Exposure of Barrett’s and esophageal adenocarcinoma cells to bile acids activates EGFR–STAT3 signaling axis via induction of APE1

Bile acids regulate intestinal cell proliferation by modulating EGFR and FXR signaling

(2016) Avafia Y. Dossa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Endothelial cell tumor growth is Ape/ref-1 dependent

(2015) Ayan Biswas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

IGFBP2 potentiates nuclear EGFR–STAT3 signaling

(2015) C Y Chua et al.   ONCOGENE

Expression and activation of EGFR and STAT3 during the multistage carcinogenesis of intrahepatic cholangiocarcinoma induced by 3’-methyl-4 dimethylaminoazobenzene in rats

(2015) Fan Zhang et al.   Journal of Toxicologic Pathology

Transcriptional Up-Regulation of APE1/Ref-1 in Hepatic Tumor: Role in Hepatocytes Resistance to Oxidative Stress and Apoptosis

(2015) Vittorio Di Maso et al.   PLoS One

The role of APE/Ref-1 signaling pathway in hepatocellular carcinoma progression

(2014) ZHEN YANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Activin A balance regulates epithelial invasiveness and tumorigenesis

(2014) Grégoire F Le Bras et al.   LABORATORY INVESTIGATION

Glutathione Peroxidase 7 Suppresses Bile Salt-Induced Expression of Pro-Inflammatory Cytokines in Barrett's Carcinogenesis

(2014) Dun-Fa Peng et al.   Journal of Cancer

Landscape of EGFR signaling network in human cancers: Biology and therapeutic response in relation to receptor subcellular locations

(2012) Woody Han et al.   CANCER LETTERS

Barrett’s to Oesophageal Cancer Sequence: A Model of Inflammatory-Driven Upper Gastrointestinal Cancer

(2012) Sarah L. Picardo et al.   DIGESTIVE SURGERY

Inflammation and Barrett's carcinogenesis

(2012) A. Poehlmann et al.   PATHOLOGY RESEARCH AND PRACTICE

Glutathione peroxidase 7 protects against oxidative DNA damage in oesophageal cells

(2011) DunFa Peng et al.   GUT

Impact of APE1/Ref-1 Redox Inhibition on Pancreatic Tumor Growth

(2011) M. L. Fishel et al.   MOLECULAR CANCER THERAPEUTICS

A Functional Nuclear Epidermal Growth Factor Receptor, Src and Stat3 Heteromeric Complex in Pancreatic Cancer Cells

(2011) Soumya Jaganathan et al.   PLoS One

Functional Analysis of Novel Analogues of E3330 That Block the Redox Signaling Activity of the Multifunctional AP Endonuclease/Redox Signaling Enzyme APE1/Ref-1

(2010) Mark R. Kelley et al.   ANTIOXIDANTS & REDOX SIGNALING

Modulation of Gene Expression and Tumor Cell Growth by Redox Modification of STAT3

(2010) L. Li et al.   CANCER RESEARCH

Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment

(2010) Gianluca Tell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis

(2010) Melissa L. Fishel et al.   EXPERIMENTAL HEMATOLOGY

Prognostic Significance of Human Apurinic/Apyrimidinic Endonuclease (APE/Ref-1) Expression in Rectal Cancer Treated With Preoperative Radiochemotherapy

(2010) Jun-Sang Kim et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Cyclooxygenase-2 Is a Novel Transcriptional Target of the Nuclear EGFR-STAT3 and EGFRvIII-STAT3 Signaling Axes

(2010) H.-W. Lo et al.   MOLECULAR CANCER RESEARCH

Oesophageal cancer incidence in the United States by race, sex and histologic type, 1977–2005

(2009) M B Cook et al.   BRITISH JOURNAL OF CANCER

In Benign Barrett's Epithelial Cells, Acid Exposure Generates Reactive Oxygen Species That Cause DNA Double-Strand Breaks

(2009) H. Y. Zhang et al.   CANCER RESEARCH

Bile Acid-induced Epidermal Growth Factor Receptor Activation in Quiescent Rat Hepatic Stellate Cells Can Trigger Both Proliferation and Apoptosis

(2009) Annika Sommerfeld et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bile acids as endogenous etiologic agents in gastrointestinal cancer

(2009) Harris Bernstein et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1

(2008) Meihua Luo et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcriptional Regulatory Functions of Mammalian AP-Endonuclease (APE1/Ref-1), an Essential Multifunctional Protein

(2008) Kishor K. Bhakat et al.   ANTIOXIDANTS & REDOX SIGNALING

The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme

(2008) Gianluca Tell et al.   ANTIOXIDANTS & REDOX SIGNALING

The EGFR-STAT3 Oncogenic Pathway Up-regulates the Eme1 Endonuclease to Reduce DNA Damage after Topoisomerase I Inhibition

(2008) A. Vigneron et al.   CANCER RESEARCH

The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF- B activation in oesophageal cells, with a mechanism of action involving ROS

(2008) G. J. S. Jenkins et al.   MUTAGENESIS