标题
Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 19, Pages 10279
出版商
MDPI AG
发表日期
2021-09-25
DOI
10.3390/ijms221910279
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours
- (2021) Silpa Gampala et al. BRITISH JOURNAL OF CANCER
- Antioxidative effects of polypyrimidine tract-binding protein-associated splicing factor against pathological retinal angiogenesis through promotion of mitochondrial function
- (2021) Lijie Dong et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures
- (2021) David Sehnal et al. NUCLEIC ACIDS RESEARCH
- Age-related macular degeneration
- (2021) Monika Fleckenstein et al. Nature Reviews Disease Primers
- Anti-VEGF-Resistant Retinal Diseases: A Review of the Latest Treatment Options
- (2021) Josh O. Wallsh et al. Cells
- Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target
- (2021) Silpa Gampala et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells
- (2021) Kannappan Sriramajayam et al. Redox Biology
- Age-related macular degeneration therapy
- (2020) Michael J. Ammar et al. CURRENT OPINION IN OPHTHALMOLOGY
- Short-term Outcomes After Very Low-Dose Intravitreous Bevacizumab for Retinopathy of Prematurity
- (2020) David K. Wallace et al. JAMA Ophthalmology
- Revascularization and limb salvage following critical limb ischemia by nanoceria-induced Ref-1/APE1-dependent angiogenesis
- (2020) In-Su Park et al. BIOMATERIALS
- Inhibition of APE1/Ref-1 Redox Signaling Alleviates Intestinal Dysfunction and Damage to Myenteric Neurons in a Mouse Model of Spontaneous Chronic Colitis
- (2020) Lauren Sahakian et al. INFLAMMATORY BOWEL DISEASES
- Phase I clinical trial of temozolomide and methoxyamine (TRC-102), an inhibitor of base excision repair, in patients with advanced solid tumors
- (2020) Jennifer R. Eads et al. INVESTIGATIONAL NEW DRUGS
- The multifunctional APE1 DNA repair–redox signaling protein as a drug target in human disease
- (2020) Rachel A. Caston et al. DRUG DISCOVERY TODAY
- Plasma APE1/Ref-1 Correlates with Atherosclerotic Inflammation in ApoE−/− Mice
- (2020) Yu Ran Lee et al. Biomedicines
- A phase I study of the APE1 protein inhibitor APX3330 in patients with advanced solid tumors.
- (2019) Safi Shahda et al. JOURNAL OF CLINICAL ONCOLOGY
- ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR INTRAVITREAL THERAPY FOR RETINOPATHY OF PREMATURITY
- (2019) Deborah K. VanderVeen et al. SEMINARS IN PERINATOLOGY
- ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1
- (2019) Yu Ran Lee et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway
- (2019) Marta Codrich et al. DNA REPAIR
- Consensus Nomenclature for Reporting Neovascular Age-Related Macular Degeneration Data
- (2019) Richard F. Spaide et al. OPHTHALMOLOGY
- Chlorogenic acid prevents diabetic nephropathy by inhibiting oxidative stress and inflammation through modulation of the Nrf2/HO-1 and NF-ĸB pathways
- (2018) Liping Bao et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Role of Inflammation in Diabetic Retinopathy
- (2018) Anne Rübsam et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Exposure of Barrett’s and esophageal adenocarcinoma cells to bile acids activates EGFR–STAT3 signaling axis via induction of APE1
- (2018) Ajaz A. Bhat et al. ONCOGENE
- A Dosing Study of Bevacizumab for Retinopathy of Prematurity
- (2018) David K. Wallace et al. OPHTHALMOLOGY
- Therapeutic positioning of secretory acetylated APE1/Ref-1 requirement for suppression of tumor growth in triple-negative breast cancer in vivo
- (2018) Yu Ran Lee et al. Scientific Reports
- APX3330 Promotes Neurorestorative Effects after Stroke in Type One Diabetic Rats
- (2018) Tao Yan et al. Aging and Disease
- Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization
- (2018) Sheik Pran Babu Sardar Pasha et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival
- (2018) Derek P. Logsdon et al. Scientific Reports
- Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis
- (2018) Zhigang Cai et al. Cell Stem Cell
- HIF signalling: The eyes have it
- (2017) D.J. Peet et al. EXPERIMENTAL CELL RESEARCH
- Elevation of Serum APE1/Ref-1 in Experimental Murine Myocarditis
- (2017) Seon-Ah Jin et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The Essential Medicinal Chemistry of Curcumin
- (2017) Kathryn M. Nelson et al. JOURNAL OF MEDICINAL CHEMISTRY
- APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma - characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing
- (2017) Fenil Shah et al. Molecular Oncology
- Ape1 protects against MPP+-induced neurotoxicity through ERK1/2 signaling in PC12 cells
- (2017) Bei Kang et al. NEUROREPORT
- Involvement of Nrf2 in Ocular Diseases
- (2017) Shehzad Batliwala et al. Oxidative Medicine and Cellular Longevity
- Cellular Senescence in Age-Related Macular Degeneration: Can Autophagy and DNA Damage Response Play a Role?
- (2017) Janusz Blasiak et al. Oxidative Medicine and Cellular Longevity
- Canonical Wnt signaling in diabetic retinopathy
- (2017) Qian Chen et al. VISION RESEARCH
- APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells
- (2017) David W. McIlwain et al. Oncotarget
- The Epidemiology of Retinopathy of Prematurity in the United States
- (2017) Cassie A. Ludwig et al. Ophthalmic Surgery Lasers & Imaging Retina
- Angiogenesis and Inflammation Crosstalk in Diabetic Retinopathy
- (2016) Margarida Capitão et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Regulation of HIF1 under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models
- (2016) D. P. Logsdon et al. MOLECULAR CANCER THERAPEUTICS
- Anti–Vascular Endothelial Growth Factor Agents in the Treatment of Retinal Disease
- (2016) Peter A. Campochiaro et al. OPHTHALMOLOGY
- APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury
- (2016) R. Anne Stetler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
- (2016) Eri H. Kobayashi et al. Nature Communications
- A novel small molecule ameliorates ocular neovascularisation and synergises with anti-VEGF therapy
- (2016) Rania S. Sulaiman et al. Scientific Reports
- Secreted APE1/Ref-1 inhibits TNF-α-stimulated endothelial inflammation via thiol-disulfide exchange in TNF receptor
- (2016) Myoung Soo Park et al. Scientific Reports
- Intravitreal Anti–Vascular Endothelial Growth Factor Treatment and the Risk of Thromboembolism
- (2015) Matthew B. Schlenker et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
- Apurinic/Apyrimidinic Endonuclease 1 Upregulation Reduces Oxidative DNA Damage and Protects Hippocampal Neurons from Ischemic Injury
- (2015) Rehana K. Leak et al. ANTIOXIDANTS & REDOX SIGNALING
- Synthesis and Biological Evaluation of Novel Homoisoflavonoids for Retinal Neovascularization
- (2015) Halesha D. Basavarajappa et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Simple Optical Coherence Tomography Quantification Method for Choroidal Neovascularization
- (2015) Rania S. Sulaiman et al. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
- Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties
- (2015) Mattia Poletto et al. MOLECULAR CARCINOGENESIS
- Unfolded protein response is activated in aged retinas
- (2015) Austin R. Lenox et al. NEUROSCIENCE LETTERS
- Diabetic Retinopathy
- (2015) Andrew M. Hendrick et al. PRIMARY CARE
- Molecular pathogenesis of retinal and choroidal vascular diseases
- (2015) Peter A. Campochiaro PROGRESS IN RETINAL AND EYE RESEARCH
- Ocular Angiogenesis
- (2015) Juliana L. Dreyfuss et al. Journal of Ophthalmology
- High-Resolution Crystal Structures Reveal Plasticity in the Metal Binding Site of Apurinic/Apyrimidinic Endonuclease I
- (2014) Hongzhen He et al. BIOCHEMISTRY
- Ocular Anti-VEGF Therapy for Diabetic Retinopathy: The Role of VEGF in the Pathogenesis of Diabetic Retinopathy
- (2014) Rafael Simó et al. DIABETES CARE
- Natural product inhibitors of ocular angiogenesis
- (2014) Rania S. Sulaiman et al. EXPERIMENTAL EYE RESEARCH
- Targeting DNA repair pathways for cancer treatment: what’s new?
- (2014) Mark R Kelley et al. Future Oncology
- Apurinic/Apyrimidinic Endonuclease/Redox Factor-1 (APE1/Ref-1) Redox Function Negatively Regulates NRF2
- (2014) Melissa L. Fishel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of the DNA Base Excision Repair Protein, APE1 in Cisplatin, Oxaliplatin, or Carboplatin Induced Sensory Neuropathy
- (2014) Mark R. Kelley et al. PLoS One
- Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis
- (2014) Wan Ling Wong et al. Lancet Global Health
- Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization
- (2014) Y. Li et al. Redox Biology
- Human Apurinic/Apyrimidinic Endonuclease 1
- (2013) Mengxia Li et al. ANTIOXIDANTS & REDOX SIGNALING
- Inhibition of Apurinic/Apyrimidinic Endonuclease I’s Redox Activity Revisited
- (2013) Jun Zhang et al. BIOCHEMISTRY
- Oxidative stress in angiogenesis and vascular disease
- (2013) Y.-W. Kim et al. BLOOD
- NRF2 plays a protective role in diabetic retinopathy in mice
- (2013) Zhenhua Xu et al. DIABETOLOGIA
- Ocular neovascularization
- (2013) Peter A. Campochiaro JOURNAL OF MOLECULAR MEDICINE-JMM
- The complexity of NF-κB signaling in inflammation and cancer
- (2013) Bastian Hoesel et al. Molecular Cancer
- The Relationship of Atherosclerosis to the 10-Year Cumulative Incidence of Age-related Macular Degeneration: The Beaver Dam Studies
- (2013) Ronald Klein et al. OPHTHALMOLOGY
- Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010
- (2013) Hannah Blencowe et al. PEDIATRIC RESEARCH
- Correction: Specific Inhibition of the Redox Activity of Ape1/Ref-1 by E3330 Blocks Tnf-Α-Induced Activation of Il-8 Production in Liver Cancer Cell Lines
- (2013) Laura Cesaratto et al. PLoS One
- Incidence of Legal Blindness From Age-Related Macular Degeneration in Denmark: Year 2000 to 2010
- (2012) Sara Brandi Bloch et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
- The worldwide epidemic of diabetic retinopathy
- (2012) Nathan Congdon et al. INDIAN JOURNAL OF OPHTHALMOLOGY
- The Expanding Role of Vascular Endothelial Growth Factor Inhibitors in Ophthalmology
- (2012) Michael W. Stewart MAYO CLINIC PROCEEDINGS
- Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex
- (2012) Imran Bhutto et al. MOLECULAR ASPECTS OF MEDICINE
- Diabetic Retinopathy
- (2012) David A. Antonetti et al. NEW ENGLAND JOURNAL OF MEDICINE
- APE1/Ref-1 Regulates STAT3 Transcriptional Activity and APE1/Ref-1–STAT3 Dual-Targeting Effectively Inhibits Pancreatic Cancer Cell Survival
- (2012) Angelo A. Cardoso et al. PLoS One
- Ocular Complications After Anti–Vascular Endothelial Growth Factor Therapy in Medicare Patients With Age-Related Macular Degeneration
- (2011) Shelley Day et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
- Characterization of the Redox Activity and Disulfide Bond Formation in Apurinic/Apyrimidinic Endonuclease
- (2011) Meihua Luo et al. BIOCHEMISTRY
- Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia–reperfusion injury
- (2011) Yanhong Wei et al. FREE RADICAL BIOLOGY AND MEDICINE
- Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth
- (2011) M. L. Fishel et al. MOLECULAR CANCER THERAPEUTICS
- APE1/Ref-1Role in Redox Signaling: Translational Applications of Targeting the Redox Function of the DNA Repair/Redox Protein APE1/Ref-1
- (2011) Mark R. Kelley et al. Current Molecular Pharmacology
- Functional Analysis of Novel Analogues of E3330 That Block the Redox Signaling Activity of the Multifunctional AP Endonuclease/Redox Signaling Enzyme APE1/Ref-1
- (2010) Mark R. Kelley et al. ANTIOXIDANTS & REDOX SIGNALING
- Interactions of Apurinic/Apyrimidinic Endonuclease with a Redox Inhibitor: Evidence for an Alternate Conformation of the Enzyme
- (2010) Dian Su et al. BIOCHEMISTRY
- Reduced Expression of DNA Repair and Redox Signaling Protein APE1/Ref-1 Impairs Human Pancreatic Cancer Cell Survival, Proliferation, and Cell Cycle Progression
- (2010) Yanlin Jiang et al. CANCER INVESTIGATION
- Current update on retinopathy of prematurity: screening and treatment
- (2010) Jing Chen et al. CURRENT OPINION IN PEDIATRICS
- Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis
- (2010) Melissa L. Fishel et al. EXPERIMENTAL HEMATOLOGY
- Design and Synthesis of Novel Quinone Inhibitors Targeted to the Redox Function of Apurinic/Apyrimidinic Endonuclease 1/Redox Enhancing Factor-1 (Ape1/Ref-1)
- (2010) Rodney L. Nyland et al. JOURNAL OF MEDICINAL CHEMISTRY
- Two-Year Outcomes of the Ranibizumab for Edema of the mAcula in Diabetes (READ-2) Study
- (2010) Quan Dong Nguyen et al. OPHTHALMOLOGY
- A Prospective Randomized Trial of Intravitreal Bevacizumab or Laser Therapy in the Management of Diabetic Macular Edema (BOLT Study)
- (2010) Michel Michaelides et al. OPHTHALMOLOGY
- Inhibition of APE1/Ref-1 redox activity with APX3330 blocks retinal angiogenesis in vitro and in vivo
- (2010) Aihua Jiang et al. VISION RESEARCH
- Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt
- (2009) Ki Cheon Kim et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process
- (2009) C. Vascotto et al. MOLECULAR AND CELLULAR BIOLOGY
- APE1/Ref-1 in Alzheimer's disease: An immunohistochemical study
- (2009) Gabriella Marcon et al. NEUROSCIENCE LETTERS
- Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1
- (2008) Meihua Luo et al. ANTIOXIDANTS & REDOX SIGNALING
- Transcriptional Regulatory Functions of Mammalian AP-Endonuclease (APE1/Ref-1), an Essential Multifunctional Protein
- (2008) Kishor K. Bhakat et al. ANTIOXIDANTS & REDOX SIGNALING
- The Ape-1/Ref-1 redox antagonist E3330 inhibits the growth of tumor endothelium and endothelial progenitor cells: Therapeutic implications in tumor angiogenesis
- (2008) Gang-Ming Zou et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease
- (2008) M.M. Georgiadis et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Epidemiology of Diabetes and Diabetes-Related Complications
- (2008) Anjali D Deshpande et al. PHYSICAL THERAPY
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