Angiotensin II blockade: how its molecular targets may signal to mitochondria and slow aging. Coincidences with calorie restriction and mTOR inhibition
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Angiotensin II blockade: how its molecular targets may signal to mitochondria and slow aging. Coincidences with calorie restriction and mTOR inhibition
Authors
Keywords
-
Journal
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Volume 309, Issue 1, Pages H15-H44
Publisher
American Physiological Society
Online
2015-05-02
DOI
10.1152/ajpheart.00459.2014
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
- (2016) Lan Ye et al. Aging-US
- Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins
- (2015) Katherine H. Schreiber et al. AGING CELL
- mTOR signaling in cellular and organismal energetics
- (2015) Verena Albert et al. CURRENT OPINION IN CELL BIOLOGY
- Nutrient-sensing mechanisms and pathways
- (2015) Alejo Efeyan et al. NATURE
- SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
- (2015) Manuele Rebsamen et al. NATURE
- Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
- (2015) S. Wang et al. SCIENCE
- Diminished mTOR signaling: a common mode of action for endocrine longevity factors
- (2015) Dudley W Lamming SpringerPlus
- Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity
- (2014) Sofiya Milman et al. AGING CELL
- The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling
- (2014) Yun Chau Long et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Autophagy revisited: A conversation with Christian de Duve
- (2014) Daniel J. Klionsky Autophagy
- Effect of adiponectin on cardiac β-catenin signaling pathway under angiotensin II infusion
- (2014) Yuya Fujishima et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The role of mitochondria in mTOR-regulated longevity
- (2014) Yuehua Wei et al. BIOLOGICAL REVIEWS
- Analysis of the quantitative balance between insulin-like growth factor (IGF)-1 ligand, receptor, and binding protein levels to predict cell sensitivity and therapeutic efficacy
- (2014) Dan Tian et al. BMC Systems Biology
- A century old renin–angiotensin system still grows with endless possibilities: AT1 receptor signaling cascades in cardiovascular physiopathology
- (2014) Pitchai Balakumar et al. CELLULAR SIGNALLING
- Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)
- (2014) Michael Ristow et al. Dose-Response
- Renin angiotensin system modulates mTOR pathway through AT2R in HIVAN
- (2014) Partab Rai et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism
- (2014) Marcin Buler et al. FASEB JOURNAL
- Revisiting an age-old question regarding oxidative stress
- (2014) Yael H. Edrey et al. FREE RADICAL BIOLOGY AND MEDICINE
- The GH-IGF1 axis and longevity. The paradigm of IGF1 deficiency
- (2014) Zvi Laron Hormones-International Journal of Endocrinology and Metabolism
- Resveratrol increases anti-aging Klotho gene expression via the activating transcription factor 3/c-Jun complex-mediated signaling pathway
- (2014) Shih-Che Hsu et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Arrestin-dependent Angiotensin AT1Receptor Signaling Regulates Akt and mTor-mediated Protein Synthesis
- (2014) Ryan T. Kendall et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cross-talk between Sirtuin and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in the Regulation of S6 Kinase 1 (S6K1) Phosphorylation
- (2014) Sungki Hong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Where is mTOR and what is it doing there?
- (2014) Charles Betz et al. JOURNAL OF CELL BIOLOGY
- Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria
- (2014) Jessica Soto Hernández et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- mTOR inhibition rescues osteopenia in mice with systemic sclerosis
- (2014) Chider Chen et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Aging and age-related diseases – From endocrine therapy to target therapy
- (2014) Qi Bao et al. MOLECULAR AND CELLULAR ENDOCRINOLOGY
- The AGC kinase SGK1 regulates TH1 and TH2 differentiation downstream of the mTORC2 complex
- (2014) Emily B Heikamp et al. NATURE IMMUNOLOGY
- Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2
- (2014) W. De Haes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of mTORC1 by amino acids
- (2014) Liron Bar-Peled et al. TRENDS IN CELL BIOLOGY
- PPARs Integrate the Mammalian Clock and Energy Metabolism
- (2014) Lihong Chen et al. PPAR Research
- Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
- (2014) Ricki J. Colman et al. Nature Communications
- The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1
- (2014) Lynne Chantranupong et al. Cell Reports
- Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity
- (2014) Pengda Liu et al. Protein & Cell
- Effect of Antioxidants Supplementation on Aging and Longevity
- (2014) Izabela Sadowska-Bartosz et al. Biomed Research International
- Aging Is Not a Disease: Implications for Intervention
- (2014) Suresh Rattan Aging and Disease
- Mitochondrial stress signaling in longevity: A new role for mitochondrial function in aging
- (2014) Shauna Hill et al. Redox Biology
- Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study “Treviso Longeva (TRELONG)”
- (2013) Diego Albani et al. AGE
- Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
- (2013) Richard A. Miller et al. AGING CELL
- Paricalcitol Downregulates Myocardial Renin-Angiotensin and Fibroblast Growth Factor Expression and Attenuates Cardiac Hypertrophy in Uremic Rats
- (2013) M. Freundlich et al. AMERICAN JOURNAL OF HYPERTENSION
- Chronic Kidney Disease: A Clinical Model of Premature Aging
- (2013) Peter Stenvinkel et al. AMERICAN JOURNAL OF KIDNEY DISEASES
- The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system
- (2013) Marcelo Ferder et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4
- (2013) Jun Mori et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway
- (2013) M. Sandri et al. BIOGERONTOLOGY
- Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer cells: tumor suppressive role of klotho in gastric cancer
- (2013) Biao Xie et al. Cancer Cell International
- Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism
- (2013) Filipe Cabreiro et al. CELL
- SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks
- (2013) Matthew J. Rardin et al. Cell Metabolism
- Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH
- (2013) Akiko Satoh et al. Cell Metabolism
- mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
- (2013) Masahiro Morita et al. Cell Metabolism
- Vitamin D receptor-modulated Hsp70/AT1 expression may protect the kidneys of SHRs at the structural and functional levels
- (2013) Isabel Mercedes García et al. CELL STRESS & CHAPERONES
- Effect of Renin-Angiotensin System Blockade on Soluble Klotho in Patients with Type 2 Diabetes, Systolic Hypertension, and Albuminuria
- (2013) J. Karalliedde et al. Clinical Journal of the American Society of Nephrology
- Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress
- (2013) Nicola E. Clarke et al. CLINICAL SCIENCE
- Genetic Deficiency of Anti-Aging GeneKlothoExacerbates Early Nephropathy in STZ-Induced Diabetes in Male Mice
- (2013) Yi Lin et al. ENDOCRINOLOGY
- Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)
- (2013) Dudley W. Lamming et al. FASEB JOURNAL
- NADPH oxidases mediate a cellular “memory” of angiotensin II stress in hypertensive cardiac hypertrophy
- (2013) Hong-Xia Wang et al. FREE RADICAL BIOLOGY AND MEDICINE
- The effects of dietary restriction on oxidative stress in rodents
- (2013) Michael E. Walsh et al. FREE RADICAL BIOLOGY AND MEDICINE
- Calorie restriction and sirtuins revisited
- (2013) L. Guarente GENES & DEVELOPMENT
- SIRT1, heme oxygenase-1 and NO-mediated vasodilation in a human model of endogenous angiotensin II type 1 receptor antagonism: implications for hypertension
- (2013) Paul A Davis et al. HYPERTENSION RESEARCH
- Autoregulation of the Mechanistic Target of Rapamycin (mTOR) Complex 2 Integrity Is Controlled by an ATP-dependent Mechanism
- (2013) Chien-Hung Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Necessity of angiotensin-converting enzyme-related gene for cardiac functions and longevity ofDrosophila melanogasterassessed by optical coherence tomography
- (2013) Fang-Tsu Liao et al. JOURNAL OF BIOMEDICAL OPTICS
- An integrated understanding of the physiological response to elevated extracellular phosphate
- (2013) Corinne E. Camalier et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Rapamycin extends murine lifespan but has limited effects on aging
- (2013) Frauke Neff et al. JOURNAL OF CLINICAL INVESTIGATION
- Rapalogs and mTOR inhibitors as anti-aging therapeutics
- (2013) Dudley W. Lamming et al. JOURNAL OF CLINICAL INVESTIGATION
- The sirtuin family’s role in aging and age-associated pathologies
- (2013) Jessica A. Hall et al. JOURNAL OF CLINICAL INVESTIGATION
- Angiotensin-converting-enzyme inhibition counteracts angiotensin II-mediated endothelial cell dysfunction by modulating the p38/SirT1 axis
- (2013) Francesco Marampon et al. JOURNAL OF HYPERTENSION
- Assessment of Mitochondrial Biogenesis and mTORC1 Signaling During Chronic Rapamycin Feeding in Male and Female Mice
- (2013) Joshua C. Drake et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3
- (2013) Julia Brenmoehl et al. MITOCHONDRION
- The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
- (2013) Zhi-Yang Tsun et al. MOLECULAR CELL
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
- Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis
- (2013) Pengda Liu et al. NATURE CELL BIOLOGY
- The GH/IGF-1 axis in ageing and longevity
- (2013) Riia K. Junnila et al. Nature Reviews Endocrinology
- Renal Expression of FGF23 in Progressive Renal Disease of Diabetes and the Effect of Ace Inhibitor
- (2013) Cristina Zanchi et al. PLoS One
- A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
- (2013) L. Bar-Peled et al. SCIENCE
- Metformin improves healthspan and lifespan in mice
- (2013) Alejandro Martin-Montalvo et al. Nature Communications
- Vitamin D — Effects on Skeletal and Extraskeletal Health and the Need for Supplementation
- (2013) Matthias Wacker et al. Nutrients
- Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice
- (2013) Liou Y Sun et al. eLife
- Mitochondrial reactive oxygen species (ROS) as signaling molecules of intracellular pathways triggered by the cardiac renin-angiotensin II-aldosterone system (RAAS)
- (2013) V. C. De Giusti et al. Frontiers in Physiology
- Impact of angiotensin II on skeletal muscle metabolism and function in mice: Contribution of IGF-1, Sirtuin-1 and PGC-1α
- (2012) Katharina Kackstein et al. ACTA HISTOCHEMICA
- Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle
- (2012) Emanuele Marzetti et al. AGE
- Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity
- (2012) Ariela Benigni et al. AGE
- Augmented autophagy pathways and MTOR modulation in fibroblasts from long-lived mutant mice
- (2012) Min Wang et al. Autophagy
- Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice
- (2012) Asuka Shiota et al. Cardiovascular Diabetology
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
- (2012) Liron Bar-Peled et al. CELL
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Sirtuins and renal diseases: relationship with aging and diabetic nephropathy
- (2012) Munehiro Kitada et al. CLINICAL SCIENCE
- The Critical Role of Metabolic Pathways in Aging
- (2012) N. Barzilai et al. DIABETES
- The orphan receptor TR3 participates in angiotensin II-induced cardiac hypertrophy by controlling mTOR signalling
- (2012) Rong-Hao Wang et al. EMBO Molecular Medicine
- Calcitriol protects renovascular function in hypertension by down-regulating angiotensin II type 1 receptors and reducing oxidative stress
- (2012) Jinghui Dong et al. EUROPEAN HEART JOURNAL
- The secreted Klotho protein restores phosphate retention and suppresses accelerated aging in Klotho mutant mice
- (2012) Tso-Hsiao Chen et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells
- (2012) David K. Finlay et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young Mice
- (2012) Wilson C. Fok et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Advancing age is associated with gene expression changes resembling mTOR inhibition: Evidence from two human populations
- (2012) Lorna W. Harries et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Defective Mitochondrial Morphology and Bioenergetic Function in Mice Lacking the Transcription Factor Yin Yang 1 in Skeletal Muscle
- (2012) S. M. Blattler et al. MOLECULAR AND CELLULAR BIOLOGY
- Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex
- (2012) Sang Gyun Kim et al. MOLECULAR CELL
- The sirtuin SIRT6 regulates lifespan in male mice
- (2012) Yariv Kanfi et al. NATURE
- mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
- (2012) Ömer H. Yilmaz et al. NATURE
- AMPK: a nutrient and energy sensor that maintains energy homeostasis
- (2012) D. Grahame Hardie et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Klotho, phosphate and inflammation/ageing in chronic kidney disease
- (2012) M. C. Izquierdo et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Rictor regulates cell migration by suppressing RhoGDI2
- (2012) N K Agarwal et al. ONCOGENE
- Regulation and Function of the FGF23/Klotho Endocrine Pathways
- (2012) Aline Martin et al. PHYSIOLOGICAL REVIEWS
- Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity
- (2012) D. W. Lamming et al. SCIENCE
- Modifications in basal and stress-induced hypothalamic AMP-activated protein kinase (AMPK) activity in rats chronically treated with an angiotensin II receptor blocker
- (2012) Mirna B. Marques et al. STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
- Transcriptional integration of mitochondrial biogenesis
