Human Apurinic/Apyrimidinic Endonuclease 1

Granzyme A activates another way to die

(2015) Judy Lieberman   IMMUNOLOGICAL REVIEWS

Inhibition of Apurinic/Apyrimidinic Endonuclease I’s Redox Activity Revisited

(2013) Jun Zhang et al.   BIOCHEMISTRY

A single strand that links multiple neuropathologies in human disease

(2013) John J. Reynolds et al.   BRAIN

Regulation of AID, the B-cell genome mutator

(2013) C. Keim et al.   GENES & DEVELOPMENT

Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes

(2013) Susan E. Tsutakawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apurinic/Apyrimidinic Endonuclease 1 Is the Essential Nuclease during Immunoglobulin Class Switch Recombination

(2013) S. Masani et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic and expressional variations of APEX1 are associated with increased risk of head and neck cancer

(2013) Ishrat Mahjabeen et al.   MUTAGENESIS

Mammalian Base Excision Repair: the Forgotten Archangel

(2013) Grigory L. Dianov et al.   NUCLEIC ACIDS RESEARCH

Serum APE1 Autoantibodies: A Novel Potential Tumor Marker and Predictor of Chemotherapeutic Efficacy in Non-Small Cell Lung Cancer

(2013) Nan Dai et al.   PLoS One

Silencing of APE1 Enhances Sensitivity of Human Hepatocellular Carcinoma Cells to Radiotherapy In Vitro and in a Xenograft Model

(2013) Yanping Cun et al.   PLoS One

Functional Assessment of Population and Tumor-Associated APE1 Protein Variants

(2013) Jennifer L. Illuzzi et al.   PLoS One

Decrease in Abundance of Apurinic/Apyrimidinic Endonuclease Causes Failure of Base Excision Repair in Culture-Adapted Human Embryonic Stem Cells

(2013) Miriama Krutá et al.   STEM CELLS

Cytoplasmic Ape1 Expression Elevated by p53 Aberration May Predict Survival and Relapse in Resected Non-Small Cell Lung Cancer

(2012) Heng-Hsiung Wu et al.   ANNALS OF SURGICAL ONCOLOGY

Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease

(2012) Renato X. Santos et al.   ANTIOXIDANTS & REDOX SIGNALING

Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers

(2012) Mattia Poletto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification and Characterization of Human Apurinic/Apyrimidinic Endonuclease-1 Inhibitors

(2012) Ajay Srinivasan et al.   BIOCHEMISTRY

Recent advances in the structural mechanisms of DNA glycosylases

(2012) Sonja C. Brooks et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Base excision repair and cancer

(2012) Susan S. Wallace et al.   CANCER LETTERS

Design and Synthesis of 3-Carbamoylbenzoic Acid Derivatives as Inhibitors of Human Apurinic/Apyrimidinic Endonuclease 1 (APE1)

(2012) Francesca Aiello et al.   ChemMedChem

Human AP endonuclease/redox factor APE1/ref-1modulates mitochondrial function after oxidative stress by regulating the transcriptional activity of NRF1

(2012) Mengxia Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of DNA glycosylases and their role in limiting disease

(2012) Harini Sampath et al.   FREE RADICAL RESEARCH

DNA Repair Genes in Parkinson's Disease

(2012) Mehmet Gencer et al.   Genetic Testing and Molecular Biomarkers

Synthetic lethal targeting of DNA double-strand break repair deficient cells by human apurinic/apyrimidinic endonuclease inhibitors

(2012) Rebeka Sultana et al.   INTERNATIONAL JOURNAL OF CANCER

Synthesis, Biological Evaluation, and Structure–Activity Relationships of a Novel Class of Apurinic/Apyrimidinic Endonuclease 1 Inhibitors

(2012) Ganesha Rai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases

(2012) Muralidhar L. Hegde et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells

(2012) Lisa Lirussi et al.   MOLECULAR BIOLOGY OF THE CELL

Diverse Small Molecule Inhibitors of Human Apurinic/Apyrimidinic Endonuclease APE1 Identified from a Screen of a Large Public Collection

(2012) Dorjbal Dorjsuren et al.   PLoS One

Killing Effect of Ad5/F35-APE1 siRNA Recombinant Adenovirus in Combination with Hematoporphrphyrin Derivative-Mediated Photodynamic Therapy on Human Nonsmall Cell Lung Cancer

(2012) Lei Xia et al.   Biomed Research International

Dietary Agents in Cancer Chemoprevention and Treatment

(2012) Julian J. Raffoul et al.   Journal of Oncology

NMR Studies Reveal an Unexpected Binding Site for a Redox Inhibitor of AP Endonuclease 1

(2011) Brittney A. Manvilla et al.   BIOCHEMISTRY

Characterization of the Redox Activity and Disulfide Bond Formation in Apurinic/Apyrimidinic Endonuclease

(2011) Meihua Luo et al.   BIOCHEMISTRY

Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines

(2011) M Z Mohammed et al.   BRITISH JOURNAL OF CANCER

The Emerging Role of Poly(ADP-Ribose) Polymerase Inhibitors in Cancer Treatment

(2011) Shahneen K. Sandhu et al.   CURRENT DRUG TARGETS

Apurinic/apyrimidinic endonuclease is inversely associated with response to radiotherapy in pediatric ependymoma

(2011) Michael S. Bobola et al.   INTERNATIONAL JOURNAL OF CANCER

S-Glutathionylation of Cysteine 99 in the APE1 Protein Impairs Abasic Endonuclease Activity

(2011) Yun-Jeong Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Characterization of the Endoribonuclease Active Site of Human Apurinic/Apyrimidinic Endonuclease 1

(2011) Wan-Cheol Kim et al.   JOURNAL OF MOLECULAR BIOLOGY

Prognostic significance of APE1 cytoplasmic localization in human epithelial ovarian cancer

(2011) Qingsong Sheng et al.   MEDICAL ONCOLOGY

Identification of Three New Autoantibodies Associated with Systemic Lupus Erythematosus Using Two Proteomic Approaches

(2011) Yasuhiro Katsumata et al.   MOLECULAR & CELLULAR PROTEOMICS

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function

(2011) Carlo Vascotto et al.   MOLECULAR BIOLOGY OF THE CELL

Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth

(2011) M. L. Fishel et al.   MOLECULAR CANCER THERAPEUTICS

The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings

(2011) Thomas Helleday   Molecular Oncology

Age-related instability in spermatogenic cell nuclear and mitochondrial DNA obtained from Apex1 heterozygous mice

(2011) Kristine S. Vogel et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Gene susceptibility to oxidative damage: From single nucleotide polymorphisms to function

(2011) Valeria Simonelli et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Ubiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5

(2011) Carlos S. Busso et al.   NUCLEIC ACIDS RESEARCH

Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability

(2011) Cornelia Meisenberg et al.   NUCLEIC ACIDS RESEARCH

Lucanthone and Its Derivative Hycanthone Inhibit Apurinic Endonuclease-1 (APE1) by Direct Protein Binding

(2011) Mamta D. Naidu et al.   PLoS One

Checkpoint Signaling, Base Excision Repair, and PARP Promote Survival of Colon Cancer Cells Treated with 5-Fluorodeoxyuridine but Not 5-Fluorouracil

(2011) Liyi Geng et al.   PLoS One

Small-Molecule Inhibitors of APE1 DNA Repair Function: An Overview

(2011) Rasha I. Al-Safi et al.   Current Molecular Pharmacology

Overview of Base Excision Repair Biochemistry

(2011) Yun-Jeong Kim et al.   Current Molecular Pharmacology

APE1/Ref-1Role in Redox Signaling: Translational Applications of Targeting the Redox Function of the DNA Repair/Redox Protein APE1/Ref-1

(2011) Mark R. Kelley et al.   Current Molecular Pharmacology

Functional Analysis of Novel Analogues of E3330 That Block the Redox Signaling Activity of the Multifunctional AP Endonuclease/Redox Signaling Enzyme APE1/Ref-1

(2010) Mark R. Kelley et al.   ANTIOXIDANTS & REDOX SIGNALING

Human apurinic/apyrimidinic endonuclease (APE1) is a prognostic factor in ovarian, gastro-oesophageal and pancreatico-biliary cancers

(2010) A Al-Attar et al.   BRITISH JOURNAL OF CANCER

Human AP endonuclease 1 (APE1): From mechanistic insights to druggable target in cancer

(2010) Rachel Abbotts et al.   CANCER TREATMENT REVIEWS

Posttranslational modification of mammalian AP endonuclease (APE1)

(2010) Carlos S. Busso et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Small molecule inhibitors of DNA repair nuclease activities of APE1

(2010) David M. Wilson et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Elevated Expression of APE1/Ref-1 and its Regulation on IL-6 and IL-8 in Bone Marrow Stromal Cells of Multiple Myeloma

(2010) Jia-Yin Xie et al.   Clinical Lymphoma Myeloma & Leukemia

Prognostic Significance of Human Apurinic/Apyrimidinic Endonuclease (APE/Ref-1) Expression in Rectal Cancer Treated With Preoperative Radiochemotherapy

(2010) Jun-Sang Kim et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Distinct Roles of Ape1 Protein in the Repair of DNA Damage Induced by Ionizing Radiation or Bleomycin

(2010) Hua Fung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Characterization of Mitochondrial Targeting Sequence of Human Apurinic/Apyrimidinic Endonuclease 1

(2010) Mengxia Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design and Synthesis of Novel Quinone Inhibitors Targeted to the Redox Function of Apurinic/Apyrimidinic Endonuclease 1/Redox Enhancing Factor-1 (Ape1/Ref-1)

(2010) Rodney L. Nyland et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Small-Molecule Inhibitor of Apurinic/Apyrimidinic Endonuclease 1 Blocks Proliferation and Reduces Viability of Glioblastoma Cells

(2010) A. Bapat et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Radiation Resistance in Glioma Cells Determined by DNA Damage Repair Activity of Ape1/Ref-1

(2010) Mamta D. NAIDU et al.   JOURNAL OF RADIATION RESEARCH

Variation in base excision repair capacity

(2010) David M. Wilson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The role of Cdk5-mediated apurinic/apyrimidinic endonuclease 1 phosphorylation in neuronal death

(2010) En Huang et al.   NATURE CELL BIOLOGY

Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions

(2010) Damiano Fantini et al.   NUCLEIC ACIDS RESEARCH

Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1

(2010) S Sengupta et al.   ONCOGENE

Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia

(2010) R. A. Stetler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Controlled DNA “damage” and repair in hypoxic signaling

(2010) Mark N. Gillespie et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

The adenoviral vector-mediated increase in apurinic/apyrimidinic endonuclease inhibits the induction of neuronal cell death after transient ischemic stroke in mice

(2009) Hyun-Woo Kim et al.   BRAIN RESEARCH

A Polymorphism in the APE1 Gene Promoter is Associated with Lung Cancer Risk

(2009) Y.-L. Lo et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Knock down of the dual functional protein apurinic /apyrimidinic endonuclease 1 enhances the killing effect of hematoporphrphyrin derivative-mediated photodynamic therapy on non-small cell lung cancer cells in vitro and in a xenograft model

(2009) Zhen-Zhou Yang et al.   CANCER SCIENCE

Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: Use of APE1 small molecule inhibitors to delineate APE1 functions

(2009) Yanlin Jiang et al.   DNA REPAIR

Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility

(2009) Juan Lu et al.   FASEB JOURNAL

Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice

(2009) Archana Unnikrishnan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Acetylation of Apurinic/Apyrimidinic Endonuclease-1 Regulates Helicobacterpylori-Mediated Gastric Epithelial Cell Apoptosis

(2009) Asima Bhattacharyya et al.   GASTROENTEROLOGY

Inhibitory effects of adenovirus mediated COX-2, Akt1 and PIK3R1 shRNA on the growth of malignant tumor cells in vitro and in vivo

(2009) Zhang   INTERNATIONAL JOURNAL OF ONCOLOGY

APE1 overexpression is associated with cisplatin resistance in non-small cell lung cancer and targeted inhibition of APE1 enhances the activity of cisplatin in A549 cells

(2009) Dong Wang et al.   LUNG CANCER

APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process

(2009) C. Vascotto et al.   MOLECULAR AND CELLULAR BIOLOGY

Impairment of APE1 Function Enhances Cellular Sensitivity to Clinically Relevant Alkylators and Antimetabolites

