Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, β-arrestin 2, PDE4D3 complex

KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation

(2010) Pieter Rondou et al.   CELLULAR SIGNALLING

AKAP79/150 Interacts with AC8 and Regulates Ca2+-dependent cAMP Synthesis in Pancreatic and Neuronal Systems

(2010) Debbie Willoughby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AKAP79 Interacts with Multiple Adenylyl Cyclase (AC) Isoforms and Scaffolds AC5 and -6 to α-Amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) Receptors

(2010) Riad Efendiev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prolonged RXFP1 and RXFP2 signaling can be explained by poor internalization and a lack of β-arrestin recruitment

(2009) Gabrielle E. Callander et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Circulating levels of relaxin and its relation to cardiovascular function in patients with hypertension

(2009) Omer Gedikli et al.   BLOOD PRESSURE

Imaging cytoplasmic cAMP in mouse brainstem neurons

(2009) SL Mironov et al.   BMC NEUROSCIENCE

Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation

(2009) Anneleen Spooren et al.   CELLULAR SIGNALLING

The Cardiac IKsPotassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3

(2009) Cecile Terrenoire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intravenous Recombinant Human Relaxin in Compensated Heart Failure: A Safety, Tolerability, and Pharmacodynamic Trial

(2009) Thomas Dschietzig et al.   JOURNAL OF CARDIAC FAILURE

Distinct pools of cAMP centre on different isoforms of adenylyl cyclase in pituitary-derived GH3B6 cells

(2009) S. Wachten et al.   JOURNAL OF CELL SCIENCE

Relaxin for the treatment of patients with acute heart failure (Pre-RELAX-AHF): a multicentre, randomised, placebo-controlled, parallel-group, dose-finding phase IIb study

(2009) John R Teerlink et al.   LANCET

Adenylyl Cyclase-A-kinase Anchoring Protein Complexes: The Next Dimension in cAMP Signaling

(2009) C. W. Dessauer   MOLECULAR PHARMACOLOGY

Cardiovascular effects of relaxin: from basic science to clinical therapy

(2009) Xiao-Jun Du et al.   Nature Reviews Cardiology

Relaxin family peptide receptors – from orphans to therapeutic targets

(2008) Emma T. van der Westhuizen et al.   DRUG DISCOVERY TODAY

Characterization of Relaxin Receptor (RXFP1) Desensitization and Internalization in Primary Human Decidual Cells and RXFP1-Transfected HEK293 Cells

(2008) András Kern et al.   ENDOCRINOLOGY

Relaxin Family Peptide Receptor (RXFP1) Coupling to G i3 Involves the C-Terminal Arg752 and Localization within Membrane Raft Microdomains

(2008) M. L. Halls et al.   MOLECULAR PHARMACOLOGY

The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain

(2008) L. A. Piggott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA