Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

A hibernating kidney – ischemic preconditioning in a renal transplant recipient with a proximal stenosis of the iliac artery

(2011) J. Warncke et al.   CLINICAL NEPHROLOGY

Activation of the oxygen-sensing signal cascade prevents mitochondrial injury after mouse liver ischemia-reperfusion

(2008) Zhi Zhong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

LPS Induces Hypoxia-Inducible Factor 1 Activation in Macrophage-Differentiated Cells in a Reactive Oxygen Species–Dependent Manner

(2008) Kenichiro Nishi et al.   ANTIOXIDANTS & REDOX SIGNALING

Up-regulated HIF-1α is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning

(2008) Zhaoyun Peng et al.   BRAIN RESEARCH

Hypoxia-Inducible Factor-1 Is Central to Cardioprotection

(2008) Tobias Eckle et al.   CIRCULATION

W1376 Tumor Necrosis Factor Alpha and Interferon Gamma Induce Apoptosis in Enteric Glia: Protective Role of Brain-Derived Neurotrophic Factor

(2008) Christoph Hartmann et al.   GASTROENTEROLOGY

The kinesin KIF1B  acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

(2008) S. Schlisio et al.   GENES & DEVELOPMENT

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Adenosine‐dependent activation of hypoxia‐inducible factor‐1 induces late preconditioning in liver cells

(2008) Elisa Alchera et al.   HEPATOLOGY

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin-Resistant Cardiomyopathy

(2008) Ronald M. Witteles et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inhibition of Hypoxia Inducible Factor Hydroxylases Protects Against Renal Ischemia-Reperfusion Injury

(2008) P. Hill et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3-/- Mice

(2008) T. Bishop et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Hypoxic reprogramming

(2008) Daniel P Kelly   NATURE GENETICS

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

(2008) Julián Aragonés et al.   NATURE GENETICS

Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney

(2008) C. Rosenberger et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A Gain-of-Function Mutation in theHIF2AGene in Familial Erythrocytosis

(2008) Melanie J. Percy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Physiology of Preconditioning-Induced Brain Tolerance to Ischemia

(2008) Tihomir Paul Obrenovitch   PHYSIOLOGICAL REVIEWS

Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury

(2008) Elizabeth Murphy et al.   PHYSIOLOGICAL REVIEWS

The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia

(2008) Almut Grenz et al.   PLOS MEDICINE

Ischemic Preconditioning: From Molecular Mechanisms to Therapeutic Opportunities

(2007) Hajime Otani   ANTIOXIDANTS & REDOX SIGNALING

Oxygen sensors in context

(2007) Jeremy P.T. Ward   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins

(2007) K. Takeda et al.   BLOOD

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

(2007) Y. A. Minamishima et al.   BLOOD

Persistent Regional Downregulation in Mitochondrial Enzymes and Upregulation of Stress Proteins in Swine With Chronic Hibernating Myocardium

(2007) Brian Page et al.   CIRCULATION RESEARCH

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY

Lipid accumulation in non-adipose tissue and lipotoxicity

(2007) N.A. van Herpen et al.   PHYSIOLOGY & BEHAVIOR