Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain

Allosteric-site and catalytic-site ligand effects on PDE5 functions are associated with distinct changes in physical form of the enzyme

(2009) Jackie D. Corbin et al.   CELLULAR SIGNALLING

Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct

(2009) J. Pandit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The properties of phosphodiesterase 11A4 GAF domains are regulated by modifications in its N-terminal domain

(2008) Marco Gross-Langenhoff et al.   FEBS Journal

Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5

(2008) Clemens C. Heikaus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change

(2008) Sergio E. Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP

(2008) Noriko Handa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Chimeras of the Phosphodiesterase 5 and 10 Tandem GAF Domains

(2008) Karina Hofbauer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Allosteric Regulation between the GAF Domain and Catalytic Domain of Photoreceptor Phosphodiesterase PDE6

(2008) Xiu-Jun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY