Recent derivatives from smaller classes of fermentation-derived antibacterials

Antimicrobial Properties of MX-2401, an Expanded-Spectrum Lipopeptide Active in the Presence of Lung Surfactant

(2011) Dominique Dugourd et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mechanism of Action and Limited Cross-Resistance of New Lipopeptide MX-2401

(2011) E. Rubinchik et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Engineering antibiotic production and overcoming bacterial resistance

(2011) Anne-Gaëlle Planson et al.   Biotechnology Journal

Novel classes of antibiotics or more of the same?

(2011) Anthony RM Coates et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel Des-Fatty Acyl-Polymyxin B Derivatives with Pseudomonas aeruginosa-Specific Antimicrobial Activity

(2011) Yuki Sato et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Critical shortage of new antibiotics in development against multidrug-resistant bacteria—Time to react is now

(2011) Laura Freire-Moran et al.   DRUG RESISTANCE UPDATES

Antibiotics in the clinical pipeline in 2011

(2011) Mark S Butler et al.   JOURNAL OF ANTIBIOTICS

Radical-mediated enzymatic carbon chain fragmentation-recombination

(2011) Qi Zhang et al.   Nature Chemical Biology

Synthesis of Peptides Containing Overlapping Lanthionine Bridges on the Solid Phase: An Analogue of Rings D and E of the Lantibiotic Nisin

(2011) Begum Mothia et al.   ORGANIC LETTERS

Fidaxomicin: A Macrocyclic Antibiotic for the Treatment ofClostridium difficileInfection

(2011) Jennifer S Hardesty et al.   PHARMACOTHERAPY

Microbial metabolites: 45 years of wandering, wondering and discovering

(2011) Satoshi Ōmura   TETRAHEDRON

Update in Tuberculosis 2009

(2010) Charles L. Daley   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Novel Polymyxin Derivative That Lacks the Fatty Acid Tail and Carries Only Three Positive Charges Has Strong Synergism with Agents Excluded by the Intact Outer Membrane

(2010) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genetically Engineered Lipopeptide Antibiotics Related to A54145 and Daptomycin with Improved Properties

(2010) K. T. Nguyen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Polymyxins and their novel derivatives

(2010) Martti Vaara   CURRENT OPINION IN MICROBIOLOGY

Daptomycin: pharmacology and clinical use

(2010) Christos Kosmidis et al.   EXPERT OPINION ON PHARMACOTHERAPY

Antibiotics versus resistant bacteria: a continual challenge

(2010) Herbert A Kirst   EXPERT OPINION ON THERAPEUTIC PATENTS

Production of novel lipopeptide antibiotics related to A54145 by Streptomyces fradiae mutants blocked in biosynthesis of modified amino acids and assignment of lptJ, lptK and lptL gene functions

(2010) Dylan C Alexander et al.   JOURNAL OF ANTIBIOTICS

Structural characterization of a lipopeptide antibiotic A54145E(Asn3Asp9) produced by a genetically engineered strain of Streptomyces fradiae

(2010) Jian-Qiao Gu et al.   JOURNAL OF ANTIBIOTICS

Antibiotic discovery in the twenty-first century: current trends and future perspectives

(2010) Stefano Donadio et al.   JOURNAL OF ANTIBIOTICS

Fundamental functionality: recent developments in understanding the structure–activity relationships of lantibiotic peptides

(2010) Avena C Ross et al.   JOURNAL OF ANTIBIOTICS

Novel polymyxin derivatives are effective in treating experimental Escherichia coli peritoneal infection in mice

(2010) C. Vingsbo Lundberg et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Chemical modification of capuramycins to enhance antibacterial activity

(2010) Elena Bogatcheva et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In vitro antimicrobial activities of capuramycin analogues against non-tuberculous mycobacteria

(2010) T. Dubuisson et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Daptomycin, a Bacterial Lipopeptide Synthesized by a Nonribosomal Machinery

(2010) Lars Robbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Function-Oriented Synthesis of Simplified Caprazamycins: Discovery of Oxazolidine-Containing Uridine Derivatives as Antibacterial Agents against Drug-Resistant Bacteria

(2010) Kensuke Ii et al.   JOURNAL OF MEDICINAL CHEMISTRY

Total Synthesis of (−)-Muraymycin D2 and Its Epimer

(2010) Tetsuya Tanino et al.   JOURNAL OF ORGANIC CHEMISTRY

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Distamycins: Strategies for Possible Enhancement of Activity and Specificity

(2010) Rita Cortesi et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Heterologous production of thiostrepton A and biosynthetic engineering of thiostrepton analogs

(2010) Chaoxuan Li et al.   Molecular BioSystems

Identification of the genecluster involved in muraymycin biosynthesis from Streptomyces sp. NRRL 30471

(2010) Lin Cheng et al.   Molecular BioSystems

An ATP-independent strategy for amide bond formation in antibiotic biosynthesis

(2010) Masanori Funabashi et al.   Nature Chemical Biology

Novel 5′-deoxy nucleosyl amino acid scaffolds for the synthesis of muraymycin analogues

(2010) Anatol P. Spork et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Structure–activity studies on novel polymyxin derivatives that carry only three positive charges

(2010) Martti Vaara et al.   PEPTIDES

Rifamycins – Obstacles and opportunities

(2010) Paul A. Aristoff et al.   TUBERCULOSIS

Thiopeptide Antibiotic Biosynthesis

(2009) Hans-Dieter Arndt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activity of SQ641, a Capuramycin Analog, in a Murine Model of Tuberculosis

(2009) B. V. Nikonenko et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Water-soluble phosphate prodrugs of pleuromutilin analogues with potent in vivo antibacterial activity against Gram-positive pathogens

(2009) Liqiang Fu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Biosynthesis of Indolocarbazole and Goadsporin, Two Different Heterocyclic Antibiotics Produced by Actinomycetes

(2009) Hiroyasu ONAKA   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Analysis of the Liposidomycin Gene Cluster Leads to the Identification of New Caprazamycin Derivatives

(2009) Leonard Kaysser et al.   CHEMBIOCHEM

The Structural Diversity of Acidic Lipopeptide Antibiotics

(2009) Matthias Strieker et al.   CHEMBIOCHEM

Development of Des-Fatty Acyl-Polymyxin B Decapeptide Analogs with Pseudomonas aeruginosa-Specific Antimicrobial Activity

(2009) Naoko Katsuma et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Novel Pleuromutilin Derivatives with Excellent Antibacterial Activity AgainstStaphylococcus aureus

(2009) Peng Xu et al.   Chemical Biology & Drug Design

Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications

(2009) Rijing Liao et al.   CHEMISTRY & BIOLOGY

Daptomycin: mechanisms of action and resistance, and biosynthetic engineering

(2009) Richard H Baltz   CURRENT OPINION IN CHEMICAL BIOLOGY

Colistin in the 21st century

(2009) Roger L Nation et al.   CURRENT OPINION IN INFECTIOUS DISEASES

New screens and targets in antibacterial drug discovery

(2009) Shannon B Falconer et al.   CURRENT OPINION IN MICROBIOLOGY

New information about the polymyxin/colistin class of antibiotics

(2009) José Molina et al.   EXPERT OPINION ON PHARMACOTHERAPY

Tuberculosis pharmacotherapy: strategies to optimize patient care

(2009) Carole D Mitnick et al.   EXPERT OPINION ON PHARMACOTHERAPY

Peptide deformylase – a promising therapeutic target for tuberculosis and antibacterial drug discovery

(2009) Anshika Sharma et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Novel antimicrobial lipopeptides with long in vivo half-lives

(2009) Chris J. Pasetka et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Rifalazil and Derivative Compounds Show Potent Efficacy in a Mouse Model of H. pylori Colonization

(2009) David M Rothstein et al.   JOURNAL OF ANTIBIOTICS

Microbial drug discovery: 80 years of progress

(2009) Arnold L Demain et al.   JOURNAL OF ANTIBIOTICS

Identification and Manipulation of the Caprazamycin Gene Cluster Lead to New Simplified Liponucleoside Antibiotics and Give Insights into the Biosynthetic Pathway

(2009) Leonard Kaysser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Chemical Space Exploration via Natural Products

(2009) Josefin Rosén et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure−Activity Relationships of Polymyxin Antibiotics

(2009) Tony Velkov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antibiotics: Natural products essential to human health

(2009) Arnold L. Demain   MEDICINAL RESEARCH REVIEWS

Mutilins Derivatives: From Veterinary to Human-used Antibiotics

(2009) Changhua Hu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Recent advances in thiopeptideantibiotic biosynthesis

(2009) Chaoxuan Li et al.   NATURAL PRODUCT REPORTS

Antimicrobial nucleoside antibiotics targeting cell wall assembly: Recent advances in structure–function studies and nucleoside biosynthesis

(2009) Michael Winn et al.   NATURAL PRODUCT REPORTS

Concise Synthesis of Capuramycin

(2009) Michio Kurosu et al.   ORGANIC LETTERS

The activity and compatibility of the antibiotic tiamulin with other drugs in poultry medicine--A review

(2009) K. M. S. Islam et al.   POULTRY SCIENCE

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Manipulation of charged residues within the two-peptide lantibiotic lacticin 3147

(2009) Lucy H. Deegan et al.   Microbial Biotechnology

Rifamycin Antibiotics for Treatment of Clostridium difficile–Associated Diarrhea

(2008) Kevin W Garey et al.   ANNALS OF PHARMACOTHERAPY

In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Microbiology Profiling Studies with Staphylococci and Streptococci

(2008) G. T. Robertson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Evaluation of CBR-2092, a Novel Rifamycin-Quinolone Hybrid Antibiotic: Studies of the Mode of Action in Staphylococcus aureus

(2008) G. T. Robertson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Polymyxin Derivatives Carrying Only Three Positive Charges Are Effective Antibacterial Agents

(2008) M. Vaara et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

New Drugs against Tuberculosis: Problems, Progress, and Evaluation of Agents in Clinical Development

(2008) J. van den Boogaard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure–activity relationship of truncated analogs of caprazamycins as potential anti-tuberculosis agents

(2008) Shinpei Hirano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pleuromutilin derivatives having a purine ring. Part 1: New compounds with promising antibacterial activity against resistant Gram-positive pathogens

(2008) Yoshimi Hirokawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pleuromutilin derivatives having a purine ring. Part 3: Synthesis and antibacterial activity of novel compounds possessing a piperazine ring spacer

(2008) Yoshimi Hirokawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pleuromutilin derivatives having a purine ring. Part 2: Influence of the central spacer on the antibacterial activity against Gram-positive pathogens

(2008) Yoshimi Hirokawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Biosynthesis and Genetic Engineering of Lipopeptide Antibiotics Related to Daptomycin

(2008) Richard Baltz   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Retapamulin

(2008) Lily P H Yang et al.   DRUGS

Water-Soluble Pleuromutilin Derivative with Excellent in Vitro and in Vivo Antibacterial Activity against Gram-Positive Pathogens

(2008) Yoshimi Hirokawa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mapping the Binding Site of Thiopeptide Antibiotics by Proximity-Induced Covalent Capture

(2008) Sascha Baumann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries

(2008) Christopher Cordier et al.   NATURAL PRODUCT REPORTS

Scaffold diversity of natural products: inspiration for combinatorial library design

(2008) Kristina Grabowski et al.   NATURAL PRODUCT REPORTS

Design and synthesis of diketopiperazine and acyclic analogs related to the caprazamycins and liposidomycins as potential antibacterial agents

(2007) Shinpei Hirano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of Caprazamycin Analogues and Their Structure−Activity Relationship for Antibacterial Activity

(2007) Shinpei Hirano et al.   JOURNAL OF ORGANIC CHEMISTRY