Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease

Glucose Specifically Regulates TRPC6 Expression in the Podocyte in an AngII-Dependent Manner

(2014) Ramon Sonneveld et al.   AMERICAN JOURNAL OF PATHOLOGY

AKT/GSK-3β regulates stability and transcription of snail which is crucial for bFGF-induced epithelial–mesenchymal transition of prostate cancer cells

(2014) Zong-cai Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Autophagy inhibition induces podocyte apoptosis by activating the pro-apoptotic pathway of endoplasmic reticulum stress

(2014) Li Fang et al.   EXPERIMENTAL CELL RESEARCH

Molecular mechanisms of diabetic kidney disease

(2014) Kimberly Reidy et al.   JOURNAL OF CLINICAL INVESTIGATION

Klotho suppresses renal tubulo-interstitial fibrosis by controlling basic fibroblast growth factor-2 signalling

(2014) Xu Guan et al.   JOURNAL OF PATHOLOGY

Antagonism of Canonical Wnt/ -Catenin Signaling: Taking RAS Blockade to the Next Level?

(2014) J. Floege   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mutual Antagonism of Wilms' Tumor 1 and  -Catenin Dictates Podocyte Health and Disease

(2014) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Shiga Toxin Promotes Podocyte Injury in Experimental Hemolytic Uremic Syndrome via Activation of the Alternative Pathway of Complement

(2014) M. Locatelli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Novel Missense Mutation of Wilms' Tumor 1 Causes Autosomal Dominant FSGS

(2014) G. Hall et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Potential Role for Mechanical Forces in the Detachment of Podocytes and the Progression of CKD

(2014) W. Kriz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Kidney Is the Principal Organ Mediating Klotho Effects

(2014) K. Lindberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Multiple Genes of the Renin-Angiotensin System Are Novel Targets of Wnt/ -Catenin Signaling

(2014) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Special deLIVERy: podocyte injury promotes renal angiotensin II generation from liver-derived angiotensinogen

(2014) David I. Ortiz-Melo et al.   KIDNEY INTERNATIONAL

The PI3K/p-Akt signaling pathway participates in calcitriol ameliorating podocyte injury in DN rats

(2014) Zhixia Song et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The novel role of TRPC6 in vitamin D ameliorating podocyte injury in STZ-induced diabetic rats

(2014) Xiaoliang Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Can we safely target the WNT pathway?

(2014) Michael Kahn   NATURE REVIEWS DRUG DISCOVERY

High Glucose Induces Podocyte Injury via Enhanced (Pro)renin Receptor-Wnt-β-Catenin-Snail Signaling Pathway

(2014) Caixia Li et al.   PLoS One

TGF- -induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops

(2014) J. Zhang et al.   Science Signaling

Wnt/β-catenin signaling and kidney fibrosis

(2014) Roderick J. Tan et al.   Kidney International Supplements

Circulating α-Klotho Levels in CKD and Relationship to Progression

(2013) Hyoung Rae Kim et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Vitamin D Down-Regulates TRPC6 Expression in Podocyte Injury and Proteinuric Glomerular Disease

(2013) Ramon Sonneveld et al.   AMERICAN JOURNAL OF PATHOLOGY

New Insights into the Pathology of Podocyte Loss

(2013) Helen Liapis et al.   AMERICAN JOURNAL OF PATHOLOGY

Wnt/β-catenin signalling pathway mediates high glucose induced cell injury through activation of TRPC6 in podocytes

(2013) Z. Li et al.   CELL PROLIFERATION

Mesangial Medium from IgA Nephropathy Patients Induces Podocyte Epithelial-to-mesenchymal Transition through Activation of the Phosphatidyl Inositol-3-kinase/Akt Signaling Pathway

(2013) Cheng Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Effect of Renin-Angiotensin System Blockade on Soluble Klotho in Patients with Type 2 Diabetes, Systolic Hypertension, and Albuminuria

(2013) J. Karalliedde et al.   Clinical Journal of the American Society of Nephrology

Generation of the podocyte and tubular components of an amniote kidney: timing of specification and a role for Wnt signaling

(2013) M. Grinstein et al.   DEVELOPMENT

High glucose induces autophagy in podocytes

(2013) Tean Ma et al.   EXPERIMENTAL CELL RESEARCH

Calmodulin-dependent Protein Kinase II/cAMP Response Element-binding Protein/Wnt/β-Catenin Signaling Cascade Regulates Angiotensin II-induced Podocyte Injury and Albuminuria

(2013) Lei Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gain-of-function Mutations in Transient Receptor Potential C6 (TRPC6) Activate Extracellular Signal-regulated Kinases 1/2 (ERK1/2)

(2013) David Chiluiza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arrestin(g) Podocyte Injury with Endothelin Antagonism

(2013) R. J. Tan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Estimating Podocyte Number and Density Using a Single Histologic Section

(2013) M. Venkatareddy et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

 -Arrestin-1 Drives Endothelin-1-Mediated Podocyte Activation and Sustains Renal Injury

(2013) S. Buelli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt4/ -Catenin Signaling in Medullary Kidney Myofibroblasts

(2013) D. P. DiRocco et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/ -Catenin Signaling

(2013) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of Heterochromatin Transcription by Snail1/LOXL2 during Epithelial-to-Mesenchymal Transition

(2013) Alba Millanes-Romero et al.   MOLECULAR CELL

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

(2013) Kun Zhang et al.   NATURE CELL BIOLOGY

Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1

(2013) Christoph A Gebeshuber et al.   NATURE MEDICINE

The role of the podocyte in albumin filtration

(2013) Paul Thomas Brinkkoetter et al.   Nature Reviews Nephrology

The podocyte slit diaphragm—from a thin grey line to a complex signalling hub

(2013) Florian Grahammer et al.   Nature Reviews Nephrology

LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1

(2013) Shuyu Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy: Emerging Therapeutic Target for Diabetic Nephropathy

(2013) Shinji Kume et al.   SEMINARS IN NEPHROLOGY

Autophagy in Glomerular Health and Disease

(2013) Björn Hartleben et al.   SEMINARS IN NEPHROLOGY

Podocyte Biology and Pathogenesis of Kidney Disease

(2012) Jochen Reiser et al.   Annual Review of Medicine

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Podocyte Mitosis - A Catastrophe

(2012) L. Lasagni et al.   CURRENT MOLECULAR MEDICINE

TGFβ1-dependent podocyte dysfunction

(2012) Michal Herman-Edelstein et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Recent advances involving the renin–angiotensin system

(2012) Steven D. Crowley et al.   EXPERIMENTAL CELL RESEARCH

The way Wnt works: Components and mechanism

(2012) Kenyi Saito-Diaz et al.   GROWTH FACTORS

Rac1/PAK1 signaling promotes epithelial-mesenchymal transition of podocytes in vitro via triggering β-catenin transcriptional activity under high glucose conditions

(2012) Zhimei Lv et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Podocyte Wnt/ß-catenin pathway is activated by integrin-linked kinase in clinical and experimental focal segmental glomerulosclerosis

(2012) Marcelo A. Naves et al.   JOURNAL OF NEPHROLOGY

Wnt signalling in kidney diseases: dual roles in renal injury and repair

(2012) Takahisa Kawakami et al.   JOURNAL OF PATHOLOGY

Renin^|^ndash;Angiotensin System, Hypertension, and Chronic Kidney Disease: Pharmacogenetic Implications

(2012) Paulo Caleb Junior Lima Santos et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Mechanisms and Treatment of CKD

(2012) P. Ruggenenti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tubular cell dedifferentiation and peritubular inflammation are coupled by the transcription regulator Id1 in renal fibrogenesis

(2012) Yingjian Li et al.   KIDNEY INTERNATIONAL

Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice

(2012) Dong Zhou et al.   KIDNEY INTERNATIONAL

Improving the efficacy of RAAS blockade in patients with chronic kidney disease

(2012) Hiddo J. Lambers Heerspink et al.   Nature Reviews Nephrology

A Novel Mouse Model of Podocyte Depletion

(2012) L. Wang et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Molecular understanding of the slit diaphragm

(2012) Florian Grahammer et al.   PEDIATRIC NEPHROLOGY

The Renin-Angiotensin-Aldosterone System in Podocytes

(2012) Dirk Oliver Wennmann et al.   SEMINARS IN NEPHROLOGY

How Many Ways Can a Podocyte Die?

(2012) Pierre-Louis Tharaux et al.   SEMINARS IN NEPHROLOGY

Repair Problems in Podocytes: Wnt, Notch, and Glomerulosclerosis

(2012) Hideki Kato et al.   SEMINARS IN NEPHROLOGY

Cell Biology and Pathology of Podocytes

(2011) Anna Greka et al.   Annual Review of Physiology

Dedifferentiation of Immortalized Human Podocytes in Response to Transforming Growth Factor- : A Model for Diabetic Podocytopathy

(2011) M. Herman-Edelstein et al.   DIABETES

Implication of dysregulation of the canonical wingless-type MMTV integration site (WNT) pathway in diabetic nephropathy

(2011) T. Zhou et al.   DIABETOLOGIA

Wnt/β-Catenin Pathway in Podocytes Integrates Cell Adhesion, Differentiation, and Survival

(2011) Hideki Kato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implication of CD38 gene in podocyte epithelial-to-mesenchymal transition and glomerular sclerosis

(2011) Krishna M. Boini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The roles of connective tissue growth factor and integrin-linked kinase in high glucose-induced phenotypic alterations of podocytes

