Oxygen Sensing, Homeostasis, and Disease

Hypoxia. 5. Hypoxia and hematopoiesis

(2011) Donghoon Yoon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue

(2011) S. Rey et al.   BLOOD

HIF-1α dysfunction in diabetes

(2011) Hariharan Thangarajah et al.   CELL CYCLE

Cardiopulmonary function in two human disorders of the hypoxia-inducible factor (HIF) pathway: von Hippel-Lindau disease and HIF-2α gain-of-function mutation

(2011) Federico Formenti et al.   FASEB JOURNAL

Cardiomyocyte-specific Prolyl-4-hydroxylase Domain 2 Knock Out Protects from Acute Myocardial Ischemic Injury

(2011) Marion Hölscher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection

(2011) Xinguo Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypoxia Inducible-Factor1α Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells

(2010) Iwona Fijalkowska et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of Bone Marrow-Derived Vascular Progenitor Cell Mobilization and Maintenance

(2010) Stefanie Dimmeler   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning

(2010) Gregg L. Semenza   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Treatment of kidney cancer

(2010) William G. Kaelin   CANCER

Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension

(2010) Stephen L. Archer et al.   CIRCULATION

Myocardial Transfection of Hypoxia Inducible Factor-1α via an Adenoviral Vector During Coronary Artery Bypass Grafting

(2010) Eckehard Gerd Kilian et al.   CIRCULATION JOURNAL

Digoxin inhibits retinal ischemia-induced HIF-1α expression and ocular neovascularization

(2010) Tsunehiko Yoshida et al.   FASEB JOURNAL

Hearts of Hypoxia-inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection against Acute Ischemia-Reperfusion Injury

(2010) Jaana Hyvärinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Natural selection on EPAS1 (HIF2 ) associated with low hemoglobin concentration in Tibetan highlanders

(2010) C. M. Beall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Evidence for High-Altitude Adaptation in Tibet

(2010) T. S. Simonson et al.   SCIENCE

Sequencing of 50 Human Exomes Reveals Adaptation to High Altitude

(2010) X. Yi et al.   SCIENCE

Erythropoietin in Combination of Tissue Plasminogen Activator Exacerbates Brain Hemorrhage When Treatment Is Initiated 6 Hours After Stroke

(2010) Longfei Jia et al.   STROKE

Identifying Signatures of Natural Selection in Tibetan and Andean Populations Using Dense Genome Scan Data

(2010) Abigail Bigham et al.   PLoS Genetics

Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection

(2009) Sarah K. Harten et al.   ANTIOXIDANTS & REDOX SIGNALING

Therapeutic Manipulation of the HIF Hydroxylases

(2009) Simon Nagel et al.   ANTIOXIDANTS & REDOX SIGNALING

Lower Mortality From Coronary Heart Disease and Stroke at Higher Altitudes in Switzerland

(2009) David Faeh et al.   CIRCULATION

Mitochondrial reactive oxygen species regulate hypoxic signaling

(2009) Robert B Hamanaka et al.   CURRENT OPINION IN CELL BIOLOGY

Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts

(2009) David R. Mole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

(2009) Peter Fraisl et al.   NATURE REVIEWS DRUG DISCOVERY

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

(2009) G L Semenza   ONCOGENE

Donor treatment with a PHD-inhibitor activating HIFs prevents graft injury and prolongs survival in an allogenic kidney transplant model

(2009) W. M. Bernhardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis

(2009) X. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adenoviral transfer of HIF-1  enhances vascular responses to critical limb ischemia in diabetic mice

(2009) K. Sarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic effect of HIF-1  gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia

(2009) S. Rey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant Human Erythropoietin in the Treatment of Acute Ischemic Stroke

(2009) Hannelore Ehrenreich et al.   STROKE

Oxygen homeostasis

(2009) Gregg L. Semenza   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Vascular Growth in Ischemic Limbs: A Review of Mechanisms and Possible Therapeutic Stimulation

(2008) V. van Weel et al.   ANNALS OF VASCULAR SURGERY

Biology of hypoxia-inducible factor-2α in development and disease

(2008) S A Patel et al.   CELL DEATH AND DIFFERENTIATION

Hypoxia-Inducible Factor-1 Is Central to Cardioprotection

(2008) Tobias Eckle et al.   CIRCULATION

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

A Gain-of-Function Mutation in theHIF2AGene in Familial Erythrocytosis

(2008) Melanie J. Percy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Digoxin and other cardiac glycosides inhibit HIF-1  synthesis and block tumor growth

(2008) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilization of HIF-1  is critical to improve wound healing in diabetic mice

(2008) I. R. Botusan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes

(2007) E. Miles Whitman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY