Article
Biochemistry & Molecular Biology
Shereen A. Howpay Manage, Aaron M. Fleming, Hsiao-Nung Chen, Cynthia J. Burrows
Summary: This study provides a quantitative survey of cysteine oxidation to sulfenic acid in APE1 and demonstrates how this modification affects APE1's function towards the NEIL3 gene promoter G4. The research suggests that cysteine oxidation to sulfenic acid enhances APE1's affinity for G4 during oxidative stress, but attenuates its endonuclease activity.
ACS CHEMICAL BIOLOGY
(2022)
Article
Medicine, General & Internal
Greta Balciuniene, Violeta Gulbiniene, Irena Dumalakiene, Rita Viliene, Daiva Bartkeviciene, Ingrida Pilypiene, Grazina S. Drasutiene, Diana Ramasauskaite
Summary: This study evaluated IL-6, TNF-alpha, and MMP-8 levels in vaginally obtained amniotic fluid as predictors for chorioamnionitis in patients with preterm premature rupture of membranes. The noninvasive technique of sampling amniotic fluid could be an alternative method to invasive amniocentesis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Alina Maria Andronovici, Irina-Draga Caruntu, Mihai Onofriescu, Loredana Liliana Hurjui, Simona-Eliza Giusca, Andreea Simona Covic, Radu Braescu, Liliana-Georgeta Foia
Summary: This study aimed to analyze the relationship between periodontitis and chronic kidney disease (CKD) and provide an inflammatory profile of dialysis patients by measuring the levels of inflammatory biomarkers in periodontitis patients. The results showed significant differences in the levels of these biomarkers between periodontitis patients with CKD and those without CKD, supporting the mutual connection between periodontitis and CKD.
APPLIED SCIENCES-BASEL
(2022)
Article
Agriculture, Dairy & Animal Science
Liangliang Li, Xinyao Hu, Shuwen Li, Ying Li, Shengmiao Zhao, Fengzhen Shen, Changfa Wang, Yubao Li, Tongtong Wang
Summary: Equid alphaherpesvirus type 8 (EqHV-8) infection causes severe respiratory disease, abortions, and neurological syndromes in equines, resulting in significant economic losses in the donkey industry. Currently, there are no therapeutic molecules available for controlling EqHV-8 infection. This study demonstrates that cobalt protoporphyrin (CoPP) possesses antiviral activity against EqHV-8 and inhibits its replication through the HO-1 mediated type I interferon response. CoPP shows promise as a potential molecule for developing an effective therapeutic strategy for preventing and controlling EqHV-8.
Review
Biochemistry & Molecular Biology
Patricia Richter, Luana Andreea Macovei, Ioana Ruxandra Mihai, Anca Cardoneanu, Maria Alexandra Burlui, Elena Rezus
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder in which cytokines, such as TNF-alpha and IL-17, play crucial roles. The modulation of these cytokines may impact disease progression and serve as potential biomarkers. Elevated levels of TNF-alpha and IL-17 are associated with high disease activity in SLE patients, although their inhibition as a treatment option is still under discussion. Further studies are needed to explore the therapeutic potential of targeting these cytokines in SLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Irene Olivera, Rebeca Sanz-Pamplona, Elixabet Bolanos, Inmaculada Rodriguez, Inaki Etxeberria, Assunta Cirella, Josune Egea, Saray Garasa, Itziar Migueliz, Inaki Eguren-Santamaria, Miguel F. Sanmamed, Javier Glez-Vaz, Arantza Azpilikueta, Maite Alvarez, Maria C. Ochoa, Beatrice Malacrida, David Propper, Carlos E. de Andrea, Pedro Berraondo, Frances R. Balkwill, Alvaro Teijeira, Ignacio Melero
Summary: In the tumor microenvironment, IL-8 correlates with poor response to checkpoint inhibitors and attracts immunosuppressive myeloid cells. TNF alpha and IL-1 beta are major inducers of IL-8 expression on malignant cells, which can be interfered with by clinically available neutralizing agents.
Article
Virology
Dayvson Mauricio da Silva, Juliana Prado Goncales, Jose Valter Joaquim Silva Junior, Thaisa Regina Rocha Lopes, Luan Araujo Bezerra, Virginia Maria Barros de Lorena, Maria Rosangela Cunha Duarte Coelho
Summary: In HIV/HHV-8 coinfection, levels of cytokines IL-4, IL-6, and IL-10 are higher in patients compared to those infected with only HIV, potentially indicating the development of HHV-8-related diseases. On the other hand, levels of IL-2, TNF-alpha, and IFN-gamma show no significant difference between the two groups.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tarek M. Okda, Gamal M. K. Atwa, Ahmed Fathy Eldehn, Naief Dahran, Khalaf F. Alsharif, Ehab Kotb Elmahallawy
Summary: This study investigated the role of new markers in the prognosis and staging of thyroid cancer. The results showed that serum TG and Gal-3 could serve as useful markers for the prognosis and staging of thyroid cancer patients. Additionally, determining the levels of Bax, Bcl-2, IL-8, and TNF-alpha could provide insight into the mechanisms of apoptosis and inflammation in thyroid cancer.
Article
Plant Sciences
Yixi Yang, Yujin Zhang, Xun Chen, Zhou Su, Yu Deng, Qi Zhao
Summary: This study explored the bioactivity of Khasianine and showed that it possessed highly anti-inflammatory bioactivity which rapidly alleviated psoriasis-like mice skin inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nadeem Akhter, Ajit Wilson, Reeby Thomas, Fatema Al-Rashed, Shihab Kochumon, Areej Al-Roub, Hossein Arefanian, Ashraf Al-Madhoun, Fahd Al-Mulla, Rasheed Ahmad, Sardar Sindhu
Summary: IL-8/MCP-1 expression in adipose tissue is elevated in obesity. The synergistic effect of ROS/TNF-alpha can drive the expression of chemokines in monocytic cells, potentially through inducing ER stress, HIF1A stabilization, and signaling via NF-kappa B/ERK-1,2. NAC may have a therapeutic significance in inhibiting oxidative stress-driven IL-8/MCP-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hanna Sternby, Hannes Hartman, Henrik Thorlacius, Sara Regner
Summary: The study found that selected biomarkers in patients with acute pancreatitis underwent significant changes within 48 hours of onset, with IL-1 beta and IL-6 showing associations with severe disease. IL-6 had the ability to differentiate severe cases of acute pancreatitis, while the prognostic capacity of the investigated biomarkers was low.
Article
Endocrinology & Metabolism
Kangkang Huang, Yunlai Liang, Yating Ma, Jiahui Wu, Huidan Luo, Bin Yi
Summary: This study discovered significant variations in adiponectin, nesfatin-1, IL-6, and TNF-alpha levels among healthy individuals, prediabetic patients, and type 2 diabetes mellitus patients, indicating a gradual change during the progression from a healthy condition to diabetes via prediabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
M. L. Cuellar-Nunez, E. Gonzalez de Mejia, G. Loarca-Pina
Summary: Moringa oleifera leaves have shown chemopreventive properties against inflammatory response and colon carcinogenesis by modulating gene expression and reducing proinflammatory mediators.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Obstetrics & Gynecology
Xiuwei Wang, Huixuan Yue, Shen Li, Jin Guo, Zhen Guan, Zhiqiang Zhu, Bo Niu, Ting Zhang, Jianhua Wang
Summary: The study found significant associations between three polymorphisms of APE1/Ref-1 and NTD subtypes, suggesting that APE1/Ref-1 may be a potential genetic risk factor for encephalocele in high-risk areas of NTDs in China.
REPRODUCTIVE SCIENCES
(2021)
Article
Immunology
Chunyun Fang, Lixia Wang, Jingting Qiao, Lina Chang, Qing He, Xiaona Zhang, Ming Liu
Summary: This study investigated the mechanism of impaired immune response in diabetic patients. By studying the production of cytokines in macrophages induced by LPS, it was found that pretreatment with palmitic acid (PA) can differentially regulate the production of TNF-alpha and IL-1 beta, and this effect is associated with the cellular metabolism of PA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
