Targeting iron assimilation to develop new antibacterials

Review article: the iron overload syndromes

(2012) A. Siddique et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Adenylating Enzymes in Mycobacterium tuberculosis as Drug Targets

(2012) Benjamin P. Duckworth et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Exploiting bacterial iron acquisition: siderophore conjugates

(2012) Cheng Ji et al.   Future Medicinal Chemistry

In vitro activity of the siderophore monosulfactam BAL30072 against meropenem-non-susceptible Acinetobacter baumannii

(2012) P. G. Higgins et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structural Characterization and High-Throughput Screening of Inhibitors of PvdQ, an NTN Hydrolase Involved in Pyoverdine Synthesis

(2011) Eric J. Drake et al.   ACS Chemical Biology

Regulation of iron transport and the role of transferrin

(2011) Konstantinos Gkouvatsos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Lactoferrin a multiple bioactive protein: An overview

(2011) Isui Abril García-Montoya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Combating Antimicrobial Resistance: Policy Recommendations to Save Lives

(2011)   CLINICAL INFECTIOUS DISEASES

The Medicinal Chemistry of Novel Iron Chelators for the Treatment of Cancer

(2011) Zaklina Kovacevic et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

In vitro activity of BAL30072 against Burkholderia pseudomallei

(2011) Takehiko Mima et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

PL-002 Synthesis and antimicrobial activity of the novel siderophore sulfactam BAL30072

(2011) M.G.P. Page et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

The Deferasirox–AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial

(2011) Brad Spellberg et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Inhibitory effects of lactoferrin on biofilm formation in clinical isolates of Pseudomonas aeruginosa

(2011) Hiroyuki Kamiya et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Design, Synthesis, and Study of a Mycobactin−Artemisinin Conjugate That Has Selective and Potent Activity against Tuberculosis and Malaria

(2011) Marvin J. Miller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Secretion, but not overall synthesis, of catecholate siderophores contributes to virulence of extraintestinal pathogenic Escherichia coli

(2011) Mélissa Caza et al.   MOLECULAR MICROBIOLOGY

How hydrophobic molecules traverse the outer membranes of Gram-negative bacteria

(2011) M. C. Wiener et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preparation, Gram-Negative Antibacterial Activity, and Hydrolytic Stability of Novel Siderophore-Conjugated Monocarbam Diols

(2011) Mark E. Flanagan et al.   ACS Medicinal Chemistry Letters

In Vitro Properties of BAL30072, a Novel Siderophore Sulfactam with Activity against Multiresistant Gram-Negative Bacilli

(2010) M. G. P. Page et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Differential Protein Expression inStreptococcus uberisunder Planktonic and Biofilm Growth Conditions

(2010) R. C. Crowley et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Abolition of Biofilm Formation in Urinary Tract Escherichia coli and Klebsiella Isolates by Metal Interference through Competition for Fur

(2010) V. Hancock et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis,

(2010) Eric J. Drake et al.   BIOCHEMISTRY

Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI)

(2010) Alexandra Manos-Turvey et al.   ChemMedChem

Inhibitors of the Salicylate Synthase (MbtI) from Mycobacterium tuberculosis Discovered by High-Throughput Screening

(2010) Mahalakshmi Vasan et al.   ChemMedChem

The 10 × ‘20 Initiative: Pursuing a Global Commitment to Develop 10 New Antibacterial Drugs by 2020

(2010)   CLINICAL INFECTIOUS DISEASES

Challenges in Anti‐Infective Development in the Era of Bad Bugs, No Drugs: A Regulatory Perspective Using the Example of Bloodstream Infection as an Indication

(2010) Helen W. Boucher   CLINICAL INFECTIOUS DISEASES

Postgenomic strategies in antibacterial drug discovery

(2010) Heike Brötz-Oesterhelt et al.   Future Microbiology

Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124

(2010) D. S. Auld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Dynamics in the Acyl-CoA Synthetases, Adenylation Domains of Non-ribosomal Peptide Synthetases, and Firefly Luciferase

(2009) Andrew M. Gulick   ACS Chemical Biology

Safety and Outcomes of Open-Label Deferasirox Iron Chelation Therapy for Mucormycosis

(2009) B. Spellberg et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antifungal Activities of Natural and Synthetic Iron Chelators Alone and in Combination with Azole and Polyene Antibiotics against Aspergillus fumigatus

(2009) K. A. Zarember et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Utilization of microbial iron assimilation processes for the development of new antibiotics and inspiration for the design of new anticancer agents

(2009) Marvin J. Miller et al.   BIOMETALS

Sideromycins: tools and antibiotics

(2009) Volkmar Braun et al.   BIOMETALS

Activity of the siderophore monobactam BAL30072 against multiresistant non-fermenters

(2009) S. Mushtaq et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Enzymatic Hydrolysis of Trilactone Siderophores: Where Chiral Recognition Occurs in Enterobactin and Bacillibactin Iron Transport(1)

(2009) Rebecca J. Abergel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of PTC124 activity in cell-based luciferase assays of nonsense codon suppression

(2009) D. S. Auld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Specific Roles of the iroBCDEN Genes in Virulence of an Avian Pathogenic Escherichia coli O78 Strain and in Production of Salmochelins

(2008) M. Caza et al.   INFECTION AND IMMUNITY

Synthesis of deuterium-labelled 5′-O-[N-(Salicyl)sulfamoyl]adenosine (Sal-AMS-d4) as an internal standard for quantitation of Sal-AMS

(2008) Amol Gupte et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Inhibition of Siderophore Biosynthesis by 2-Triazole Substituted Analogues of 5′-O-[N-(Salicyl)sulfamoyl]adenosine: Antibacterial Nucleosides Effective againstMycobacterium tuberculosis

(2008) Amol Gupte et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biosynthesis and IroC-dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium

(2008) Marie-Laure V. Crouch et al.   MOLECULAR MICROBIOLOGY