Wnt signaling in bone, kidney, intestine, and adipose tissue and interorgan interaction in aging

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

(2018) Netusha Thevaranjan et al.   Cell Host & Microbe

Renal Tubule Repair: Is Wnt/β-Catenin a Friend or Foe?

(2018) Leslie Gewin   Genes

Specific Deletion of β-Catenin in Col2-Expressing Cells Leads to Defects in Epiphyseal Bone

(2017) Tingyu Wang et al.   International Journal of Biological Sciences

The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis

(2017) Heather Fairfield et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The emerging role of bone marrow adipose tissue in bone health and dysfunction

(2017) Thomas H. Ambrosi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

(2017) Arianna Fumagalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes

(2017) Soohyun P. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

(2017) Kodandaramireddy Nalapareddy et al.   Cell Reports

The Research Progress on Intestinal Stem Cells and Its Relationship with Intestinal Microbiota

(2017) Qihang Hou et al.   Frontiers in Immunology

Osteomicrobiology: The influence of gut microbiota on bone in health and disease

(2017) Rheinallt M. Jones et al.   BONE

Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics

(2016) Jau-Yi Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche

(2016) Henner F. Farin et al.   NATURE

Erratum: The genetics of bone mass and susceptibility to bone diseases

(2016) David Karasik et al.   Nature Reviews Rheumatology

Cortical-Bone Fragility — Insights from sFRP4 Deficiency in Pyle’s Disease

(2016) Pelin O. Simsek Kiper et al.   NEW ENGLAND JOURNAL OF MEDICINE

Romosozumab Treatment in Postmenopausal Women with Osteoporosis

(2016) Felicia Cosman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction

(2016) Corinna Wehmeyer et al.   Science Translational Medicine

Osteoporosis: The Result of an ‘Aged’ Bone Microenvironment

(2016) Bo Yu et al.   TRENDS IN MOLECULAR MEDICINE

Bone Marrow Adipose Tissue: To Be or Not To Be a Typical Adipose Tissue?

(2016) Pierre Hardouin et al.   Frontiers in Endocrinology

LRP5 Regulates Human Body Fat Distribution by Modulating Adipose Progenitor Biology in a Dose- and Depot-Specific Fashion

(2015) Nellie Y. Loh et al.   Cell Metabolism

Ascl2 Acts as an R-spondin/Wnt-Responsive Switch to Control Stemness in Intestinal Crypts

(2015) Jurian Schuijers et al.   Cell Stem Cell

A Role for MYC in Lithium-Stimulated Repair of the Colonic Epithelium After DSS-Induced Damage in Mice

(2015) Wesley M. Raup-Konsavage et al.   DIGESTIVE DISEASES AND SCIENCES

Loss of Bone and Wnt10b Expression in Male Type 1 Diabetic Mice Is Blocked by the ProbioticLactobacillus reuteri

(2015) Jing Zhang et al.   ENDOCRINOLOGY

Endocrine role of bone: recent and emerging perspectives beyond osteocalcin

(2015) K. J. Oldknow et al.   JOURNAL OF ENDOCRINOLOGY

Aberrant Wnt signaling pathway in medial temporal lobe structures of Alzheimer’s disease

(2015) Jesper Riise et al.   JOURNAL OF NEURAL TRANSMISSION

Role of inflammation in the aging bones

(2015) Samir M. Abdelmagid et al.   LIFE SCIENCES

Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease

(2015) Lili Zhou et al.   Nature Reviews Nephrology

Stromally Expressed β-Catenin Modulates Wnt9b Signaling in the Ureteric Epithelium

(2015) Felix J. Boivin et al.   PLoS One

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

(2015) Xiaolin Tu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of Age and Estrogen on Skeletal Gene Expression in Humans as Assessed by RNA Sequencing

(2015) Joshua N. Farr et al.   PLoS One

Gut Commensal Bacteria and Regional Wnt Gene Expression in the Proximal Versus Distal Colon

(2014) Philipp-Alexander Neumann et al.   AMERICAN JOURNAL OF PATHOLOGY

Intestinal permeability – a new target for disease prevention and therapy

(2014) Stephan C Bischoff et al.   BMC GASTROENTEROLOGY

ProbioticL. reuteriTreatment Prevents Bone Loss in a Menopausal Ovariectomized Mouse Model

(2014) Robert A. Britton et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Kidney Is the Principal Organ Mediating Klotho Effects

(2014) K. Lindberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lrp5 regulation of bone mass and serotonin synthesis in the gut

(2014) Aruna Kode et al.   NATURE MEDICINE

Reply to Lrp5 regulation of bone mass and gut serotonin synthesis

(2014) Yajun Cui et al.   NATURE MEDICINE

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

(2014) Sofia Movérare-Skrtic et al.   NATURE MEDICINE

Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB

(2014) Bo Yu et al.   NATURE MEDICINE

Chronic kidney disease and premature ageing

(2014) Jeroen P. Kooman et al.   Nature Reviews Nephrology

Coordination of kidney organogenesis by Wnt signaling

(2014) Kimmo Halt et al.   PEDIATRIC NEPHROLOGY

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

(2014) H. Clevers et al.   SCIENCE

In Vivo Clonal Analysis Reveals Lineage-Restricted Progenitor Characteristics in Mammalian Kidney Development, Maintenance, and Regeneration

(2014) Yuval Rinkevich et al.   Cell Reports

Mechanisms linking dietary fiber, gut microbiota and colon cancer prevention

(2014) Huawei Zeng   World Journal of Gastrointestinal Oncology

Fibroblast Growth Factor 23 and Klotho: Physiology and Pathophysiology of an Endocrine Network of Mineral Metabolism

(2013) Ming Chang Hu et al.   Annual Review of Physiology

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The Intestinal Crypt, A Prototype Stem Cell Compartment

(2013) Hans Clevers   CELL

Deletion of a Single β-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading

(2013) Behzad Javaheri et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/ -Catenin Signaling

(2013) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Age-Associated Remodeling of the Intestinal Epithelial Barrier

(2013) L. Tran et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

(2013) Nick Barker   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The regulation and deregulation of Wnt signaling by PARK genes in health and disease

(2013) D. C. Berwick et al.   Journal of Molecular Cell Biology

Chondrocyte β-Catenin Signaling Regulates Postnatal Bone Remodeling Through Modulation of Osteoclast Formation in a Murine Model

(2013) Baoli Wang et al.   Arthritis & Rheumatology

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

(2012) Atsuhiko T. Naito et al.   CELL

Wnt Signaling Activation in Adipose Progenitors Promotes Insulin-Independent Muscle Glucose Uptake

(2012) Daniel Zeve et al.   Cell Metabolism

Six2 and Wnt Regulate Self-Renewal and Commitment of Nephron Progenitors through Shared Gene Regulatory Networks

(2012) Joo-Seop Park et al.   DEVELOPMENTAL CELL

Cross-talk between Insulin and Wnt Signaling in Preadipocytes

(2012) Jane Palsgaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High serum sclerostin predicts the occurrence of osteoporotic fractures in postmenopausal women: The center of excellence for osteoporosis research study

(2012) Mohammed-Salleh M Ardawi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin Levels Associated with Inhibition of the Wnt/β-Catenin Signaling and Reduced Bone Turnover in Type 2 Diabetes Mellitus

(2012) Agostino Gaudio et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Serum Sclerostin and Risk of Hip Fracture in Older Caucasian Women

(2012) Aarthi Arasu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Circulating Sclerostin Levels and Bone Turnover in Type 1 and Type 2 Diabetes

(2012) Luigi Gennari et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

(2012) Karol Estrada et al.   NATURE GENETICS

The skeleton as an endocrine organ

(2012) Douglas J. DiGirolamo et al.   Nature Reviews Rheumatology

Regulation and Function of the FGF23/Klotho Endocrine Pathways

(2012) Aline Martin et al.   PHYSIOLOGICAL REVIEWS

Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila

(2012) M. Rera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secreted and Transmembrane Wnt Inhibitors and Activators

(2012) C.-M. Cruciat et al.   Cold Spring Harbor Perspectives in Biology

Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development

(2011) Courtney M. Karner et al.   DEVELOPMENT

Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo

(2011) Kyu Sang Joeng et al.   DEVELOPMENTAL BIOLOGY

Circulating Levels of Sclerostin Are Increased in Patients with Type 2 Diabetes Mellitus

(2011) Antonia García-Martín et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection

(2011) Dallas Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone: from a reservoir of minerals to a regulator of energy metabolism

(2011) Cyrille B. Confavreux   KIDNEY INTERNATIONAL

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Lrp5 functions in bone to regulate bone mass

(2011) Yajun Cui et al.   NATURE MEDICINE

Building strong bones: molecular regulation of the osteoblast lineage

(2011) Fanxin Long   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Notch-1 Signaling Regulates Intestinal Epithelial Barrier Function, Through Interaction With CD4+ T Cells, in Mice and Humans

(2010) Stephanie Dahan et al.   GASTROENTEROLOGY

Leptin stimulates fibroblast growth factor 23 expression in bone and suppresses renal 1α,25-dihydroxyvitamin D3 synthesis in leptin-deficient ob/ob Mice

(2010) Kiyomi Tsuji et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Serum Sclerostin Levels Negatively Correlate with Parathyroid Hormone Levels and Free Estrogen Index in Postmenopausal Women

(2010) Faryal S. Mirza et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Osteocyte Wnt/ -Catenin Signaling Is Required for Normal Bone Homeostasis

(2010) I. Kramer et al.   MOLECULAR AND CELLULAR BIOLOGY

APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex

(2010) Yutaka Shimomura et al.   NATURE

Effect of Probiotics on Intestinal Barrier Function

(2009) Rudolf Mennigen et al.   Annals of the New York Academy of Sciences

Klotho and aging

(2009) Makoto Kuro-o   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

High-Density Association Study of 383 Candidate Genes for Volumetric BMD at the Femoral Neck and Lumbar Spine Among Older Men

(2009) Laura M Yerges et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling

(2009) Chuwen Lin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Axin2 controls bone remodeling through the  -catenin-BMP signaling pathway in adult mice

(2009) Y. Yan et al.   JOURNAL OF CELL SCIENCE

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

(2009) Fernando Rivadeneira et al.   NATURE GENETICS

The FGF23–Klotho axis: endocrine regulation of phosphate homeostasis

(2009) M. Shawkat Razzaque   Nature Reviews Endocrinology

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

The Binding Between Sclerostin and LRP5 is Altered by DKK1 and by High-Bone Mass LRP5 Mutations

(2008) Wendy Balemans et al.   CALCIFIED TISSUE INTERNATIONAL

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

(2008) Vijay K. Yadav et al.   CELL

A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney

(2008) J. Yu et al.   DEVELOPMENT

Canonical WNT/β-catenin signaling is required for ureteric branching

(2008) Darren Bridgewater et al.   DEVELOPMENTAL BIOLOGY

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Multiple Genetic Loci for Bone Mineral Density and Fractures

(2008) Unnur Styrkarsdottir et al.   NEW ENGLAND JOURNAL OF MEDICINE