Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury

(2011) Otgonchimeg Rentsendorj et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hard Times for Oncogenic BRAF-Expressing Melanoma Cells

(2011) Miles D. Houslay   CANCER CELL

Oncogenic BRAF Induces Melanoma Cell Invasion by Downregulating the cGMP-Specific Phosphodiesterase PDE5A

(2011) Imanol Arozarena et al.   CANCER CELL

Phosphodiesterase-5A (PDE5A) is localized to the endothelial caveolae and modulates NOS3 activity

(2011) M. A. Gebska et al.   CARDIOVASCULAR RESEARCH

Treatment-Related Mortality With Bevacizumab in Cancer Patients

(2011) Vishal Ranpura et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Phosphodiesterase 3B-based Signaling Complex Integrates Exchange Protein Activated by cAMP 1 and Phosphatidylinositol 3-Kinase Signals in Human Arterial Endothelial Cells

(2011) Lindsay S. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidation of a Structural Basis for the Inhibitor-Driven, p62 (SQSTM1)-Dependent Intracellular Redistribution of cAMP Phosphodiesterase-4A4 (PDE4A4)

(2011) Jonathan P. Day et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

(2011) Y.Y. Sin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Integrating Cardiac PIP3 and cAMP Signaling through a PKA Anchoring Function of p110γ

(2011) Alessia Perino et al.   MOLECULAR CELL

PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: A key step in parkinsonism physiopathology

(2011) M. Giorgi et al.   NEUROBIOLOGY OF DISEASE

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

(2011) P.H. Hutson et al.   NEUROPHARMACOLOGY

Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions

(2011) Sharron H. Francis et al.   PHYSIOLOGICAL REVIEWS

Phosphodiesterase 10A Upregulation Contributes to Pulmonary Vascular Remodeling

(2011) Xia Tian et al.   PLoS One

Role of phosphodiesterase 5 in synaptic plasticity and memory

(2011) Daniela Puzzo   Neuropsychiatric Disease and Treatment

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors

(2010) Renee Aspiotis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Use of a Schizosaccharomyces pombe PKA-repressible reporter to study cGMP metabolising phosphodiesterases

(2010) Didem Demirbas et al.   CELLULAR SIGNALLING

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis

(2010) Abdurazzag Abusnina et al.   CELLULAR SIGNALLING

Oxidative Stress Regulates Left Ventricular PDE5 Expression in the Failing Heart

(2010) Zhongbing Lu et al.   CIRCULATION

PDE5 Inhibition With Sildenafil Improves Left Ventricular Diastolic Function, Cardiac Geometry, and Clinical Status in Patients With Stable Systolic Heart Failure

(2010) Marco Guazzi et al.   Circulation-Heart Failure

Cyclic Nucleotide Phosphodiesterases (PDE) and Peptide Motifs

(2010) Therese Keravis et al.   CURRENT PHARMACEUTICAL DESIGN

Insulin inhibits human erythrocyte cAMP accumulation and ATP release: role of phosphodiesterase 3 and phosphoinositide 3-kinase

(2010) Madelyn S Hanson et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A Crystal Structure of the Cyclic GMP-dependent Protein Kinase Iβ Dimerization/Docking Domain Reveals Molecular Details of Isoform-specific Anchoring

(2010) Darren E. Casteel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain

(2010) Huanchen Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability

(2010) Sarah N. Rampersad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dlg1 binds GKAP to control dynein association with microtubules, centrosome positioning, and cell polarity

(2010) Jean-Baptiste Manneville et al.   JOURNAL OF CELL BIOLOGY

Frequent Phosphodiesterase 11A Gene (PDE11A) Defects in Patients with Carney Complex (CNC) Caused byPRKAR1AMutations:PDE11AMay Contribute to Adrenal and Testicular Tumors in CNC as a Modifier of the Phenotype

(2010) Rossella Libé et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Phosphodiesterase 8A (PDE8A) regulates excitation–contraction coupling in ventricular myocytes

(2010) Enrico Patrucco et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phosphodiesterases Catalyze Hydrolysis of cAMP-bound to Regulatory Subunit of Protein Kinase A and Mediate Signal Termination

(2010) Balakrishnan Shenbaga Moorthy et al.   MOLECULAR & CELLULAR PROTEOMICS

Networking with AKAPs: Context-dependent Regulation of Anchored Enzymes

(2010) E. J. Welch et al.   MOLECULAR INTERVENTIONS

Cyclic GMP and Nitric Oxide Synthase in Aging and Alzheimer's Disease

(2010) Katarzyna Urszula Domek-Łopacińska et al.   MOLECULAR NEUROBIOLOGY

The High-Affinity cAMP-Specific Phosphodiesterase 8B Controls Steroidogenesis in the Mouse Adrenal Gland

(2010) L.-C. L. Tsai et al.   MOLECULAR PHARMACOLOGY

PDE8 Regulates Rapid Teff Cell Adhesion and Proliferation Independent of ICER

(2010) Amanda G. Vang et al.   PLoS One

Inhibition of the Striatal Specific Phosphodiesterase PDE10A Ameliorates Striatal and Cortical Pathology in R6/2 Mouse Model of Huntington's Disease

(2010) Carmela Giampà et al.   PLoS One

Concerted Regulation of cGMP and cAMP Phosphodiesterases in Early Cardiac Hypertrophy Induced by Angiotensin II