- (2012) Richard C. Scarpulla et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- PPARs at the crossroads of lipid signaling and inflammation
- (2012) Walter Wahli et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2
- (2012) Lan Ye et al. Frontiers in Genetics
- AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network
- (2011) Antero Salminen et al. AGEING RESEARCH REVIEWS
- Angiotensin II Activation of mTOR Results in Tubulointerstitial Fibrosis through Loss of N-Cadherin
- (2011) Adam Whaley-Connell et al. AMERICAN JOURNAL OF NEPHROLOGY
- Mineralocorticoid Receptor-Dependent Proximal Tubule Injury Is Mediated by a Redox-Sensitive mTOR/S6K1 Pathway
- (2011) Adam T. Whaley-Connell et al. AMERICAN JOURNAL OF NEPHROLOGY
- Vitamin D receptor controls expression of the anti-aging klotho gene in mouse and human renal cells
- (2011) Ryan E. Forster et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity
- (2011) Vittorio Calabrese et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Akt, FoxO and regulation of apoptosis
- (2011) Xinbo Zhang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Metformin slows down aging and extends life span of female SHR mice
- (2011) Vladimir N. Anisimov et al. CELL CYCLE
- Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure
- (2011) Dao-Fu Dai et al. CIRCULATION RESEARCH
- Aging increases mitochondrial DNA damage and oxidative stress in liver of rhesus monkeys
- (2011) María del R. Castro et al. EXPERIMENTAL GERONTOLOGY
- The β-Arrestin Pathway-selective Type 1A Angiotensin Receptor (AT1A) Agonist [Sar1,Ile4,Ile8]Angiotensin II Regulates a Robust G Protein-independent Signaling Network
- (2011) Ryan T. Kendall et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sirtuins at a glance
- (2011) T. Nakagawa et al. JOURNAL OF CELL SCIENCE
- Signalling by insulin and IGF receptors: supporting acts and new players
- (2011) Kenneth Siddle JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Cross Talk Between the Renin-Angiotensin-Aldosterone System and Vitamin D-FGF-23-klotho in Chronic Kidney Disease
- (2011) M. H. de Borst et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Phosphate and Klotho
- (2011) Makoto Kuro-o KIDNEY INTERNATIONAL
- The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore
- (2011) Pinadda Varanyuwatana et al. MITOCHONDRION
- Sirt3 Promotes the Urea Cycle and Fatty Acid Oxidation during Dietary Restriction
- (2011) William C. Hallows et al. MOLECULAR CELL
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- Calorie Restriction: Is AMPK a Key Sensor and Effector?
- (2011) Carles Cantó et al. PHYSIOLOGY
- Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1
- (2011) Colin Selman et al. PLoS One
- Identification and characterization of a functional mitochondrial angiotensin system
- (2011) P. M. Abadir et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
- (2011) Y. Yu et al. SCIENCE
- The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
- (2011) P. P. Hsu et al. SCIENCE
- Losartan Restores Skeletal Muscle Remodeling and Protects Against Disuse Atrophy in Sarcopenia
- (2011) T. N. Burks et al. Science Translational Medicine
- Commonly adopted caloric restriction protocols often involve malnutrition
- (2010) Fernanda M. Cerqueira et al. AGEING RESEARCH REVIEWS
- AMPK and SIRT1: a long-standing partnership?
- (2010) Neil B. Ruderman et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- PGC-1α is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle
- (2010) Lotte Leick et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- IGF-1 prevents ANG II-induced skeletal muscle atrophy via Akt- and Foxo-dependent inhibition of the ubiquitin ligase atrogin-1 expression
- (2010) Tadashi Yoshida et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Nuclear Control of Respiratory Chain Expression by Nuclear Respiratory Factors and PGC-1-Related Coactivator
- (2010) Richard C. Scarpulla Annals of the New York Academy of Sciences
- Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease
- (2010) Geneviève Deblois et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria?
- (2010) E. M. V. de Cavanagh et al. CARDIOVASCULAR RESEARCH
- Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction
- (2010) Shinichi Someya et al. CELL
- Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
- (2010) Ivana Bjedov et al. Cell Metabolism
- Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation
- (2010) Xiaolei Qiu et al. Cell Metabolism
- With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging
- (2010) Pankaj Kapahi et al. Cell Metabolism
- Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance
- (2010) Hui-Young Lee et al. Cell Metabolism
- AMP-activated protein kinase and its downstream transcriptional pathways
- (2010) Carles Cantó et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin–angiotensin system
- (2010) Andreas Tomaschitz et al. CLINICA CHIMICA ACTA
- Reciprocal Control of 1,25-Dihydroxyvitamin D and FGF23 Formation Involving the FGF23/Klotho System
- (2010) D. Prie et al. Clinical Journal of the American Society of Nephrology
- ACE2: more of Ang-(1–7) or less Ang II?
