Regulation and cellular functions of class II phosphoinositide 3-kinases

Phosphatidylinositol 3-Kinase-C2β Inhibits Cisplatin-Mediated Apoptosis via the Akt Pathway in Oesophageal Squamous Cell Carcinoma

(2013) Z Liu et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Intersectin 1 is required for neuroblastoma tumorigenesis

(2012) A Russo et al.   ONCOGENE

Two PI 3-Kinases and One PI 3-Phosphatase Together Establish the Cyclic Waves of Phagosomal PtdIns(3)P Critical for the Degradation of Apoptotic Cells

(2012) Nan Lu et al.   PLOS BIOLOGY

Myotubularin Regulates Akt-dependent Survival Signaling via Phosphatidylinositol 3-Phosphate

(2011) Gina L. Razidlo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells

(2011) Barthelemy Diouf et al.   NATURE MEDICINE

Attenuation of the beta-catenin/TCF4 complex in colorectal cancer cells induces several growth-suppressive microRNAs that target cancer promoting genes

(2011) T Schepeler et al.   ONCOGENE

Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2 

(2011) X. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphoinositide Regulation of Integrin Trafficking Required for Muscle Attachment and Maintenance

(2011) Inês Ribeiro et al.   PLoS Genetics

Overexpression of phosphoinositide-3-kinase class II alpha enhances mesenchymal stem cell survival in infarcted myocardium

(2010) Lucy Youngmin Eun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pooled Analysis of Phosphatidylinositol 3-Kinase Pathway Variants and Risk of Prostate Cancer

(2010) S. Koutros et al.   CANCER RESEARCH

Class IA Phosphatidylinositol 3-Kinase in Pancreatic β Cells Controls Insulin Secretion by Multiple Mechanisms

(2010) Kazuma Kaneko et al.   Cell Metabolism

Key Role of Phosphoinositide 3-Kinase Class IB in Pancreatic Cancer

(2010) C. E. Edling et al.   CLINICAL CANCER RESEARCH

PI3K/Akt Signalling Pathway Specific Inhibitors: A Novel Strategy to Sensitize Cancer Cells to Anti-Cancer Drugs

(2010) Marco Falasca   CURRENT PHARMACEUTICAL DESIGN

Insulin-feedback via PI3K-C2α activated PKBα/Akt1 is required for glucose-stimulated insulin secretion

(2010) Barbara Leibiger et al.   FASEB JOURNAL

Enhanced Ca 2+ -Dependent Activation of Phosphoinositide 3-Kinase Class IIα Isoform-Rho Axis in Blood Vessels of Spontaneously Hypertensive Rats

(2010) Young Mi Seok et al.   HYPERTENSION

Class II Phosphoinositide 3-Kinase Regulates Exocytosis of Insulin Granules in Pancreatic β Cells

(2010) Veronica Dominguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DrosophilaMtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions

(2010) Michaella Velichkova et al.   JOURNAL OF CELL BIOLOGY

PI3KC2 , a class II PI3K, is required for dynamin-independent internalization pathways

(2010) C. Krag et al.   JOURNAL OF CELL SCIENCE

Inhibition of class II phosphoinositide 3-kinase γ expression by p185Bcr–Ablcontributes to impaired chemotaxis and aberrant homing of leukemic cells

(2010) Weidong Yu et al.   LEUKEMIA & LYMPHOMA

The α-isoform of class II phosphoinositide 3-kinase is necessary for the activation of ERK but not Akt/PKB

(2010) Z. G. Cui et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Requirement for Class II Phosphoinositide 3-Kinase C2  in Maintenance of Glomerular Structure and Function

(2010) D. P. Harris et al.   MOLECULAR AND CELLULAR BIOLOGY

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ablation of phosphoinositide-3-kinase class II alpha suppresses hepatoma cell proliferation

(2009) Stanley K.L. Ng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epidermal growth factor stimulates translocation of the class II phosphoinositide 3-kinase PI3K-C2β to the nucleus

(2009) Hrvoje Banfic et al.   BIOCHEMICAL JOURNAL

Rethinking phosphatidylinositol 3-monophosphate

(2009) Marco Falasca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Targeting the PI3K signaling pathway in cancer

(2009) Kwok-Kin Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Insulin Granule Recruitment and Exocytosis Is Dependent on p110  in Insulinoma and Human  -Cells

(2009) G. M. Pigeau et al.   DIABETES

A survey of glioblastoma genomic amplifications and deletions

(2009) Shailaja K. Rao et al.   JOURNAL OF NEURO-ONCOLOGY

The Class II Phosphatidylinositol 3 kinase C2β Is Required for the Activation of the K+ Channel KCa3.1 and CD4 T-Cells

(2009) Shekhar Srivastava et al.   MOLECULAR BIOLOGY OF THE CELL

Mutations in Phosphoinositide Metabolizing Enzymes and Human Disease

(2009) Heather J. McCrea et al.   PHYSIOLOGY

Phosphoinositides in insulin action on GLUT4 dynamics: not just PtdIns(3,4,5)P3

(2008) Assia Shisheva   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The regulation and function of Class III PI3Ks: novel roles for Vps34

(2008) Jonathan M. Backer   BIOCHEMICAL JOURNAL

Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization

(2008) Elizabeth Iorns et al.   BIOCHEMICAL JOURNAL

Insulin Stimulates Phosphatidylinositol 3-Phosphate Production via the Activation of Rab5

(2008) Irfan J. Lodhi et al.   MOLECULAR BIOLOGY OF THE CELL

Ca2+-regulated Pool of Phosphatidylinositol-3-phosphate Produced by Phosphatidylinositol 3-Kinase C2α on Neurosecretory Vesicles

(2008) Peter J. Wen et al.   MOLECULAR BIOLOGY OF THE CELL

Sequential Actions of Myotubularin Lipid Phosphatases Regulate Endosomal PI(3)P and Growth Factor Receptor Trafficking

(2008) Canhong Cao et al.   MOLECULAR BIOLOGY OF THE CELL

Down-Regulation of Class II Phosphoinositide 3-Kinase   Expression below a Critical Threshold Induces Apoptotic Cell Death

(2008) W. Elis et al.   MOLECULAR CANCER RESEARCH

The p110  isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110 

(2008) J. Guillermet-Guibert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endosomal Phosphoinositides and Human Diseases

(2008) Anne-Sophie Nicot et al.   TRAFFIC

Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population

(2007) Makoto Daimon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS