The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring

O-GlcNAcylation modulates PKA-CREB signaling in a manner specific to PKA catalytic subunit isoforms

(2018) Nana Jin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The carnitine system and cancer metabolic plasticity

(2018) Mariarosa Anna Beatrice Melone et al.   Cell Death & Disease

Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis

(2018) Francesca Ricciardiello et al.   Cell Death & Disease

OGT-mediated O-GlcNAcylation on GLDC promotes metastasis in cervical cancer

(2018) Pingsheng Cai et al.   Oncotarget

Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

(2018) Hao Shi et al.   Molecular Metabolism

Fatty acid synthase inhibits theO-GlcNAcase during oxidative stress

(2017) Jennifer A. Groves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MitochondrialO-GlcNAc Transferase (mOGT) Regulates Mitochondrial Structure, Function, and Survival in HeLa Cells

(2017) Juliana L. Sacoman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein O-GlcNAcylation: emerging mechanisms and functions

(2017) Xiaoyong Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Elucidating crosstalk mechanisms between phosphorylation and O-GlcNAcylation

(2017) Aneika C. Leney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

O-GlcNAcylation destabilizes the active tetrameric PKM2 to promote the Warburg effect

(2017) Yang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative investigation of human cell surface N-glycoprotein dynamics

(2017) Haopeng Xiao et al.   Chemical Science

O-linked N-acetylglucosamine transferase enhances secretory clusterin expression via liver X receptors and sterol response element binding protein regulation in cervical cancer

(2017) Min Jun Kim et al.   Oncotarget

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

(2017) Jeff Charles Kremer et al.   Cell Reports

Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation

(2017) Lindsey Araujo et al.   eLife

Hyperglycemia exacerbates colon cancer malignancy through hexosamine biosynthetic pathway

(2017) A Vasconcelos-dos-Santos et al.   Oncogenesis

O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1α

(2017) Pedro Latorre et al.   PLoS One

Hyper-O-GlcNAcylation induces cisplatin resistance via regulation of p53 and c-Myc in human lung carcinoma

(2017) Sudjit Luanpitpong et al.   Scientific Reports

O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease

(2016) Shutao Xie et al.   AGING CELL

GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis

(2016) Darya Zibrova et al.   BIOCHEMICAL JOURNAL

Carnitine transport and fatty acid oxidation

(2016) Nicola Longo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tumour microenvironment factors shaping the cancer metabolism landscape

(2016) Dimitrios Anastasiou   BRITISH JOURNAL OF CANCER

The Emerging Hallmarks of Cancer Metabolism

(2016) Natalya N. Pavlova et al.   Cell Metabolism

Changes inO-LinkedN-Acetylglucosamine (O-GlcNAc) Homeostasis Activate the p53 Pathway in Ovarian Cancer Cells

(2016) Rafaela Muniz de Queiroz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Functions of Glycoconjugates in Autophagy

(2016) Kamau Fahie et al.   JOURNAL OF MOLECULAR BIOLOGY

The Nutrient-Dependent O -GlcNAc Modification Controls the Expression of Liver Fatty Acid Synthase

(2016) Steffi F. Baldini et al.   JOURNAL OF MOLECULAR BIOLOGY

O-GlcNAcylation in Cancer Biology: Linking Metabolism and Signaling

(2016) Christina M. Ferrer et al.   JOURNAL OF MOLECULAR BIOLOGY

Expression of serine/glycine metabolism-related proteins is different according to the thyroid cancer subtype

(2016) Woo Young Sun et al.   Journal of Translational Medicine

Facilitative glucose transporters: Implications for cancer detection, prognosis and treatment

(2016) Carly C. Barron et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The Role of PGC1  in Cancer Metabolism and its Therapeutic Implications

(2016) Z. Tan et al.   MOLECULAR CANCER THERAPEUTICS

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1

(2016) Joseph G. Moloughney et al.   MOLECULAR CELL

FOXO1 couples metabolic activity and growth state in the vascular endothelium

(2016) Kerstin Wilhelm et al.   NATURE

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

(2016) Mahima Swamy et al.   NATURE IMMUNOLOGY

Fucosylation of LAMP-1 and LAMP-2 by FUT1 correlates with lysosomal positioning and autophagic flux of breast cancer cells

(2016) Keng-Poo Tan et al.   Cell Death & Disease

Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma

(2016) Lan V. Pham et al.   Oncotarget

Inhibition of glucose metabolism prevents glycosylation of the glutamine transporter ASCT2 and promotes compensatory LAT1 upregulation in leukemia cells

(2016) Florence Polet et al.   Oncotarget

AMPK and PKA interaction in the regulation of survival of liver cancer cells subjected to glucose starvation

(2016) Anabela C. Ferretti et al.   Oncotarget

Hallmarks of glycosylation in cancer

(2016) Jennifer Munkley et al.   Oncotarget

Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis

(2016) Roberta Palorini et al.   PLoS Genetics

Hypoxia and metabolic adaptation of cancer cells

(2016) K L Eales et al.   Oncogenesis

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

Hijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated Neoplastic Phenotypes

(2016) Kekoa Taparra et al.   Frontiers in Oncology

Metabolic Reprogramming by Hexosamine Biosynthetic and Golgi N-Glycan Branching Pathways

(2016) Michael C. Ryczko et al.   Scientific Reports

Nutrient shortage triggers the hexosamine biosynthetic pathway via the GCN2-ATF4 signalling pathway

(2016) Cédric Chaveroux et al.   Scientific Reports

O-linked N-acetylglucosaminylation of Sp1 interferes with Sp1 activation of glycolytic genes

(2015) Kihong Lim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulatory O-GlcNAcylation sites on FoxO1 are yet to be identified

(2015) Yann Fardini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

N-linked Glycosylation of human SLC1A5 (ASCT2) transporter is critical for trafficking to membrane

(2015) Lara Console et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial ATP synthase activity is impaired by suppressedO-GlcNAcylation in Alzheimer's disease

(2015) Moon-Yong Cha et al.   HUMAN MOLECULAR GENETICS

Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners

(2015) Takashi Muramatsu   JOURNAL OF BIOCHEMISTRY

O-GlcNAcomic Profiling Identifies WidespreadO-Linked β-N-Acetylglucosamine Modification (O-GlcNAcylation) in Oxidative Phosphorylation System Regulating Cardiac Mitochondrial Function

(2015) Junfeng Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAPK/ERK signaling pathway-induced hyper-O-GlcNAcylation enhances cancer malignancy

(2015) Xinling Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

mTOR/MYC Axis Regulates O-GlcNAc Transferase Expression and O-GlcNAcylation in Breast Cancer

(2015) V. L. Sodi et al.   MOLECULAR CANCER RESEARCH

Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells

(2015) PARUNYA CHAIYAWAT et al.   ONCOLOGY REPORTS

Glycosylation inhibition reduces cholesterol accumulation in NPC1 protein-deficient cells

(2015) Jian Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth

(2015) Xiongjian Rao et al.   Nature Communications

CD147-CD98hc Complex Contributes to Poor Prognosis of Non-Small Cell Lung Cancer Patients Through Promoting Cell Proliferation Via the PI3K/Akt Signaling Pathway

(2014) Fei Fei et al.   ANNALS OF SURGICAL ONCOLOGY

Posttranslational modification of autophagy-related proteins in macroautophagy

(2014) Yangchun Xie et al.   Autophagy

Regulation of sodium glucose co-transporter SGLT1 through altered glycosylation in the intestinal epithelial cells

(2014) Subha Arthur et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life

(2014) Martin S. Denzel et al.   CELL

O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond

(2014) Scott A. Yuzwa et al.   CHEMICAL SOCIETY REVIEWS

AlteringO-Linked β-N-Acetylglucosamine Cycling Disrupts Mitochondrial Function

(2014) Ee Phie Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-talk between Two Essential Nutrient-sensitive Enzymes

(2014) John W. Bullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer Metabolism and ElevatedO-GlcNAc in Oncogenic Signaling

(2014) Zhiyuan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-specific metabolic phenotypes in metastatic breast cancer

(2014) Hye Min Kim et al.   Journal of Translational Medicine

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

AMPK regulates histone H2B O-GlcNAcylation

(2014) Qiuran Xu et al.   NUCLEIC ACIDS RESEARCH

Expression of metabolism-related proteins in invasive lobular carcinoma: comparison to invasive ductal carcinoma

(2014) Yon Hee Kim et al.   TUMOR BIOLOGY

Expression levels of serine/glycine metabolism-related proteins in triple negative breast cancer tissues

(2014) Songmi Noh et al.   TUMOR BIOLOGY

FOXO Transcription Factors: Their Clinical Significance and Regulation

(2014) Yu Wang et al.   Biomed Research International

O-GlcNAcylation: The Sweet Side of the Cancer

(2014) Rafaela Muniz de Queiroz et al.   Frontiers in Oncology

Probing the Hexosamine Biosynthetic Pathway in Human Tumor Cells by Multitargeted Tandem Mass Spectrometry

(2013) Anas M. Abdel Rahman et al.   ACS Chemical Biology

4F2hc-silencing impairs tumorigenicity of HeLa cells via modulation of galectin-3 and β-catenin signaling, and MMP-2 expression

(2013) Angélica Santiago-Gómez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

LKB1 and AMPK and the cancer-metabolism link - ten years after

(2013) D Hardie et al.   BMC BIOLOGY

Role of carbohydrate response element-binding protein (ChREBP) in generating an aerobic metabolic phenotype and in breast cancer progression

(2013) R E Airley et al.   BRITISH JOURNAL OF CANCER

O-GlcNAc Transferase Integrates Metabolic Pathways to Regulate the Stability of c-MYC in Human Prostate Cancer Cells

(2013) H. M. Itkonen et al.   CANCER RESEARCH

Triptolide-induced Cell Death in Pancreatic Cancer Is Mediated byO-GlcNAc Modification of Transcription Factor Sp1

(2013) Sulagna Banerjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyper-O-GlcNAcylation Is Anti-apoptotic and Maintains Constitutive NF-κB Activity in Pancreatic Cancer Cells

(2013) Zhiyuan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oleic Acid Stimulates Complete Oxidation of Fatty Acids through Protein Kinase A-dependent Activation of SIRT1-PGC1α Complex

(2013) Ji-Hong Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteome Wide Purification and Identification of O-GlcNAc-Modified Proteins Using Click Chemistry and Mass Spectrometry

(2013) Hannes Hahne et al.   JOURNAL OF PROTEOME RESEARCH

Hexosamine Biosynthesis Impairs Insulin Action via a Cholesterolgenic Response

(2013) Brent A. Penque et al.   MOLECULAR ENDOCRINOLOGY

Aberrant O-GlcNAc-modified proteins expressed in primary colorectal cancer

(2013) THANONG PHUEAOUAN et al.   ONCOLOGY REPORTS

Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

(2013) F. Guillaumond et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic analysis and abrogated expression ofO-GlcNAcylated proteins associated with primary breast cancer

(2013) Voraratt Champattanachai et al.   PROTEOMICS

Excess of O-linked N-acetylglucosamine modifies human pluripotent stem cell differentiation

(2013) Julien Jean Pierre Maury et al.   Stem Cell Research

Nutrient transporters: the Achilles’ heel of anabolism

(2013) Alison N. McCracken et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response

(2013) R Palorini et al.   Cell Death & Disease

O-GlcNAcylation: A New Cancer Hallmark?

(2013) Yann Fardini et al.   Frontiers in Endocrinology

SLC22A5/OCTN2 expression in breast cancer is induced by estrogen via a novel intronic estrogen-response element (ERE)

(2012) Chunyu Wang et al.   BREAST CANCER RESEARCH AND TREATMENT

Glycine Decarboxylase Activity Drives Non-Small Cell Lung Cancer Tumor-Initiating Cells and Tumorigenesis

(2012) Wen Cai Zhang et al.   CELL

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

(2012) Haoqiang Ying et al.   CELL

O-GlcNAc Transferase/Host Cell Factor C1 Complex Regulates Gluconeogenesis by Modulating PGC-1α Stability

(2012) Hai-Bin Ruan et al.   Cell Metabolism

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Modulation of Dynamin-related Protein 1 (DRP1) Function by IncreasedO-linked-β-N-acetylglucosamine Modification (O-GlcNAc) in Cardiac Myocytes

(2012) Thomas Gawlowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose Deprivation-induced Increase in ProteinO-GlcNAcylation in Cardiomyocytes Is Calcium-dependent

(2012) Luyun Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxO1 Inhibits Sterol Regulatory Element-binding Protein-1c (SREBP-1c) Gene Expression via Transcription Factors Sp1 and SREBP-1c

(2012) Xiong Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role ofO-Linked β-N-Acetylglucosamine Transferase in Prostate Cancer Invasion, Angiogenesis, and Metastasis

(2012) Thomas P. Lynch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A metabolic prosurvival role for PML in breast cancer

(2012) Arkaitz Carracedo et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of SLC3A2 Cell Membrane Protein as a Potential Gastric Cancer Biomarker: Implications in Molecular Imaging

(2012) Yixuan Yang et al.   JOURNAL OF PROTEOME RESEARCH

ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

(2012) Weiwei Yang et al.   NATURE CELL BIOLOGY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

(2012) Dimitrios Anastasiou et al.   Nature Chemical Biology

Vertebrate protein glycosylation: diversity, synthesis and function

(2012) Kelley W. Moremen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oncogenic K-ras expression is associated with derangement of the cAMP/PKA pathway and forskolin-reversible alterations of mitochondrial dynamics and respiration

(2012) R Palorini et al.   ONCOGENE

Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

(2012) W. Yi et al.   SCIENCE

The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation

(2012) Laura Tornatore et al.   TRENDS IN CELL BIOLOGY

Regulation of mitochondrial morphology and function by O-GlcNAcylation in neonatal cardiac myocytes

(2011) Ayako Makino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy

(2011) Wenyi Mi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PGC1  Promotes Tumor Growth by Inducing Gene Expression Programs Supporting Lipogenesis

(2011) K. Bhalla et al.   CANCER RESEARCH

O-GlcNAc transferase: A sweet new cancer target

(2011) Thomas P. Lynch et al.   CELL CYCLE

Gene expression of O-GlcNAc cycling enzymes in human breast cancers

(2011) Anna Krześlak et al.   CLINICAL AND EXPERIMENTAL MEDICINE

O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver

(2011) C. Guinez et al.   DIABETES

Fat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscle

(2011) K. M. Habegger et al.   DIABETOLOGIA

Evidence Coupling Increased Hexosamine Biosynthesis Pathway Activity to Membrane Cholesterol Toxicity and Cortical Filamentous Actin Derangement Contributing to Cellular Insulin Resistance†

(2011) Padma Bhonagiri et al.   ENDOCRINOLOGY

N-Glycosylation Is Critical for the Stability and Intracellular Trafficking of Glucose Transporter GLUT4

(2011) Yoshimi Haga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic regulation by p53

(2011) Oliver D. K. Maddocks et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

O-GlcNAcylation plays a role in tumor recurrence of hepatocellular carcinoma following liver transplantation

(2011) Qianqian Zhu et al.   MEDICAL ONCOLOGY

The cAMP/PKA Pathway Rapidly Activates SIRT1 to Promote Fatty Acid Oxidation Independently of Changes in NAD+

(2011) Zachary Gerhart-Hines et al.   MOLECULAR CELL

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

(2011) D. Gaglio et al.   Molecular Systems Biology

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

(2011) Ryan D. Morin et al.   NATURE

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration

(2011) Claudio Mauro et al.   NATURE CELL BIOLOGY

CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors

(2011) R. Le Floch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of O-linked GlcNAc modification on the glucose response of ChREBP

(2010) Haruhiko Sakiyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Glycosylation of the OCTN2 carnitine transporter: Study of natural mutations identified in patients with primary carnitine deficiency

(2010) Cristina Amat di San Filippo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Elevated O-LinkedN-Acetylglucosamine Correlated with Reduced Sp1 Cooperative DNA Binding with Its Collaborating Factorsin Vivo

(2010) Kihong LIM et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Impairment of mitochondrial respiration in mouse fibroblasts byoncogenic H-RASQ61L

(2010) Dianer Yang et al.   CANCER BIOLOGY & THERAPY

GlcNAcylation Plays an Essential Role in Breast Cancer Metastasis

(2010) Y. Gu et al.   CANCER RESEARCH

The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

(2010) K. E. Wellen et al.   GENES & DEVELOPMENT

Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC

(2010) Kazuki Nakajima et al.   GLYCOBIOLOGY

A novel sialyltransferase inhibitor AL10 suppresses invasion and metastasis of lung cancer cells by inhibiting integrin-mediated signaling

(2010) Chi-Hsiang Chiang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1

(2010) S A Caldwell et al.   ONCOGENE

Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity

(2009) Christine R. Hamiel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells

(2009) Alessandra Baracca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

(2009) T Mashima et al.   BRITISH JOURNAL OF CANCER

Metabolism, Cell Surface Organization, and Disease

(2009) James W. Dennis et al.   CELL

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis

(2009) Nabil Djouder et al.   EMBO JOURNAL

AMP-activated protein kinase phosphorylates glutamine : fructose-6-phosphate amidotransferase 1 at Ser243 to modulate its enzymatic activity

(2009) Satoshi Eguchi et al.   GENES TO CELLS

Sp1 coordinately regulatesde novolipogenesis and proliferation in cancer cells

(2009) Suying Lu et al.   INTERNATIONAL JOURNAL OF CANCER

Homo sapiens Lactate Dehydrogenase c (Ldhc) Gene Expression in Cancer Cells Is Regulated by Transcription Factor Sp1, CREB, and CpG Island Methylation

(2009) H. Tang et al.   JOURNAL OF ANDROLOGY

Peroxisome Proliferator-Activated Receptor γ Coactivator-1α Interacts with the Androgen Receptor (AR) and Promotes Prostate Cancer Cell Growth by Activating the AR

(2009) Masaki Shiota et al.   MOLECULAR ENDOCRINOLOGY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

mTOR and HIF-1 -mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

(2009) D. B. Shackelford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation

(2009) X. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of PPARγ negatively regulates O-GlcNAcylation of Sp1

(2008) Sung Soo Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

O-GlcNAcylation disrupts glyceraldehyde-3-phosphate dehydrogenase homo-tetramer formation and mediates its nuclear translocation

(2008) Jungeun Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

O-GlcNAc modification of FoxO1 increases its transcriptional activity: A role in the glucotoxicity phenomenon?

(2008) MeiShiue Kuo et al.   BIOCHIMIE

O-GlcNAc modification of Sp1 inhibits the functional interaction between Sp1 and Oct1

(2008) Kihong Lim et al.   FEBS LETTERS

N-Glycans in cancer progression

(2008) K. S Lau et al.   GLYCOBIOLOGY

Up-regulation ofO-GlcNAc Transferase with Glucose Deprivation in HepG2 Cells Is Mediated by Decreased Hexosamine Pathway Flux

(2008) Rodrick P. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose Deprivation StimulatesO-GlcNAc Modification of Proteins through Up-regulation ofO-LinkedN-Acetylglucosaminyltransferase

(2008) Rodrick P. Taylor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-GlcNAc Regulates FoxO Activation in Response to Glucose

(2008) Michael P. Housley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Enzymatic O-GlcNAcylation of Mitochondrial Proteins Impairs Mitochondrial Function in Cardiac Myocytes Exposed to High Glucose

(2008) Yong Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct In-Gel Fluorescence Detection and Cellular Imaging ofO-GlcNAc-Modified Proteins

(2008) Peter M. Clark et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Nutrient transporters in cancer: Relevance to Warburg hypothesis and beyond

(2008) Vadivel Ganapathy et al.   PHARMACOLOGY & THERAPEUTICS

NF B activation is associated with its O-GlcNAcylation state under hyperglycemic conditions

(2008) W. H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

O-GlcNAc modification of transcription factors, glucose sensing and glucotoxicity

(2008) Tarik Issad et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM