The Future of Peptide-based Drugs

Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment

(2012) Clarence T. T. Wong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Converting Peptides into Drug Leads by Lipidation

(2012) L. Zhang et al.   CURRENT MEDICINAL CHEMISTRY

Engineering of Conotoxins for the Treatment of Pain

(2012) Bodil B. Carstens et al.   CURRENT PHARMACEUTICAL DESIGN

Cyclotides, a Novel Ultrastable Polypeptide Scaffold for Drug Discovery

(2012) Andrew Gould et al.   CURRENT PHARMACEUTICAL DESIGN

Cyclotides as a basis for drug design

(2012) David J Craik et al.   Expert Opinion on Drug Discovery

A comparison of currently available GLP-1 receptor agonists for the treatment of type 2 diabetes

(2012) Eduard Montanya   EXPERT OPINION ON PHARMACOTHERAPY

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Intestinal Permeability of Cyclic Peptides: Common Key Backbone Motifs Identified

(2012) Johannes G. Beck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Introducing Lasso Peptides as Molecular Scaffolds for Drug Design: Engineering of an Integrin Antagonist

(2011) Thomas A. Knappe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition

(2011) Michael M. Madden et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds

(2011) L. Y. Chan et al.   BLOOD

Ribosomal synthesis of backbone macrocyclic peptides

(2011) Takayuki Katoh et al.   CHEMICAL COMMUNICATIONS

Studying protein–protein interactions using peptide arrays

(2011) Chen Katz et al.   CHEMICAL SOCIETY REVIEWS

Protein epitope mimetics as anti-infectives

(2011) John A Robinson   CURRENT OPINION IN CHEMICAL BIOLOGY

Peptide and peptoid foldamers in medicinal chemistry

(2011) W Seth Horne   Expert Opinion on Drug Discovery

Identification and Characterization of a New Family of Cell-penetrating Peptides

(2011) Laura Cascales et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways

(2011) Janette Contreras et al.   JOURNAL OF CONTROLLED RELEASE

Chemical Re-engineering of Chlorotoxin Improves Bioconjugation Properties for Tumor Imaging and Targeted Therapy

(2011) Muharrem Akcan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assessing Helical Protein Interfaces for Inhibitor Design

(2011) Brooke N. Bullock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds

(2011) Tina R White et al.   Nature Chemical Biology

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis

(2011) Young-Woo Kim et al.   Nature Protocols

The biosynthesis of Caryophyllaceae-like cyclic peptides in Saponaria vaccaria L. from DNA-encoded precursors

(2011) Janet A. Condie et al.   PLANT JOURNAL

The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain

(2010) Richard J. Clark et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Dual-Labeled Knottin Peptide for PET and Near-Infrared Fluorescence Imaging of Integrin Expression in Living Subjects

(2010) Richard H. Kimura et al.   BIOCONJUGATE CHEMISTRY

Update 1 of: Proteases Universally Recognize Beta Strands In Their Active Sites

(2010) Praveen K. Madala et al.   CHEMICAL REVIEWS

Update 1 of: Beta-Strand Mimetics

(2010) Wendy A. Loughlin et al.   CHEMICAL REVIEWS

Naturally occurring circular proteins: distribution, biosynthesis and evolution

(2010) Laura Cascales et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

(2010) R. S. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide drugs to target G protein-coupled receptors

(2010) Kathrin Bellmann-Sickert et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

An Engineered Knottin Peptide Labeled with18F for PET Imaging of Integrin Expression

(2009) Zheng Miao et al.   BIOCONJUGATE CHEMISTRY

Engineered Knottin Peptides: A New Class of Agents for Imaging Integrin Expression in Living Subjects

(2009) R. H. Kimura et al.   CANCER RESEARCH

Cyclotides: macrocyclic peptides with applications in drug design and agriculture

(2009) David J. Craik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cyclotides as templates in drug design

(2009) Sónia Troeira Henriques et al.   DRUG DISCOVERY TODAY

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Potent Inhibitors of β-Tryptase and Human Leukocyte Elastase Based on the MCoTI-II Scaffold

(2009) Panumart Thongyoo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metal Clips That Induce Unstructured Pentapeptides To Be α-Helical In Water

(2009) Michelle T. Ma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Conotoxins: natural product drug leads

(2009) Reena Halai et al.   NATURAL PRODUCT REPORTS

Exploring β-Sheet Structure and Interactions with Chemical Model Systems

(2008) James S. Nowick   ACCOUNTS OF CHEMICAL RESEARCH

N-Methylation of Peptides: A New Perspective in Medicinal Chemistry

(2008) Jayanta Chatterjee et al.   ACCOUNTS OF CHEMICAL RESEARCH

Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues

(2008) Eric Biron et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Contemporary strategies for the stabilization of peptides in the α-helical conformation

(2008) Laura K Henchey et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A new orally available glucagon-like peptide-1 receptor agonist, biotinylated exendin-4, displays improved hypoglycemic effects in db/db mice

(2008) Cheng-Hao Jin et al.   JOURNAL OF CONTROLLED RELEASE

Engineering Stabilized Vascular Endothelial Growth Factor-A Antagonists: Synthesis, Structural Characterization, and Bioactivity of Grafted Analogues of Cyclotides

(2008) Sunithi Gunasekera et al.   JOURNAL OF MEDICINAL CHEMISTRY

Knottin cyclization: impact on structure and dynamics

(2008) Annie Heitz et al.   BMC STRUCTURAL BIOLOGY

Preparation, Characterization, and Application of Biotinylated and Biotin−PEGylated Glucagon-Like Peptide-1 Analogues for Enhanced Oral Delivery

(2007) Su Young Chae et al.   BIOCONJUGATE CHEMISTRY