Review
Endocrinology & Metabolism
Sharon Baumel-Alterzon, Donald K. Scott
Summary: The beta-cell identity gene Pdx1 plays critical roles in beta-cell function, and oxidative stress can inhibit Pdx1 expression and function. The Nrf2 antioxidant pathway may preserve Pdx1 levels and potentially alleviate diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tianyang Wang, Jian Zhang, Haokai Wei, Xi Wang, Minjuan Xie, Yinjie Jiang, Jie Zhou
Summary: This study investigated the roles of oxidative stress and mitochondria in Matrine-induced kidney toxicity. The results showed that Matrine caused nephrotoxicity accompanied by an increase in reactive oxygen species accumulation and mitochondrial dysfunction. Additionally, GSK-3 beta and Nrf2 might serve as promising nephroprotective targets for Matrine-induced kidney injury.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Shweta Thakur, Bibekananda Sarkar, Monisha Dhiman, Anil K. Mantha
Summary: This study found that exposure to low concentrations of MCP and CP can lead to oxidative stress, DNA damage, modulate apoptosis, and APE1-mediated Nrf2 activation, which may be a potential mechanism promoting survival of lung cancer cells.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Cell & Tissue Engineering
Rika Sakuma, Miku Kobayashi, Rui Kobashi, Mako Onishi, Mitsuyo Maeda, Yosky Kataoka, Susumu Imaoka
Summary: Pericytes (PCs) are mural support cells that are activated in response to tissue injury and contribute to the regenerative process. This study isolated normal brain pericytes (nPCs) and compared them with ischemic pericytes (iPCs) in a mouse model of ischemic stroke. The results showed that iPCs have higher levels of reactive oxygen species and nuclear factor Nrf2, and can differentiate into neurons under certain conditions.
Review
Pharmacology & Pharmacy
Sepideh Mirzaei, Aliasghar Tabatabaei Mohammadi, Mohammad Hossein Gholami, Farid Hashemi, Ali Zarrabi, Amirhossein Zabolian, Kiavash Hushmandi, Pooyan Makvandi, Marek Samec, Alena Liskova, Peter Kubatka, Noushin Nabavi, Amir Reza Aref, Milad Ashrafizadeh, Haroon Khan, Masoud Najafi
Summary: Nrf2 signaling plays a crucial role in protecting against oxidative damage, but its activation in cancer cells can lead to chemoresistance. Modulating Nrf2 signaling during cisplatin treatment can suppress the development of chemoresistance and alleviate drug toxicity. Activating Nrf2 signaling can help prevent the side effects of cisplatin.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Marta Cykowiak, Violetta Krajka-Kuzniak
Summary: Pancreatic tumors are a serious health issue with a high mortality rate. Inflammation and oxidative stress play crucial roles in their development. Maintaining a balance between free radicals and the antioxidant system is essential for homeostasis. The Nrf2 signaling pathway is being explored as a potential target for pancreatic disease treatment. This review presents the latest evidence on the activation of the Nrf2 signaling pathway and its importance in pancreatic cancer, as well as recent discoveries of novel treatments related to the antioxidant system.
Article
Biochemistry & Molecular Biology
Nayoung Lee, Kumju Youn, Jeong-Hyun Yoon, Bokyung Lee, Dong Hyun Kim, Mira Jun
Summary: This study found that fucoxanthin, a major marine carotenoid found in brown algae, has antioxidant and anti-apoptotic effects against neuronal injury caused by amyloid-beta peptide (A beta). The study also revealed that fucoxanthin can enhance the expression of nuclear factor E2-related factor 2 (Nrf2) through the Akt/GSK-3 beta/Fyn signaling pathway, providing a potential intervention for Alzheimer's disease prevention.
Article
Biochemistry & Molecular Biology
Juanjuan Zhu, Hao Sun, Xinle Kang, Haixue Zhu, Xiaoteng Yan
Summary: This study verifies that acid polysaccharides from Buddleja officinalis Maxim can relieve diabetic retinopathy through inhibition of angiogenesis via activation of the Nrf2/ARE signaling pathway.
Article
Medicine, Research & Experimental
Xiao-Hui Guo, Li Pang, Chong-Yong Gao, Fan-Lin Meng, Wei Jin
Summary: Stroke is a major cause of death and disability. Neuroprotection is considered a promising treatment for stroke, but current drugs have failed in clinical trials. This study found that Lyoniresinol (LNO), a natural lignan, has neuroprotective effects by inhibiting cell apoptosis and improving nerve function and brain injury in stroke rats. Further molecular mechanism studies showed that LNO activates specific signaling pathways to improve oxidative stress in cells. These findings are important for the development of LNO as a new drug for stroke and related diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Dong-yue Ma, Jin-xia Liu, Lu-di Wang, Xin-yu Zhi, Li Luo, Jiang-yue Zhao, Yu Qin
Summary: This study identified ferroptosis as a major pathological process in lens epithelial cells (LECs) of age-related cataract (ARC) patients. The essential role of Nrf2 in ferroptosis was verified in mice and cell models. The increased expression of GSK-30 was found in low Nrf2-expressed tissues and cells, and inhibition of GSK-30 alleviated LECs ferroptosis in vitro and in vivo. Targeting GSK-30/Nrf2 balance could be a promising therapeutic strategy for ARC.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Medicine, Research & Experimental
Alexey Ulasov, Andrey A. Rosenkranz, Georgii P. Georgiev, Alexander S. Sobolev
Summary: The Nrf2 transcription factor regulates the expression of genes involved in cell defense against oxidative stress, which is associated with various diseases. The interactions between Nrf2 and Keap1 protein play a crucial role in this regulation. The activation of the Nrf2 system is considered as a promising strategy to treat diseases related to oxidative stress, including COVID-19. Two approaches are being developed to inactivate the Keap1 guardian function and enhance Nrf2 activity.
Review
Biochemistry & Molecular Biology
Ruolei Wang, Lirong Liang, Misaki Matsumoto, Kazumi Iwata, Atsushi Umemura, Feng He
Summary: The imbalance between reactive oxygen species (ROS) production and clearance causes oxidative stress and plays a central role in regulating cell and tissue physiology and pathology. ROS can either stimulate cancer survival and growth or cause cell death depending on their concentration. The transcription factor NRF2 has dual roles in carcinogenesis, where short-term activation suppresses tissue injury, inflammation, and cancer initiation, while constitutive activation confers advantages for cancer cells' survival and growth. NRF2 hyperactivation, as an adaptive cancer phenotype, regulates multiple aspects of cancer development, metastasis, and resistance to anticancer therapy.
Article
Immunology
Kang Huo, Kai-Ge Ma, Qin-Yue Guo, Peng Duan, Jing Xu
Summary: This study found that Plin5 can provide neuroprotection in oxygen-glucose deprivation/reoxygenation (OGD/R)-injured neurons through the regulation of the Nrf2-Akt-GSK-3 beta pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Zhuoran Wang, Mengran Yao, Leyu Jiang, Lingyan Wang, Yuqiao Yang, Quan Wang, Xi Qian, Yu Zhao, Jinqiao Qian
Summary: In this study, it was found that dexmedetomidine protects the heart against myocardial ischemia/reperfusion injury-induced ferroptosis by activating Nrf2 through the AMPK/GSK-3 beta signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Qianhua Ke, Jiao Yang, Huan Liu, Zhuoquan Huang, Lingling Bu, Dengpeng Jin, Chunhong Liu
Summary: The study indicates that low dose and short-term exposure to Nonylphenol may activate the Keap1-Nrf2 pathway, reducing oxidative stress damage; however, high dose and long-term exposure can inhibit this pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Pritha Dasgupta, Priyanka Kulkarni, Nadeem S. Bhat, Shahana Majid, Marisa Shiina, Varahram Shahryari, Soichiro Yamamura, Yuichiro Tanaka, Ravi Kumar Gupta, Rajvir Dahiya, Yutaka Hashimoto
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2020)
Article
Cell Biology
Pritha Dasgupta, Priyanka Kulkarni, Shahana Majid, Yutaka Hashimoto, Marisa Shiina, Varahram Shahryari, Nadeem S. Bhat, Laura Tabatabai, Soichiro Yamamura, Sharanjot Saini, Yuichiro Tanaka, Rajvir Dahiya
CELL DEATH & DISEASE
(2020)
Article
Pharmacology & Pharmacy
Priyanka Kulkarni, Pritha Dasgupta, Nadeem S. Bhat, Yutaka Hashimoto, Sharanjot Saini, Varahram Shahryari, Soichiro Yamamura, Marisa Shiina, Yuichiro Tanaka, Rajvir Dahiya, Shahana Majid
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2020)
Article
Oncology
Mohammed Soutto, Nadeem Bhat, Shayan Khalafi, Shoumin Zhu, Julio Poveda, Monica Garcia-Buitrago, Alexander Zaika, Wael El-Rifai
Summary: This study revealed that H. pylori infection can activate NF-kB and STAT3 to promote gastric cancer, with TFF1 acting as a suppressor of NF-kB activity and inflammatory response induced by H. pylori.
CANCER CELL INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Longlong Cao, Shoumin Zhu, Heng Lu, Mohammed Soutto, Nadeem Bhat, Zheng Chen, Dunfa Peng, Jianxian Lin, Jun Lu, Ping Li, Chaohui Zheng, Changming Huang, Wael El-Rifai
Summary: H. pylori infection induced the expression of RASAL2 through NF-kappa B, promoting beta-catenin activity. RASAL2 inhibited protein phosphatase 2A activity, activating the AKT/beta-catenin signaling axis.
Article
Gastroenterology & Hepatology
Xing Zhang, Mohammed Soutto, Zheng Chen, Nadeem Bhat, Shoumin Zhu, Moritz F. Eissmann, Matthias Ernst, Heng Lu, Dunfa Peng, Zekuan Xu, Wael El-Rifai
Summary: This study reveals the link between H pylori infection, inflammation, and FGFR4 activation, and identifies the important role of FGFR4 in gastric cancer development. The activation loop between FGFR4 and STAT3, mediated by steroid receptor coactivator, protects against H pylori-induced DNA damage and cell death.
Meeting Abstract
Oncology
Nadeem S. Bhat, Mohammed Soutto, Xing Zhang, Zheng Chen, Shoumin Zhu, Heng Lu, Dunfa Peng, Zekuan Xu, Wael El-Rifai
Meeting Abstract
Oncology
Nadeem S. Bhat, Mohammed Soutto, Xing Zhang, Zheng Chen, Shoumin Zhu, Heng Lu, Dunfa Peng, Zekuan Xu, Wael El-Rifai
Meeting Abstract
Gastroenterology & Hepatology
Ahmed R. Gomaa, Zheng Chen, Mohammed Soutto, Shoumin Zhu, Nadeem S. Bhat, Wael El-Rifai
Meeting Abstract
Gastroenterology & Hepatology
Mohammed Soutto, Nadeem S. Bhat, Shayan Khalafi, Shoumin Zhu, Julio Poveda, Monica Garcia-Buitrago, Alexander Zaika, Wael El-Rifai
Meeting Abstract
Gastroenterology & Hepatology
Shayan Khalafi, Shoumin Zhu, Mohammed Soutto, Nadeem S. Bhat, Wael El-Rifai
Meeting Abstract
Gastroenterology & Hepatology
Ahmed R. Gomaa, Zheng Chen, Mohammed Soutto, Nadeem S. Bhat, Shoumin Zhu, Wael El-Rifai
Meeting Abstract
Gastroenterology & Hepatology
Mohammed Soutto, Nadeem S. Bhat, Shoumin Zhu, Gomaa R. Ahmed, Zheng Chen, Dunfa Peng, Julio Poveda, Richard M. Peek, Wael El-Rifai
Meeting Abstract
Oncology
Priyanka Kulkarni, Pritha Dasgupta, Nadeem S. Bhat, Yutaka Hashimoto, Sharanjot Saini, Altaf A. Dar, Varahram Shahryari, Marisa Shiina, Soichiro Yamamura, Yuichiro Tanaka, Rajvir Dahiya, Shahana Majid