YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting

Metabolic features of cancer stem cells: the emerging role of lipid metabolism

(2018) Rita Mancini et al.   ONCOGENE

YAP triggers the Wnt/β-catenin signalling pathway and promotes enterocyte self-renewal, regeneration and tumorigenesis after DSS-induced injury

(2018) Feihong Deng et al.   Cell Death & Disease

Immunotherapy revolutionises non-small-cell lung cancer therapy: Results, perspectives and new challenges

(2017) Etienne Giroux Leprieur et al.   EUROPEAN JOURNAL OF CANCER

β-catenin-mediated YAP signaling promotes human glioma growth

(2017) Yan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Emerging roles of lipid metabolism in cancer metastasis

(2017) Xiangjian Luo et al.   Molecular Cancer

Ski regulates Smads and TAZ signaling to suppress lung cancer progression

(2017) Mian Xie et al.   MOLECULAR CARCINOGENESIS

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3

(2017) S Sengupta et al.   ONCOGENE

Stearoyl-CoA-desaturase 1 regulates lung cancer stemness via stabilization and nuclear localization of YAP/TAZ

(2017) A Noto et al.   ONCOGENE

Molecular Alterations and Expression Dynamics of LATS1 and LATS2 Genes in Non-Small-Cell Lung Carcinoma

(2017) Showkat A. Malik et al.   PATHOLOGY & ONCOLOGY RESEARCH

Statin improves survival in patients with EGFR-TKI lung cancer: A nationwide population-based study

(2017) Ming-Szu Hung et al.   PLoS One

TAZ induces lung cancer stem cell properties and tumorigenesis by up-regulating ALDH1A1

(2017) Jihang Yu et al.   Oncotarget

YAP regulates PD-L1 expression in human NSCLC cells

(2017) Jinbai Miao et al.   Oncotarget

The Hippo pathway in tissue homeostasis and regeneration

(2017) Yu Wang et al.   Protein & Cell

EGFR tyrosine kinase inhibitors as first-line therapy in advanced EGFR mutation-positive non-small cell lung cancer: strategies to improve clinical outcome

(2017) Andreas Tiefenbacher et al.   Journal of Thoracic Disease

Hippo pathway in lung development

(2017) Yuyuan Dai et al.   Journal of Thoracic Disease

YAP-Dependent AXL Overexpression Mediates Resistance to EGFR Inhibitors in NSCLC

(2017) Elena Ghiso et al.   NEOPLASIA

Yes-Associated Protein 1 Promotes Adenocarcinoma Growth and Metastasis through Activation of the Receptor Tyrosine Kinase Axl

(2017) Z-L. Cui et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex

(2017) Hung Yi Kristal Kaan et al.   Scientific Reports

PD-L1 expression in lung cancer and its correlation with driver mutations: a meta-analysis

(2017) Minghui Zhang et al.   Scientific Reports

Honokiol inhibits EMT-mediated motility and migration of human non-small cell lung cancer cells in vitro by targeting c-FLIP

(2016) Xiao-qin Lv et al.   ACTA PHARMACOLOGICA SINICA

Hippo pathway effector YAP inhibition restores the sensitivity of EGFR-TKI in lung adenocarcinoma having primary or acquired EGFR-TKI resistance

(2016) Jeong Eun Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Honokiol Decreases Lung Cancer Metastasis through Inhibition of the STAT3 Signaling Pathway

(2016) Jing Pan et al.   Cancer Prevention Research

RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

(2016) Fatéméh Dubois et al.   CANCER RESEARCH

Loss ofYAP1defines neuroendocrine differentiation of lung tumors

(2016) Takeshi Ito et al.   CANCER SCIENCE

YAP and TAZ modulate cell phenotype in a subset of small cell lung cancer

(2016) Masafumi Horie et al.   CANCER SCIENCE

MCM7and its hosted miR-25, 93 and 106b cluster elicit YAP/TAZ oncogenic activity in lung cancer

(2016) Federica Lo Sardo et al.   CARCINOGENESIS

The Hippo pathway, p53 and cholesterol

(2016) Yael Aylon et al.   CELL CYCLE

Protective Effects of Statins in Cancer: Should They Be Prescribed for High-Risk Patients?

