The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling

Controlling SIRT1 expression by microRNAs in health and metabolic disease

(2016) Jiyoung Lee et al.   Aging-US

The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction

(2016) Brenda Rascón et al.   Aging-US

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

(2014) Márton L. Tóth et al.   Autophagy

MicroRNAs linking inflamm-aging, cellular senescence and cancer

(2013) Fabiola Olivieri et al.   AGEING RESEARCH REVIEWS

Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts

(2013) Chad Lerner et al.   AGING CELL

Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile

(2013) Evi M. Mercken et al.   AGING CELL

The Free Radical Theory of Aging Revisited: The Cell Signaling Disruption Theory of Aging

(2013) Jose Viña et al.   ANTIOXIDANTS & REDOX SIGNALING

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice

(2013) Zhuofeng Lin et al.   Cell Metabolism

Loss of Cytochrome c Oxidase Promotes RAS-Dependent ROS Production from the ER Resident NADPH Oxidase, Yno1p, in Yeast

(2013) Jane E. Leadsham et al.   Cell Metabolism

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

MicroRNAs in age-related diseases

(2013) Stefanie Dimmeler et al.   EMBO Molecular Medicine

Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders

(2013) Motoko Kawashima et al.   EXPERIMENTAL GERONTOLOGY

MitomiRs delineating the intracellular localization of microRNAs at mitochondria

(2013) S. Bandiera et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirtuins: the molecular basis of beneficial effects of physical activity

(2013) Bruna Pucci et al.   Internal and Emergency Medicine

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics

(2013) Manti Guha et al.   MITOCHONDRION

Superoxide radicals have a protective role during H2O2 stress

(2013) Geoffrey W. Thorpe et al.   MOLECULAR BIOLOGY OF THE CELL

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

(2013) Kathrin Schmeisser et al.   Nature Chemical Biology

FGF21 regulates metabolism and circadian behavior by acting on the nervous system

(2013) Angie L Bookout et al.   NATURE MEDICINE

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways

(2013) S. Chae et al.   Science Signaling

Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond

(2013) Cole M. Haynes et al.   TRENDS IN CELL BIOLOGY

Humanin: a harbinger of mitochondrial-derived peptides?

(2013) Changhan Lee et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation

(2013) Kazuhiko Higashida et al.   PLOS BIOLOGY

Neuronal ROS signaling rather than AMPK/sirtuin-mediated energy sensing links dietary restriction to lifespan extension

(2013) Sebastian Schmeisser et al.   Molecular Metabolism

Flies, worms and the Free Radical Theory of ageing

(2012) David Clancy et al.   AGEING RESEARCH REVIEWS

Signaling the mitochondrial unfolded protein response

(2012) Mark W. Pellegrino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

(2012) Thomas A. Rando et al.   CELL

Chronic Caloric Restriction Preserves Mitochondrial Function in Senescence without Increasing Mitochondrial Biogenesis

(2012) Ian R. Lanza et al.   Cell Metabolism

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Impaired Insulin/IGF1 Signaling Extends Life Span by Promoting Mitochondrial L-Proline Catabolism to Induce a Transient ROS Signal

(2012) Kim Zarse et al.   Cell Metabolism

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Neuroinflamm-Aging and Neurodegenerative Diseases: An Overview

(2012) Vincenzo Pizza et al.   CNS & Neurological Disorders-Drug Targets

Mitochondria and Organismal Longevity

(2012) Ara B. Hwang et al.   CURRENT GENOMICS

Inflamm-ageing

(2012) Elisa Cevenini et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The emerging role of the mitochondrial-derived peptide humanin in stress resistance

(2012) Kelvin Yen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice

(2012) Sarah Hempenstall et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Endoplasmic reticulum–mitochondria contacts: function of the junction

(2012) Ashley A. Rowland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tissue-Specific Responses of IGF-1/Insulin and mTOR Signaling in Calorie Restricted Rats

(2012) Naveen Sharma et al.   PLoS One

Downregulation of miR-205 Modulates Cell Susceptibility to Oxidative and Endoplasmic Reticulum Stresses in Renal Tubular Cells

(2012) Shiyo Muratsu-Ikeda et al.   PLoS One

Superoxide dismutase is dispensable for normal animal lifespan

(2012) J. M. Van Raamsdonk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Resveratrol as a calorie restriction mimetic: therapeutic implications

(2012) Jay H. Chung et al.   TRENDS IN CELL BIOLOGY

Insights into the beneficial effect of caloric/ dietary restriction for a healthy and prolonged life

(2012) Rani Pallavi et al.   Frontiers in Physiology

The Yeast Retrograde Response as a Model of Intracellular Signaling of Mitochondrial Dysfunction

(2012) S. Michal Jazwinski et al.   Frontiers in Physiology

Caloric restriction improves efficiency and capacity of the mitochondrial electron transport chain in Saccharomyces cerevisiae

(2011) Joon-Seok Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan

(2011) John R. Speakman et al.   BIOESSAYS

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Calorie restriction: Decelerating mTOR-driven aging from cells to organisms (including humans)

(2011) Mikhail V Blagosklonny   CELL CYCLE

A CRTCal Link between Energy and Life Span

(2011) Anne Brunet   Cell Metabolism

Regulation of Yeast Chronological Life Span by TORC1 via Adaptive Mitochondrial ROS Signaling

(2011) Yong Pan et al.   Cell Metabolism

Extending life span by increasing oxidative stress

(2011) Michael Ristow et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria at the Interface Between Danger Signaling and Metabolism: Role of Unfolded Protein Responses in Chronic Inflammation

(2011) Eva Rath et al.   INFLAMMATORY BOWEL DISEASES

Signal Transduction by Mitochondrial Oxidants

(2011) Toren Finkel   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-335 and miR-34a Promote Renal Senescence by Suppressing Mitochondrial Antioxidative Enzymes

(2011) X.-Y. Bai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Caloric restriction

(2011) John R. Speakman et al.   MOLECULAR ASPECTS OF MEDICINE

Regulation of reactive oxygen species generation in cell signaling

(2011) Yun Soo Bae et al.   MOLECULES AND CELLS

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

(2011) William Mair et al.   NATURE

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

(2011) Eric L. Greer et al.   NATURE

Aging and disease: connections to sirtuins

(2010) Gizem Donmez et al.   AGING CELL

Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans

(2010) Wen Yang et al.   AGING CELL

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Epigenetic Control of Aging

(2010) Ursula Muñoz-Najar et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

(2010) Pankaj Kapahi et al.   Cell Metabolism

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

Vitamin E and C supplementation reduces oxidative stress, improves antioxidant enzymes and positive muscle work in chronically loaded muscles of aged rats

(2010) Michael J. Ryan et al.   EXPERIMENTAL GERONTOLOGY

Novel modulators of senescence, aging, and longevity: Small non-coding RNAs enter the stage

(2010) Johannes Grillari et al.   EXPERIMENTAL GERONTOLOGY

How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)

(2010) Michael Ristow et al.   EXPERIMENTAL GERONTOLOGY

Exercise-induced oxidative stress in humans: Cause and consequences

(2010) Scott K. Powers et al.   FREE RADICAL BIOLOGY AND MEDICINE

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways

(2010) Y. C. Long et al.   MOLECULAR AND CELLULAR BIOLOGY

Nox4-Derived H2O2 Mediates Endoplasmic Reticulum Signaling through Local Ras Activation

(2010) R.-F. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aquaporin-3 mediates hydrogen peroxide uptake to regulate downstream intracellular signaling

(2010) E. W. Miller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Sirt1's systemic protective roles and its promise as a target in antiaging medicine

(2010) Bor Luen Tang   Translational Research

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Redox Regulation of Nuclear Post-Translational Modifications During NF-κB Activation

(2009) Geoffrey Gloire et al.   ANTIOXIDANTS & REDOX SIGNALING

Is the oxidative stress theory of aging dead?

(2009) Viviana I. Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1

(2009) Tanja Heidler et al.   BIOGERONTOLOGY

MicroRNA-210 Controls Mitochondrial Metabolism during Hypoxia by Repressing the Iron-Sulfur Cluster Assembly Proteins ISCU1/2

(2009) Stephen Y. Chan et al.   Cell Metabolism

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

Alterations in Oxygen Consumption, Respiratory Quotient, and Heat Production in Long-Lived GHRKO and Ames Dwarf Mice, and Short-Lived bGH Transgenic Mice

(2009) Reyhan Westbrook et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Histone H4 lysine 16 acetylation regulates cellular lifespan

(2009) Weiwei Dang et al.   NATURE

Direct control of mitochondrial function by mTOR

(2009) Arvind Ramanathan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antioxidants prevent health-promoting effects of physical exercise in humans

(2009) M. Ristow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans

(2009) David Cristina et al.   PLoS Genetics

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL

Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

(2008) Kevin J. Pearson et al.   Cell Metabolism

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Increased Respiration in thesch9ΔMutant Is Required for Increasing Chronological Life Span but Not Replicative Life Span

(2008) Hugo Lavoie et al.   EUKARYOTIC CELL

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

(2008) R. Doonan et al.   GENES & DEVELOPMENT

Role of Adenosine 5′-Monophosphate-Activated Protein Kinase Subunits in Skeletal Muscle Mammalian Target of Rapamycin Signaling

(2008) Atul S. Deshmukh et al.   MOLECULAR ENDOCRINOLOGY