The regulation and deregulation of Wnt signaling by PARK genes in health and disease

The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease

(2016) Antonio Currais et al.   Aging-US

TheVPS35gene and Parkinson's disease

(2013) Hao Deng et al.   MOVEMENT DISORDERS

Physiological Role of β-Catenin/TCF Signaling in Neurons of the Adult Brain

(2013) Marta B. Wisniewska   NEUROCHEMICAL RESEARCH

Wnt your brain be inflamed? Yes, it Wnt!

(2013) Bianca Marchetti et al.   TRENDS IN MOLECULAR MEDICINE

The importance of Wnt signalling for neurodegeneration in Parkinson's disease

(2012) Daniel C. Berwick et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity

(2012) Marija Usenovic et al.   HUMAN MOLECULAR GENETICS

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

(2012) Daniel C. Berwick et al.   HUMAN MOLECULAR GENETICS

The retromer complex - endosomal protein recycling and beyond

(2012) M. N. J. Seaman   JOURNAL OF CELL SCIENCE

Wnt Signaling: Role in Alzheimer Disease and Schizophrenia

(2012) Nibaldo C. Inestrosa et al.   Journal of Neuroimmune Pharmacology

Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/ -Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair

(2012) F. L'Episcopo et al.   JOURNAL OF NEUROSCIENCE

The Secreted Wnt Antagonist Dickkopf-1 Is Required for Amyloid  -Mediated Synaptic Loss

(2012) S. A. Purro et al.   JOURNAL OF NEUROSCIENCE

Inhibition of the canonical Wnt pathway by Dickkopf-1 contributes to the neurodegeneration in 6-OHDA-lesioned rats

(2012) Yaoyan Dun et al.   NEUROSCIENCE LETTERS

LRRK2 I2020T mutation is associated with tau pathology

(2012) Sachiko Ujiie et al.   PARKINSONISM & RELATED DISORDERS

LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth

(2012) Fumitaka Kawakami et al.   PLoS One

Concordant Signaling Pathways Produced by Pesticide Exposure in Mice Correspond to Pathways Identified in Human Parkinson's Disease

(2012) Seema Gollamudi et al.   PLoS One

LRRK2 and Human Disease: A Complicated Question or a Question of Complexes?

(2012) P. A. Lewis et al.   Science Signaling

Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

(2012) Z. Sheng et al.   Science Translational Medicine

SFRP1 and SFRP2 Dose-Dependently Regulate Midbrain Dopamine Neuron Development In Vivo and in Embryonic Stem Cells

(2012) Julianna Kele et al.   STEM CELLS

A review of the evidence for the canonical Wnt pathway in autism spectrum disorders

(2012) Hans Kalkman   Molecular Autism

A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

(2011) Alexander Zimprich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

VPS35 Mutations in Parkinson Disease

(2011) Carles Vilariño-Güell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-Wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population

(2011) Xinmin Liu et al.   BMC Medical Genetics

LRRK2 Parkinson disease mutations enhance its microtubule association

(2011) Lauren R. Kett et al.   HUMAN MOLECULAR GENETICS

VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology

(2011) Lei Wen et al.   JOURNAL OF CELL BIOLOGY

A Novel Role of the WNT-Dishevelled-GSK3  Signaling Cascade in the Mouse Nucleus Accumbens in a Social Defeat Model of Depression

(2011) M. B. Wilkinson et al.   JOURNAL OF NEUROSCIENCE

A Wnt1 regulated Frizzled-1/β-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection

(2011) Francesca L'Episcopo et al.   Molecular Neurodegeneration

Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles

(2011) Radek Dobrowolski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

En1 and Wnt signaling in midbrain dopaminergic neuronal development

(2011) Maria TM Alves dos Santos et al.   Neural Development

Multiple Recurrent De Novo CNVs, Including Duplications of the 7q11.23 Williams Syndrome Region, Are Strongly Associated with Autism

(2011) Stephan J. Sanders et al.   NEURON

The dynamic role of beta-catenin in synaptic plasticity

(2011) Kimberly A. Maguschak et al.   NEUROPHARMACOLOGY

Dkk1 Regulates Ventral Midbrain Dopaminergic Differentiation and Morphogenesis

(2011) Diogo Ribeiro et al.   PLoS One

LRRK2 signaling pathways: the key to unlocking neurodegeneration?

(2011) Daniel C. Berwick et al.   TRENDS IN CELL BIOLOGY

GSK-3: Functional Insights from Cell Biology and Animal Models

(2011) Oksana Kaidanovich-Beilin et al.   Frontiers in Molecular Neuroscience

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

(2010) Nicolas Dzamko et al.   BIOCHEMICAL JOURNAL

Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, α-synuclein, and tau

(2010) Jean-Marc Taymans et al.   BIOESSAYS

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

SNCA,MAPT, andGSK3Bin Parkinson disease: a gene-gene interaction study

(2010) C. Wider et al.   EUROPEAN JOURNAL OF NEUROLOGY

The Wnt /β-catenin signaling pathway in the adult neurogenesis

(2010) Lin Zhang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Generation of mice with a conditional null allele for Wntless

