The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes

Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice

(2012) Odile Gabay et al.   ANNALS OF THE RHEUMATIC DISEASES

Tumor necrosis factor α-mediated cleavage and inactivation of SirT1 in human osteoarthritic chondrocytes

(2011) Mona Dvir-Ginzberg et al.   ARTHRITIS AND RHEUMATISM

Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity

(2011) Ming Lei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

ADAMTS-4 and ADAMTS-5: Key enzymes in osteoarthritis

(2011) Priyanka Verma et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

(2010) Norifumi Fujita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

SIRT1 regulation of apoptosis of human chondrocytes

(2009) Koji Takayama et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Resveratrol suppresses interleukin-1β-induced inflammatory signaling and apoptosis in human articular chondrocytes: Potential for use as a novel nutraceutical for the treatment of osteoarthritis

(2008) Mehdi Shakibaei et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase

(2008) Mona Dvir-Ginzberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis

(2008) Massoud Daheshia et al.   JOURNAL OF RHEUMATOLOGY