(2010) Walid Mokni et al.   PLoS One

Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes

(2010) M. P. Kelly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vinpocetine inhibits NF- B-dependent inflammation via an IKK-dependent but PDE-independent mechanism

(2010) K.-I. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

(2010) Armin Hatzelmann et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Cooperative and uncooperative cyclic-nucleotide-gated ion channels

(2010) Abhishek Cukkemane et al.   TRENDS IN BIOCHEMICAL SCIENCES

A pooled analysis of the durability and predictors of treatment response of cilostazol in patients with intermittent claudication

(2010) Reena L Pande et al.   VASCULAR MEDICINE

Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the β3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes

(2009) Faiyaz Ahmad et al.   BIOCHEMICAL JOURNAL

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1

(2009) Mahmoud Alhosin et al.   BIOCHEMICAL PHARMACOLOGY

The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents

(2009) Michael P. DeNinno et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

EPAC proteins transduce diverse cellular actions of cAMP

(2009) Gillian Borland et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease

(2009) Katharine H Banner et al.   BRITISH JOURNAL OF PHARMACOLOGY

The role of Epac proteins, novel cAMP mediators, in the regulation of immune, lung and neuronal function

(2009) Maria Grandoch et al.   BRITISH JOURNAL OF PHARMACOLOGY

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

(2009) Tania Castaño et al.   ChemMedChem

Role of Ca 2+ /Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy

(2009) Clint L. Miller et al.   CIRCULATION RESEARCH

The flavonoid dioclein is a selective inhibitor of cyclic nucleotide phosphodiesterase type 1 (PDE1) and a cGMP-dependent protein kinase (PKG) vasorelaxant in human vascular tissue

(2009) Roberta L. Gonçalves et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PDE4 inhibitors: a review of current developments (2005 – 2009)

(2009) Lluís Pagès et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-γ production by mouse activated T lymphocytes

(2009) Kumiko Kadoshima-Yamaoka et al.   IMMUNOLOGY LETTERS

Chronic Lymphocytic Leukemia and B and T Cells Differ in Their Response to Cyclic Nucleotide Phosphodiesterase Inhibitors

(2009) J. A. Meyers et al.   JOURNAL OF IMMUNOLOGY

Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia

(2009) S. M. Grauer et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Anxiolytic Effects of Phosphodiesterase-2 Inhibitors Associated with Increased cGMP Signaling

(2009) A. Masood et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Short term effects of milrinone on biomarkers of necrosis, apoptosis, and inflammation in patients with severe heart failure

(2009) David E Lanfear et al.   Journal of Translational Medicine

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

(2009) H. N. Tinsley et al.   MOLECULAR CANCER THERAPEUTICS

Sleep deprivation impairs cAMP signalling in the hippocampus

(2009) Christopher G. Vecsey et al.   NATURE

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Phosphodiesterase 5 inhibition in heart failure: mechanisms and clinical implications

(2009) Praneet Kumar et al.   Nature Reviews Cardiology

Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics

(2009) Emily J. Tsai et al.   PHARMACOLOGY & THERAPEUTICS

Phosphodiesterase 3B Is Localized in Caveolae and Smooth ER in Mouse Hepatocytes and Is Important in the Regulation of Glucose and Lipid Metabolism

(2009) Karin Berger et al.   PLoS One

Cyclic Nucleotide Binding GAF Domains from Phosphodiesterases: Structural and Mechanistic Insights

(2009) Clemens C. Heikaus et al.   STRUCTURE

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

Short-term or long-term treatments with a phosphodiesterase-4 (PDE4) inhibitor result in opposing agonist-induced Ca2+responses in endothelial cells

(2008) M Campos-Toimil et al.   BRITISH JOURNAL OF PHARMACOLOGY

PDE4 inhibitors: current status

(2008) D Spina   BRITISH JOURNAL OF PHARMACOLOGY

Sildenafil

(2008) Katherine F Croom et al.   DRUGS

Molecular mechanisms that could contribute to prolonged effectiveness of PDE5 inhibitors to improve erectile function

(2008) S H Francis et al.   INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH

The Use of Continuous Milrinone Therapy as Bridge to Transplant Is Safe in Patients With Short Waiting Times

(2008) Christian Assad-Kottner et al.   JOURNAL OF CARDIAC FAILURE

Preclinical Characterization of Selective Phosphodiesterase 10A Inhibitors: A New Therapeutic Approach to the Treatment of Schizophrenia

(2008) C. J. Schmidt et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A Novel PDE2A Reporter Cell Line: Characterization of the Cellular Activity of PDE Inhibitors

(2008) Frank Wunder et al.   MOLECULAR PHARMACEUTICS

The novel selective PDE9 inhibitor BAY 73-6691 improves learning and memory in rodents

(2008) F. Josef van der Staay et al.   NEUROPHARMACOLOGY

Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

(2008) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement

(2008) Olga A. H. Reneerkens et al.   PSYCHOPHARMACOLOGY

Signal transducing membrane complexes of photoreceptor outer segments

(2008) Theodore G. Wensel   VISION RESEARCH

Phosphodiesterase inhibitors

(2006) Victoria Boswell-Smith et al.   BRITISH JOURNAL OF PHARMACOLOGY