Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases
出版年份 2014 全文链接
标题
Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume 13, Issue 11, Pages 852-869
出版商
Springer Nature
发表日期
2014-10-31
DOI
10.1038/nrd4422
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation
- (2014) Eric L. Campbell et al. IMMUNITY
- Endothelial HIF-2 mediates protection and recovery from ischemic kidney injury
- (2014) Pinelopi P. Kapitsinou et al. JOURNAL OF CLINICAL INVESTIGATION
- Nucleotide signalling during inflammation
- (2014) Marco Idzko et al. NATURE
- Neutrophil Intercellular Communication in Acute Lung Injury. Emerging Roles of Microparticles and Gap Junctions
- (2013) Viola Dengler et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Perioperative Organ Injury
- (2013) Karsten Bartels et al. ANESTHESIOLOGY
- CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury
- (2013) Heidi Ehrentraut et al. FASEB JOURNAL
- Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury
- (2013) Tobias Eckle et al. FASEB JOURNAL
- Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice
- (2013) Xiang Xue et al. GASTROENTEROLOGY
- Type 1 diabetes
- (2013) Mark A Atkinson et al. LANCET
- Fundamental role for HIF-1α in constitutive expression of human β defensin-1
- (2013) C J Kelly et al. Mucosal Immunology
- Succinate is an inflammatory signal that induces IL-1β through HIF-1α
- (2013) G. M. Tannahill et al. NATURE
- AstraZeneca bets on FibroGen's anaemia drug
- (2013) Monica Hoyos Flight NATURE REVIEWS DRUG DISCOVERY
- Metabolic targets for cancer therapy
- (2013) Lorenzo Galluzzi et al. NATURE REVIEWS DRUG DISCOVERY
- Hypoxia Modulates Infection of Epithelial Cells by Pseudomonas aeruginosa
- (2013) Bettina Schaible et al. PLoS One
- Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart
- (2013) Z. Cai et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of IL-1 -induced NF- B by hydroxylases links key hypoxic and inflammatory signaling pathways
- (2013) C. C. Scholz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Control of creatine metabolism by HIF is an endogenous mechanism of barrier regulation in colitis
- (2013) L. E. Glover et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hypoxia and inflammation are two sides of the same coin
- (2013) K. Bartels et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Attenuating myocardial ischemia by targeting A2B adenosine receptors
- (2013) Holger K. Eltzschig et al. TRENDS IN MOLECULAR MEDICINE
- HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium
- (2013) Tobias Eckle et al. PLOS BIOLOGY
- Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success
- (2012) Cristina Branco-Price et al. CANCER CELL
- Hypoxia-Inducible Factors in Physiology and Medicine
- (2012) Gregg L. Semenza CELL
- Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors
- (2012) Yan Xia et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Acute Respiratory Distress Syndrome
- (2012) JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Central Role for Endothelial Human Deneddylase-1/SENP8 in Fine-Tuning the Vascular Inflammatory Response
- (2012) S. F. Ehrentraut et al. JOURNAL OF IMMUNOLOGY
- Paneth Cell-Mediated Multiorgan Dysfunction after Acute Kidney Injury
- (2012) S. W. Park et al. JOURNAL OF IMMUNOLOGY
- A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection
- (2012) Cheryl Y. M. Okumura et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia
- (2012) Tobias Eckle et al. NATURE MEDICINE
- Purinergic Signaling during Inflammation
- (2012) Holger K. Eltzschig et al. NEW ENGLAND JOURNAL OF MEDICINE
- Adora2b Adenosine Receptor Engagement Enhances Regulatory T Cell Abundance during Endotoxin-Induced Pulmonary Inflammation
- (2012) Heidi Ehrentraut et al. PLoS One
- Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
- (2012) E. T. Clambey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In Vivo Hypoxic Preconditioning Protects From Warm Liver Ischemia-Reperfusion Injury Through the Adenosine A2B Receptor
- (2012) Alexander Choukèr et al. TRANSPLANTATION
- New Anemia Therapies: Translating Novel Strategies From Bench to Bedside
- (2011) Iain C. Macdougall AMERICAN JOURNAL OF KIDNEY DISEASES
- Cardiopulmonary Bypass–associated Acute Kidney Injury
- (2011) Avinash B. Kumar et al. ANESTHESIOLOGY
- Adenosine and Hypoxia-Inducible Factor Signaling in Intestinal Injury and Recovery
- (2011) Sean P. Colgan et al. Annual Review of Physiology
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
- (2011) Eric V. Dang et al. CELL
- Effect of Hypoxia-Inducible Factor-1α Gene Therapy on Walking Performance in Patients With Intermittent Claudication
- (2011) Mark A. Creager et al. CIRCULATION
- Cancer Therapeutic Agents Targeting Hypoxia-Inducible Factor-1
- (2011) R. Wang et al. CURRENT MEDICINAL CHEMISTRY
- Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis
- (2011) Carol M Aherne et al. GUT
- Vasodilator Phosphostimulated Protein (VASP) Protects Endothelial Barrier Function During Hypoxia
- (2011) Marthe A. Schmit et al. INFLAMMATION
- HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells
- (2011) Lewis Z. Shi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Hypoxia-Inducible Factor-1α–Dependent Protection from Intestinal Ischemia/Reperfusion Injury Involves Ecto-5′-Nucleotidase (CD73) and the A2B Adenosine Receptor
- (2011) Melanie L. Hart et al. JOURNAL OF IMMUNOLOGY
- Neddylation-Induced Conformational Control Regulates Cullin RING Ligase Activity In Vivo
- (2011) Boon Kim Boh et al. JOURNAL OF MOLECULAR BIOLOGY
- Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1
- (2011) Bjoern O. Schroeder et al. NATURE
- Ischemia and reperfusion—from mechanism to translation
- (2011) Holger K Eltzschig et al. NATURE MEDICINE
- Hypoxia and Inflammation
- (2011) Holger K. Eltzschig et al. NEW ENGLAND JOURNAL OF MEDICINE
- Oxygen Sensing, Homeostasis, and Disease
- (2011) Gregg L. Semenza NEW ENGLAND JOURNAL OF MEDICINE
- Functional Disability 5 Years after Acute Respiratory Distress Syndrome
- (2011) Margaret S. Herridge et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Hydroxylase Inhibitor Dimethyloxallyl Glycine Attenuates Endotoxic Shock Via Alternative Activation of Macrophages and IL-10 Production by B1 Cells
- (2011) Emily Hams et al. SHOCK
- The resurgence of A2B adenosine receptor signaling
- (2010) Carol M. Aherne et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation
- (2010) A.-K. Riegel et al. BLOOD
- Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function
- (2010) Murtaza M. Tambuwala et al. GASTROENTEROLOGY
- Differential activation and antagonistic function of HIF- isoforms in macrophages are essential for NO homeostasis
- (2010) N. Takeda et al. GENES & DEVELOPMENT
- Hypoxia-inducible factor-1α regulates β cell function in mouse and human islets
- (2010) Kim Cheng et al. JOURNAL OF CLINICAL INVESTIGATION
- The Antimicrobial Peptide DEFB1 Is Associated with Caries
- (2010) A. Ozturk et al. JOURNAL OF DENTAL RESEARCH
- SP1-Dependent Induction of CD39 Facilitates Hepatic Ischemic Preconditioning
- (2010) M. L. Hart et al. JOURNAL OF IMMUNOLOGY
- Signaling through the A2B Adenosine Receptor Dampens Endotoxin-Induced Acute Lung Injury
- (2010) U. Schingnitz et al. JOURNAL OF IMMUNOLOGY
- Metabolic Shifts in Immunity and Inflammation
- (2010) D. J. Kominsky et al. JOURNAL OF IMMUNOLOGY
- Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD
- (2010) W. M. Bernhardt et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial
- (2010) Hans Erik Bøtker et al. LANCET
- Hypoxia: an alarm signal during intestinal inflammation
- (2010) Sean P. Colgan et al. Nature Reviews Gastroenterology & Hepatology
- Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans
- (2010) Cormac T. Taylor et al. PHYSIOLOGY
- Activation of Hypoxia Inducible Factor 1 Is a General Phenomenon in Infections with Human Pathogens
- (2010) Nadine Werth et al. PLoS One
- Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon
- (2010) L. Peyrin-Biroulet et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic Evidence for High-Altitude Adaptation in Tibet
- (2010) T. S. Simonson et al. SCIENCE
- Adenosine: An Old Drug Newly Discovered
- (2009) Holger K. Eltzschig ANESTHESIOLOGY
- MicroRNA Control in the Immune System: Basic Principles
- (2009) Changchun Xiao et al. CELL
- Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization
- (2009) Massimiliano Mazzone et al. CELL
- Crohn’s Disease: an Immune Deficiency State
- (2009) Daniel J. B. Marks et al. CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
- Regulation of Angiogenesis by Oxygen and Metabolism
- (2009) Peter Fraisl et al. DEVELOPMENTAL CELL
- Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation
- (2009) Holger K Eltzschig et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury
- (2009) Martin Schneider et al. GASTROENTEROLOGY
- A 3′ UTR transition within DEFB1 is associated with chronic and aggressive periodontitis
- (2009) A S Schaefer et al. GENES AND IMMUNITY
- Contribution of Adenosine A2B Receptors to Inflammatory Parameters of Experimental Colitis
- (2009) J.-S. Frick et al. JOURNAL OF IMMUNOLOGY
- Translation of remote ischaemic preconditioning into clinical practice
- (2009) Rajesh K Kharbanda et al. LANCET
- An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
- (2009) Teresa A. Soucy et al. NATURE
- A protective function for interleukin 17A in T cell–mediated intestinal inflammation
- (2009) William O'Connor Jr et al. NATURE IMMUNOLOGY
- Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease
- (2009) Peter Fraisl et al. NATURE REVIEWS DRUG DISCOVERY
- Inflammatory Bowel Disease
- (2009) Clara Abraham et al. NEW ENGLAND JOURNAL OF MEDICINE
- Arterial Blood Gases and Oxygen Content in Climbers on Mount Everest
- (2009) Michael P.W. Grocott et al. NEW ENGLAND JOURNAL OF MEDICINE
- Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
- (2009) G L Semenza ONCOGENE
- Role of Extracellular Adenosine in Acute Lung Injury
- (2009) Tobias Eckle et al. PHYSIOLOGY
- Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
- (2009) Gregg L. Semenza PHYSIOLOGY
- Adenosine A2A receptor is a unique angiogenic target of HIF-2 in pulmonary endothelial cells
- (2009) A. Ahmad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synergistic effect of HIF-1 gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia
- (2009) S. Rey et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effect of dutasteride on the expression of hypoxia-inducible factor-1α, vascular endothelial growth factor and microvessel density in rat and human prostate tissue
- (2009) Ja Hyeon Ku et al. SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY
- HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak
- (2008) J. C. Morote-Garcia et al. BLOOD
- Central role of Sp1-regulated CD39 in hypoxia/ischemia protection
- (2008) H. K. Eltzschig et al. BLOOD
- Camptothecins: A SAR/QSAR Study
- (2008) Rajeshwar P. Verma et al. CHEMICAL REVIEWS
- Hypoxia-Inducible Factor-1 Is Central to Cardioprotection
- (2008) Tobias Eckle et al. CIRCULATION
- Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1α
- (2008) Jeremy Ben-Shoshan et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- W1376 Tumor Necrosis Factor Alpha and Interferon Gamma Induce Apoptosis in Enteric Glia: Protective Role of Brain-Derived Neurotrophic Factor
- (2008) Christoph Hartmann et al. GASTROENTEROLOGY
- Extracellular Adenosine Production by Ecto-5′-Nucleotidase Protects During Murine Hepatic Ischemic Preconditioning
- (2008) Melanie L. Hart et al. GASTROENTEROLOGY
- Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade
- (2008) Yatrik M. Shah et al. GASTROENTEROLOGY
- Hypoxia-Inducible Factor–Dependent Repression of Equilibrative Nucleoside Transporter 2 Attenuates Mucosal Inflammation During Intestinal Hypoxia
- (2008) Julio C. Morote–Garcia et al. GASTROENTEROLOGY
- PX-478, an inhibitor of hypoxia-inducible factor-1α, enhances radiosensitivity of prostate carcinoma cells
- (2008) Sanjeewani T. Palayoor et al. INTERNATIONAL JOURNAL OF CANCER
- Critical Role of HIF-1α in Keratinocyte Defense against Bacterial Infection
- (2008) Carole Peyssonnaux et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Interdependent roles for hypoxia inducible factor and nuclear factor-κB in hypoxic inflammation
- (2008) Cormac T. Taylor JOURNAL OF PHYSIOLOGY-LONDON
- Inhibition of Hypoxia Inducible Factor Hydroxylases Protects Against Renal Ischemia-Reperfusion Injury
- (2008) P. Hill et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1 and -2
- (2008) M. Puppo et al. MOLECULAR CANCER THERAPEUTICS
- Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
- (2008) William G. Kaelin et al. MOLECULAR CELL
- NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
- (2008) Jordi Rius et al. NATURE
- Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
- (2008) Julián Aragonés et al. NATURE GENETICS
- A Gain-of-Function Mutation in theHIF2AGene in Familial Erythrocytosis
- (2008) Melanie J. Percy et al. NEW ENGLAND JOURNAL OF MEDICINE
- ATP Release from Vascular Endothelia Occurs Across Cx43 Hemichannels and Is Attenuated during Hypoxia
- (2008) Marion Faigle et al. PLoS One
- Oxygen-Independent Stabilization of Hypoxia Inducible Factor (HIF)-1 during RSV Infection
- (2008) Helene A. Haeberle et al. PLoS One
- Digoxin and other cardiac glycosides inhibit HIF-1 synthesis and block tumor growth
- (2008) H. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease
- (2008) Ágnes Katalin Kocsis et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia
- (2008) Almut Grenz et al. PLOS MEDICINE
- The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis
- (2007) Eoin P. Cummins et al. GASTROENTEROLOGY
- Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition
- (2007) Andreas Robinson et al. GASTROENTEROLOGY
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