Biochemical Basis of Asthma Therapy

Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease

(2010) Yasuo To et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Statins enhance the anti-inflammatory effects of inhaled corticosteroids in asthmatic patients through increased induction of indoleamine 2, 3-dioxygenase

(2010) Kittipong Maneechotesuwan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Location, Location, Location: Compartmentalization of Early Events in Leukotriene Biosynthesis

(2010) Marcia E. Newcomer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eosinophil Cysteinyl Leukotriene Synthesis Mediated by Exogenous Secreted Phospholipase A2Group X

(2010) Ying Lai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tiotropium Bromide Step-Up Therapy for Adults with Uncontrolled Asthma

(2010) Stephen P. Peters et al.   NEW ENGLAND JOURNAL OF MEDICINE

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

(2010) Armin Hatzelmann et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

QVA149 demonstrates superior bronchodilation compared with indacaterol or placebo in patients with chronic obstructive pulmonary disease

(2010) J. A. van Noord et al.   THORAX

New therapies for asthma: is there any progress?

(2010) Peter J. Barnes   TRENDS IN PHARMACOLOGICAL SCIENCES

Inhibition of PI3Kδ Restores Glucocorticoid Function in Smoking-induced Airway Inflammation in Mice

(2009) John A. Marwick et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Both Hematopoietic-Derived and Non–Hematopoietic-Derived β-Arrestin–2 Regulates Murine Allergic Airway Disease

(2009) John W. Hollingsworth et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Immunobiology of Asthma

(2009) Qutayba Hamid et al.   Annual Review of Physiology

Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2

(2009) Grace O. Osoata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phospholipase A2 inhibitors

(2009) Hector M Garcia-Garcia et al.   CURRENT OPINION IN LIPIDOLOGY

Emerging inhaled bronchodilators: an update

(2009) M. Cazzola et al.   EUROPEAN RESPIRATORY JOURNAL

Counterregulation of β2-adrenoceptor function in human mast cells by stem cell factor

(2009) Glenn Cruse et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hypoxia-inducible Factor 1α Induces Corticosteroid-insensitive Inflammation via Reduction of Histone Deacetylase-2 Transcription

(2009) Catherine E. Charron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid resistance in inflammatory diseases

(2009) Peter J Barnes et al.   LANCET

Pharmacological strategies for improving the efficacy and therapeutic ratio of glucocorticoids in inflammatory lung diseases

(2009) Robert Newton et al.   PHARMACOLOGY & THERAPEUTICS

 2-Adrenoceptor signaling is required for the development of an asthma phenotype in a murine model

(2009) L. P. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative mechanisms for tiotropium

(2009) E.D. Bateman et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The human glucocorticoid receptor: Molecular basis of biologic function

(2009) Nicolas C. Nicolaides et al.   STEROIDS

Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

(2009) Kittipong Maneechotesuwan et al.   PLOS MEDICINE

Role of HDAC2 in the Pathophysiology of COPD

(2008) Peter J. Barnes   Annual Review of Physiology

Activation of Human Phospholipase C-η2 by Gβγ†

(2008) Yixing Zhou et al.   BIOCHEMISTRY

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

(2008) I Wessler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adenosine receptors and asthma in humans

(2008) C N Wilson   BRITISH JOURNAL OF PHARMACOLOGY

Global strategy for asthma management and prevention: GINA executive summary

(2008) E. D. Bateman et al.   EUROPEAN RESPIRATORY JOURNAL

The epithelial cholinergic system of the airways

(2008) W. Kummer et al.   HISTOCHEMISTRY AND CELL BIOLOGY

M2Muscarinic Receptors Induce Airway Smooth Muscle Activation via a Dual, Gβγ-mediated Inhibition of Large Conductance Ca2+-activated K+Channel Activity

(2008) Xiao-Bo Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Protein Kinase A-independent, β-Arrestin-1-dependent Signaling Pathway for p38 Mitogen-activated Protein Kinase Activation by β2-Adrenergic Receptors

(2008) Kaizheng Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The cytokine network in asthma and chronic obstructive pulmonary disease

(2008) Peter J. Barnes   JOURNAL OF CLINICAL INVESTIGATION

Interaction of the Glucocorticoid Receptor with the Chromatin Landscape

(2008) Sam John et al.   MOLECULAR CELL

Clinical consequences of ADRβ2 polymorphisms

(2008) Gregory A Hawkins et al.   PHARMACOGENOMICS

Physiological and pharmacological implications of beta-arrestin regulation

(2008) Cullen L. Schmid et al.   PHARMACOLOGY & THERAPEUTICS

Inhibition of human airway smooth muscle cell proliferation by β2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement

(2007) Karen M. Kassel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sputum indoleamine-2, 3-dioxygenase activity is increased in asthmatic airways by using inhaled corticosteroids

(2007) Kittipong Maneechotesuwan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The safety and effects of the beta-blocker, nadolol, in mild asthma: An open-label pilot study

(2007) Nicola A. Hanania et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

How corticosteroids control inflammation: Quintiles Prize Lecture 2005

(2006) Peter J Barnes   BRITISH JOURNAL OF PHARMACOLOGY