Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

PHENIX: a comprehensive Python-based system for macromolecular structure solution

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U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

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Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics inMycobacterium smegmatisby perturbation of the drug binding pocket

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Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome

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Structures of the Ribosome in Intermediate States of Ratcheting

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Macrolide myths

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An Indigenous Posttranscriptional Modification in the Ribosomal Peptidyl Transferase Center Confers Resistance to an Array of Protein Synthesis Inhibitors

(2008) Seok-Ming Toh et al.   JOURNAL OF MOLECULAR BIOLOGY

Mutations Outside the Anisomycin-Binding Site Can Make Ribosomes Drug-Resistant

(2008) Gregor Blaha et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Mechanism of Drug-Dependent Ribosome Stalling

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Mutation from guanine to adenine in 25S rRNA at the position equivalent to E. coli A2058 does not confer erythromycin sensitivity in Sacchromyces cerevisae

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