Are pleuromutilin antibiotics finally fit for human use?

Eight-year (2002-2009) Summary of the Linezolid (Zyvox®Annual Appraisal of potency and Spectrum; ZAAPS) Program in European Countries

(2014) J.E. Ross et al.   JOURNAL OF CHEMOTHERAPY

LEADER Program Results for 2009: an Activity and Spectrum Analysis of Linezolid Using 6,414 Clinical Isolates from 56 Medical Centers in the United States

(2011) David J. Farrell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibiotics in the clinical pipeline in 2011

(2011) Mark S Butler et al.   JOURNAL OF ANTIBIOTICS

Structural Basis for Methyl Transfer by a Radical SAM Enzyme

(2011) A. K. Boal et al.   SCIENCE

Challenges of antibacterial discovery revisited

(2010) Michael N. Gwynn et al.   Annals of the New York Academy of Sciences

Elevated Linezolid Resistance in Clinical cfr-Positive Staphylococcus aureus Isolates Is Associated with Co-Occurring Mutations in Ribosomal Protein L3

(2010) J. B. Locke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multicity Outbreak of Linezolid‐ResistantStaphylococcus epidermidisAssociated with Clonal Spread of acfr‐Containing Strain

(2010) Hector Bonilla et al.   CLINICAL INFECTIOUS DISEASES

Clinical Outbreak of Linezolid-Resistant Staphylococcus aureus in an Intensive Care Unit

(2010) Miguel Sánchez García   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Assessment of linezolid resistance mechanisms among Staphylococcus epidermidis causing bacteraemia in Rome, Italy

(2010) R. E. Mendes et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Updated Functional Classification of  -Lactamases

(2009) K. Bush et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The A–Z of bacterial translation inhibitors

(2009) Daniel N. Wilson   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

U2504 Determines the Species Specificity of the A-Site Cleft Antibiotics:

(2009) Güliz Gürel et al.   JOURNAL OF MOLECULAR BIOLOGY

Emergence of community-acquired meticillin-resistant Staphylococcus aureus strain USA300 as a cause of necrotising community-onset pneumonia

(2009) Alicia I Hidron et al.   LANCET INFECTIOUS DISEASES

Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics inMycobacterium smegmatisby perturbation of the drug binding pocket

(2009) Katherine S. Long et al.   MOLECULAR MICROBIOLOGY

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

(2009) A. M. B. Giessing et al.   RNA

Linezolid and Tiamulin Cross-Resistance in Staphylococcus aureus Mediated by Point Mutations in the Peptidyl Transferase Center

(2008) K. Miller et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Genetic Characterization of Vga ABC Proteins Conferring Reduced Susceptibility to Pleuromutilins in Staphylococcus aureus

(2008) D. R. Gentry et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Update on macrolide-lincosamide-streptogramin, ketolide, and oxazolidinone resistance genes

(2008) Marilyn C. Roberts   FEMS MICROBIOLOGY LETTERS

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

(2008) D. N. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America

(2007) B. Spellberg et al.   CLINICAL INFECTIOUS DISEASES

The pleuromutilin drugs tiamulin and valnemulin bind to the RNA at the peptidyl transferase centre on the ribosome

(2003) Susan M. Poulsen et al.   MOLECULAR MICROBIOLOGY