Diminished mTOR signaling: a common mode of action for endocrine longevity factors

Coinjection of CCK and leptin reduces food intake via increased CART/TRH and reduced AMPK phosphorylation in the hypothalamus

(2014) Sayaka Akieda-Asai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Chronic rapamycin treatment causes diabetes in male mice

(2014) Christine E. Schindler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

(2014) Rajesh R. Rao et al.   CELL

Leptin Enhances Insulin Sensitivity by Direct and Sympathetic Nervous System Regulation of Muscle IGFBP-2 Expression: Evidence From Nonrodent Models

(2014) Steven W. Yau et al.   ENDOCRINOLOGY

Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

(2014) Wilson C. Fok et al.   PLoS One

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Pancreatic β-Cell Proliferation in Obesity

(2014) Amelia K. Linnemann et al.   Advances in Nutrition

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

(2013) Wilson C. Fok et al.   AGING CELL

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive

(2013) Dudley W. Lamming et al.   AGING CELL

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

(2013) Evi M. Mercken et al.   AGING CELL

Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

(2013) Richard A. Miller et al.   AGING CELL

PRLR Regulates Hepatic Insulin Sensitivity in Mice via STAT5

(2013) Junjie Yu et al.   DIABETES

Metabolic adaptations to short-term every-other-day feeding in long-living Ames dwarf mice

(2013) Holly M. Brown-Borg et al.   EXPERIMENTAL GERONTOLOGY

Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell

(2013) Regina Kuliawat et al.   FASEB JOURNAL

Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)

(2013) Dudley W. Lamming et al.   FASEB JOURNAL

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

Lifelong Caloric Restriction Reprograms Hepatic Fat Metabolism in Mice

(2013) A. Kuhla et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Mice Producing Reduced Levels of Insulin-Like Growth Factor Type 1 Display an Increase in Maximum, but not Mean, Life Span

(2013) A. Lorenzini et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Role of GH in Adipose Tissue: Lessons from Adipose-Specific GH Receptor Gene-Disrupted Mice

(2013) Edward O. List et al.   MOLECULAR ENDOCRINOLOGY

Haploinsufficiency of Akt1 Prolongs the Lifespan of Mice

(2013) Aika Nojima et al.   PLoS One

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

Long-TermFgf23Deficiency Does Not Influence Aging, Glucose Homeostasis, or Fat Metabolism in Mice with a Nonfunctioning Vitamin D Receptor

(2012) Carmen Streicher et al.   ENDOCRINOLOGY

Discovery of a New Role of Human Resistin in Hepatocyte Low-Density Lipoprotein Receptor Suppression Mediated in Part by Proprotein Convertase Subtilisin/Kexin Type 9

(2012) Michelle Melone et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Probing the Relationship Between Insulin Sensitivity and Longevity Using Genetically Modified Mice

(2012) James F. Nelson et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTOR pathway

(2012) Zhuo Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Central Prolactin Modulates Insulin Sensitivity and Insulin Secretion in Diabetic Rats

(2012) Sunmin Park et al.   NEUROENDOCRINOLOGY

Fibroblast Growth Factor-21 Is a Promising Dietary Restriction Mimetic

(2012) Andrew R. Mendelsohn et al.   REJUVENATION RESEARCH

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

Metabolic effects of intra-abdominal fat in GHRKO mice

(2011) Michal M. Masternak et al.   AGING CELL

Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues

(2011) Ligen Lin et al.   AGING CELL

High fat diet induced insulin resistance and glucose intolerance are gender-specific in IGF-1R heterozygous mice

(2011) Neha Garg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1

(2011) Colin Selman et al.   PLoS One

Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?

(2011) Alex F. Bokov et al.   PLoS One

Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor

(2010) Nazif Alic et al.   AGING CELL

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Acute Humanin Therapy Attenuates Myocardial Ischemia and Reperfusion Injury in Mice

(2010) Radhika H. Muzumdar et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene

(2010) Kristina Hedbacker et al.   Cell Metabolism

Cholecystokinin Is Up-Regulated in Obese Mouse Islets and Expands β-Cell Mass by Increasing β-Cell Survival

(2010) Jeremy A. Lavine et al.   ENDOCRINOLOGY

Improving insulin sensitivity via activation of PPAR-γ increases telomerase activity in the heart of OLETF rats

(2009) Naoki Makino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Identification of MUP1 as a Regulator for Glucose and Lipid Metabolism in Mice

(2009) Yingjiang Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The neurosurvival factor Humanin inhibits β-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice

(2009) Phuong T. Hoang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Humanin: A Novel Central Regulator of Peripheral Insulin Action

(2009) Radhika H. Muzumdar et al.   PLoS One

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

(2009) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Metabolic reprogramming, caloric restriction and aging

(2009) Rozalyn M. Anderson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

(2008) Takeshi Inagaki et al.   Cell Metabolism

Exendin-4 Improves Glycemic Control, Ameliorates Brain and Pancreatic Pathologies, and Extends Survival in a Mouse Model of Huntington's Disease

(2008) B. Martin et al.   DIABETES

Efficacy of Ghrelin as a Therapeutic Approach for Age-Related Physiological Changes

(2008) Hiroyuki Ariyasu et al.   ENDOCRINOLOGY

Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness: Relationship with caloric restriction

(2008) Takuya Chiba et al.   EXPERIMENTAL GERONTOLOGY

FGF21 is an Akt-regulated myokine

(2008) Yasuhiro Izumiya et al.   FEBS LETTERS

The Klotho gene family as a regulator of endocrine fibroblast growth factors

(2008) Hiroshi Kurosu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY