Review
Biochemistry & Molecular Biology
Xi Guo, Hong Yi, Tin Chiu Li, Yu Wang, Huilin Wang, Xiaoyan Chen
Summary: VEGF is a well-known angiogenic factor that plays a critical role in embryo implantation by enhancing embryo development and facilitating interactions between the embryo and endometrium. Changes in VEGF expression are correlated with reproductive failure, including recurrent implantation failure and recurrent miscarriage. This study aimed to clarify the role of VEGF in embryo implantation by reviewing recent literature and exploring its effects and underlying mechanisms.
Review
Physiology
Xueli Liu, Bin Zhu, Yujie Li, Xinyue Liu, Sheng Guo, Chenglong Wang, Sen Li, Dingxuan Wang
Summary: Angiogenesis and VEGF play crucial roles in tendon healing, but the effects of exogenous VEGF application are controversial and require further research.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Shuqi Dai, Yu Zhong, Hongxia Cui, Jin Zhao, Su Li
Summary: Vascular endothelial growth factor (VEGF) plays a role in angiogenesis and vasculogenesis. Tumors are associated with angiogenesis. Vascular endothelial growth factor inhibitors (VEGFI) have been used in anti-tumor treatment. However, aortic dissection (AD) is a severe adverse reaction of VEGFI, and this review discusses its pathology, risk factors, diagnosis, and treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Letter
Medicine, General & Internal
Benjamin Sommer Thinggaard, Frederik Pedersen, Jakob Grauslund, Lonny Stokholm
Summary: This cohort study examines the use and forecast of intravitreal injections of vascular endothelial growth factor inhibitor in Denmark from 2007 through 2022.
Article
Biochemistry & Molecular Biology
Barbara Vizio, Ornella Bosco, Ezio David, Gian Paolo Caviglia, Maria Lorena Abate, Martina Schiavello, Angela Pucci, Antonina Smedile, Gianluca Paraluppi, Renato Romagnoli, Enrico Lupia, Graziella Bellone, Giuseppe Montrucchio
Summary: The study revealed that THPO and VEGF-A expression levels were significantly elevated in tumor tissues compared to liver cirrhosis tissues in HCC patients. There was a linear correlation between THPO and VEGF-A transcripts in HCC, indicating a potential interdependent regulation between the two growth factors in promoting cellular growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Giovanni Vitale, Alessia Cozzolino, Pasqualino Malandrino, Roberto Minotta, Giulia Puliani, Davide Saronni, Antongiulio Faggiano, Annamaria Colao
Summary: Neuroendocrine neoplasms are tumors originating from neuroendocrine cells in different organs, with dysregulation of receptor tyrosine kinases playing a crucial role in their development and progression. Research on the role of the fibroblast growth factor receptor system in NENs and the potential of FGFR selective inhibitors shows promising anti-tumor activity in advanced NEN patients, with further studies needed for confirmation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Emily R. Mahoney, Logan Dumitrescu, Annah M. Moore, Francis E. Cambronero, Philip L. De Jager, Mary Ellen Koran, Vladislav A. Petyuk, Rena A. S. Robinson, Sandeep Goyal, Julie A. Schneider, David A. Bennett, Angela L. Jefferson, Timothy J. Hohman
Summary: The study revealed that the VEGF gene family plays a complex role in neuroprotection and is associated with cognitive performance, cognitive decline, and Alzheimer's disease pathology.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Yolanda Fernandez-Cladera, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Agustin F. Gonzalez-Rivero, Antonia De Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study analyzed the relationship between VEGF and sVEGFR with SLE disease-related features and found that serum levels of VEGF and sVEGFR in SLE patients were associated with disease damage, with musculoskeletal manifestations being the most commonly associated feature.
Review
Biochemistry & Molecular Biology
Jean-Luc Wautier, Marie-Paule Wautier
Summary: The study of vascular permeability is important for understanding the mechanism that maintains the exchange between blood, tissues, and organs. Recent research has provided a better understanding of vascular cell functions and interactions between blood vessels. The identification of endothelial cell receptors and mediators and their role in homeostasis and disease has shed light on the maintenance of vascular permeability. Additionally, drugs and specific antibodies have been found to reduce the severity and mortality of diseases with enhanced vascular permeability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mannon Geindreau, Francois Ghiringhelli, Melanie Bruchard
Summary: VEGF plays a crucial role in tumor growth by promoting angiogenesis and modulating the immune response. Clinical approval has been given to therapies targeting VEGF for the treatment of various cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Dairy & Animal Science
Pedro Pinto-Bravo, Maria Rosa Rebordao, Ana Amaral, Carina Fernandes, Antonio Galvao, Elisabete Silva, Pedro Pessa-Santos, Graca Alexandre-Pires, Rosario P. Roberto da Costa, Dariusz J. Skarzynski, Graca Ferreira-Dias
Summary: The oviduct provides ideal conditions for fertilization and early embryonic development, with proper vascularization being essential for its physiological function. This study examined differences in microvascular density across different portions of the equine oviduct and found that angiogenic factors and their receptors are expressed in all studied regions, in line with microvascular patterns.
Article
Biochemistry & Molecular Biology
Tiziana Genovese, Daniela Impellizzeri, Ramona D'Amico, Roberta Fusco, Alessio Filippo Peritore, Davide Di Paola, Livia Interdonato, Enrico Gugliandolo, Rosalia Crupi, Rosanna Di Paola, Salvatore Cuzzocrea, Marika Cordaro, Rosalba Siracusa
Summary: This study evaluated the effects of bevacizumab on ApoE(-/-) mice undergoing TBI, and found that bevacizumab improved motor deficits, reduced VEGF levels and brain edema, preserved BBB integrity, and mitigated neuroinflammation induced by TBI. Additionally, it was observed for the first time that bevacizumab prevented the acceleration of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Il-doo Kim, John W. Cave, Sunghee Cho
Summary: Obese mice with acute stroke showed increased mortality, infarct volume, swelling, and blood-brain barrier disruption, along with elevated VEGF-A and VEGFR2 expression. Aflibercept could reduce brain edema and vascular permeability, improving stroke outcomes in obese subjects.
Article
Pharmacology & Pharmacy
Yusuke Masuo, Ken-ichi Fujita, Kazuhiro Shimada, Noriho Iida, Tomohiko Wakayama, Yukio Kato, Aya Hasan Alshammari
Summary: This study explains the occurrence of hand-foot skin reaction (HFSR) in patients treated with tyrosine kinase inhibitors (TKIs) by examining keratinocyte toxicity and VEGFR-2 inhibition.
BIOCHEMICAL PHARMACOLOGY
(2022)