Analysis of the quantitative balance between insulin-like growth factor (IGF)-1 ligand, receptor, and binding protein levels to predict cell sensitivity and therapeutic efficacy

Epitope-Specific Mechanisms of IGF1R Inhibition by Ganitumab

(2013) Frank J. Calzone et al.   PLoS One

Modeling the Insulin-Like Growth Factor System in Articular Cartilage

(2013) Lihai Zhang et al.   PLoS One

Insulin and insulin-like growth factor signaling increases proliferation and hyperplasia of the ovarian surface epithelium and decreases follicular integrity through upregulation of the PI3-kinase pathway

(2013) Shelby M King et al.   Journal of Ovarian Research

Contact inhibition (of proliferation) redux

(2012) Andrea I McClatchey et al.   CURRENT OPINION IN CELL BIOLOGY

The Insulin-Like Growth Factor System in Cancer

(2012) S. John Weroha et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Insulin-like Growth Factor Receptor Inhibitors: Baby or the Bathwater?

(2012) D. Yee   JNCI-Journal of the National Cancer Institute

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Knockout of Insulin-Like Growth Factor-1 Receptor Impairs Distal Lung Morphogenesis

(2012) Ralph Epaud et al.   PLoS One

A multivariate model of ErbB network composition predicts ovarian cancer cell response to canertinib

(2011) Rexxi D. Prasasya et al.   BIOTECHNOLOGY AND BIOENGINEERING

IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-β1 resulting in epithelial to mesenchymal transition

(2011) Logan A Walsh et al.   Cell Communication and Signaling

IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer

(2011) Carly Jade Dool et al.   ENDOCRINE-RELATED CANCER

Signalling by insulin and IGF receptors: supporting acts and new players

(2011) Kenneth Siddle   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Tumor-Associated Retinal Astrocytes Promote Retinoblastoma Cell Proliferation Through Production of IGFBP-5

(2010) Xiaoliang L. Xu et al.   AMERICAN JOURNAL OF PATHOLOGY

Insulin-Mediated Acceleration of Breast Cancer Development and Progression in a Nonobese Model of Type 2 Diabetes

(2010) R. Novosyadlyy et al.   CANCER RESEARCH

Identification of Optimal Drug Combinations Targeting Cellular Networks: Integrating Phospho-Proteomics and Computational Network Analysis

(2010) S. Iadevaia et al.   CANCER RESEARCH

Insulin and Insulin-like Growth Factor-1 Receptors Act as Ligand-specific Amplitude Modulators of a Common Pathway Regulating Gene Transcription

(2010) Jeremie Boucher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

(2010) J. B. Spangler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antitumor Activity of GSK1904529A, a Small-molecule Inhibitor of the Insulin-like Growth Factor-I Receptor Tyrosine Kinase

(2009) P. Sabbatini et al.   CLINICAL CANCER RESEARCH

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease

(2009) Antonino Belfiore et al.   ENDOCRINE REVIEWS

Human aortic smooth muscle cells are insulin resistant at the receptor level but sensitive to IGF1 and IGF2

(2009) S I Chisalita et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Safety, Pharmacokinetics, and Pharmacodynamics of the Insulin-Like Growth Factor Type 1 Receptor Inhibitor Figitumumab (CP-751,871) in Combination with Paclitaxel and Carboplatin

(2009) Daniel D. Karp et al.   Journal of Thoracic Oncology

Transforming Growth Factor   Depletion Is the Primary Determinant of Smad Signaling Kinetics

(2009) D. C. Clarke et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer

(2009) J. Zha et al.   MOLECULAR CANCER THERAPEUTICS

AMG 479, a fully human anti-insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells

(2009) P. J. Beltran et al.   MOLECULAR CANCER THERAPEUTICS

Local Expression of Insulin-Like Growth Factor-I, Insulin-Like Growth Factor-I Receptor, and Estrogen Receptor Alpha in Ovarian Cancer

(2009) Yuan An et al.   ONKOLOGIE

Identification of c-Cbl as a New Ligase for Insulin-like Growth Factor-I Receptor with Distinct Roles from Mdm2 in Receptor Ubiquitination and Endocytosis

(2008) B. Sehat et al.   CANCER RESEARCH