Genetics of childhood-onset inflammatory bowel disease

Autophagy 16-like 1 rs2241880 G allele is associated with Crohn’s disease in German children

(2009) Martin Lacher et al.   ACTA PAEDIATRICA

Genetic Analysis in A Dutch Study Sample Identifies More Ulcerative Colitis Susceptibility Loci and Shows Their Additive Role in Disease Risk

(2009) Eleonora AM Festen et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Phenotypic and Genotypic Characteristics of Inflammatory Bowel Disease in French Canadians: Comparison With a Large North American Repository

(2009) Mamatha Bhat et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Investigation of Reported Associations Between the 20q13 and 21q22 Loci and Pediatric-Onset Crohn's Disease in Canadian Children

(2009) Devendra K Amre et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

TNFSF15 Polymorphisms Are Associated With Susceptibility to Inflammatory Bowel Disease in a New European Cohort

(2009) R Thiébaut et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Diverse Genome-wide Association Studies Associate the IL12/IL23 Pathway with Crohn Disease

(2009) Kai Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation and Function of Proinflammatory TH17 Cells

(2009) Gustavo J. Martinez et al.   Annals of the New York Academy of Sciences

The Genetics of Crohn's Disease

(2009) Johan Van Limbergen et al.   Annual Review of Genomics and Human Genetics

Regulatory Lymphocytes and Intestinal Inflammation

(2009) Ana Izcue et al.   Annual Review of Immunology

Parkinson disease, LRRK2 and the endocytic-autophagic pathway

(2009) Javier Alegre-Abarrategui et al.   Autophagy

Environmental Factors Affecting Inflammatory Bowel Disease: Have We Made Progress?

(2009) Peter Laszlo Lakatos   DIGESTIVE DISEASES

Growth Retardation in Early-Onset Inflammatory Bowel Disease: Should We Monitor and Treat These Patients Differently?

(2009) Anne M. Griffiths   DIGESTIVE DISEASES

Paediatric inflammatory bowel disease during a 44-year period in Copenhagen County: occurrence, course and prognosis – a population-based study from the Danish Crohn Colitis Database

(2009) Christian Jakobsen et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Induction of peripheral CD4+ T-cell tolerance and CD8+ T-cell cross-tolerance by dendritic cells

(2009) Manfred B. Lutz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: a meta-analysis approach

(2009) R J Palomino-Morales et al.   GENES AND IMMUNITY

Germline variants of IRGM in childhood-onset Crohn's disease

(2009) J Van Limbergen et al.   GUT

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

Increasing incidence of paediatric inflammatory bowel disease in Ontario, Canada: evidence from health administrative data

(2009) E I Benchimol et al.   GUT

The asthma-associated ORMDL3 gene product regulates endoplasmic reticulum-mediated calcium signaling and cellular stress

(2009) Gerard Cantero-Recasens et al.   HUMAN MOLECULAR GENETICS

Alteration of the unfolded protein response modifies neurodegeneration in a mouse model of Marinesco–Sjögren syndrome

(2009) Lihong Zhao et al.   HUMAN MOLECULAR GENETICS

Regulation of immune responses by interleukin-27

(2009) Hiroki Yoshida et al.   IMMUNOLOGICAL REVIEWS

Increased number and activation of colonic macrophages in pediatric patients with untreated Crohnʼs disease

(2009) Gøri Perminow et al.   INFLAMMATORY BOWEL DISEASES

Bacteria-free solution derived from lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function

(2009) Elaine O. Petrof et al.   INFLAMMATORY BOWEL DISEASES

Established genetic risk factors do not distinguish early and later onset Crohnʼs disease

(2009) Jonah B. Essers et al.   INFLAMMATORY BOWEL DISEASES

Genetic Variants in IL-23R and ATG16L1 Independently Predispose to Increased Susceptibility to Crohnʼs Disease in a Canadian Population

(2009) William G. Newman et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

IL-27 Regulates Homeostasis of the Intestinal CD4+ Effector T Cell Pool and Limits Intestinal Inflammation in a Murine Model of Colitis

(2009) A. E. Troy et al.   JOURNAL OF IMMUNOLOGY

IL-27 Is a Key Regulator of IL-10 and IL-17 Production by Human CD4+ T Cells

(2009) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

IL-27 Abrogates Receptor Activator of NF- B Ligand-Mediated Osteoclastogenesis of Human Granulocyte-Macrophage Colony-Forming Unit Cells through STAT1-Dependent Inhibition of c-Fos

(2009) M. Furukawa et al.   JOURNAL OF IMMUNOLOGY

Impaired CD4 and CD8 Effector Function and Decreased Memory T Cell Populations in ICOS-Deficient Patients

(2009) N. Takahashi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: IL-27 Induces the Transcription Factor c-Maf, Cytokine IL-21, and the Costimulatory Receptor ICOS that Coordinately Act Together to Promote Differentiation of IL-10-Producing Tr1 Cells

(2009) C. Pot et al.   JOURNAL OF IMMUNOLOGY

Interleukin 27: a double-edged sword for offense and defense

(2009) Hiroki Yoshida et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epidemiology of Pediatric Chronic Inflammatory Bowel Disease in Central and Western Slovenia, 1994–2005

(2009) Rok Orel et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Early-onset Crohn Disease Is Associated With Male Sex and a Polymorphism in the IL-6 Promoter

(2009) Keren Sagiv-Friedgut et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

The incidence of inflammatory bowel disease in the pediatric population of Southwestern Ontario

(2009) Tanya Grieci et al.   JOURNAL OF PEDIATRIC SURGERY

Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome

(2009) Claudio Hetz et al.   MOLECULAR CELL

Endoplasmic reticulum stress and intestinal inflammation

(2009) A Kaser et al.   Mucosal Immunology

Common variants at five new loci associated with early-onset inflammatory bowel disease

(2009) Marcin Imielinski et al.   NATURE GENETICS

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

Autoimmunity: increasing suspects in the CD4+ T cell lineup

(2009) Matthew T Palmer et al.   NATURE IMMUNOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Genetic Association Analysis of the Functional c.714T>G Polymorphism and Mucosal Expression of Dectin-1 in Inflammatory Bowel Disease

(2009) Hilbert S. de Vries et al.   PLoS One

Nod2 is required for the regulation of commensal microbiota in the intestine

(2009) T. Petnicki-Ocwieja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response

(2009) K. Brandl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A characterization in childhood inflammatory bowel disease, a new population-based inception cohort from South-Eastern Norway, 2005–07, showing increased incidence in Crohn's disease

(2009) Gøri perminow et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history

(2009) Charlie W Lees et al.   Expert Review of Gastroenterology & Hepatology

ATG16L1andIL23RAre Associated With Inflammatory Bowel Diseases but Not With Celiac Disease in The Netherlands

(2008) Rinse K. Weersma et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

TheATG16L1Gene Variants rs2241879 and rs2241880 (T300A) Are Strongly Associated With Susceptibility to Crohn's Disease in the German Population

(2008) Jürgen Glas et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The Risk of Oral Contraceptives in the Etiology of Inflammatory Bowel Disease: A Meta-Analysis

(2008) J.A. Cornish et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

ATG16L1 T300A Shows Strong Associations With Disease Subgroups in a Large Australian IBD Population: Further Support for Significant Disease Heterogeneity

(2008) Elizabeth V. Fowler et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Regulation of the class II and class I MHC pathways in human THP-1 monocytic cells by interleukin-27

(2008) Xiao Ming Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

Circulating levels of TNF-like cytokine 1A (TL1A) and its decoy receptor 3 (DcR3) in rheumatoid arthritis

(2008) Giorgos Bamias et al.   CLINICAL IMMUNOLOGY

MEKK4 Sequesters RIP2 to Dictate NOD2 Signal Specificity

(2008) Nivedita M. Clark et al.   CURRENT BIOLOGY

Clustering of (auto)immune diseases with early-onset and complicated inflammatory bowel disease

(2008) Mirjam Bueno de Mesquita et al.   EUROPEAN JOURNAL OF PEDIATRICS

Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP)

(2008) Yasuhiro Tagawa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Definition of Phenotypic Characteristics of Childhood-Onset Inflammatory Bowel Disease

(2008) Johan Van Limbergen et al.   GASTROENTEROLOGY

Natural History of Pediatric Crohn's Disease: A Population-Based Cohort Study

(2008) Gwenola Vernier–Massouille et al.   GASTROENTEROLOGY

Smad7 Controls Resistance of Colitogenic T Cells to Regulatory T Cell-Mediated Suppression

(2008) Massimo C. Fantini et al.   GASTROENTEROLOGY

RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F

(2008) Moritz Leppkes et al.   GASTROENTEROLOGY

MAST3: a novel IBD risk factor that modulates TLR4 signaling

(2008) C Labbé et al.   GENES AND IMMUNITY

Functional characterisation of decoy receptor 3 in Crohn's disease

(2008) B Funke et al.   GUT

IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn's disease

(2008) T Kobayashi et al.   GUT

IL23R haplotypes provide a large population attributable risk for Crohnʼs disease

(2008) Kent D. Taylor et al.   INFLAMMATORY BOWEL DISEASES

Contribution of TNFSF15 gene variants to Crohnʼs disease susceptibility confirmed in UK population

(2008) Mark Tremelling et al.   INFLAMMATORY BOWEL DISEASES

Comparative expression analysis and characterization of 20S proteasomes in human intestinal tissues

(2008) Alexander Visekruna et al.   INFLAMMATORY BOWEL DISEASES

DcR3 as a diagnostic parameter and risk factor for systemic lupus erythematosus

(2008) B. Han et al.   INTERNATIONAL IMMUNOLOGY

The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation

(2008) Elisa Greggio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

(2008) Bhanu P. Pappu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Smad3 knockout mice exhibit impaired intestinal mucosal healing

(2008) Cheri R Owen et al.   LABORATORY INVESTIGATION

Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis

(2008) P Goyette et al.   Mucosal Immunology

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

(2008) Sheila A Fisher et al.   NATURE GENETICS

Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease

(2008) Subra Kugathasan et al.   NATURE GENETICS

Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease

(2008) Steven A McCarroll et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY

A Genome-Wide Association Study of Psoriasis and Psoriatic Arthritis Identifies New Disease Loci

(2008) Ying Liu et al.   PLoS Genetics

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE

Targeting of the molecular chaperone oxygen-regulated protein 150 (ORP150) to mitochondria and its induction by cellular stress

(2007) David D. Arrington et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohnʼs disease in Northern Europe

(2007) J. Van Limbergen et al.   INFLAMMATORY BOWEL DISEASES

Linking genetic susceptibility to Crohnʼs disease with Th17 cell function: IL-22 serum levels are increased in Crohnʼs disease and correlate with disease activity and IL23R genotype status

(2007) Silke Schmechel et al.   INFLAMMATORY BOWEL DISEASES

New links to the pathogenesis of Crohn disease provided by genome-wide association scans

(2007) Christopher G. Mathew   NATURE REVIEWS GENETICS