Phosphatidylinositol 4-Kinases and PI4P Metabolism in the Nervous System: Roles in Psychiatric and Neurological Diseases

Effects of Membrane Lipids on the Activity and Processivity of Purified γ-Secretase

(2012) Oliver Holmes et al.   BIOCHEMISTRY

Trisomy for Synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes

(2012) Jack-Christophe Cossec et al.   HUMAN MOLECULAR GENETICS

Role of Phosphatidylinositol Clathrin Assembly Lymphoid-Myeloid Leukemia (PICALM) in Intracellular Amyloid Precursor Protein (APP) Processing and Amyloid Plaque Pathogenesis

(2012) Qingli Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase

(2012) Marko Jović et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane-localized  -subunits alter the PIP2 regulation of high-voltage activated Ca2+ channels

(2012) B.-C. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI4P and PI(4,5)P2 Are Essential But Independent Lipid Determinants of Membrane Identity

(2012) G. R. V. Hammond et al.   SCIENCE

Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL

(2012) Michelle Pirruccello et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity

(2012) Annalisa Bianco et al.   PLoS Pathogens

Synaptojanin 1-Mediated PI(4,5)P2 Hydrolysis Is Modulated by Membrane Curvature and Facilitates Membrane Fission

(2011) Belle Chang-Ileto et al.   DEVELOPMENTAL CELL

OCRL controls trafficking through early endosomes via PtdIns4,5P2-dependent regulation of endosomal actin

(2011) Mariella Vicinanza et al.   EMBO JOURNAL

Structure of a Ca2+-Myristoyl Switch Protein That Controls Activation of a Phosphatidylinositol 4-Kinase in Fission Yeast

(2011) Sunghyuk Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Depolarization Increases Membrane PtdIns(4,5)P2Levels through Mechanisms Involving PKC βII and PI4 Kinase

(2011) Xingjuan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human Protein Atlas as a proteomic resource for biomarker discovery

(2011) F. Pontén et al.   JOURNAL OF INTERNAL MEDICINE

Probing the regulation of TASK potassium channels by PI(4,5)P2with switchable phosphoinositide phosphatases

(2011) Moritz Lindner et al.   JOURNAL OF PHYSIOLOGY-LONDON

The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapse

(2011) Jennifer Larimore et al.   MOLECULAR BIOLOGY OF THE CELL

A Sensitized RNA Interference Screen Identifies a Novel Role for the PI3K p110  Isoform in Medulloblastoma Cell Proliferation and Chemoresistance

(2011) A. S. Guerreiro et al.   MOLECULAR CANCER RESEARCH

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Functional Links Between A  Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

(2011) S. Treusch et al.   SCIENCE

From lowe syndrome to Dent disease: correlations between mutations of the OCRL1 gene and clinical and biochemical phenotypes

(2010) Haifa Hichri et al.   HUMAN MUTATION

Depolarization Increases Phosphatidylinositol (PI) 4,5-Bisphosphate Level and KCNQ Currents through PI 4-Kinase Mechanisms

(2010) Xuan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined Phosphoinositide and Ca2+Signals Mediating Receptor Specificity toward Neuronal Ca2+Channels

(2010) Oleg Zaika et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol-4-Phosphate 5-Kinases and Phosphatidylinositol 4,5-Bisphosphate Synthesis in the Brain

(2010) Laura A. Volpicelli-Daley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detergent-free isolation and characterization of cholesterol-rich membrane domains fromtrans-Golgi network vesicles

(2010) Mark G. Waugh et al.   JOURNAL OF LIPID RESEARCH

Phosphatidylinositol 4-Kinase III Beta Is a Target of Enviroxime-Like Compounds for Antipoliovirus Activity

(2010) M. Arita et al.   JOURNAL OF VIROLOGY

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

Phenylarsine Oxide Binding Reveals Redox-Active and Potential Regulatory Vicinal Thiols on the Catalytic Subunit of Protein Phosphatase 2A

(2010) Timothy D. Foley et al.   NEUROCHEMICAL RESEARCH

Acute manipulation of Golgi phosphoinositides to assess their importance in cellular trafficking and signaling

(2010) Z. Szentpetery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential effects of the phosphatidylinositol 4-kinases, PI4KIIα and PI4KIIIβ, on Akt activation and apoptosis

(2010) K M E Chu et al.   Cell Death & Disease

The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease

(2009) Lisa M. Ooms et al.   BIOCHEMICAL JOURNAL

Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4Pand PtdIns(4,5)P2

(2009) Gerald R. V. Hammond et al.   BIOCHEMICAL JOURNAL

A PH domain within OCRL bridges clathrin-mediated membrane trafficking to phosphoinositide metabolism

(2009) Yuxin Mao et al.   EMBO JOURNAL

Dependence of STIM1/Orai1-mediated Calcium Entry on Plasma Membrane Phosphoinositides

(2009) Marek K. Korzeniowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Clathrin Binding and Subcellular Localization of OCRL1 Splice Isoforms

(2009) Rawshan Choudhury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crucial role of phosphatidylinositol 4-kinase III  in development of zebrafish pectoral fin is linked to phosphoinositide 3-kinase and FGF signaling

(2009) H. Ma et al.   JOURNAL OF CELL SCIENCE

A case-control association study and family-based expression analysis of the bipolar disorder candidate gene PI4K2B

(2009) Lorna M. Houlihan et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking

(2009) M. Mikhaylova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of phosphatidylinositol 4-kinase 2α activity causes late onset degeneration of spinal cord axons

(2009) J. Paul Simons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Failure to confirm the association between thePIK4CAgene and schizophrenia in a Japanese population

(2008) Nobuhisa Kanahara et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Association of the PIK4CA schizophrenia-susceptibility gene in adults with the 22q11.2 deletion syndrome

(2008) Jacob A.S. Vorstman et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

PIP2 Is a Necessary Cofactor for Ion Channel Function: How and Why?

(2008) Byung-Chang Suh et al.   Annual Review of Biophysics

All known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 binding

(2008) Heather J. McCrea et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Design of Drug-Resistant Alleles of Type-III Phosphatidylinositol 4-Kinases Using Mutagenesis and Molecular Modeling†

(2008) Andras Balla et al.   BIOCHEMISTRY

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

(2008) Pamela Osenkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bulk Synaptic Vesicle Endocytosis Is Rapidly Triggered during Strong Stimulation

(2008) E. L. Clayton et al.   JOURNAL OF NEUROSCIENCE

Phosphoinositides Regulate P2X4 ATP-Gated Channels through Direct Interactions

(2008) L.-P. Bernier et al.   JOURNAL OF NEUROSCIENCE

Phosphatidylinositol-4-Kinase Type II Alpha Contains an AP-3–sorting Motif and a Kinase Domain That Are Both Required for Endosome Traffic

(2008) Branch Craige et al.   MOLECULAR BIOLOGY OF THE CELL

Direct Modulation of P2X1 Receptor-Channels by the Lipid Phosphatidylinositol 4,5-Bisphosphate

(2008) L.-P. Bernier et al.   MOLECULAR PHARMACOLOGY

Oligomeric amyloid-β peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism

(2008) Diego E Berman et al.   NATURE NEUROSCIENCE

Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels

(2008) Mohamed Trebak et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators

(2008) Yuji Karashima et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

(2008) S. V. Voronov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Inhibition of the Alzheimer's Disease  -Secretase by Membrane Targeting

(2008) L. Rajendran et al.   SCIENCE