- (2010) Carlos M Ferrario CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
- New insights into angiotensin receptor actions: from blood pressure to aging
- (2010) Johannes Stegbauer et al. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
- Vitamin D: Metabolism
- (2010) Sylvia Christakos et al. ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
- How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
- (2010) Michael Ristow et al. EXPERIMENTAL GERONTOLOGY
- Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
- (2010) Ming Chang Hu et al. FASEB JOURNAL
- Amino Acids Activate Mammalian Target of Rapamycin Complex 2 (mTORC2) via PI3K/Akt Signaling
- (2010) Irantzu Tato et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metabolic Regulator βKlotho Interacts with Fibroblast Growth Factor Receptor 4 (FGFR4) to Induce Apoptosis and Inhibit Tumor Cell Proliferation
- (2010) Yongde Luo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria
- (2010) Katia Aquilano et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Angiotensin II receptor blocker telmisartan enhances running endurance of skeletal muscle through activation of the PPAR-δ/AMPK pathway
- (2010) Xiaoli Feng et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- The nuclear vitamin D receptor controls the expression of genes encoding factors which feed the “Fountain of Youth” to mediate healthful aging
- (2010) Mark R. Haussler et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Forging Forward with 10 Burning Questions on FGF23 in Kidney Disease
- (2010) M. Wolf JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
- (2010) Richard A. Miller et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Role of Fosinopril and Valsartan on Klotho Gene Expression Induced by Angiotensin II in Rat Renal Tubular Epithelial Cells
- (2010) Q. Zhou et al. KIDNEY & BLOOD PRESSURE RESEARCH
- Regulation of ion channels by secreted Klotho: mechanisms and implications
- (2010) Chou-Long Huang KIDNEY INTERNATIONAL
- Hyperphosphatemia-induced nanocrystals upregulate the expression of bone morphogenetic protein-2 and osteopontin genes in mouse smooth muscle cells in vitro
- (2010) Andrew P. Sage et al. KIDNEY INTERNATIONAL
- A potential link between phosphate and aging—Lessons from Klotho-deficient mice
- (2010) Makoto Kuro-o MECHANISMS OF AGEING AND DEVELOPMENT
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
- (2010) Matthew D. Hirschey et al. NATURE
- Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy
- (2010) H. E. Yoon et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility
- (2010) E H Jeninga et al. ONCOGENE
- SIRT1 Negatively Regulates the Mammalian Target of Rapamycin
- (2010) Hiyaa Singhee Ghosh et al. PLoS One
- Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
- (2010) Brian Onken et al. PLoS One
- Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis
- (2010) Xingxing Kong et al. PLoS One
- Human SIRT6 Promotes DNA End Resection Through CtIP Deacetylation
- (2010) Abderrahmane Kaidi et al. SCIENCE
- Extending Healthy Life Span--From Yeast to Humans
- (2010) L. Fontana et al. SCIENCE
- PPARs in the Renal Regulation of Systemic Blood Pressure
- (2010) Tamás Rőszer et al. PPAR Research
- Angiotensin II, mitochondria, cytoskeletal, and extracellular matrix connections: an integrating viewpoint
- (2009) Elena MV de Cavanagh et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Angiotensin type 1 receptor mediates thyroid hormone-induced cardiomyocyte hypertrophy through the Akt/GSK-3β/mTOR signaling pathway
- (2009) Gabriela Placoná Diniz et al. BASIC RESEARCH IN CARDIOLOGY
- Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats
- (2009) Edson Lucas Santos et al. BIOCHEMICAL PHARMACOLOGY
- SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
- (2009) Takashi Nakagawa et al. CELL
- SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span
- (2009) Tiara L.A. Kawahara et al. CELL
- mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and Aging
- (2009) Rogerio M. Castilho et al. Cell Stem Cell
- Mineral Metabolism and Inflammation in Chronic Kidney Disease Patients: A Cross-Sectional Study
- (2009) J. F. Navarro-Gonzalez et al. Clinical Journal of the American Society of Nephrology
- PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
- (2009) Carles Cantó et al. CURRENT OPINION IN LIPIDOLOGY
- Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis
- (2009) A. Grob et al. JOURNAL OF CELL SCIENCE
- mTOR signaling at a glance
- (2009) M. Laplante et al. JOURNAL OF CELL SCIENCE
- Disruption of the Ang II type 1 receptor promotes longevity in mice
- (2009) Ariela Benigni et al. JOURNAL OF CLINICAL INVESTIGATION
- Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin
- (2009) Mohga M. El-Abbadi et al. KIDNEY INTERNATIONAL
- mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
- (2009) L.-A. Julien et al. MOLECULAR AND CELLULAR BIOLOGY
- AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
- (2009) Carles Cantó et al. NATURE
- Adequate phosphate binding with lanthanum carbonate attenuates arterial calcification in chronic renal failure rats
- (2009) E. Neven et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Angiotensin receptors as determinants of life span
- (2009) Paola Cassis et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Disruption of Growth Hormone Receptor Prevents Calorie Restriction from Improving Insulin Action and Longevity
- (2009) Michael S. Bonkowski et al. PLoS One
- Direct control of mitochondrial function by mTOR
- (2009) Arvind Ramanathan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
- (2009) R. J. Colman et al. SCIENCE
- Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
- (2009) C. Selman et al. SCIENCE
- mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
- (2009) C. Chen et al. Science Signaling
- Aging and hormones of the hypothalamo-pituitary axis: Gonadotropic axis in men and somatotropic axes in men and women
- (2008) Johannes D. Veldhuis AGEING RESEARCH REVIEWS
- mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
- (2008) Juan M. García-Martínez et al. BIOCHEMICAL JOURNAL
- Klotho as a regulator of oxidative stress and senescence
- (2008) Makoto Kuro-o BIOLOGICAL CHEMISTRY
- Transcriptional control of mitochondrial biogenesis: the central role of PGC-1
- (2008) R. Ventura-Clapier et al. CARDIOVASCULAR RESEARCH
- Low Doses of Insulin-Like Growth Factor-I Induce Mitochondrial Protection in Aging Rats
- (2008) Juan E. Puche et al. ENDOCRINOLOGY
- Angiotensin inhibition stimulates PPARγ and the release of visfatin
- (2008) A. Storka et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Fibroblast growth factor-23 is associated with parathyroid hormone and renal function in a population-based cohort of elderly men
- (2008) Richard Marsell et al. EUROPEAN JOURNAL OF ENDOCRINOLOGY
- Renin–angiotensin system inhibitors protect against age-related changes in rat liver mitochondrial DNA content and gene expression
- (2008) Elena M.V. de Cavanagh et al. EXPERIMENTAL GERONTOLOGY
- Regulation of SIRT6 protein levels by nutrient availability
- (2008) Yariv Kanfi et al. FEBS LETTERS
- Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling
- (2008) M. P. DeYoung et al. GENES & DEVELOPMENT
- Metabolic Switch and Hypertrophy of Cardiomyocytes following Treatment with Angiotensin II Are Prevented by AMP-activated Protein Kinase
- (2008) Bettina Johanna Stuck et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Resveratrol Inhibits Cardiac Hypertrophy via AMP-activated Protein Kinase and Akt
- (2008) Anita Y. M. Chan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Serum Phosphorus Levels Associate with Coronary Atherosclerosis in Young Adults
- (2008) R. N. Foley et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Targeted vitamin D receptor expression in juxtaglomerular cells suppresses renin expression independent of parathyroid hormone and calcium
- (2008) Juan Kong et al. KIDNEY INTERNATIONAL
- Klotho is a target gene of PPAR-γ
- (2008) Hong Zhang et al. KIDNEY INTERNATIONAL
- The positive inotropic effect of endothelin-1 is mediated by mitochondrial reactive oxygen species
- (2008) V.C. De Giusti et al. LIFE SCIENCES
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- The -glucuronidase klotho exclusively activates the epithelial Ca2+ channels TRPV5 and TRPV6
- (2008) P. Lu et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Effect of caloric restriction in non-obese humans on physiological, psychological and behavioral outcomes
- (2008) Leanne M. Redman et al. PHYSIOLOGY & BEHAVIOR
- A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans
- (2008) Malene Hansen et al. PLoS Genetics
- In Vitro Cellular Adaptations of Indicators of Longevity in Response to Treatment with Serum Collected from Humans on Calorie Restricted Diets
- (2008) Joanne S. Allard et al. PLoS One
- Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance
- (2008) A. P. Jayasooriya et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Renal mitochondrial impairment is attenuated by AT1 blockade in experimental Type I diabetes
- (2007) Elena M. V. de Cavanagh et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Molecular Mechanisms of Angiotensin II–Mediated Mitochondrial Dysfunction
- (2007) Abdulrahman K. Doughan et al. CIRCULATION RESEARCH
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started