MAPK/ERK signaling pathway-induced hyper-O-GlcNAcylation enhances cancer malignancy

Hyper-O-GlcNAcylation Is Anti-apoptotic and Maintains Constitutive NF-κB Activity in Pancreatic Cancer Cells

(2013) Zhiyuan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Signal Transducer and Activator of Transcription 5b (Stat5b) Serine 193 Is a Novel Cytokine-induced Phospho-regulatory Site That Is Constitutively Activated in Primary Hematopoietic Malignancies

(2012) Abhisek Mitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

O-Linked β-N-Acetylglucosaminylation (O-GlcNAcylation) in Primary and Metastatic Colorectal Cancer Clones and Effect ofN-Acetyl-β-d-glucosaminidase Silencing on Cell Phenotype and Transcriptome

(2012) Galit Yehezkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Increase inO-LinkedN-Acetylglucosamine Protein Modification Stimulates Chondrogenic Differentiation Bothin Vitroandin Vivo

(2012) Jessica Andrés-Bergós et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role ofO-Linked β-N-Acetylglucosamine Transferase in Prostate Cancer Invasion, Angiogenesis, and Metastasis

(2012) Thomas P. Lynch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation

(2012) Jessica E Rexach et al.   Nature Chemical Biology

O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy

(2011) Wenyi Mi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

TP53 genomics predict higher clinical and pathologic tumor response in operable early-stage breast cancer treated with docetaxel-capecitabine ± trastuzumab

(2011) Stefan Glück et al.   BREAST CANCER RESEARCH AND TREATMENT

Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas

(2011) H. Okayama et al.   CANCER RESEARCH

O-GlcNAcylation plays a role in tumor recurrence of hepatocellular carcinoma following liver transplantation

(2011) Qianqian Zhu et al.   MEDICAL ONCOLOGY

GlcNAcylation Plays an Essential Role in Breast Cancer Metastasis

(2010) Y. Gu et al.   CANCER RESEARCH

A ‘metastasis-prone’ signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics

(2010) Yi Hong et al.   CLINICAL & EXPERIMENTAL METASTASIS

Targeting CREB for Cancer Therapy: Friend or Foe

(2010) X. Xiao et al.   CURRENT CANCER DRUG TARGETS

Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition

(2010) Sang Yoon Park et al.   EMBO JOURNAL

Regulation of AMPA Receptor Trafficking by O-Glycosylation

(2010) Takeshi Kanno et al.   NEUROCHEMICAL RESEARCH

Stage-Associated Dynamic Activity Profile of Transcription Factors in Nasopharyngeal Carcinoma Progression Based on Protein/DNA Array Analysis

(2010) Bo Su et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1

(2010) S A Caldwell et al.   ONCOGENE

Modeling Oncogenic Signaling in Colon Tumors by Multidirectional Analyses of Microarray Data Directed for Maximization of Analytical Reliability

(2010) Magdalena Skrzypczak et al.   PLoS One

O-linked β-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress

(2009) Chutikarn Butkinaree et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Gene expression profiling of advanced-stage serous ovarian cancers distinguishes novel subclasses and implicatesZEB2in tumor progression and prognosis

(2009) Kosuke Yoshihara et al.   CANCER SCIENCE

CREB in the Pathophysiology of Cancer: Implications for Targeting Transcription Factors for Cancer Therapy

(2009) K. M. Sakamoto et al.   CLINICAL CANCER RESEARCH

Identification of the Transcription Factor Single-Minded Homologue 2 as a Potential Biomarker and Immunotherapy Target in Prostate Cancer

(2009) M. S. Arredouani et al.   CLINICAL CANCER RESEARCH

Tumor Immunobiological Differences in Prostate Cancer between African-American and European-American Men

(2008) T. A. Wallace et al.   CANCER RESEARCH

Advances in Targeting the Ras/Raf/MEK/Erk Mitogen-Activated Protein Kinase Cascade with MEK Inhibitors for Cancer Therapy

(2008) B. B. Friday et al.   CLINICAL CANCER RESEARCH

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

(2008) Scott A Yuzwa et al.   Nature Chemical Biology