(2016) Ange Wang et al.   Current Atherosclerosis Reports

EGFR Transactivation by Peptide G Protein-Coupled Receptors in Cancer

(2016) Terry W. Moody et al.   CURRENT DRUG TARGETS

Inflammation and cancer: tissue regeneration gone awry

(2016) Marina Pesic et al.   CURRENT OPINION IN CELL BIOLOGY

Integrin signalling regulates YAP and TAZ to control skin homeostasis

(2016) Ahmed Elbediwy et al.   DEVELOPMENT

Somatically mutated ABL1 is an actionable and essential NSCLC survival gene

(2016) E. Testoni et al.   EMBO Molecular Medicine

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

(2016) Thomas Bertero et al.   JOURNAL OF CLINICAL INVESTIGATION

The effect of statins on survival in patients with stage IV lung cancer

(2016) Jenny J. Lin et al.   LUNG CANCER

Long Noncoding RNA PVT1 Promotes Non-Small Cell Lung Cancer Cell Proliferation through Epigenetically Regulating LATS2 Expression

(2016) L. Wan et al.   MOLECULAR CANCER THERAPEUTICS

Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

(2016) Andrew G. Cox et al.   NATURE CELL BIOLOGY

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

(2016) Joshua D Campbell et al.   NATURE GENETICS

Targeting the KRAS Pathway in Non-Small Cell Lung Cancer

(2016) P. Tomasini et al.   ONCOLOGIST

Anexelekto (AXL) Increases Resistance to EGFR-TKI and Activation of AKT and ERK1/2 in Non-Small Cell Lung Cancer Cells

(2016) Yaqiong Tian et al.   ONCOLOGY RESEARCH

Implications of MDSCs-targeting in lung cancer chemo-immunotherapeutics

(2016) Dickson Adah et al.   PHARMACOLOGICAL RESEARCH

Emerging role of long noncoding RNAs in lung cancer: Current status and future prospects

(2016) Hui Tao et al.   RESPIRATORY MEDICINE

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

(2016) Weiping Zou et al.   Science Translational Medicine

Control of YAP/TAZ Activity by Metabolic and Nutrient-Sensing Pathways

(2016) Giulia Santinon et al.   TRENDS IN CELL BIOLOGY

Upregulated long non-coding RNA AGAP2-AS1 represses LATS2 and KLF2 expression through interacting with EZH2 and LSD1 in non-small-cell lung cancer cells

(2016) W Li et al.   Cell Death & Disease

Rottlerin exhibits antitumor activity via down-regulation of TAZ in non-small cell lung cancer

(2016) Zhe Zhao et al.   Oncotarget

Repression of YAP by NCTD disrupts NSCLC progression

(2016) Jiwei Guo et al.   Oncotarget

Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells

(2016) Xiao-Yang Dai et al.   Oncotarget

YAP promotes erlotinib resistance in human non-small cell lung cancer cells

(2016) Ping-Chih Hsu et al.   Oncotarget

Non-Coding RNAs in Lung Cancer: Contribution of Bioinformatics Analysis to the Development of Non-Invasive Diagnostic Tools

(2016) Meik Kunz et al.   Genes

Lipid metabolic reprogramming in cancer cells

(2016) S Beloribi-Djefaflia et al.   Oncogenesis

Expression of programmed death ligand-1 on tumor cells varies pre and post chemotherapy in non-small cell lung cancer

(2016) Jin Sheng et al.   Scientific Reports

EGFR over-expression in non-small cell lung cancers harboring EGFR mutations is associated with marked down-regulation of CD82

(2015) Chi-Hwa Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Loss of RhoA expression prevents proliferation and metastasis of SPCA1 lung cancer cells in vitro

(2015) Xueying Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Prognostic role of serum p53 antibodies in lung cancer