(2011) Hou-Yong Dai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

WT1-Dependent Sulfatase Expression Maintains the Normal Glomerular Filtration Barrier

(2011) V. A. Schumacher et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TRPC6 Enhances Angiotensin II-induced Albuminuria

(2011) J. Eckel et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Matrix Metalloproteinase-7 as a Surrogate Marker Predicts Renal Wnt/ -Catenin Activity in CKD

(2011) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeted Inhibition of  -Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis

(2011) S. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria

(2011) Dan Wang et al.   KIDNEY INTERNATIONAL

S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells

(2011) Ulrike Sack et al.   MOLECULAR BIOLOGY OF THE CELL

Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling

(2011) Marina Shkreli et al.   NATURE MEDICINE

The podocyte as a target for therapies—new and old

(2011) Peter W. Mathieson   Nature Reviews Nephrology

Epithelial-to-mesenchymal transition in podocytes mediated by activation of NADPH oxidase in hyperhomocysteinemia

(2011) Chun Zhang et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

PINCH1 Is Transcriptional Regulator in Podocytes That Interacts with WT1 and Represses Podocalyxin Expression

(2011) Dan Wang et al.   PLoS One

Acute Multiple Organ Failure in Adult Mice Deleted for the Developmental Regulator Wt1

(2011) You-Ying Chau et al.   PLoS Genetics

A Novel WT1 Gene Mutation in a Three-Generation Family with Progressive Isolated Focal Segmental Glomerulosclerosis

(2010) E. Benetti et al.   Clinical Journal of the American Society of Nephrology

Plasminogen Activator Inhibitor-1 Is a Transcriptional Target of the Canonical Pathway of Wnt/β-Catenin Signaling

(2010) Weichun He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Wilms Tumor 1 (WT1) Target Gene Negatively Regulates the WNT Signaling Pathway

(2010) Myoung Shin Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

Blockade of Wnt/ -Catenin Signaling by Paricalcitol Ameliorates Proteinuria and Kidney Injury

(2010) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Klotho Deficiency Causes Vascular Calcification in Chronic Kidney Disease

(2010) M. C. Hu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hepatocyte growth factor signaling ameliorates podocyte injury and proteinuria

(2010) Chunsun Dai et al.   KIDNEY INTERNATIONAL

Inhibition of integrin-linked kinase blocks podocyte epithelial–mesenchymal transition and ameliorates proteinuria

(2010) Young Sun Kang et al.   KIDNEY INTERNATIONAL

Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial

(2010) Dick de Zeeuw et al.   LANCET

 -Catenin mediates adriamycin-induced albuminuria and podocyte injury in adult mouse kidneys

(2010) E. Heikkila et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Role of the podocyte in proteinuria

(2010) Sylvia Menzel et al.   PEDIATRIC NEPHROLOGY

Podocyte-Specific Overexpression of Wild Type or Mutant Trpc6 in Mice Is Sufficient to Cause Glomerular Disease

(2010) Paola Krall et al.   PLoS One

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial-Mesenchymal Transition as a Potential Explanation for Podocyte Depletion in Diabetic Nephropathy

(2009) Yukinari Yamaguchi et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

(2009) Sara A Wickström et al.   EMBO JOURNAL

Biomarkers for epithelial-mesenchymal transitions

(2009) Michael Zeisberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt/ -Catenin Signaling Promotes Podocyte Dysfunction and Albuminuria

(2009) C. Dai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis

(2009) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis

(2009) Y. Liu   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Advanced oxidation protein products: a causative link between oxidative stress and podocyte depletion

(2009) Youhua Liu   KIDNEY INTERNATIONAL

Accumulation of advanced oxidation protein products induces podocyte apoptosis and deletion through NADPH-dependent mechanisms

(2009) Li Li Zhou et al.   KIDNEY INTERNATIONAL

Proteinuria: an enzymatic disease of the podocyte?

(2009) Peter Mundel et al.   KIDNEY INTERNATIONAL

Integrin-linked kinase is an adaptor with essential functions during mouse development

(2009) Anika Lange et al.   NATURE

New insights into the role of podocytes in proteinuria

(2009) Jaakko Patrakka et al.   Nature Reviews Nephrology

An olive branch to two theories

(2009) Leonie Welberg   NATURE REVIEWS NEUROSCIENCE

An integrated genome screen identifies the Wnt signaling pathway as a major target of WT1

(2009) M. K.-H. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epithelial-to-Mesenchymal Transition Is a Potential Pathway Leading to Podocyte Dysfunction and Proteinuria

(2008) Yingjian Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Wt1 negatively regulates  -catenin signaling during testis development

(2008) H. Chang et al.   DEVELOPMENT

Mechanisms of angiotensin II signaling on cytoskeleton of podocytes

(2008) Hsiang-Hao Hsu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM