Hijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated Neoplastic Phenotypes
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Hijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated Neoplastic Phenotypes
Authors
Keywords
-
Journal
Frontiers in Oncology
Volume 6, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2016-04-18
DOI
10.3389/fonc.2016.00085
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression
- (2016) Ashik Jawahar Deen et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Catabolic metabolism during cancer EMT
- (2015) Yong Hoon Cha et al. ARCHIVES OF PHARMACAL RESEARCH
- Hyaluronidases and hyaluronan synthases expression is inversely correlated with malignancy in lung/bronchial pre-neoplastic and neoplastic lesions, affecting prognosis
- (2015) V.K. de Sá et al. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
- The galectin lattice at a glance
- (2015) I. R. Nabi et al. JOURNAL OF CELL SCIENCE
- Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
- (2015) Xiaofeng Zheng et al. NATURE
- Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance
- (2015) Kari R. Fischer et al. NATURE
- Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer
- (2015) S Carvalho et al. ONCOGENE
- N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes
- (2015) Karol Kaszuba et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling
- (2015) Suresh Marada et al. PLoS Genetics
- Epithelial-to-Mesenchymal Plasticity Harnesses Endocytic Circuitries
- (2015) Salvatore Corallino et al. Frontiers in Oncology
- Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against Cancer
- (2015) Andréia Vasconcelos-dos-Santos et al. Frontiers in Oncology
- Hyaluronan: Biosynthesis and signaling
- (2014) Davide Vigetti et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Overexpression of N-acetylglucosaminyltransferases III and V in human melanoma cells. Implications for MCAM N-glycosylation
- (2014) Monika Bubka et al. BIOCHIMIE
- Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition
- (2014) Yoav D. Shaul et al. CELL
- O-GlcNAcylation stabilizes β-catenin through direct competition with phosphorylation at threonine 41
- (2014) Stéphanie Olivier-Van Stichelen et al. FASEB JOURNAL
- Knockdown of Mgat5 Inhibits Breast Cancer Cell Growth with Activation of CD4+ T Cells and Macrophages
- (2014) D. Li et al. JOURNAL OF IMMUNOLOGY
- The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc
- (2014) Vincent C. Hascall et al. MATRIX BIOLOGY
- O-GlcNAcylation Regulates Cancer Metabolism and Survival Stress Signaling via Regulation of the HIF-1 Pathway
- (2014) Christina M. Ferrer et al. MOLECULAR CELL
- O-GlcNAcylation is increased in prostate cancer tissues and enhances malignancy of prostate cancer cells
- (2014) YUCHAO GU et al. Molecular Medicine Reports
- Molecular mechanisms of epithelial–mesenchymal transition
- (2014) Samy Lamouille et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- UAP1 is overexpressed in prostate cancer and is protective against inhibitors of N-linked glycosylation
- (2014) H M Itkonen et al. ONCOGENE
- Regulation of the protein stability of EMT transcription factors
- (2014) VM Díaz et al. Cell Adhesion & Migration
- Probing the Hexosamine Biosynthetic Pathway in Human Tumor Cells by Multitargeted Tandem Mass Spectrometry
- (2013) Anas M. Abdel Rahman et al. ACS Chemical Biology
- Hyaluronan synthases (HAS1–3) in stromal and malignant cells correlate with breast cancer grade and predict patient survival
- (2013) Päivi Auvinen et al. BREAST CANCER RESEARCH AND TREATMENT
- EMT in developmental morphogenesis
- (2013) Yukiko Nakaya et al. CANCER LETTERS
- Expression of integrins α3β1 and α5β1 and GlcNAc β1,6 glycan branching influences metastatic melanoma cell migration on fibronectin
- (2013) Ewa Pocheć et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- Hyper-O-GlcNAcylation Is Anti-apoptotic and Maintains Constitutive NF-κB Activity in Pancreatic Cancer Cells
- (2013) Zhiyuan Ma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Comparative N-Glycan Profiling of Colorectal Cancer Cell Lines Reveals Unique Bisecting GlcNAc and α-2,3-Linked Sialic Acid Determinants Are Associated with Membrane Proteins of the More Metastatic/Aggressive Cell Lines
- (2013) Manveen K. Sethi et al. JOURNAL OF PROTEOME RESEARCH
- The epigenetics of epithelial-mesenchymal plasticity in cancer
- (2013) Wai Leong Tam et al. NATURE MEDICINE
- Aberrant O-GlcNAc-modified proteins expressed in primary colorectal cancer
- (2013) THANONG PHUEAOUAN et al. ONCOLOGY REPORTS
- Prognostic Impact of Hyaluronan and Its Regulators in Pancreatic Ductal Adenocarcinoma
- (2013) Xiao-Bo Cheng et al. PLoS One
- Overexpression of O-GlcNAc by prostate cancer cells is significantly associated with poor prognosis of patients
- (2013) T Kamigaito et al. PROSTATE CANCER AND PROSTATIC DISEASES
- Proteomic analysis and abrogated expression ofO-GlcNAcylated proteins associated with primary breast cancer
- (2013) Voraratt Champattanachai et al. PROTEOMICS
- Prediction of glycan motifs using quantitative analysis of multi-lectin binding: Motifs on MUC1 produced by cultured pancreatic cancer cells
- (2013) Calvin McCarter et al. Proteomics Clinical Applications
- TGF-β sensitivity is determined by N-linked glycosylation of the type II TGF-β receptor
- (2012) Young-Woong Kim et al. BIOCHEMICAL JOURNAL
- EMT and MET in Metastasis: Where Are the Cancer Stem Cells?
- (2012) Thomas Brabletz CANCER CELL
- Increased hyaluronan content and stromal cell CD44 associate withHER2positivity and poor prognosis in human breast cancer
- (2012) Päivi Auvinen et al. INTERNATIONAL JOURNAL OF CANCER
- Galectin-3 Protein Regulates Mobility of N-cadherin and GM1 Ganglioside at Cell-Cell Junctions of Mammary Carcinoma Cells
- (2012) Cécile Boscher et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- O-Linked β-N-Acetylglucosaminylation (O-GlcNAcylation) in Primary and Metastatic Colorectal Cancer Clones and Effect ofN-Acetyl-β-d-glucosaminidase Silencing on Cell Phenotype and Transcriptome
- (2012) Galit Yehezkel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Critical Role ofO-Linked β-N-Acetylglucosamine Transferase in Prostate Cancer Invasion, Angiogenesis, and Metastasis
- (2012) Thomas P. Lynch et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Loss and Recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation Is a Mechanism Involved in Epithelial-Mesenchymal-Epithelial Transitions
- (2012) Salomé S. Pinho et al. PLoS One
- Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF- B acetylation and transcription
- (2012) D. F. Allison et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism
- (2012) W. Yi et al. SCIENCE
- Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression
- (2012) M. L. Stallings-Mann et al. Science Translational Medicine
- Twist1 Suppresses Senescence Programs and Thereby Accelerates and Maintains Mutant Kras-Induced Lung Tumorigenesis
- (2012) Phuoc T. Tran et al. PLoS Genetics
- Serum-stimulated cell cycle entry promotes ncOGT synthesis required for cyclin D expression
- (2012) S Olivier-Van Stichelen et al. Oncogenesis
- O-GlcNAcylation is a novel regulator of lung and colon cancer malignancy
- (2011) Wenyi Mi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- E/N-cadherin switch mediates cancer progression via TGF-β-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma
- (2011) K Araki et al. BRITISH JOURNAL OF CANCER
- Engagement of I-Branching -1, 6-N-Acetylglucosaminyltransferase 2 in Breast Cancer Metastasis and TGF- Signaling
- (2011) H. Zhang et al. CANCER RESEARCH
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Gene expression of O-GlcNAc cycling enzymes in human breast cancers
- (2011) Anna Krześlak et al. CLINICAL AND EXPERIMENTAL MEDICINE
- O-Glucose Trisaccharide Is Present at High but Variable Stoichiometry at Multiple Sites on Mouse Notch1
- (2011) Nadia A. Rana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Heterotrimeric GiProteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration
- (2011) Ariel H. Polizio et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- O-GlcNAcylation plays a role in tumor recurrence of hepatocellular carcinoma following liver transplantation
- (2011) Qianqian Zhu et al. MEDICAL ONCOLOGY
- Epithelial to Mesenchymal Transition in Human Skin Wound Healing Is Induced by Tumor Necrosis Factor-α through Bone Morphogenic Protein-2
- (2010) Chunli Yan et al. AMERICAN JOURNAL OF PATHOLOGY
- Oncogenic KRas Suppresses Inflammation-Associated Senescence of Pancreatic Ductal Cells
- (2010) Kyoung Eun Lee et al. CANCER CELL
- The Bisecting GlcNAc on N-Glycans Inhibits Growth Factor Signaling and Retards Mammary Tumor Progression
- (2010) Y. Song et al. CANCER RESEARCH
- GlcNAcylation Plays an Essential Role in Breast Cancer Metastasis
- (2010) Y. Gu et al. CANCER RESEARCH
- Transcriptional crosstalk between TGFβ and stem cell pathways in tumor cell invasion: Role of EMT promoting Smad complexes
- (2010) Jonas Fuxe et al. CELL CYCLE
- Modulation of E-cadherin function and dysfunction by N-glycosylation
- (2010) Salomé S. Pinho et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition
- (2010) Sang Yoon Park et al. EMBO JOURNAL
- Integrin–TGF-β crosstalk in fibrosis, cancer and wound healing
- (2010) Coert Margadant et al. EMBO REPORTS
- The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
- (2010) K. E. Wellen et al. GENES & DEVELOPMENT
- Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC
- (2010) Kazuki Nakajima et al. GLYCOBIOLOGY
- N-Glycosylation GeneDPAGT1Is a Target of the Wnt/β-Catenin Signaling Pathway
- (2010) Pritam K. Sengupta et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
- (2010) Hui-Kuan Lin et al. NATURE
- Role of CK1 in GSK3β-mediated phosphorylation and degradation of Snail
- (2010) Y Xu et al. ONCOGENE
- Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1
- (2010) S A Caldwell et al. ONCOGENE
- ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI/SNF chromatin-remodeling protein BRG1
- (2010) E Sánchez-Tilló et al. ONCOGENE
- EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
- (2010) A Singh et al. ONCOGENE
- Snail
- (2010) Yadi Wu et al. Cell Adhesion & Migration
- Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-β1 in Renal Tubular Epithelial Cells
- (2009) Guoping Zheng et al. AMERICAN JOURNAL OF PATHOLOGY
- Role of E-cadherin N-glycosylation profile in a mammary tumor model
- (2009) Salomé S. Pinho et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The hexosamine signaling pathway: O-GlcNAc cycling in feast or famine
- (2009) John A. Hanover et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Importance of N-Glycosylation on α5β1 Integrin for Its Biological Functions
- (2009) Jianguo Gu et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- EMT, the cytoskeleton, and cancer cell invasion
- (2009) Mahmut Yilmaz et al. CANCER AND METASTASIS REVIEWS
- The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
- (2009) Raphael Kopan et al. CELL
- Epithelial-Mesenchymal Transitions in Development and Disease
- (2009) Jean Paul Thiery et al. CELL
- EMT 2.0: shaping epithelia through collective migration
- (2009) Céline Revenu et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Inflammation and EMT: an alliance towards organ fibrosis and cancer progression
- (2009) Jose Miguel López-Novoa et al. EMBO Molecular Medicine
- Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation
- (2009) Kelly M Kennedy et al. Future Oncology
- AnN-Glycosylation Site on theβ-Propeller Domain of the Integrin α5 Subunit Plays Key Roles in Both Its Function and Site-specific Modification byβ1,4-N-Acetylglucosaminyltransferase III
- (2009) Yuya Sato et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- O-LinkedN-Acetylglucosamine Modification on CCAAT Enhancer-binding Protein β
- (2009) Xi Li et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Homotypic Cell-Cell Adhesion by BranchedN-Glycosylation of N-cadherin Extracellular EC2 and EC3 Domains
- (2009) Hua-Bei Guo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Collective cell migration in morphogenesis, regeneration and cancer
- (2009) Peter Friedl et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells
- (2009) Olivier Feron RADIOTHERAPY AND ONCOLOGY
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Glucose induces an autocrine activation of the Wnt/β-catenin pathway in macrophage cell lines
- (2008) Sasha H. Anagnostou et al. BIOCHEMICAL JOURNAL
- Deregulating EMT and Senescence: Double Impact by a Single Twist
- (2008) Marjon A. Smit et al. CANCER CELL
- Induction of EMT by Twist Proteins as a Collateral Effect of Tumor-Promoting Inactivation of Premature Senescence
- (2008) Stéphane Ansieau et al. CANCER CELL
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- N-Glycans in cancer progression
- (2008) K. S Lau et al. GLYCOBIOLOGY
- Unglycosylation at Asn-633 made extracellular domain of E-cadherin folded incorrectly and arrested in endoplasmic reticulum, then sequentially degraded by ERAD
- (2008) Feng Zhou et al. GLYCOCONJUGATE JOURNAL
- O-LinkedN-Acetylglucosamine Is Present on the Extracellular Domain of Notch Receptors
- (2008) Aiko Matsuura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- O-GlcNAc Regulates FoxO Activation in Response to Glucose
- (2008) Michael P. Housley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells
- (2008) Celeste M. Nelson et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Tumor metabolism: cancer cells give and take lactate
- (2008) Gregg L. Semenza JOURNAL OF CLINICAL INVESTIGATION
- Transcriptional regulation of cell polarity in EMT and cancer
- (2008) G Moreno-Bueno et al. ONCOGENE
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
- (2008) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- NF B activation is associated with its O-GlcNAcylation state under hyperglycemic conditions
- (2008) W. H. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
- (2007) Farhad Vesuna et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExplorePublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More