Novel agents to inhibit microbial virulence and pathogenicity

Antivirulence drugs to target bacterial secretion systems

(2010) Christian Baron   CURRENT OPINION IN MICROBIOLOGY

Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents

(2010) B. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase 1/2 Double-Blind, Placebo-Controlled, Dose Escalation, Safety, and Pharmacokinetic Study of Pagibaximab (BSYX-A110), an Antistaphylococcal Monoclonal Antibody for the Prevention of Staphylococcal Bloodstream Infections, in Very-Low-Birth-Weight Neonates

(2009) L. E. Weisman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Computer-Aided Identification of Recognized Drugs as Pseudomonas aeruginosa Quorum-Sensing Inhibitors

(2009) L. Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Tethered thiazolidinone dimers as inhibitors of the bacterial type III secretion system

(2009) Toni Kline et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Microbial quorum sensing: a tool or a target for antimicrobial therapy?

(2009) Sheetal Raina et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules

(2009) Paul Williams et al.   CURRENT OPINION IN MICROBIOLOGY

Quorum sensing inhibitors: a patent overview

(2009) Jiachuan Pan et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Has the era of untreatable infections arrived?

(2009) D. M. Livermore   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

N-Hydroxybenzimidazole Inhibitors of the Transcription Factor LcrF inYersinia: Novel Antivirulence Agents

(2009) Oak K. Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quorum sensing and social networking in the microbial world

(2009) S. Atkinson et al.   Journal of the Royal Society Interface

A Quorum-Sensing Antagonist Targets Both Membrane-Bound and Cytoplasmic Receptors and Controls Bacterial Pathogenicity

(2009) Lee R. Swem et al.   MOLECULAR CELL

The two-component system QseEF and the membrane protein QseG link adrenergic and stress sensing to bacterial pathogenesis

(2009) N. C. Reading et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Type III Secretion in Yersinia pestis

(2008) N. J. Pan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Aryl Acid Adenylating Enzymes Involved in Siderophore Biosynthesis: Fluorescence Polarization Assay, Ligand Specificity, and Discovery of Non-nucleoside Inhibitors via High-Throughput Screening†

(2008) João Neres et al.   BIOCHEMISTRY

Towards Gram-negative antivirulence drugs: New inhibitors of HldE kinase

(2008) Nicolas Desroy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pyrogallol and its analogs can antagonize bacterial quorum sensing in Vibrio harveyi

(2008) Nanting Ni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective Killing of Nonreplicating Mycobacteria

(2008) Ruslana Bryk et al.   Cell Host & Microbe

An Inhibitor of Gram-Negative Bacterial Virulence Protein Secretion

(2008) Heather B. Felise et al.   Cell Host & Microbe

Discovery of virulence factors of pathogenic bacteria

(2008) Hsing-Ju Wu et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Antivirulence as a new antibacterial approach for chemotherapy

(2008) Sonia Escaich   CURRENT OPINION IN CHEMICAL BIOLOGY

Control of gene expression by type III secretory activity

(2008) Evan D Brutinel et al.   CURRENT OPINION IN MICROBIOLOGY

What is in the pipeline for Gram-negative pathogens?

(2008) George H Talbot   Expert Review of Anti-Infective Therapy

Staphylococcus aureus--Probing for Host Weakness?

(2008) I. L. B. C. Camargo et al.   JOURNAL OF BACTERIOLOGY

Inhibition of Siderophore Biosynthesis inMycobacterium tuberculosiswith Nucleoside Bisubstrate Analogues: Structure−Activity Relationships of the Nucleobase Domain of 5′-O-[N-(Salicyl)sulfamoyl]adenosine

(2008) João Neres et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cyclic Peptide Inhibitors of Staphylococcal Virulence Prepared by Fmoc-Based Thiolactone Peptide Synthesis

(2008) Elizabeth A. George et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibitors and antagonists of bacterial quorum sensing

(2008) Nanting Ni et al.   MEDICINAL RESEARCH REVIEWS

Teichoic acids and related cell-wall glycopolymers in Gram-positive physiology and host interactions

(2008) Christopher Weidenmaier et al.   NATURE REVIEWS MICROBIOLOGY

Sortase as a Target of Anti-Infective Therapy

(2008) A. W. Maresso et al.   PHARMACOLOGICAL REVIEWS

A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence

(2008) C.-I Liu et al.   SCIENCE

Targeting QseC Signaling and Virulence for Antibiotic Development

(2008) D. A. Rasko et al.   SCIENCE

Synthesis of and evaluation of lipid A modification by 4-substituted 4-deoxy arabinose analogs as potential inhibitors of bacterial polymyxin resistance

(2007) T. Kline et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase A

(2007) Bala Chandra Chenna et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The biology and future prospects of antivirulence therapies

(2007) Lynette Cegelski et al.   NATURE REVIEWS MICROBIOLOGY