(2009) D. R. McNeill et al.   MOLECULAR CANCER RESEARCH

The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1

(2009) Youngsoo Lee et al.   NATURE NEUROSCIENCE

APE1/Ref-1 in Alzheimer's disease: An immunohistochemical study

(2009) Gabriella Marcon et al.   NEUROSCIENCE LETTERS

SIRT1 deacetylates APE1 and regulates cellular base excision repair

(2009) Tohru Yamamori et al.   NUCLEIC ACIDS RESEARCH

Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA

(2009) T. Barnes et al.   NUCLEIC ACIDS RESEARCH

Role of PCNA-dependent stimulation of 3'-phosphodiesterase and 3'-5' exonuclease activities of human Ape2 in repair of oxidative DNA damage

(2009) P. Burkovics et al.   NUCLEIC ACIDS RESEARCH

Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53–MDM2 signaling pathway

(2009) C S Busso et al.   ONCOGENE

Identification and Characterization of Inhibitors of Human Apurinic/apyrimidinic Endonuclease APE1

(2009) Anton Simeonov et al.   PLoS One

Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells

(2009) Carlo Vascotto et al.   PROTEOMICS

Downregulation of APE1/Ref-1 Is Involved in the Senescence of Mesenchymal Stem Cells

(2009) Jun-Young Heo et al.   STEM CELLS

The SET Complex Acts as a Barrier to Autointegration of HIV-1

(2009) Nan Yan et al.   PLoS Pathogens

The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme

(2008) Gianluca Tell et al.   ANTIOXIDANTS & REDOX SIGNALING

Enzymatic Mechanism of Human Apurinic/Apyrimidinic Endonuclease against a THF AP Site Model Substrate†

(2008) Sophia T. Mundle et al.   BIOCHEMISTRY

Chimeric adenoviral vector Ad5/F35-mediated APE1 siRNA enhances sensitivity of human colorectal cancer cells to radiotherapy in vitro and in vivo

(2008) D-B Xiang et al.   CANCER GENE THERAPY

Mitochondrial DNA, base excision repair and neurodegeneration

(2008) Nadja C. de Souza-Pinto et al.   DNA REPAIR

Targeting truncated APE1 in mitochondria enhances cell survival after oxidative stress

(2008) Meng-Xia Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacophore Guided Discovery of Small-Molecule Human Apurinic/Apyrimidinic Endonuclease 1 Inhibitors

(2008) Zahrah Zawahir et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of Abasic Endonuclease Activity of Human Ape1 on Alternative Substrates, as Well as Effects of ATP and Sequence Context on AP Site Incision

(2008) Brian R. Berquist et al.   JOURNAL OF MOLECULAR BIOLOGY

Characterization of Mg2+Binding to the DNA Repair Protein Apurinic/Apyrimidic Endonuclease 1 via Solid-State25Mg NMR Spectroscopy

(2008) A. S. Lipton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regulatory Role of Human AP-Endonuclease (APE1/Ref-1) in YB-1-Mediated Activation of the Multidrug Resistance Gene MDR1

(2008) R. Chattopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration

(2008) G.-M. Zou et al.   MOLECULAR CANCER THERAPEUTICS

Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity

(2008) Yuming Guo et al.   MOLECULAR IMMUNOLOGY

Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease

(2008) M.M. Georgiadis et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Single-strand break repair and genetic disease

(2008) Keith W. Caldecott   NATURE REVIEWS GENETICS

Lack of association between the APEX1 Asp148Glu polymorphism and sporadic amyotrophic lateral sclerosis

(2008) Fabio Coppedè et al.   NEUROBIOLOGY OF AGING

Single nucleotide polymorphisms in base-excision repair genes hOGG1, APE1 and XRCC1 do not alter risk of Alzheimer's disease

(2008) Hande Parıldar-Karpuzoğlu et al.   NEUROSCIENCE LETTERS

Knockdown of the DNA repair and redox signaling protein Ape1/Ref-1 blocks ovarian cancer cell and tumor growth

(2007) Melissa L. Fishel et al.   DNA REPAIR