cells

(2008) Tsukasa Oikawa et al.   JOURNAL OF CELL BIOLOGY

SNX9 regulates tubular invagination of the plasma membrane through interaction with actin cytoskeleton and dynamin 2

(2008) N. Shin et al.   JOURNAL OF CELL SCIENCE

SNX18 is an SNX9 paralog that acts as a membrane tubulator in AP-1-positive endosomal trafficking

(2008) K. Haberg et al.   JOURNAL OF CELL SCIENCE

Sorting nexin-1 defines an early phase of Salmonella-containing vacuole-remodeling during Salmonella infection

(2008) M. V. Bujny et al.   JOURNAL OF CELL SCIENCE

SNX9 - a prelude to vesicle release

(2008) R. Lundmark et al.   JOURNAL OF CELL SCIENCE

Nischarin Inhibits LIM Kinase To Regulate Cofilin Phosphorylation and Cell Invasion

(2008) Y. Ding et al.   MOLECULAR AND CELLULAR BIOLOGY

The DHR1 Domain of DOCK180 Binds to SNX5 and Regulates Cation-independent Mannose 6-phosphate Receptor Transport

(2008) Shigeo Hara et al.   MOLECULAR BIOLOGY OF THE CELL

Opposing Activities of the Snx3-Retromer Complex and ESCRT Proteins Mediate Regulated Cargo Sorting at a Common Endosome

(2008) Todd I. Strochlic et al.   MOLECULAR BIOLOGY OF THE CELL

Polarized Traffic of LRP1 Involves AP1B and SNX17 Operating on Y-dependent Sorting Motifs in Different Pathways

(2008) Maribel Donoso et al.   MOLECULAR BIOLOGY OF THE CELL

Evidence for efficient phosphorylation of EGFR and rapid endocytosis of phosphorylated EGFR via the early/late endocytic pathway in a gefitinib-sensitive non-small cell lung cancer cell line

(2008) Yukio Nishimura et al.   Molecular Cancer

Distinct Functions of Natural ADAM-15 Cytoplasmic Domain Variants in Human Mammary Carcinoma

(2008) J. L. Zhong et al.   MOLECULAR CANCER RESEARCH

Effects of Active and Inactive Phospholipase D2 on Signal Transduction, Adhesion, Migration, Invasion, and Metastasis in EL4 Lymphoma Cells

(2008) S. M. Knoepp et al.   MOLECULAR PHARMACOLOGY

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Membrane recognition by phospholipid-binding domains

(2008) Mark A. Lemmon   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endosomal sorting and signalling: an emerging role for sorting nexins

(2008) Peter J. Cullen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Jpred 3 secondary structure prediction server

(2008) C. Cole et al.   NUCLEIC ACIDS RESEARCH

An RGS-Containing Sorting Nexin Controls Drosophila Lifespan

(2008) Jae Myoung Suh et al.   PLoS One

Dystroglycan, Tks5 and Src Mediated Assembly of Podosomes in Myoblasts

(2008) Oliver Thompson et al.   PLoS One

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and A  accumulation

(2008) A. Muhammad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trafficking, a key player in regulated intramembrane proteolysis

(2008) Ragna Sannerud et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structure and Plasticity of Endophilin and Sorting Nexin 9

(2008) Qi Wang et al.   STRUCTURE

Endosomal Phosphoinositides and Human Diseases

(2008) Anne-Sophie Nicot et al.   TRAFFIC

The Novel Sorting Nexin SNX33 Interferes with Cellular PrPScFormation by Modulation of PrPcShedding

(2008) Andreas Heiseke et al.   TRAFFIC

The Structure and Function of the Retromer Protein Complex

(2008) Brett M. Collins   TRAFFIC

Endothelium–platelet interactions in inflammatory lung disease

(2008) Arata Tabuchi et al.   VASCULAR PHARMACOLOGY

Hrs and SNX3 Functions in Sorting and Membrane Invagination within Multivesicular Bodies

(2008) Véronique Pons et al.   PLOS BIOLOGY

SNX9 Activities are Regulated by Multiple Phosphoinositides Through both PX and BAR Domains

(2007) Defne Yarar et al.   TRAFFIC