Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction
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Title
Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction
Authors
Keywords
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Journal
Science Translational Medicine
Volume 8, Issue 330, Pages 330ra35-330ra35
Publisher
American Association for the Advancement of Science (AAAS)
Online
2016-03-17
DOI
10.1126/scitranslmed.aac4351
References
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Note: Only part of the references are listed.- A Randomized, Double-Blind Phase 2 Clinical Trial of Blosozumab, a Sclerostin Antibody, in Postmenopausal Women with Low Bone Mineral Density
- (2015) Robert R. Recker et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways
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- Effect of sclerostin antibody treatment in a mouse model of severe osteogenesis imperfecta
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- Progressive Increases in Bone Mass and Bone Strength in an Ovariectomized Rat Model of Osteoporosis After 26 Weeks of Treatment With a Sclerostin Antibody
- (2014) Xiaodong Li et al. ENDOCRINOLOGY
- TNF-α Upregulates Sclerostin Expression in Obese Mice Fed a High-Fat Diet
- (2014) Kyunghwa Baek et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Romosozumab in Postmenopausal Women with Low Bone Mineral Density
- (2014) Michael R. McClung et al. NEW ENGLAND JOURNAL OF MEDICINE
- Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis
- (2013) Xiao-Xiang Chen et al. ANNALS OF THE RHEUMATIC DISEASES
- Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling
- (2013) Maarten van Dinther et al. PLoS One
- LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1
- (2013) Shuyu Ren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effect of sclerostin-neutralising antibody on periarticular and systemic bone in a murine model of rheumatoid arthritis: a microCT study
- (2013) Massimo Marenzana et al. ARTHRITIS RESEARCH & THERAPY
- Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury
- (2012) Martine Roudier et al. ARTHRITIS AND RHEUMATISM
- TNF-α mediates the stimulation of sclerostin expression in an estrogen-deficient condition
- (2012) Beom-Jun Kim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis
- (2011) B.Y. Chan et al. OSTEOARTHRITIS AND CARTILAGE
- Regulatory T cells control the transition from acute into chronic inflammation in glucose-6-phosphate isomerase-induced arthritis
- (2010) O. Frey et al. ANNALS OF THE RHEUMATIC DISEASES
- Mitogen-Activated Protein Kinases Promote WNT/ -Catenin Signaling via Phosphorylation of LRP6
- (2010) I. Cervenka et al. MOLECULAR AND CELLULAR BIOLOGY
- Pro-Inflammatory Cytokines TNF-Related Weak Inducer of Apoptosis (TWEAK) and TNFα Induce the Mitogen-Activated Protein Kinase (MAPK)-Dependent Expression of Sclerostin in Human Osteoblasts*
- (2009) Cristina Vincent et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Parathyroid hormone (PTH)–induced bone gain is blunted in SOST overexpressing and deficient mice
- (2009) Ina Kramer et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength
- (2008) Xiaodong Li et al. JOURNAL OF BONE AND MINERAL RESEARCH
- Therapeutic effects of antibodies to tumor necrosis factor-α, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis
- (2008) Isao Matsumoto et al. ARTHRITIS RESEARCH & THERAPY
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