Engineering antibiotic production and overcoming bacterial resistance

Properties of metabolic graphs: biological organization or representation artifacts?

(2011) Wanding Zhou et al.   BMC BIOINFORMATICS

Studies on amino acid replacement and inhibitory activity of a β-lactamase inhibitory peptide

(2010) Liping Xie et al.   BIOCHEMISTRY-MOSCOW

Pathway discovery in metabolic networks by subgraph extraction

(2010) Karoline Faust et al.   BIOINFORMATICS

Finding metabolic pathways using atom tracking

(2010) Allison P. Heath et al.   BIOINFORMATICS

Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor

(2010) Mohammad T Alam et al.   BMC GENOMICS

Prediction of novel synthetic pathways for the production of desired chemicals

(2010) Ayoun Cho et al.   BMC Systems Biology

An engineered riboswitch as a potential gene-regulatory platform for reducing antibacterial drug resistance

(2010) Xuli Feng et al.   CHEMICAL COMMUNICATIONS

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Proteomic analysis of polyketide and nonribosomal peptide biosynthesis

(2010) Jordan L Meier et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Therapeutic applications of ribozymes and riboswitches

(2010) Jérôme Mulhbacher et al.   CURRENT OPINION IN PHARMACOLOGY

Diversity of Monomers in Nonribosomal Peptides: towards the Prediction of Origin and Biological Activity

(2010) S. Caboche et al.   JOURNAL OF BACTERIOLOGY

Daptomycin, a Bacterial Lipopeptide Synthesized by a Nonribosomal Machinery

(2010) Lars Robbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial charity work leads to population-wide resistance

(2010) Henry H. Lee et al.   NATURE

Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

(2010) Marnix H. Medema et al.   NATURE REVIEWS MICROBIOLOGY

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

PathPred: an enzyme-catalyzed metabolic pathway prediction server

(2010) Y. Moriya et al.   NUCLEIC ACIDS RESEARCH

SBSPKS: structure based sequence analysis of polyketide synthases

(2010) Swadha Anand et al.   NUCLEIC ACIDS RESEARCH

Blueprint for antimicrobial hit discovery targeting metabolic networks

(2010) Y. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tracking, tuning, and terminating microbial physiology using synthetic riboregulators

(2010) J. M. Callura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Bacteriophages as potential new therapeutics to replace or supplement antibiotics

(2010) Mzia Kutateladze et al.   TRENDS IN BIOTECHNOLOGY

Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus

(2010) Marnix H. Medema et al.   Microbial Biotechnology

Rahnuma: hypergraph-based tool for metabolic pathway prediction and network comparison

(2009) Aziz Mithani et al.   BIOINFORMATICS

MapsiDB: an integrated web database for type I polyketide synthases

(2009) Hongseok Tae et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Industrial systems biology

(2009) José Manuel Otero et al.   BIOTECHNOLOGY AND BIOENGINEERING

Inferring branching pathways in genome-scale metabolic networks

(2009) Esa Pitkänen et al.   BMC Systems Biology

Beta-lactams and Beta-lactamase-inhibitors in current- or potential-clinical practice: A comprehensive update

(2009) M. Shahid et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Revisiting the modularity of modular polyketide synthases

(2009) Chaitan Khosla et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Comparative Genome-Scale Metabolic Reconstruction and Flux Balance Analysis of Multiple Staphylococcus aureus Genomes Identify Novel Antimicrobial Drug Targets

(2009) D.-S. Lee et al.   JOURNAL OF BACTERIOLOGY

Combinatorial expression of bacterial whole mevalonate pathway for the production of β-carotene in E. coli

(2009) Sang-Hwal Yoon et al.   JOURNAL OF BIOTECHNOLOGY

Route Designer: A Retrosynthetic Analysis Tool Utilizing Automated Retrosynthetic Rule Generation

(2009) James Law et al.   Journal of Chemical Information and Modeling

Computational analysis of phenotypic space in heterologous polyketide biosynthesis—Applications to Escherichia coli, Bacillus subtilis, and Saccharomyces cerevisiae

(2009) Brett A. Boghigian et al.   JOURNAL OF THEORETICAL BIOLOGY

Synthetic protein scaffolds provide modular control over metabolic flux

(2009) John E Dueber et al.   NATURE BIOTECHNOLOGY

The University of Minnesota Biocatalysis/Biodegradation Database: improving public access

(2009) Junfeng Gao et al.   NUCLEIC ACIDS RESEARCH

An Engineered Yeast Efficiently Secreting Penicillin

(2009) Loknath Gidijala et al.   PLoS One

Computational structure-based redesign of enzyme activity

(2009) C.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy

(2009) T. K. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Biology for Synthetic Chemistry

(2008) Jay D. Keasling   ACS Chemical Biology

Mechanisms of drug efflux and strategies to combat them: Challenging the efflux pump of Gram-negative bacteria

(2008) Jean-Marie Pagès et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Outer membrane permeability and antibiotic resistance

(2008) Anne H. Delcour   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Data-driven extraction of relative reasoning rules to limit combinatorial explosion in biodegradation pathway prediction

(2008) Kathrin Fenner et al.   BIOINFORMATICS

MetaRoute: fast search for relevant metabolic routes for interactive network navigation and visualization

(2008) Torsten Blum et al.   BIOINFORMATICS

Reconstruction and analysis of the genetic and metabolic regulatory networks of the central metabolism of Bacillus subtilis

(2008) Anne Goelzer et al.   BMC Systems Biology

Metabolic engineering of microorganisms: general strategies and drug production

(2008) Sang Yup Lee et al.   DRUG DISCOVERY TODAY

Genome-Scale Reconstruction and Analysis of the Pseudomonas putida KT2440 Metabolic Network Facilitates Applications in Biotechnology

(2008) Jacek Puchałka et al.   PLoS Computational Biology

The Chemical Versatility of Natural-Product Assembly Lines

(2007) Christopher T. Walsh   ACCOUNTS OF CHEMICAL RESEARCH