Article
Neurosciences
Poornima Venkat, Ruizhuo Ning, Alex Zacharek, Lauren Culmone, Linlin Liang, Julie Landschoot-Ward, Michael Chopp
Summary: Delayed treatment with 3 μg/kg of VT significantly improves neurological function, reduces infarct volume and cell death, promotes vascular and white matter remodeling, and decreases inflammation in T1DM rats after ischemic stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Neurosciences
Qingbo Yu, Zhang Jian, Dan Yang, Tao Zhu
Summary: Ischemic stroke is a globally prevalent neurological disorder with a high disability and mortality rate. Tissue plasminogen activator and thrombectomy can restore blood flow and improve outcomes, but are limited by a narrow time window. Biomaterials have emerged as a potential treatment option for ischemic stroke, with the ability to deliver therapeutic drugs and improve brain-targeting property.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Adjanie Patabendige, Ayesha Singh, Stuart Jenkins, Jon Sen, Ruoli Chen
Summary: Ischaemic stroke can cause damage to the neurovasculature, leading to long-term motor and cognitive deficits. Current neuroprotective therapies are lacking, with many studies focusing on neurons and neglecting the important roles of other cells in the neurovascular unit, such as astrocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Ting Zhu, Lei Wang, Li-ping Wang, Qi Wan
Summary: Neuroprotective and neurorestorative therapy are two major strategies for treating ischemic stroke. Traditional Chinese medicine (TCM) has advantages in comprehensive treatment and natural compounds from medicinal herbs have shown activities in promoting neuroprotection and neurorestoration. This review explores the active compounds and underlying mechanisms of TCMs in ischemic stroke treatment, and provides a reference for the development of precise clinical medications.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Xiongfeng Pan, Atipatsa C. Kaminga, Sanjay Kinra, Shi Wu Wen, Hongying Liu, Xinrui Tan, Aizhong Liu
Summary: This study summarized the associations of different chemokines with T1DM, revealing that circulating concentrations of CCL5 and CXCL1 were significantly higher in T1DM patients compared to controls. Circulating CCL5 ranked highest among all the chemokines investigated in T1DM.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Endocrinology & Metabolism
Xuan Chen, Alison H. Affinati, Yungchun Lee, Adina F. Turcu, Norah Lynn Henry, Elena Schiopu, Angel Qin, Megan Othus, Dan Clauw, Nithya Ramnath, Lili Zhao
Summary: This study found that the risk of developing ICI-T1DM is associated with the type of ICI therapy, patient age, and preexisting non-T1DM diabetes. The development of ICI-T1DM does not seem to significantly impact patient survival.
Review
Biochemistry & Molecular Biology
Lingling Jiang, Weiqi Chen, Jinyi Ye, Yilong Wang
Summary: Ischemic stroke is a life-threatening disease that causes disability and death globally. Currently, there are no effective treatments available in clinical practice, but exosome-based therapy has shown potential. Exosomes play a positive role in neurorestoration through the delivery of microRNA cargo, providing a viable treatment strategy for ischemic stroke patients.
Article
Endocrinology & Metabolism
Robert French, Dylan Kneale, Justin T. Warner, Holly Robinson, James Rafferty, Adrian Sayers, Peter Taylor, John W. Gregory, Colin M. Dayan
Summary: There is no strong evidence to suggest a significant association between type 1 diabetes and educational outcomes. However, the level of blood glucose control (HbA(1c)) is related to academic achievements.
Article
Cardiac & Cardiovascular Systems
David D. Berg, Filipe A. Moura, Andrea Bellavia, Benjamin M. Scirica, Stephen D. Wiviott, Deepak L. Bhatt, Itamar Raz, Erin A. Bohula, Robert P. Giugliano, Jeong-Gun Park, Mark W. Feinberg, Eugene Braunwald, David A. Morrow, Marc S. Sabatine
Summary: A risk model for atherothrombosis in patients with type 2 diabetes mellitus (T2DM) was developed and validated using data from 42,181 patients. The model identified 16 independent predictors of myocardial infarction (MI) or ischemic stroke (IS). The model performed well in validation and has the potential to improve risk assessment and clinical decision-making.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Emil F. Coccaro, Sophie Lazarus, Joshua Joseph, Kathline Wyne, Tina Drossos, Louis Phillipson, Mary de Groot
Summary: The study found that negative emotional experience is positively related to diabetes-related distress, while the skill at regulating these emotions is negatively related to diabetes-related distress, with a medium-size relationship between these emotional regulation variables and diabetes-related distress. The data suggest that diabetes-related distress in adults with diabetes is meaningfully linked to negative emotionality and skill at regulating such emotions, with a stronger relationship than perceived psychological stress or diabetes self-care.
Article
Cell & Tissue Engineering
Yanju Li, Feiqing Wang, Huiling Liang, Dongxin Tang, Mei Huang, Jianing Zhao, Xu Yang, Yanqing Liu, Liping Shu, Jishi Wang, Zhixu He, Yang Liu
Summary: The meta-analysis included 10 studies with a total of 239 participants, evaluating the efficacy of mesenchymal stem cells (MSCs) therapy in treating diabetes mellitus. The results showed that MSC treatment led to significantly lower HbA1c levels, higher fasting C-peptide levels, and reduced insulin requirement in T1DM patients.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Ronald M. Goldenberg, Alice Y. Y. Cheng, Tess Fitzpatrick, Jeremy D. Gilbert, Subodh Verma, Julia J. Hopyan
Summary: People with diabetes face higher stroke risks and poorer outcomes. GLP-1RAs have been shown to reduce stroke risk in individuals with type 2 diabetes. This study provides evidence supporting the use of GLP-1RAs for stroke reduction and offers practical resources for neurologists considering this treatment.
Article
Cardiac & Cardiovascular Systems
Dae Young Cheon, Kyungdo Han, Ye Seul Yang, Yerim Kim, Sang-Hwa Lee, Chulho Kim, Jong-Hee Sohn, Mi Sun Oh, Byung-Chul Lee, Minwoo Lee, Kyung-Ho Yu
Summary: This study found a significant association between migraines and major cardiovascular events, including myocardial infarction, ischemic stroke, and cardiovascular death, in individuals with type 2 diabetes. The presence of aura symptoms in migraines further increased the risk of myocardial infarction.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Stephen T. O'Brien, Orla M. Neylon, Timothy O'Brien
Summary: Cardiovascular disease is the leading cause of death in Type 1 Diabetes, with the molecular basis for atherosclerosis heavily influenced by hyperglycaemia. Current tools for assessing CVD risk in Type 1 Diabetes patients are limited, posing challenges for selecting appropriate lipid-lowering therapies. Best practice guidance for managing dyslipidaemia in Type 1 Diabetes is mainly based on evidence from Type 2 Diabetes patients and expert opinions.