(2010) April C. Carpenter et al.   GENESIS

The neuron-specific isoform of glycogen synthase kinase-3β is required for axon growth

(2010) Zafira Castaño et al.   JOURNAL OF NEUROCHEMISTRY

LEF1/ -Catenin Complex Regulates Transcription of the Cav3.1 Calcium Channel Gene (Cacna1g) in Thalamic Neurons of the Adult Brain

(2010) M. B. Wisniewska et al.   JOURNAL OF NEUROSCIENCE

LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3 

(2010) C.-H. Lin et al.   JOURNAL OF NEUROSCIENCE

Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles

(2010) Emma L Clayton et al.   NATURE NEUROSCIENCE

GSK3 signalling in neural development

(2010) Eun-Mi Hur et al.   NATURE REVIEWS NEUROSCIENCE

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

(2010) H.L. Melrose et al.   NEUROBIOLOGY OF DISEASE

Reactive astrocytes and Wnt/β-catenin signaling link nigrostriatal injury to repair in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

(2010) F. L'Episcopo et al.   NEUROBIOLOGY OF DISEASE

Regulation of GABAergic synapse formation and plasticity by GSK3 -dependent phosphorylation of gephyrin

(2010) S. K. Tyagarajan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genetics of Crohn's Disease

(2009) Johan Van Limbergen et al.   Annual Review of Genomics and Human Genetics

Parkin protects dopaminergic neurons from excessive Wnt/β-catenin signaling

(2009) Nina Rawal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

Molecular pathogenesis of Parkinson disease: insights from genetic studies

(2009) Thomas Gasser   EXPERT REVIEWS IN MOLECULAR MEDICINE

LRRK2 in Parkinson’s disease: genetic and clinical studies from patients

(2009) Udhaya Kumari et al.   FEBS Journal

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

(2009) Rosa M. Sancho et al.   HUMAN MOLECULAR GENETICS

Association between autism and variants in the wingless-type MMTV integration site family member 2 ( WNT2) gene

(2009) Tetsuya Marui et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?

(2009) Frank Gillardon   JOURNAL OF NEUROCHEMISTRY

The leucine rich repeat kinase 2 (LRRK2) G2019S substitution mutation

(2009) Sharon Hassin-Baer et al.   JOURNAL OF NEUROLOGY

Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons

(2009) B. Kadkhodaei et al.   JOURNAL OF NEUROSCIENCE

Xenopus Wntless and the Retromer Complex Cooperate To Regulate XWnt4 Secretion

(2009) H. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

An alternatively spliced form of glycogen synthase kinase-3β is targeted to growing neurites and growth cones

(2009) Alison Wood-Kaczmar et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

(2009) Yanping Li et al.   NATURE NEUROSCIENCE

Emerging roles of Wnts in the adult nervous system

(2009) Nibaldo C. Inestrosa et al.   NATURE REVIEWS NEUROSCIENCE

GSK3β polymorphisms, MAPT H1 haplotype and Parkinson's disease in a Greek cohort

(2009) Kallirhoe Kalinderi et al.   NEUROBIOLOGY OF AGING

Wnt signaling in development and disease

(2009) Jennifer L. Freese et al.   NEUROBIOLOGY OF DISEASE

Whole-genome conditional two-locus analysis identifies novel candidate genes for late-onset Parkinson’s disease

(2009) A. González-Pérez et al.   NEUROGENETICS

Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro

(2009) F. Gillardon   NEUROSCIENCE

Characterisation of a novel NR4A2 mutation in Parkinson's disease brain

(2009) P.M.A. Sleiman et al.   NEUROSCIENCE LETTERS

Genomewide Association Study of Leprosy

(2009) Fu-Ren Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glycogen synthase kinase-3β and tau genes interact in Alzheimer's disease

(2008) John B. J. Kwok et al.   ANNALS OF NEUROLOGY

The Roco protein family: a functional perspective

(2008) Ignacio Marín et al.   FASEB JOURNAL

The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

(2008) Payal N. Gandhi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

(2008) Nibaldo C Inestrosa et al.   Molecular Neurodegeneration

Wingless secretion promotes and requires retromer-dependent cycling of Wntless

(2008) Fillip Port et al.   NATURE CELL BIOLOGY

Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex

(2008) Xavier Franch-Marro et al.   NATURE CELL BIOLOGY

Nurr1 transcriptionally regulates the expression of ??-synuclein

(2008) Yan Xiang Yang et al.   NEUROREPORT

From 1997 to 2007: A decade journey through the H1 haplotype on 17q21 chromosome

(2008) Kallirhoe Kalinderi et al.   PARKINSONISM & RELATED DISORDERS

Genetic factors influencing age at onset in LRRK2-linked Parkinson disease

(2008) Yulia Golub et al.   PARKINSONISM & RELATED DISORDERS

The Wnt signaling pathway: Aging gracefully as a protectionist?

(2008) Kenneth Maiese et al.   PHARMACOLOGY & THERAPEUTICS

The Retromer Complex Influences Wnt Secretion by Recycling Wntless from Endosomes to the Trans-Golgi Network

(2007) Tatyana Y. Belenkaya et al.   DEVELOPMENTAL CELL