Hypoxia Promotes the Production and Inhibits the Destruction of Human Articular Cartilage

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

Expression of Prolyl Hydroxylases (PHDs) Is Selectively Controlled by HIF-1 and HIF-2 Proteins in Nucleus Pulposus Cells of the Intervertebral Disc

(2012) Nobuyuki Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolyl Hydroxylase 3 (PHD3) Modulates Catabolic Effects of Tumor Necrosis Factor-α (TNF-α) on Cells of the Nucleus Pulposus through Co-activation of Nuclear Factor κB (NF-κB)/p65 Signaling

(2012) Nobuyuki Fujita et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A large-scale replication study for the association of rs17039192 in HIF-2α with knee osteoarthritis

(2012) Masahiro Nakajima et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Knee replacement

(2012) Andrew J Carr et al.   LANCET

Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage

(2012) F. Wei et al.   OSTEOARTHRITIS AND CARTILAGE

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Replication studies in various ethnic populations do not support the association of the HIF-2α SNP rs17039192 with knee osteoarthritis

(2011) Masahiro Nakajima et al.   NATURE MEDICINE

The human side of hypoxia-inducible factor

(2010) Thomas G. Smith et al.   BRITISH JOURNAL OF HAEMATOLOGY

Inhibition of Hypoxia-inducible Factor-targeting Prolyl Hydroxylase Domain-containing Protein 2 (PHD2) Enhances Matrix Synthesis by Human Chondrocytes

(2010) Brendan L. Thoms et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Hypoxia, RONS and energy metabolism in articular cartilage

(2010) B. Fermor et al.   OSTEOARTHRITIS AND CARTILAGE

Oxygen tension differentially regulates the functional properties of cartilaginous tissues engineered from infrapatellar fat pad derived MSCs and articular chondrocytes

(2010) C.T. Buckley et al.   OSTEOARTHRITIS AND CARTILAGE

Anabolic and catabolic responses of human articular chondrocytes to varying oxygen percentages

(2010) Simon Ströbel et al.   ARTHRITIS RESEARCH & THERAPY

Regulation of autophagy in human and murine cartilage: Hypoxia-inducible factor 2 suppresses chondrocyte autophagy

(2009) Jolene Bohensky et al.   ARTHRITIS AND RHEUMATISM

Sustained hypoxia enhances chondrocyte matrix synthesis

(2008) Christian H. Coyle et al.   JOURNAL OF ORTHOPAEDIC RESEARCH