Article
Clinical Neurology
Poornima Venkat, Chengcheng Cui, Zhili Chen, Michael Chopp, Alex Zacharek, Julie Landschoot-Ward, Lauren Culmone, Xiao-Ping Yang, Jiang Xu, Jieli Chen
Summary: Cardiac complications are common after a stroke, especially in diabetes patients. Treatment with exosomes derived from CD133+ cells can improve cardiac function in type 2 diabetes mellitus stroke mice by increasing left ventricular ejection fraction, decreasing left ventricular diastolic dimension, and reducing cardiac pathological changes.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Clinical Neurology
Wei Li, Michael Chopp, Alex Zacharek, Wei Yang, Zhili Chen, Julie Landschoot-Ward, Poornima Venkat, Jieli Chen
Summary: This study demonstrated that SUMO1 deficiency leads to worsened brain and heart dysfunction after intracerebral hemorrhage in aged female mice, indicating the crucial role of SUMO1 in regulating brain-heart interaction.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Neurosciences
Poornima Venkat, Ruizhuo Ning, Alex Zacharek, Lauren Culmone, Linlin Liang, Julie Landschoot-Ward, Michael Chopp
Summary: Delayed treatment with 3 μg/kg of VT significantly improves neurological function, reduces infarct volume and cell death, promotes vascular and white matter remodeling, and decreases inflammation in T1DM rats after ischemic stroke.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Neurosciences
Poornima Venkat, Alex Zacharek, Julie Landschoot-Ward, Fengjie Wang, Lauren Culmone, Zhili Chen, Michael Chopp, Jieli Chen
EXPERIMENTAL NEUROLOGY
(2020)
Article
Neurosciences
Liqun Zhang, Jimusi Wuri, Lulu An, Xiaoxuan Liu, Ye Wu, Haotian Hu, Ruixia Wu, Yue Su, Quan Yuan, Tao Yan
Summary: This study found that sympathetic overactivity induced by ICH may play a significant role in post-ICH cardiac dysfunction by mediating inflammatory response. Treating ICH mice with metoprolol to suppress sympathetic overactivity improved cardiac and neurological function.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2021)
Article
Neurosciences
Yuan Zhang, Hongxi Yang, Shu Li, Zhi Cao, Wei-Dong Li, Tao Yan, Yaogang Wang
Summary: The relationship between coffee consumption and dementia risk is complex, with different effects on dementia risk depending on the type of coffee consumed. Heavy coffee drinking was associated with a higher risk of Alzheimer's disease in individuals with high genetic susceptibility for dementia.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Immunology
Quan Yuan, Ling Xin, Song Han, Yue Su, Ruixia Wu, Xiaoxuan Liu, Jimusi Wuri, Ran Li, Tao Yan
Summary: The study demonstrates that lactulose supplementation improves neurological function after stroke by reducing inflammation, repairing intestinal barrier damage, and ameliorating gut dysbiosis and metabolic disorders.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lulu An, Jimusi Wuri, Zhitong Zheng, Wenqui Li, Tao Yan
Summary: Chemotherapy, specifically Doxorubicin, can induce microbiome imbalance and intestinal damage which may lead to cardiac dysfunction. Fecal microbiota transplantation can improve cardiac function and reduce gut damage caused by Doxorubicin. The microbiota plays a significant role in heart-gut interaction in the context of chemotherapy-induced cardiac dysfunction.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Editorial Material
Cell Biology
Poornima Venkat, Michael Chopp
NEURAL REGENERATION RESEARCH
(2022)
Article
Medicine, General & Internal
Zhi Cao, Shu Li, Hongxi Yang, Chenjie Xu, Yuan Zhang, Xueli Yang, Tao Yan, Tong Liu, Yaogang Wang
Summary: The study revealed inverse linear associations of healthy behaviors, biological phenotypes, and cardiovascular health with long-term risks of stroke and stroke subtypes (excluding SAH), emphasizing the benefits of maintaining better CVH status as a primary prevention strategy for stroke.
Article
Neurosciences
Ruixia Wu, Yue Su, Quan Yuan, Linlin Li, Jimusi Wuri, Xiaoxuan Liu, Tao Yan
Summary: EAE increases inflammatory factor expression and aggravates cardiac dysfunction in male mice compared with female mice, which may contribute to different cardiac outcomes in EAE mice.
Meeting Abstract
Clinical Neurology
Poornima Venkat, Alex Zacharek, Michael Chopp, Jieli Chen
Meeting Abstract
Clinical Neurology
Lulu An, Michael Chopp, Yi Shen, Poornima Venkat, Zhili Chen, Alex Zacharek, Wei Li, Yu Qian, Julie Landschoot-Ward, Jieli Chen
Meeting Abstract
Clinical Neurology
Zhili Chen, Michael Chopp, Alex Zacharek, Wei Li, Poornima Venkat, Fengjie Wang, Julie Landschoot-Ward, Jieli Chen
Meeting Abstract
Clinical Neurology
Wei Li, Michael Chopp, Poornima Venkat, Zhili Chen, Alex Zacharek, Julie Landschoot-Ward, Jieli Chen