Building strong bones: molecular regulation of the osteoblast lineage

Distinct effects of loss of classical estrogen receptor signaling versus complete deletion of estrogen receptor alpha on bone

(2011) Farhan A. Syed et al.   BONE

Endocrine Regulation of Male Fertility by the Skeleton

(2011) Franck Oury et al.   CELL

Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo

(2011) Kyu Sang Joeng et al.   DEVELOPMENTAL BIOLOGY

Circulating osteogenic cells: Implications for injury, repair, and regeneration

(2011) Robert J Pignolo et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Efficacy of serotonin inhibition in mouse models of bone loss

(2011) Hiroyuki Inose et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Skeletal phenotype of the leptin receptor-deficient db/db mouse

(2011) Garry A Williams et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in patients with high-bone-mass phenotype due to a mutation in Lrp5

(2011) Morten Frost et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Control of bone formation by the serpentine receptor Frizzled-9

(2011) Joachim Albers et al.   JOURNAL OF CELL BIOLOGY

Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses

(2011) William F Powell et al.   JOURNAL OF ENDOCRINOLOGY

Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis

(2011) Bertrand Isidor et al.   NATURE GENETICS

Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

(2011) Michael A Simpson et al.   NATURE GENETICS

Lrp5 functions in bone to regulate bone mass

(2011) Yajun Cui et al.   NATURE MEDICINE

The elusive nature and function of mesenchymal stem cells

(2011) César Nombela-Arrieta et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetic Analysis of Lrp5 Function in Osteoblast Progenitors

(2010) Vijay K. Yadav et al.   CALCIFIED TISSUE INTERNATIONAL

Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition

(2010) Keertik Fulzele et al.   CELL

Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism

(2010) Mathieu Ferron et al.   CELL

FoxO-Mediated Defense against Oxidative Stress in Osteoblasts Is Indispensable for Skeletal Homeostasis in Mice

(2010) Elena Ambrogini et al.   Cell Metabolism

FoxO1 Is a Positive Regulator of Bone Formation by Favoring Protein Synthesis and Resistance to Oxidative Stress in Osteoblasts

(2010) Marie-Therese Rached et al.   Cell Metabolism

Suppression of Wnt Signaling by Dkk1 Attenuates PTH-Mediated Stromal Cell Response and New Bone Formation

(2010) Jun Guo et al.   Cell Metabolism

Inhibition of Sca-1-Positive Skeletal Stem Cell Recruitment by Alendronate Blunts the Anabolic Effects of Parathyroid Hormone on Bone Remodeling

(2010) Xiangwei Wu et al.   Cell Stem Cell

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

(2010) Christa Maes et al.   DEVELOPMENTAL CELL

Distinct Modes of Inhibition by Sclerostin on Bone Morphogenetic Protein and Wnt Signaling Pathways

(2010) Carola Krause et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent

(2010) Jianning Tao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity

(2010) Eric Hesse et al.   JOURNAL OF CELL BIOLOGY

Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation

(2010) Keizo Nishikawa et al.   JOURNAL OF CLINICAL INVESTIGATION

Rb regulates fate choice and lineage commitment in vivo

(2010) Eliezer Calo et al.   NATURE

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Pharmacological inhibition of gut-derived serotonin synthesis is a potential bone anabolic treatment for osteoporosis

(2010) Vijay K Yadav et al.   NATURE MEDICINE

Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice

(2010) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone

(2009) Rishard Salie et al.   BONE

A Serotonin-Dependent Mechanism Explains the Leptin Regulation of Bone Mass, Appetite, and Energy Expenditure

(2009) Vijay K. Yadav et al.   CELL

Hand2 controls osteoblast differentiation in the branchial arch by inhibiting DNA binding of Runx2

(2009) N. Funato et al.   DEVELOPMENT

Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription

(2009) W. Wang et al.   DEVELOPMENT

The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularization

(2009) K. S. Joeng et al.   DEVELOPMENT

Notch signaling contributes to the pathogenesis of human osteosarcomas

(2009) F. Engin et al.   HUMAN MOLECULAR GENETICS

Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts

(2009) Nobuhiro Kamiya et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

(2009) Satoru Morikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

The FGF23–Klotho axis: endocrine regulation of phosphate homeostasis

(2009) M. Shawkat Razzaque   Nature Reviews Endocrinology

Transient Inhibition of the Hedgehog Pathway in Young Mice Causes Permanent Defects in Bone Structure

(2008) Hiromichi Kimura et al.   CANCER CELL

Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling

(2008) Ximei Wu et al.   CELL

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

(2008) Vijay K. Yadav et al.   CELL

Mesenchymal Stem Cells: Revisiting History, Concepts, and Assays

(2008) Paolo Bianco et al.   Cell Stem Cell

BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway

(2008) N. Kamiya et al.   DEVELOPMENT

Patched1 Haploinsufficiency Increases Adult Bone Mass and Modulates Gli3 Repressor Activity

(2008) Shinsuke Ohba et al.   DEVELOPMENTAL CELL

Hedgehog Signaling in Mature Osteoblasts Regulates Bone Formation and Resorption by Controlling PTHrP and RANKL Expression

(2008) Kinglun Kingston Mak et al.   DEVELOPMENTAL CELL

Growth Hormone, Insulin-Like Growth Factors, and the Skeleton

(2008) Andrea Giustina et al.   ENDOCRINE REVIEWS

Notch Inhibits Osteoblast Differentiation and Causes Osteopenia

(2008) Stefano Zanotti et al.   ENDOCRINOLOGY

Disruption of BMP Signaling in Osteoblasts Through Type IA Receptor (BMPRIA) Increases Bone Mass*

(2008) Nobuhiro Kamiya et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Dimorphic effects of Notch signaling in bone homeostasis

(2008) Feyza Engin et al.   NATURE MEDICINE

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

(2008) Matthew J Hilton et al.   NATURE MEDICINE

Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo

(2008) Y. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA