Oncogenic K-ras expression is associated with derangement of the cAMP/PKA pathway and forskolin-reversible alterations of mitochondrial dynamics and respiration

From cancer metabolism to new biomarkers and drug targets

(2011) F. Chiaradonna et al.   BIOTECHNOLOGY ADVANCES

The regulation of mitochondrial morphology: Intricate mechanisms and dynamic machinery

(2011) Catherine S. Palmer et al.   CELLULAR SIGNALLING

Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth

(2011) D. Gaglio et al.   Molecular Systems Biology

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

Mechanism of Neuroprotective Mitochondrial Remodeling by PKA/AKAP1

(2011) Ronald A. Merrill et al.   PLOS BIOLOGY

Mitochondrial respiratory chain super-complex I–III in physiology and pathology

(2010) Giorgio Lenaz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The β-adrenoceptor agonist isoproterenol promotes the activity of respiratory chain complex I and lowers cellular reactive oxygen species in fibroblasts and heart myoblasts

(2010) Domenico De Rasmo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-Talk Between PKA and Akt Protects Endothelial Cells From Apoptosis in the Late Ischemic Preconditioning

(2009) Alessandro Bellis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Mitochondrial Complex I decrease is responsible for bioenergetic dysfunction in K-ras transformed cells

(2009) Alessandra Baracca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Data recovery and integration from public databases uncovers transformation-specific transcriptional downregulation of cAMP-PKA pathway-encoding genes

(2009) Chiara Balestrieri et al.   BMC BIOINFORMATICS

Cyclic AMP Produced inside Mitochondria Regulates Oxidative Phosphorylation

(2009) Rebeca Acin-Perez et al.   Cell Metabolism

Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis

(2009) Jianxin Lu et al.   CELL RESEARCH

cAMP response element-binding protein (CREB) is imported into mitochondria and promotes protein synthesis

(2009) Domenico De Rasmo et al.   FEBS Journal

Mitochondrial DNA Instability and Metabolic Shift in Human Cancers

(2009) Hsin-Chen Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oncogenic Ras Blocks the cAMP Pathway and Dedifferentiates Thyroid Cells Via an Impairment of Pax8 Transcriptional Activity

(2009) Maria Giuseppina Baratta et al.   MOLECULAR ENDOCRINOLOGY

Inducible cAMP Early Repressor (ICER) and Brain Functions

(2009) Gilyana Borlikova et al.   MOLECULAR NEUROBIOLOGY

Glutamine Deprivation Induces Abortive S-Phase Rescued by Deoxyribonucleotides in K-Ras Transformed Fibroblasts

(2009) Daniela Gaglio et al.   PLoS One

Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

(2009) J. Yun et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Mitochondrial oxidative phosphorylation and energetic status are reflected by morphology of mitochondrial network in INS-1E and HEP-G2 cells viewed by 4Pi microscopy

(2008) Lydie Plecitá-Hlavatá et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mammalian complex I: A regulable and vulnerable pacemaker in mitochondrial respiratory function

(2008) Sergio Papa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility

(2008) Nancy Gerits et al.   CELLULAR SIGNALLING

RAS and PKA pathways in cancer: new insight from transcriptional analysis

(2008) Ferdinando Chiaradonna   Frontiers in Bioscience-Landmark

Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

(2008) Thomas McFate et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial dynamics and cancer

(2008) Stéphanie Grandemange et al.   SEMINARS IN CANCER BIOLOGY