(2015) Manlio Mattioni et al.   BMC CANCER

Targeting LKB1 in cancer – exposing and exploiting vulnerabilities

(2015) M Momcilovic et al.   BRITISH JOURNAL OF CANCER

ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors

(2015) Liem T. Nguyen et al.   CANCER CELL

Statin Use and Survival from Lung Cancer: A Population-Based Cohort Study

(2015) C. R. Cardwell et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

YAP Promotes Malignant Progression ofLkb1-Deficient Lung Adenocarcinoma through Downstream Regulation of Survivin

(2015) Wenjing Zhang et al.   CANCER RESEARCH

An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell-like Behaviors Contributing to Disease Progression

(2015) H. Hayashi et al.   CANCER RESEARCH

Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade

(2015) Yonggang Zheng et al.   DEVELOPMENTAL CELL

Crumbs3-Mediated Polarity Directs Airway Epithelial Cell Fate through the Hippo Pathway Effector Yap

(2015) Aleksander D. Szymaniak et al.   DEVELOPMENTAL CELL

Aerobic glycolysis tunes YAP/TAZ transcriptional activity

(2015) E. Enzo et al.   EMBO JOURNAL

YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins

(2015) Silvia Di Agostino et al.   EMBO REPORTS

Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP

(2015) Qian Chen et al.   GENES & DEVELOPMENT

TAZ Protein Accumulation Is Negatively Regulated by YAP Abundance in Mammalian Cells

(2015) Megan L. Finch-Edmondson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MST kinases in development and disease

(2015) Barry J. Thompson et al.   JOURNAL OF CELL BIOLOGY

R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability

(2015) Hsuan-Yu Chen et al.   JOURNAL OF CLINICAL ONCOLOGY

Implementation of Lung Cancer Screening in the United States

(2015) Jan M. Eberth et al.   JOURNAL OF THORACIC IMAGING

Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin

(2015) Matthew G Oser et al.   LANCET ONCOLOGY

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

(2015) Jung-Soon Mo et al.   NATURE CELL BIOLOGY

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

(2015) Luping Lin et al.   NATURE GENETICS

YAP Regulates S-Phase Entry in Endothelial Cells

(2015) Zhewei Shen et al.   PLoS One

YAP and TAZ: a nexus for Hippo signaling and beyond

(2015) Carsten Gram Hansen et al.   TRENDS IN CELL BIOLOGY

Statins augment efficacy of EGFR-TKIs in patients with advanced-stage non-small cell lung cancer harbouring KRAS mutation

(2015) Ondrej Fiala et al.   TUMOR BIOLOGY

MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway

(2015) Zhipeng Meng et al.   Nature Communications

Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer

(2015) E. M. Tricker et al.   Cancer Discovery

Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

(2015) G. Wang et al.   Cancer Discovery

Functional genomics screen identifies YAP1 as a key determinant to enhance treatment sensitivity in lung cancer cells

(2015) Haiying Cheng et al.   Oncotarget

Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status

(2015) Luigi Formisano et al.   Oncotarget

MDP, a database linking drug response data to genomic information, identifies dasatinib and statins as a combinatorial strategy to inhibit YAP/TAZ in cancer cells

(2015) Cristian Taccioli et al.   Oncotarget

Inhibition of ERK1/2 down-regulates the Hippo/YAP signaling pathway in human NSCLC cells

(2015) Bin You et al.   Oncotarget

Systematic analysis of design and stratification for phase III trials in first-line advanced non-small cell lung cancer

(2015) Takefumi Komiya et al.   Thoracic Cancer

Transcriptional Co-repressor Function of the Hippo Pathway Transducers YAP and TAZ

(2015) Minchul Kim et al.   Cell Reports

Overcoming resistance to targeted therapies in NSCLC: current approaches and clinical application

(2015) Paolo Maione et al.   Therapeutic Advances in Medical Oncology

A novel subset of B7-H3+CD14+HLA-DR−/lowmyeloid-derived suppressor cells are associated with progression of human NSCLC

(2015) Guangbo Zhang et al.   OncoImmunology

YAP1 acts as oncogenic target of 11q22 amplification in multiple cancer subtypes.

