Antibiotic discovery in the twenty-first century: current trends and future perspectives

Insights into the Mode of Action of the Two-Peptide Lantibiotic Haloduracin

(2009) Trent J. Oman et al.   ACS Chemical Biology

The Lipopeptide Antibiotic Friulimicin B Inhibits Cell Wall Biosynthesis through Complex Formation with Bactoprenol Phosphate

(2009) T. Schneider et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In Vitro Activity of NXL104 in Combination with  -Lactams against Klebsiella pneumoniae Isolates Producing KPC Carbapenemases

(2009) A. Endimiani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and biological evaluation of platensimycin analogs

(2009) Hong C. Shen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Functional and biochemical analysis of a key series of ramoplanin analogues

(2009) Xiao Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Future antibiotics scenarios: is the tide starting to turn?

(2009) Ursula Theuretzbacher   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Activity of the siderophore monobactam BAL30072 against multiresistant non-fermenters

(2009) S. Mushtaq et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

In vitro activity of the  -lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases

(2009) T. Stachyra et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Diazo Transfer−Click Reaction Route to New, Lipophilic Teicoplanin and Ristocetin Aglycon Derivatives with High Antibacterial and Anti-influenza Virus Activity: An Aggregation and Receptor Binding Study

(2009) Gábor Pintér et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure Revision of the Lantibiotic 97518

(2009) Sonia I. Maffioli et al.   JOURNAL OF NATURAL PRODUCTS

Ribosomally Synthesized Thiopeptide Antibiotics Targeting Elongation Factor Tu

(2009) Rowan P. Morris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Generation of Thiocillin Variants by Prepeptide Gene Replacement and in Vivo Processing byBacillus cereus

(2009) Michael G. Acker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organization of the genes encoding the biosynthesis of actagardine and engineering of a variant generation system

(2009) Steven Boakes et al.   MOLECULAR MICROBIOLOGY

Antibiotic-Resistant Bugs in the 21st Century — A Clinical Super-Challenge

(2009) Cesar A. Arias et al.   NEW ENGLAND JOURNAL OF MEDICINE

Production of the Novel Two-Peptide Lantibiotic Lichenicidin by Bacillus licheniformis DSM 13

(2009) Jasmin Dischinger et al.   PLoS One

Synthesis of Platensimycin

(2008) Konrad Tiefenbacher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effects of Exposure of Clostridium difficile PCR Ribotypes 027 and 001 to Fluoroquinolones in a Human Gut Model

(2008) K. Saxton et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Determining the Structure and Mode of Action of Microbisporicin, a Potent Lantibiotic Active Against Multiresistant Pathogens

(2008) Franca Castiglione et al.   CHEMISTRY & BIOLOGY

A Randomized, Double-Blind Trial Comparing Ceftobiprole Medocaril with Vancomycin plus Ceftazidime for the Treatment of Patients with Complicated Skin and Skin-Structure Infections

(2008) G. J. Noel et al.   CLINICAL INFECTIOUS DISEASES

NXL104 combinations versus Enterobacteriaceae with CTX-M extended-spectrum  -lactamases and carbapenemases

(2008) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

New Strategies and Methods in the Discovery of Natural Product Anti-Infective Agents: The Mannopeptimycins

(2008) Frank E. Koehn   JOURNAL OF MEDICINAL CHEMISTRY

Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?

(2008) David J. Newman   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Platensimycin Analogues with Varying Degrees of Molecular Complexity

(2008) K. C. Nicolaou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Robust Platform for the Synthesis of New Tetracycline Antibiotics

(2008) Cuixiang Sun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isolation, Structure, and Antibacterial Activity of Philipimycin, A Thiazolyl Peptide Discovered fromActinoplanes philippinensisMA7347

(2008) Chaowei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural products to drugs: natural product-derived compounds in clinical trials

(2008) Mark S. Butler   NATURAL PRODUCT REPORTS