Developing new antibacterials through natural product research

Discovery, Biosynthesis, and Engineering of Lantipeptides

(2012) Patrick J. Knerr et al.   Annual Review of Biochemistry

Chemical Inhibitors of the Type Three Secretion System: Disarming Bacterial Pathogens

(2012) Miles C. Duncan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy of LFF571 in a Hamster Model of Clostridium difficile Infection

(2012) Anna Trzasko et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroandIn VivoCharacterization of CB-183,315, a Novel Lipopeptide Antibiotic for Treatment of Clostridium difficile

(2012) Carmela T. M. Mascio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobial Activity of the Investigational Pleuromutilin Compound BC-3781 Tested against Gram-Positive Organisms Commonly Associated with Acute Bacterial Skin and Skin Structure Infections

(2012) Helio S. Sader et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Target- and Resistance-Based Mechanistic Studies with TP-434, a Novel Fluorocycline Antibiotic

(2012) Trudy H. Grossman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antimicrobials, drug discovery, and genome mining

(2012) R. J. Scheffler et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Design, Synthesis, and Antibacterial Activity of Novel Pleuromutilin Derivatives Bearing an Amino Thiazolyl Ring

(2012) Yong Ling et al.   ARCHIV DER PHARMAZIE

Novel pleuromutilin derivatives as antibacterial agents: Synthesis, biological evaluation and molecular docking studies

(2012) Xinyang Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bioactive compounds synthesized by non-ribosomal peptide synthetases and type-I polyketide synthases discovered through genome-mining and metagenomics

(2012) Katerina Nikolouli et al.   BIOTECHNOLOGY LETTERS

Development of Antibiotic Activity Profile Screening for the Classification and Discovery of Natural Product Antibiotics

(2012) Weng Ruh Wong et al.   CHEMISTRY & BIOLOGY

Genome-based bioprospecting of microbes for new therapeutics

(2012) Sergey B Zotchev et al.   CURRENT OPINION IN BIOTECHNOLOGY

Combinatorial biosynthesis of polyketides—a perspective

(2012) Fong T Wong et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

New classes of antibiotics

(2012) Donald T Moir et al.   CURRENT OPINION IN PHARMACOLOGY

New horizons for host defense peptides and lantibiotics

(2012) Michael John Dawson et al.   CURRENT OPINION IN PHARMACOLOGY

Improving known classes of antibiotics: an optimistic approach for the future

(2012) Karen Bush   CURRENT OPINION IN PHARMACOLOGY

A minimalist fragment approach for the design of natural-product-like synthetic scaffolds

(2012) Dmitry Genis et al.   DRUG DISCOVERY TODAY

Non-genetic mechanisms communicating antibiotic resistance: rethinking strategies for antimicrobial drug design

(2012) Omar M El-Halfawy et al.   Expert Opinion on Drug Discovery

Increasing the success rate of lantibiotic drug discovery by Synthetic Biology

(2012) Manuel Montalbán-López et al.   Expert Opinion on Drug Discovery

Targeting iron assimilation to develop new antibacterials

(2012) Timothy L Foley et al.   Expert Opinion on Drug Discovery

The influence of lipophilicity in drug discovery and design

(2012) John A Arnott et al.   Expert Opinion on Drug Discovery

Thoughts and facts about antibiotics: Where we are now and where we are heading

(2012) János Bérdy   JOURNAL OF ANTIBIOTICS

Lessons from Natural Products Chemistry Can Offer Novel Approaches for Synthetic Chemistry in Drug Discovery

(2012) Natalya I. Vasilevich et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Click Chemistry Approach to Pleuromutilin Derivatives, Part 2: Conjugates with Acyclic Nucleosides and Their Ribosomal Binding and Antibacterial Activity

(2012) Ida Dreier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Charting, Navigating, and Populating Natural Product Chemical Space for Drug Discovery

(2012) Hugo Lachance et al.   JOURNAL OF MEDICINAL CHEMISTRY

Immunotherapies in Infectious Diseases

(2012) Vivek Kak et al.   MEDICAL CLINICS OF NORTH AMERICA

A turning point for natural product discovery - ESF-EMBO research conference: synthetic biology of antibiotic production

(2012) Eriko Takano et al.   MOLECULAR MICROBIOLOGY

Ancient fungi found in deep-sea mud

(2012) Richard Monastersky   NATURE

FDA under pressure to relax drug rules

(2012) Heidi Ledford   NATURE

Synthesis: A constructive debate

(2012) Jay D. Keasling et al.   NATURE

Automated design of ligands to polypharmacological profiles

(2012) Jérémy Besnard et al.   NATURE

Natural-product-derived fragments for fragment-based ligand discovery

(2012) Björn Over et al.   Nature Chemistry

Novel polymyxin derivatives are less cytotoxic than polymyxin B to renal proximal tubular cells

(2012) Marie-Paule Mingeot-Leclercq et al.   PEPTIDES

In Vivo-Validated Essential Genes Identified in Acinetobacter baumannii by Using Human Ascites Overlap Poorly with Essential Genes Detected on Laboratory Media

(2012) T. C. Umland et al.   mBio

Introduction to Antimicrobial Therapeutics Reviews

(2011) Karen Bush   Annals of the New York Academy of Sciences

The history of the tetracyclines

(2011) Mark L. Nelson et al.   Annals of the New York Academy of Sciences

Antibiotics in development targeting protein synthesis

(2011) Joyce A. Sutcliffe   Annals of the New York Academy of Sciences

Are pleuromutilin antibiotics finally fit for human use?

(2011) Rodger Novak   Annals of the New York Academy of Sciences

New approaches for treating staphylococcal biofilm infections

(2011) Megan R. Kiedrowski et al.   Annals of the New York Academy of Sciences

The oxazolidinones: past, present, and future

(2011) Karen Joy Shaw et al.   Annals of the New York Academy of Sciences

On the specificity of antibiotics targeting the large ribosomal subunit

(2011) Daniel N. Wilson   Annals of the New York Academy of Sciences

In VitroandIn VivoActivities of Novel, Semisynthetic Thiopeptide Inhibitors of Bacterial Elongation Factor Tu

(2011) J. A. Leeds et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Battacin (Octapeptin B5), a New Cyclic Lipopeptide Antibiotic from Paenibacillus tianmuensis Active against Multidrug-Resistant Gram-Negative Bacteria

(2011) Chao-Dong Qian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The great screen anomaly—a new frontier in product discovery through functional metagenomics

(2011) David Matthias Ekkers et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

New antimicrobial agents on the horizon

(2011) Karen Bush et al.   BIOCHEMICAL PHARMACOLOGY

Engineering antibiotic production and overcoming bacterial resistance

(2011) Anne-Gaëlle Planson et al.   Biotechnology Journal

Novel classes of antibiotics or more of the same?

(2011) Anthony RM Coates et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antibiotics as Signal Molecules

(2011) Diego Romero et al.   CHEMICAL REVIEWS

Confronting the Challenges of Natural Product-Based Antifungal Discovery

(2011) Terry Roemer et al.   CHEMISTRY & BIOLOGY

Paenibacillus polymyxa PKB1 Produces Variants of Polymyxin B-Type Antibiotics

(2011) Mohamed Shaheen et al.   CHEMISTRY & BIOLOGY

Forgotten Antibiotics: An Inventory in Europe, the United States, Canada, and Australia

(2011) Céline Pulcini et al.   CLINICAL INFECTIOUS DISEASES

Rare actinomycetes: a potential storehouse for novel antibiotics

(2011) Kavita Tiwari et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Drug discovery management, small is still beautiful: Why a number of companies get it wrong

(2011) Lars J.S. Knutsen   DRUG DISCOVERY TODAY

Critical shortage of new antibiotics in development against multidrug-resistant bacteria—Time to react is now

(2011) Laura Freire-Moran et al.   DRUG RESISTANCE UPDATES

Discovery and development of lantibiotics; antimicrobial agents that have significant potential for medical application

(2011) Mohammed M Al-Mahrous et al.   Expert Opinion on Drug Discovery

Recent derivatives from smaller classes of fermentation-derived antibacterials

(2011) Herbert A Kirst   EXPERT OPINION ON THERAPEUTIC PATENTS

Will new antimicrobials overcome resistance among Gram-negatives?

(2011) Matteo Bassetti et al.   Expert Review of Anti-Infective Therapy

Platensimycin and platencin: promising antibiotics for future application in human medicine

(2011) Evan Martens et al.   JOURNAL OF ANTIBIOTICS

Antibiotics in the clinical pipeline in 2011

(2011) Mark S Butler et al.   JOURNAL OF ANTIBIOTICS

Function of MbtH homologs in nonribosomal peptide biosynthesis and applications in secondary metabolite discovery

(2011) Richard H. Baltz   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Modeling Cellular Pharmacokinetics of 14- and 15-Membered Macrolides with Physicochemical Properties

(2011) Višnja Stepanić et al.   JOURNAL OF MEDICINAL CHEMISTRY

Isolation and identification of lipopeptide antibiotics from Paenibacillus elgii B69 with inhibitory activity against methicillin-resistant Staphylococcus aureus

(2011) Rui Ding et al.   JOURNAL OF MICROBIOLOGY

Drug-like Properties: Guiding Principles for the Design of Natural Product Libraries

(2011) David Camp et al.   JOURNAL OF NATURAL PRODUCTS

Dereplication of Microbial Natural Products by LC-DAD-TOFMS

(2011) Kristian F. Nielsen et al.   JOURNAL OF NATURAL PRODUCTS

Total Synthesis and Complete Structural Assignment of Thiocillin I

(2011) Virender S. Aulakh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activity of Polymyxin B and the Novel Polymyxin Analogue CB-182,804 Against Contemporary Gram-Negative Pathogens in New York City

(2011) John Quale et al.   Microbial Drug Resistance

Pleuromutilin and its Derivatives-The Lead Compounds for Novel Antibiotics

(2011) Y. -Z. Tang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Fix the antibiotics pipeline

(2011) Matthew A. Cooper et al.   NATURE

A stereoselective, Sm(ii)-mediated approach to decorated cis-hydrindanes: synthetic studies on faurinone and pleuromutilin

(2011) Thomas J. K. Findley et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of the Pyridine Core of Cyclothiazomycin

(2011) Yan Zou et al.   ORGANIC LETTERS

Isolation and characterization of peptide antibiotics LI-F04 and polymyxin B6 produced by Paenibacillus polymyxa strain JSa-9

(2011) Yang Deng et al.   PEPTIDES

Microbial metabolites: 45 years of wandering, wondering and discovering

(2011) Satoshi Ōmura   TETRAHEDRON

Expanding the pleuromutilin class of antibiotics by de novo chemical synthesis

(2011) Stephen D. Lotesta et al.   Chemical Science

Chemoselective enrichment for natural products discovery

(2011) Antoinette Y. Odendaal et al.   Chemical Science

Structure-based design of anti-infectives

(2010) Anil K Agarwal et al.   Annals of the New York Academy of Sciences

Approaches to Capturing and Designing Biologically Active Small Molecules Produced by Uncultured Microbes

(2010) Jörn Piel   Annual Review of Microbiology

Metagenomic Analyses: Past and Future Trends

(2010) Carola Simon et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Prevention of bacterial adhesion

(2010) Per Klemm et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A concise synthesis of the molecular framework of pleuromutilin

(2010) Junjia Liu et al.   CHEMICAL COMMUNICATIONS

Daptomycin: From the Mountain to the Clinic, with Essential Help from Francis Tally, MD

(2010) Barry I. Eisenstein et al.   CLINICAL INFECTIOUS DISEASES

How to discover new antibiotics: harvesting the parvome

(2010) Julian Davies   CURRENT OPINION IN CHEMICAL BIOLOGY

Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules

(2010) Jacob J Banik et al.   CURRENT OPINION IN MICROBIOLOGY

Polymyxins and their novel derivatives

(2010) Martti Vaara   CURRENT OPINION IN MICROBIOLOGY

Drug discovery from uncultivable microorganisms

(2010) Brajesh K. Singh et al.   DRUG DISCOVERY TODAY

Lipophilicity in drug discovery

(2010) Michael J Waring   Expert Opinion on Drug Discovery

Antibiotics versus resistant bacteria: a continual challenge

(2010) Herbert A Kirst   EXPERT OPINION ON THERAPEUTIC PATENTS

New β-lactam antibiotics and β-lactamase inhibitors

(2010) Karen Bush et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Novel agents to inhibit microbial virulence and pathogenicity

(2010) Sonia Escaich   EXPERT OPINION ON THERAPEUTIC PATENTS

Bioprospecting microbial natural product libraries from the marine environment for drug discovery

(2010) Xiangyang Liu et al.   JOURNAL OF ANTIBIOTICS

Antibiotic discovery in the twenty-first century: current trends and future perspectives

(2010) Stefano Donadio et al.   JOURNAL OF ANTIBIOTICS

Fundamental functionality: recent developments in understanding the structure–activity relationships of lantibiotic peptides

(2010) Avena C Ross et al.   JOURNAL OF ANTIBIOTICS

The spinosyn family of insecticides: realizing the potential of natural products research

(2010) Herbert A Kirst   JOURNAL OF ANTIBIOTICS

Current approaches to exploit actinomycetes as a source of novel natural products

(2010) Olga Genilloud et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

The importance of new companies for drug discovery: origins of a decade of new drugs

(2010) Robert Kneller   NATURE REVIEWS DRUG DISCOVERY

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

(2010) J. A. Dunkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Simulating activity of the bacterial ribosome

(2010) Joanna Trylska   QUARTERLY REVIEWS OF BIOPHYSICS

Antibiotics that target protein synthesis

(2010) Lisa S. McCoy et al.   Wiley Interdisciplinary Reviews-RNA

Recent Advances in the Chemistry and Biology of Naturally Occurring Antibiotics

(2009) K. C. Nicolaou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Establishing Molecular Tools for Genetic Manipulation of the Pleuromutilin-Producing Fungus Clitopilus passeckerianus

(2009) S. Kilaru et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The chemical biology of modular biosynthetic enzymes

(2009) Jordan L. Meier et al.   CHEMICAL SOCIETY REVIEWS

Non-antibiotic strategies for sepsis

(2009) J. Cohen   CLINICAL MICROBIOLOGY AND INFECTION

Modern Approaches in the Search for New Lead Antiparasitic Compounds from Higher Plants

(2009) Emerson Queiroz et al.   CURRENT DRUG TARGETS

New screens and targets in antibacterial drug discovery

(2009) Shannon B Falconer et al.   CURRENT OPINION IN MICROBIOLOGY

Microbial drug discovery: 80 years of progress

(2009) Arnold L Demain et al.   JOURNAL OF ANTIBIOTICS

Novel Chemical Space Exploration via Natural Products

(2009) Josefin Rosén et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure−Activity Relationships of Polymyxin Antibiotics

(2009) Tony Velkov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibiotics: Natural products essential to human health

(2009) Arnold L. Demain   MEDICINAL RESEARCH REVIEWS

An Overview of Highly Optically Pure Chloramphenicol Bases: Applications and Modifications

(2009) Kanghui Yang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Bioinformatic perspectives on NRPS/PKS megasynthases: Advances and challenges

(2009) Holger Jenke-Kodama et al.   NATURAL PRODUCT REPORTS

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

The Antibiotics in the Chemical Space

(2008) Maxime Gualtieri et al.   CURRENT MEDICINAL CHEMISTRY

The impact of natural products upon modern drug discovery

(2008) A Ganesan   CURRENT OPINION IN CHEMICAL BIOLOGY

Targeting virulence traits: potential strategies to combat extraintestinal pathogenic E. coli infections

(2008) Ulrich Dobrindt et al.   CURRENT OPINION IN MICROBIOLOGY

Renaissance in antibacterial discovery from actinomycetes

(2008) R BALTZ   CURRENT OPINION IN PHARMACOLOGY

Role of bioinformatics in the development of new antibacterial therapy

(2008) Arvind K Bansal   Expert Review of Anti-Infective Therapy

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evolving Trends in the Dereplication of Natural Product Extracts. 2. The Isolation of Chrysaibol, an Antibiotic Peptaibol from a New Zealand Sample of the Mycoparasitic FungusSepedonium chrysospermum

(2008) Maya I. Mitova et al.   JOURNAL OF NATURAL PRODUCTS

Developing a Drug-like Natural Product Library⊥

(2008) Ronald J. Quinn et al.   JOURNAL OF NATURAL PRODUCTS

A Scalable Synthesis of 2S-Hydroxymutilin via a Modified Rubottom Oxidation

(2008) Huan Wang et al.   JOURNAL OF ORGANIC CHEMISTRY