(2015) Erica Lorenzetto et al.   Oncotarget

Label-free quantitative proteomic analysis of the YAP/TAZ interactome

(2014) Priyanka Kohli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Myeloid-derived suppressor cell heterogeneity in human cancers

(2014) Samantha Solito et al.   Annals of the New York Academy of Sciences

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

Hippo Coactivator YAP1 Upregulates SOX9 and Endows Esophageal Cancer Cells with Stem-like Properties

(2014) S. Song et al.   CANCER RESEARCH

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

(2014) Diane D. Shao et al.   CELL

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer

(2014) Masaki Mori et al.   CELL

c-Abl antagonizes the YAP oncogenic function

(2014) R Keshet et al.   CELL DEATH AND DIFFERENTIATION

VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex

(2014) Wenjing Zhang et al.   CELL RESEARCH

An Integrative Analysis of the Tumorigenic Role of TAZ in Human Non-Small Cell Lung Cancer

(2014) S. Noguchi et al.   CLINICAL CANCER RESEARCH

Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis

(2014) A. N. Lau et al.   EMBO JOURNAL

Effect of simvastatin on the resistance to EGFR tyrosine kinase inhibitors in a non-small cell lung cancer with the T790M mutation of EGFR

(2014) Ki-Eun Hwang et al.   EXPERIMENTAL CELL RESEARCH

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

(2014) Boon Chuan Low et al.   FEBS LETTERS

Clinician Roles in Early Integrated Palliative Care for Patients with Advanced Cancer: A Qualitative Study

(2014) Anthony L. Back et al.   JOURNAL OF PALLIATIVE MEDICINE

MEK inhibition in non-small cell lung cancer

(2014) Thomas E. Stinchcombe et al.   LUNG CANCER

Aberrant large tumor suppressor 2 (LATS2) gene expression correlates with EGFR mutation and survival in lung adenocarcinomas

(2014) Susan Y. Luo et al.   LUNG CANCER

Comprehensive molecular profiling of lung adenocarcinoma

(2014) Eric A. Collisson et al.   NATURE

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase

(2014) Biao Ma et al.   NATURE CELL BIOLOGY

Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers

(2014) Francesca Cottini et al.   NATURE MEDICINE

Angiomotin decreases lung cancer progression by sequestering oncogenic YAP/TAZ and decreasing Cyr61 expression

(2014) Y-L Hsu et al.   ONCOGENE

TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells

(2014) M Bartucci et al.   ONCOGENE

The Biology of YAP/TAZ: Hippo Signaling and Beyond

(2014) Stefano Piccolo et al.   PHYSIOLOGICAL REVIEWS

Inhibition of Tumor Vasculogenic Mimicry and Prolongation of Host Survival in Highly Aggressive Gallbladder Cancers by Norcantharidin via Blocking the Ephrin Type a Receptor 2/Focal Adhesion Kinase/Paxillin Signaling Pathway

(2014) Hui Wang et al.   PLoS One

Assessment of the Potential Diagnostic Value of Serum p53 Antibody for Cancer: A Meta-Analysis

(2014) Jun Zhang et al.   PLoS One

Neuregulin 1-activated ERBB4 interacts with YAP to induce Hippo pathway target genes and promote cell migration

(2014) J. W. Haskins et al.   Science Signaling

Down-regulation of LATS2 in non-small cell lung cancer promoted the growth and motility of cancer cells

(2014) Feng Yao et al.   TUMOR BIOLOGY

Expression of LATS1 contributes to good prognosis and can negatively regulate YAP oncoprotein in non-small-cell lung cancer

(2014) Xu-Yong Lin et al.   TUMOR BIOLOGY

Early integration of palliative care services with standard oncology care for patients with advanced cancer

(2013) Joseph A. Greer et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Mst1 overexpression inhibited the growth of human non-small cell lung cancer in vitro and in vivo

(2013) C M Xu et al.   CANCER GENE THERAPY

Basic Mechanisms of Therapeutic Resistance to Radiation and Chemotherapy in Lung Cancer

(2013) Henning Willers et al.   CANCER JOURNAL

The TEAD4-YAP/TAZ Protein-Protein Interaction: Expected Similarities and Unexpected Differences

(2013) Jean Christophe Hau et al.   CHEMBIOCHEM

The Hippo superhighway: signaling crossroads converging on the Hippo/Yap pathway in stem cells and development

(2013) Evan R Barry et al.   CURRENT OPINION IN CELL BIOLOGY

Control of the Hippo Pathway by Set7-Dependent Methylation of Yap

(2013) Menno J. Oudhoff et al.   DEVELOPMENTAL CELL

Regulation of Hippo Signaling by EGFR-MAPK Signaling through Ajuba Family Proteins

(2013) B.V.V.G. Reddy et al.   DEVELOPMENTAL CELL

GPR87 Is an Overexpressed G-Protein Coupled Receptor in Squamous Cell Carcinoma of the Lung

(2013) Mathias Gugger et al.   DISEASE MARKERS

The Synthetic Compound Norcantharidin Induced Apoptosis in Mantle Cell Lymphoma In Vivo and In Vitro through the PI3K-Akt-NF-κB Signaling Pathway

(2013) Hongyan Lv et al.   Evidence-based Complementary and Alternative Medicine

Evidence for a Tumor Suppressor Role for the Large Tumor Suppressor Genes LATS1 and LATS2 in Human Cancer

(2013) Tian Yu et al.   GENETICS

The Hippo Pathway Effectors TAZ/YAP Regulate Dicer Expression and MicroRNA Biogenesis through Let-7

(2013) Steven G. Chaulk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

(2013) Morvarid Mohseni et al.   NATURE CELL BIOLOGY

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2

(2013) Yasuhiro Maejima et al.   NATURE MEDICINE

SIRT1 regulates YAP2-mediated cell proliferation and chemoresistance in hepatocellular carcinoma

(2013) B Mao et al.   ONCOGENE

Depletion of minichromosome maintenance protein 7 inhibits glioblastoma multiforme tumor growth in vivo

(2013) E P Erkan et al.   ONCOGENE

Simvastatin Inhibits Proliferation and Induces Apoptosis in Human Lung Cancer Cells

(2013) Xiaofeng Yu et al.   ONCOLOGY RESEARCH

Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta

(2013) Shalom Madar et al.   PLoS One

Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility

(2013) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switch Enhancers Interpret TGF-β and Hippo Signaling to Control Cell Fate in Human Embryonic Stem Cells

(2013) Tobias A. Beyer et al.   Cell Reports

Myeloid-Derived Suppressor Cells in the Development of Lung Cancer

(2013) M. L. Ortiz et al.   Cancer Immunology Research

SnapShot: Non-Small Cell Lung Cancer

(2012) Rebecca S. Heist et al.   CANCER CELL

Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling

(2012) Fa-Xing Yu et al.   CELL

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway

(2012) William A. Freed-Pastor et al.   CELL

Norcantharidin enhances ABT-737-induced apoptosis in hepatocellular carcinoma cells by transcriptional repression of Mcl-1

(2012) Shuijun Zhang et al.   CELLULAR SIGNALLING

Induction of apoptosis in human Hep3B hepatoma cells by norcantharidin through a p53 independent pathway via TRAIL/DR5 signal transduction

(2012) Chung-hsin Yeh et al.   Chinese Journal of Integrative Medicine

An Apoptosis Methylation Prognostic Signature for Early Lung Cancer in the IFCT-0002 Trial

(2012) F. de Fraipont et al.   CLINICAL CANCER RESEARCH

A Novel Acetylation Cycle of Transcription Co-activator Yes-associated Protein That Is Downstream of Hippo Pathway Is Triggered in Response toSN2 Alkylating Agents

(2012) Shoji Hata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prognostic Significance of TAZ Expression in Resected Non-Small Cell Lung Cancer

(2012) Mian Xie et al.   Journal of Thoracic Oncology

Prognostic significance of MCM7 expression in the bronchial brushings of patients with non-small cell lung cancer (NSCLC)

(2012) Yi-Zhen Liu et al.   LUNG CANCER

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

(2012) Karen Tumaneng et al.   NATURE CELL BIOLOGY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap

(2012) H B Nguyen et al.   ONCOGENE

YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes

(2012) T Mizuno et al.   ONCOGENE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

The genetics and biology of KRAS in lung cancer

(2012) Peter M. K. Westcott et al.   Chinese Journal of Cancer

Usefulness of Serum Anti-p53 Antibody Assay for Lung Cancer Diagnosis

(2011) Yongjung Park et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

The Tumor Suppressor RASSF1A Prevents Dephosphorylation of the Mammalian STE20-like Kinases MST1 and MST2

(2011) Cai Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer

(2011) Gouji Toyokawa et al.   Molecular Cancer

The biology of brain metastases—translation to new therapies

(2011) April F. Eichler et al.   Nature Reviews Clinical Oncology

TAZ is a novel oncogene in non-small cell lung cancer

(2011) Z Zhou et al.   ONCOGENE

Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer

(2010) Yang Wang et al.   CANCER SCIENCE

YAP is a candidate oncogene for esophageal squamous cell carcinoma

(2010) Tomoki Muramatsu et al.   CARCINOGENESIS

Src Inhibitors in Lung Cancer: Current Status and Future Directions

(2010) Sacha I. Rothschild et al.   Clinical Lung Cancer

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

(2010) I. Lian et al.   GENES & DEVELOPMENT

Differential expression of Yes-associated protein is correlated with expression of cell cycle markers and pathologic TNM staging in non–small-cell lung carcinoma☆

(2010) Jin Man Kim et al.   HUMAN PATHOLOGY

Convergence between Wnt-β-catenin and EGFR signaling in cancer

(2010) Tianhui Hu et al.   Molecular Cancer

Identification of the miR-106b 25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation

(2010) L. Poliseno et al.   Science Signaling

Norcantharidin induces cell cycle arrest and inhibits progression of human leukemic Jurkat T cells through mitogen-activated protein kinase-mediated regulation of interleukin-2 production

(2010) Hui-Fen Liao et al.   TOXICOLOGY IN VITRO

JNK phosphorylates Yes-associated protein (YAP) to regulate apoptosis

(2010) V Tomlinson et al.   Cell Death & Disease

A small-molecule metastasis inhibitor, norcantharidin, downregulates matrix metalloproteinase-9 expression by inhibiting Sp1 transcriptional activity in colorectal cancer cells

(2009) Yu-Jen Chen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Predicting drug susceptibility of non–small cell lung cancers based on genetic lesions

(2009) Martin L. Sos et al.   JOURNAL OF CLINICAL INVESTIGATION

Norcantharidin is a small-molecule synthetic compound with anti-angiogenesis effect

(2009) Yu-Jen Chen et al.   LIFE SCIENCES

Expression of minichromosome maintenance 7 (MCM7) in small lung adenocarcinomas (pT1): Prognostic implication

(2009) Shinji Fujioka et al.   LUNG CANCER

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Src as a potential therapeutic target in non-small-cell lung cancer

(2008) G. Giaccone et al.   ANNALS OF ONCOLOGY

The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

(2008) Shian Wu et al.   DEVELOPMENTAL CELL

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

LATS2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma

(2008) Mojca Stražišar et al.   LUNG CANCER

MicroRNAs in the miR-106b Family Regulate p21/CDKN1A and Promote Cell Cycle Progression

(2008) I. Ivanovska et al.   MOLECULAR AND CELLULAR BIOLOGY

Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

(2008) Dan Levy et al.   MOLECULAR CELL

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE